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JOURNAL ARTICLE
Aidan Sharkey, Adnan A Khan, Rayaan Yunus, Taha Rehman, Yifan Bu, Shirin Saeed, Robina Matyal, Feroze Mahmood
OBJECTIVES: This study aimed to evaluate the accuracy of identifying the true aortic valve (AV) annulus using 2-dimensional (2D) echocardiography, with the goal of highlighting potential misidentification issues in clinical practice. DESIGN: An observational study employing 3-dimensional (3D) datasets to generate 2D images of the AV annulus for analysis. SETTING: The study was conducted in an academic medical center. PARTICIPANTS: Three-dimensional transesophageal echocardiography datasets were obtained from 11 patients with normal AV and aortic root anatomies undergoing coronary artery bypass surgery...
March 8, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#2
REVIEW
Adnan A Khan, Rayaan Yunus, Mahad Sohail, Taha A Rehman, Shirin Saeed, Yifan Bu, Cullen D Jackson, Aidan Sharkey, Feroze Mahmood, Robina Matyal
New artificial intelligence tools have been developed that have implications for medical usage. Large language models (LLMs), such as the widely used ChatGPT developed by OpenAI, have not been explored in the context of anesthesiology education. Understanding the reliability of various publicly available LLMs for medical specialties could offer insight into their understanding of the physiology, pharmacology, and practical applications of anesthesiology. An exploratory prospective review was conducted using 3 commercially available LLMs--OpenAI's ChatGPT GPT-3...
February 1, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#3
Lisa Huang, Feroze Mahmood, Roger Laham, Ravi K Sharma, Kiran Belani
No abstract text is available yet for this article.
February 1, 2024: Journal of Cardiothoracic and Vascular Anesthesia
#4
JOURNAL ARTICLE
Anastasia Katsiampoura, Taha A Rehman, Guanqing Chen, Shahzad Shaefi, Feroze Mahmood, Ruma R Bose
No abstract text is available yet for this article.
February 12, 2024: Anesthesia and Analgesia
#5
JOURNAL ARTICLE
Rayaan A Yunus, Shirin Saeed, Nadav Levy, Raffaele Di Fenza, Aidan Sharkey, Susan Pobywajlo, Patric Liang, Marc Schermerhorn, Feroze Mahmood, Robina Matyal, Sara Neves
OBJECTIVES: To investigate whether implementation of a multidisciplinary protocol for ruptured abdominal aortic aneurysm (rAAA) management reduces rates of adverse complications. DESIGN: A retrospective before-after study. SETTING: A tertiary-care academic hospital. PARTICIPANTS: Adult patients who underwent open or endovascular rAAA repair; data were stratified into before-protocol implementation (group 1: 2015-2018) and after-protocol implementation (group 2: 2019-2022) groups...
December 17, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#6
JOURNAL ARTICLE
Leo Marcoff, Konstantinos Koulogiannis, Lilian Aldaia, Anuj Mediratta, Scott M Chadderdon, Moody M Makar, Tobias Friedrich Ruf, Theresa Gößler, Jonathan G Zaroff, Gordon K Leung, Ivy A Ku, Michael Nabauer, Paul A Grayburn, Zuyue Wang, Katie M Hawthorne, Dale E Fowler, Jacob P Dal-Bianco, Mani A Vannan, Carmine Bevilacqua, Massimiliano Meineri, Joerg Ender, Anna Flo Forner, Jyothy J Puthumana, Atizazul Hassan Mansoor, Dustin J Lloyd, Steven J Voskanian, Andrew Ghobrial, Rebecca T Hahn, Feroze Mahmood, Christiane Haeffele, Geraldine Ong, Leonhard Moritz Schneider, Dee Dee Wang, Nishant K Sekaran, Elana Koss, Priti Mehla, Serge Harb, Rhonda Miyasaka, Maria Ivannikova, Terri Stewart-Dehner, Lucas Mitchel, Sasan R Raissi, Daniel Kalbacher, Santanu Biswas, Edwin C Ho, Ythan Goldberg, Robert L Smith, Jörg Hausleiter, D Scott Lim, Linda D Gillam
BACKGROUND: The CLASP IID randomized trial (Edwards PASCAL TrAnScatheter Valve RePair System Pivotal Clinical Trial; NCT03706833) demonstrated the safety and effectiveness of the PASCAL system for mitral transcatheter edge-to-edge repair (M-TEER) in patients at prohibitive surgical risk with significant symptomatic degenerative mitral regurgitation (DMR). OBJECTIVES: This study describes the echocardiographic methods and outcomes from the CLASP IID trial and analyzes baseline variables associated with residual mitral regurgitation (MR) ≤1+...
December 1, 2023: JACC. Cardiovascular Imaging
#7
JOURNAL ARTICLE
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm
LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cell-derived microglia-like cells (iMGLs) and how it corresponds to microglia in idiopathic PD brain is not known. Here we demonstrate that LRRK2-G2019S carrying iMGL recapitulate aspects of the transcriptional signature of human idiopathic PD midbrain microglia. LRRK2-G2019S induced subtle and donor-dependent alterations in iMGL mitochondrial respiration, phagocytosis and cytokine secretion...
December 13, 2023: Scientific Reports
#8
Aidan Sharkey, Ruma R Bose, Taha A Rehman, Adnan Ali Khan, Shirin Saeed, Feroze Mahmood
Double orifice mitral valve is a rare congenital anomaly that is often associated with other congenital cardiac abnormalities. Patients may present with valvular dysfunction or may be asymptomatic and have an incidental diagnosis of double outlet mitral valve. Whether symptoms due to this pathology are present or not it is important to accurately characterize this lesion. Three-dimensional imaging is a powerful diagnostic modality for diagnosing and characterizing lesions such as this as highlighted in this case image series where we describe how three-dimensional transesophageal echocardiography was utilized to characterize both complete and incomplete bridge type double orifice mitral valve...
November 3, 2023: Echocardiography
#9
JOURNAL ARTICLE
Kendra Derry, Taha A Rehman, Aidan Sharkey, Roger J Laham, Anastasia Katsiampoura, Rayaan Ahmed Yunus, Mahnoor Sohail, Feroze Mahmood, Sohail K Mahboobi, Ruma R Bose
Transcatheter edge-to-edge repair (TEER) of the mitral valve is a complex procedure requiring continuous image guidance with 2-dimensional and 3-dimensional transesophageal echocardiography. In this context, the role of the echocardiographer is of paramount importance. Training in interventional echocardiography for procedures such as TEER requires comprehending the complicated workflow of the hybrid operating room and advanced imaging skills that go beyond traditional echocardiography training to guide the procedure...
November 2023: Journal of Cardiothoracic and Vascular Anesthesia
#10
REVIEW
Yifan Bu, Aidan Sharkey, Ruma Bose, Taha Abdul Rehman, Shirin Saeed, Adnan Khan, Rayaan Yunus, Feroze Mahmood, Robina Matyal, Sara Neves
Simulation-based training is an essential component in the education of transthoracic echocardiography (TTE). Nevertheless, current TTE teaching methods may be subject to certain limitations. Hence, the authors in this study aimed to invent a novel TTE training system employing three-dimensional (3D) printing technology to teach the basic principles and psychomotor skills of TTE imaging more intuitively and understandably. This training system comprises a 3D-printed ultrasound probe simulator and a sliceable heart model...
May 6, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#11
JOURNAL ARTICLE
Dominic Recco, Sumedh Kaul, Michelle Doherty, Dawn McDougal, Feroze Mahmood, Kamal R Khabbaz
OBJECTIVES: Residual neuromuscular blockade is associated with increased postoperative pulmonary complications. This study aimed to evaluate the effect of an extubation protocol incorporating neuromuscular blockade reversal (NMBR) by train-of-four monitoring on "fast-track" cardiac surgery outcomes. DESIGN: A retrospective cohort study. SETTING: At a university hospital. PARTICIPANTS: Out of 1,843 cardiac surgery patients, from February 2, 2015, to March 31, 2017, 957 (52%) underwent cardiac surgery on or after February 29, 2016...
July 2023: Journal of Cardiothoracic and Vascular Anesthesia
#12
JOURNAL ARTICLE
Taha A Rehman, Adnan Ali Khan, Rayaan Ahmed Yunus, Yifan Bu, Ahmed Sohail, Robina Matyal, Feroze Mahmood, Aidan Sharkey
The clinical utility of transesophageal echocardiography (TEE) is well-established for patients undergoing cardiac surgery. With the increase in percutaneous structural heart disease procedures that rely on TEE for procedural guidance, the use of TEE probes is expanding. Although there are well-established protocols for routine cleaning and decontaminating TEE probes between patient use, there is a lack of awareness and misconceptions about maintaining TEE probes' structural and electrical integrity. The electrical leakage test (ELT) is routinely performed between patient use...
July 2023: Journal of Cardiothoracic and Vascular Anesthesia
#13
JOURNAL ARTICLE
Aidan Sharkey, Feroze Mahmood, Ting Hai, Arash Khamooshian, Zhifeng Gao, Yannis Amador, Kamal Khabbaz
OBJECTIVE: Demonstrate that regional geometric differences exist between regurgitant and non-regurgitant mitral valves (MV's) in patients with coronary artery disease and due to the heterogenous and regional nature of ischemic remodeling in patients with coronary artery disease (CAD), that the available anatomical reserve and likelihood of developing mitral regurgitation (MR) is variable in non-regurgitant MV's in patients with CAD. METHODS: In this retrospective, observational study intraoperative three-dimensional transesophageal echocardiographic data was analyzed in patients undergoing coronary revascularization with MR (IMR group) and without MR (NMR group)...
April 1, 2023: Echocardiography
#14
REVIEW
Syed H Mufarrih, Rayaan A Yunus, Taha A Rehman, Mario Montealegre-Gallegos, Ruma Bose, Sohail K Mahboobi, Nada Q Qureshi, Aidan Sharkey, Feroze Mahmood
Transseptal puncture is an increasingly common procedure undertaken to gain access to the left side of the heart during structural heart disease interventions. Precision guidance during this procedure is paramount to ensure success and patient safety. As such, multimodality imaging, such as echocardiography, fluoroscopy, and fusion imaging, is routinely used to guide safe transseptal puncture. Despite the use of multimodal imaging, there is currently no uniform nomenclature of cardiac anatomy between the various imaging modes and proceduralists, and echocardiographers tend to use imaging modality-specific terminology when communicating among the various imaging modes...
June 2023: Journal of Cardiothoracic and Vascular Anesthesia
#15
JOURNAL ARTICLE
Vincent Baribeau, Kadhiresan Murugappan, Aidan Sharkey, Derek N Lodico, Daniel P Walsh, Dustin C Lin, Vanessa T Wong, Jeffrey Weinstein, Robina Matyal, Feroze Mahmood, John D Mitchell
BACKGROUND: Point-of-care ultrasound (POCUS) is commonly employed to image the heart, lungs, and abdomen. Rapid ultrasound for shock and hypotension (RUSH) exams are a critical component of POCUS employed in austere environments by Special Operations Forces (SOF) and tactical medics for triage and diagnosis. Despite its utility, training for POCUS remains largely unstandardized with respect to feedback and markers of proficiency. We hypothesized that motion analysis could objectively identify improvement in medics' performance of RUSH exams...
March 15, 2023: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
#16
EDITORIAL
Taha A Rehman, Feroze Mahmood, Aidan Sharkey
No abstract text is available yet for this article.
January 30, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#17
JOURNAL ARTICLE
Timing of Blood Transfusions and 30-Day Patient Outcomes After Coronary Artery Bypass Graft Surgery.
Syed H Mufarrih, Feroze Mahmood, Nada Q Qureshi, Rayaan A Yunus, Robina Matyal, Adnan A Khan, David C Liu, Louis Chu, Venkatachalam Senthilnathan, Michelle Doherty, Aidan Sharkey, Kamal R Khabbaz
OBJECTIVE: Packed red blood cell transfusion during coronary artery bypass graft surgery is known to be associated with adverse outcomes. However, the association of the timing between transfusions in relation to discharge and 30-day postoperative outcomes has not been studied. The study authors investigated the impact of transfusion timing on 30-day surgical outcomes. DESIGN: A retrospective review. SETTING: At a single tertiary-care academic hospital...
November 26, 2022: Journal of Cardiothoracic and Vascular Anesthesia
#18
JOURNAL ARTICLE
Jayant S Jainandunsing, Dario Massari, Jaap Jan Vos, Inez J Wijdh-den Hamer, Ad Fm van den Heuvel, Massimo A Mariani, Feroze Mahmood, Wobbe Bouma, Thomas W L Scheeren
OBJECTIVES: The objective of this study was to develop a mathematical model for mitral annular dilatation simulation and determine its effects on the individualized mitral valve (MV) coaptation reserve index (CRI). DESIGN: A retrospective analysis of intraoperative transesophageal 3-dimensionalechocardiographic MV datasets was performed. A mathematical model was created to assess the mitral CRI for each leaflet segment (A1-P1, A2-P2, A3-P3). Mitral CRI was defined as the ratio between the coaptation reserve (measured coaptation length along the closure line) and an individualized correction factor...
November 13, 2022: Journal of Cardiothoracic and Vascular Anesthesia
#19
JOURNAL ARTICLE
Syed Hamza Mufarrih, Aidan Sharkey, Feroze Mahmood, Rayaan Ahmed Yunus, Nada Qaisar Qureshi, Venkatachalam Senthilnathan, Louis Chu, David Liu, Kamal Khabbaz
OBJECTIVES: Ischemic remodeling of the left ventricle in patients with coronary artery disease (CAD) results in geometric changes of the mitral valve (MV) apparatus, leading to reduced MV leaflet coaptation. Although the calculation of the coaptation area has value in assessing the effects of left ventricular remodeling on the MV, it is difficult and time-consuming to measure. In this study the authors hypothesized that the tenting volume (TV) would have a greater association with coaptation area than tenting height (TH) or tenting area (TA)...
October 10, 2022: Journal of Cardiothoracic and Vascular Anesthesia
#20
REVIEW
Syed H Mufarrih, Nada Q Qureshi, Rayaan A Yunus, Anastasia Katsiampoura, Ibrahim Quraishi, Aidan Sharkey, Feroze Mahmood, Robina Matyal
OBJECTIVE: Postoperative morbidity in patients undergoing lower extremity amputation (LEA) has remained high. Studies investigating the influence of the anesthetic modality on the postoperative outcomes have yielded conflicting results. The aim of our study was to assess the effects of regional anesthesia vs general anesthesia on postoperative complications for patients undergoing LEA. METHODS: We systematically searched PubMed, Embase, MEDLINE, Web of Science, and Google Scholar from 1990 to 2022 for studies investigating the effect of the anesthetic modality on the postoperative outcomes after LEA...
May 2023: Journal of Vascular Surgery
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