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https://www.readbyqxmd.com/read/27836795/ultrasound%C3%A2-for%C3%A2-patients%C3%A2-in-a-high-hiv-tb-prevalence-setting-a%C3%A2-needs-assessment-and-review-of-focused-applications-for-sub-saharan-africa
#1
REVIEW
Tom Heller, Eric A Mtemang'ombe, Michaëla A M Huson, Charlotte C Heuvelings, Sabine Bélard, Saskia Janssen, Sam Phiri, Martin P Grobusch
Ultrasound is increasingly used in point-of-care applications and has great potential to support the diagnosis of infectious diseases, especially in resource-limited settings. We performed a cross-sectional study including 100 Malawian patients with a clinical indication for ultrasound and reviewed the literature on point-of-care ultrasound (POCUS) in Sub-Saharan Africa to establish its applicability, most frequent indications, findings, and implications for treatment, and therefore relevance in POCUS curricula, with a main focus on infectious diseases...
November 8, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27753744/healthy-life-years-lost-and-excess-bed-days-due-to-6-patient-safety-incidents-empirical-evidence-from-english-hospitals
#2
Katharina D Hauck, Shaolin Wang, Charles Vincent, Peter C Smith
BACKGROUND: There is little satisfactory evidence on the harm of safety incidents to patients, in terms of lost potential health and life-years. OBJECTIVE: To estimate the healthy life-years (HLYs) lost due to 6 incidents in English hospitals between the years 2005/2006 and 2009/2010, to compare burden across incidents, and estimate excess bed-days. RESEARCH DESIGN: The study used cross-sectional analysis of the medical records of all inpatients treated in 273 English hospitals...
October 6, 2016: Medical Care
https://www.readbyqxmd.com/read/27274846/challenges-in-achieving-a-target-international-normalized-ratio-for-deep-vein-thrombosis-among-hiv-infected-patients-with-tuberculosis-a-case-series
#3
C Sekaggya, D Nalwanga, A Von Braun, R Nakijoba, A Kambugu, J Fehr, M Lamorde, B Castelnuovo
BACKGROUND: Tuberculosis (TB) and HIV are among the risk factors for deep vein thrombosis (DVT). There are several challenges in the management of DVT patients with TB-HIV co-infection including drug-drug interactions and non-adherence due to pill burden. METHODS: HIV infected patients starting treatment for TB were identified and followed up two weekly. Cases of DVT were diagnosed with Doppler ultrasound and patients were initiated on oral anticoagulation with warfarin and followed up with repeated INR measurements and warfarin dose adjustment...
2016: BMC Hematology
https://www.readbyqxmd.com/read/25983290/deep-vein-thrombosis-of-the-lower-limbs-in-intravenous-drug-users
#4
REVIEW
Wiesława Kwiatkowska, Brygida Knysz, Jacek Gąsiorowski, Wojciech Witkiewicz
BACKGROUND: Addiction to intravenously administered drugs has been a serious epidemiological problem for years. Among the related health complications, deep vein thrombosis (DVT) is one of the most important. This paper provides an illustrative presentation of DVT in intravenous drug users (IDUs), HIV-positive subjects among them. METHODS: We searched PubMed, Ovid Journals, Scopus, ScienceDirect, Cochrane Library, Google Scholar and references from articles obtained...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/25892316/cardiovascular-disease-in-human-immunodeficiency-virus-infection-as-a-cause-of-hospitalization-a-case-series-in-a-general-hospital-in-peru
#5
Germán Valenzuela-Rodríguez, Edward Mezones-Holguín, Fernando Mendo-Urbina, Alfonso J Rodríguez-Morales
BACKGROUND: Cardiovascular disease in the context of human immunodeficiency virus infection has become a major clinical concern in recent years. In the current report we assess hospitalizations due to cardiovascular disease in human immunodeficiency virus patients in a Social Security reference hospital in Peru. METHODS: A retrospective study was carried out between January 1996 and December 2012 in a General Hospital in Lima, Peru. RESULTS: We included 26 patients hospitalized due to cardiovascular disease...
July 2015: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25334175/inh-resistance-on-effective-antituberculous-therapy-when-do-we-need-molecular-testing
#6
Ahmed Abuzaid, Cezarina Mindru
Infectious Disease Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: There is 7% prevalence of INH resistant MTB strains in US population, mostly in immigrant population. We rarely question the efficacy of the 4 anti-tuberculous regimen for the treatment of pansensitive strains.CASE PRESENTATION: A 53 years old white homeless male was admitted with dyspnea of few days duration, associated with subjective fever...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/24436593/a-case-series-of-hiv-seropositive-patients-and-hypercoagulable-state-is-it-difficult-to-treat-even-with-therapeutic-anticoagulation
#7
Ashish Anil Sule, Nihar Pandit, Pankaj Handa, Veerandra Chadachan, Endean Tan, Faith Nadine Choo Yun Sum, Er Hui Ling Joyce, Tay Jam Chin
Patients with human immunodeficiency virus (HIV) are at risk of developing thrombosis and are 8 to 10 times more likely to develop thrombosis than the general population. Moreover, if they have hypercoagulable state they can have severe thrombosis and life-threatening thrombotic events. The purpose of this retrospective study is to analyze hypercoagulable state in HIV-seropositive patients who have been diagnosed with venous thromboembolism (VTE). This study is a subgroup study of a larger cohort group of HIV-seropositive patients with VTE followed up with our vascular medicine outpatient clinic...
June 2013: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/24436591/risk-of-venous-thromboembolism-in-patients-infected-with-hiv-a-cohort-study
#8
Ashish Anil Sule, Nihar Pandit, Pankaj Handa, Veerandra Chadachan, Endean Tan, Faith Nadine Choo Yun Sum, Er Hui Ling Joyce, Tay Jam Chin
Introduction Human immunodeficiency virus (HIV) patients are at risk of developing thrombosis than general population. There are several intersecting mechanisms associated with HIV infection and antiviral therapy that are emerging, which may lead to vasculopathy and hypercoagulability in these patients. Methods We analyzed the HIV patients who followed up with our Vascular Medicine outpatient clinic with venous thromboembolism (VTE) over the past 3 years and followed them prospectively. The patients included were those who had minimum, regular follow-up of 3 months, with a Doppler scan in the beginning and last follow-up...
June 2013: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/24012101/the-role-of-soluble-p-selectin-in-the-diagnosis-of-venous-thromboembolism
#9
REVIEW
Constantine N Antonopoulos, George S Sfyroeras, John D Kakisis, Konstantinos G Moulakakis, Christos D Liapis
INTRODUCTION: Soluble P selectin (sPsel), a member of the selectin family of cell adhesion receptors, has been proposed as a key molecule in hemostasis and thrombosis mediating platelet rolling, generating procoagulant microparticles and enhancing fibrin deposition. The aim of this study was to examine the role of sPsel in the diagnosis of venous thromboembolism (VTE). MATERIALS AND METHODS: We performed a systematic review and we used meta-analysis to synthesize data from published studies reporting sPsel levels in patients with i) VTE (deep venous thrombosis; DVT or DVT and pulmonary embolism; PE) and ii) DVT only...
January 2014: Thrombosis Research
https://www.readbyqxmd.com/read/23699228/elevation-of-activated-partial-thromboplastin-time-after-low-dose-unfractionated-heparin
#10
Sadaf Mir, Peter Smith, Taiyo Nishimoto, Phani Surapaneni, Louis Gerolemou, Michael Elias, Elpidio Jimenez, Patricia O'Neill
SESSION TYPE: DVT/PE/Pulmonary Hypertension Posters IPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Low dose unfractionated heparin (LDUH) is used for thrombophylaxis world-wide. Elevation of activated partial thromboplastin time (APTT) and hemorrhagic complications are not expected, and APTT monitoring is not advised. Anecdotal experience at our institution suggests that in some patients LDUH may significantly raise APTT. A small number of reports in the literature are consistent with our experience...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/23115227/a-probable-interaction-between-warfarin-and-the-antiretroviral-trio-study-regimen
#11
Michelle D Liedtke, Amulya Vanguri, R Chris Rathbun
OBJECTIVE: To report a probable drug interaction between the antiretroviral TRIO regimen (ritonavir-boosted darunavir, etravirine, and raltegravir) and warfarin in an HIV-infected patient. CASE SUMMARY: In January 2010, a 50-year-old transgender female with HIV infection and recurrent deep vein thrombosis began treatment with the TRIO study regimen. Treatment had been maintained with warfarin for the past 5 years and emtricitabine monotherapy for the preceding 22 months...
November 2012: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/23068309/-beh%C3%A3-et-s-disease-revealed-by-deep-vein-thrombosis-in-an-hiv-1-infected-patient
#12
L Marih, M Sodqi, K Marhoum El Filali, A Chakib
Behçet's disease is a multisystemic vasculitis characterized by the association of recurrent oral and genital ulcers with systemic involvements, particularly ocular, nervous and vascular manifestations. The association of Behçet's disease and aids/HIV infection is rare. The role of HIV infection in the pathomechanism of both diseases is unclear. We report a 28-year-old HIV-positive patient who presented Behçet's disease complicated by deep vein thrombosis and left lateral sinus thrombosis. This rare association raises questions about the etiopathogenic process and therapeutic management...
December 2012: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/22934233/left-hemibody-swelling-in-an-hiv-positive-patient-with-congenital-heart-disease
#13
Matteo Boattini, André Almeida, Rita Barata Moura, Miguel Toscano Rico
We report the case of a 50-year-old HIV-positive woman with a congenital cyanotic heart disease who developed left axillary, subclavian, and brachiocephalic vein thrombosis and left lower aortopulmonary collateral arterial thrombosis, presenting as left hemibody swelling. We also briefly overview the literature regarding upper extremity deep vein thrombosis (UEDVT). Given the absence of other risk factors, it was our firm believe that our patient's UEDVT was due to a hypercoagulable state associated with congestive heart failure (CHF) and HIV infection...
2012: Case Reports in Vascular Medicine
https://www.readbyqxmd.com/read/22581880/complicated-lymphogranuloma-venereum-infection-mimicking-deep-vein-thrombosis-in-an-hiv-positive-man
#14
J E Kennedy, S P Higgins
A 41-year-old HIV-positive man who has sex with men (MSM) with a family history of deep vein thrombosis (DVT) presented to the emergency department with an acutely swollen lower limb. The initial clinical diagnosis was of a possible DVT and the patient was anticoagulated. However, investigations subsequently excluded DVT and sexually acquired reactive arthropathy (SARA) was eventually diagnosed. This complication followed an earlier attendance at the emergency department, where proctitis due to lymphogranuloma venereum (LGV) infection went unrecognized...
March 2012: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/22498980/cause-of-deep-venous-thrombosis-and-pulmonary-embolism-in-young-patients-from-india-as-compared-with-other-ethnic-groups
#15
Navin Pai, Kanjaksha Ghosh, Shrimati Shetty
Venous thromboembolism (VTE), which consists of deep vein thrombosis (DVT) and pulmonary embolism, is a potentially fatal disease. The existing Asian literature has shown a wide variation in the prevalence of VTE, with very limited data from India. In the present study, the risk factors for VTE in Indian patients were compared with Caucasians and Blacks. We used data prospectively collected from total of 1396 Indian patients (716 males, 680 females) enrolled over a decade and compared with White (n = 2002) and Black (n = 395) patients objectively diagnosed with VTE...
June 2012: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/22349419/recommendations-for-sepsis-management-in-resource-limited-settings
#16
REVIEW
Martin W Dünser, Emir Festic, Arjen Dondorp, Niranjan Kissoon, Tsenddorj Ganbat, Arthur Kwizera, Rashan Haniffa, Tim Baker, Marcus J Schultz
PURPOSE: To provide clinicians practicing in resource-limited settings with a framework to improve the diagnosis and treatment of pediatric and adult patients with sepsis. METHODS: The medical literature on sepsis management was reviewed. Specific attention was paid to identify clinical evidence on sepsis management from resource-limited settings. RESULTS: Recommendations are grouped into acute and post-acute interventions. Acute interventions include liberal fluid resuscitation to achieve adequate tissue perfusion, normal heart rate and arterial blood pressure, use of epinephrine or dopamine for inadequate tissue perfusion despite fluid resuscitation, frequent measurement of arterial blood pressure in hemodynamically unstable patients, administration of hydrocortisone or prednisolone to patients requiring catecholamines, oxygen administration to achieve an oxygen saturation >90%, semi-recumbent and/or lateral position, non-invasive ventilation for increased work of breathing or hypoxemia despite oxygen therapy, timely administration of adequate antimicrobials, thorough clinical investigation for infectious source identification, fluid/tissue sampling and microbiological work-up, removal, drainage or debridement of the infectious source...
April 2012: Intensive Care Medicine
https://www.readbyqxmd.com/read/21896711/delayed-diagnosis-of-kaposi-s-sarcoma-in-a-hiv-positive-man-with-a-high-cd4-count-and-suppressed-viral-load
#17
Sum Yee Chan, Mark Pakianathan
A HIV positive man with a CD4 count of 777×10(6)/l and suppressed viral load on antiretroviral medication had a delayed diagnosis of Kaposi's sarcoma (KS) affecting his left leg. He was diabetic and on a controlled diet and had a previous deep vein thrombosis affecting the same leg. Factors that have been studied in HIV-related KS as well as classical KS, such as diabetes mellitus, not smoking and previous deep vein thrombosis, may have increased our patient's risk for the development of this disease. Clinicians should consider KS as a possible diagnosis even in patients with well-controlled HIV...
December 2011: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/21674133/pulmonary-thromboembolism-in-an-east-african-tertiary-referral-hospital
#18
Julius A Ogeng'o, Moses M Obimbo, Beda O Olabu, Patrick M Gatonga, Denis Ong'era
Pulmonary thromboembolism (PTE) is a frequent cause of mortality in Kenya, but its characteristics are hardly reported in Subsaharan Africa. To describe the pattern of PTE among black Africans, in a Kenyan referral hospital. Retrospective study at Kenyatta National Hospital (KNH), Nairobi, Kenya. Records of patients seen between January 2005 and December 2009 were examined for mode of diagnosis, comorbidities, age, gender, treatment and outcome. Data were analyzed using SPSS version 15.0 and are presented in tables and bar charts...
October 2011: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/21189363/a-potential-interaction-between-warfarin-and-atovaquone
#19
Kathleen Hidalgo, Adraine Lyles, Stacey R Dean
OBJECTIVE: To report a case of increased international normalized ratio (INR) in a patient established on warfarin therapy who was then initiated on atovaquone therapy. CASE SUMMARY: A 53-year-old African American male with HIV was prescribed warfarin 5 mg/day for 12 months after diagnosis of idiopathic deep vein thrombosis and bilateral pulmonary emboli (target INR 2.5 [range 2.0-3.0]). The patient required Pneumocystis jiroveci pneumonia prophylaxis and was prescribed atovaquone instead of trimethoprim/sulfamethoxazole therapy because of the latter drug's known interaction with warfarin...
January 2011: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/20974576/development-of-diagnostic-criteria-for-serious-non-aids-events-in-hiv-clinical-trials
#20
Alan R Lifson, Waldo H Belloso, Richard T Davey, Daniel Duprez, Jose M Gatell, Jennifer F Hoy, Eric A Krum, Ray Nelson, Court Pedersen, George Perez, Richard W Price, Ronald J Prineas, Frank S Rhame, James H Sampson, John Worley, INSIGHT Study Group
PURPOSE: Serious non-AIDS (SNA) diseases are important causes of morbidity and mortality in the HAART era. We describe development of standard criteria for 12 SNA events for Endpoint Review Committee (ERC) use in START, a multicenter international HIV clinical trial. METHODS: SNA definitions were developed based upon the following: (1) criteria from a previous trial (SMART), (2) review of published literature, (3) an iterative consultation and review process with the ERC and other content experts, and (4) evaluation of draft SNA criteria using retrospectively collected reports in another trial (ESPRIT)...
July 2010: HIV Clinical Trials
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