keyword
MENU ▼
Read by QxMD icon Read
search

Cytomegalovirus newborn

keyword
https://www.readbyqxmd.com/read/29921033/surveillance-of-microcephaly-and-selected-brain-anomalies-in-argentina-relationship-with-zika-virus-and-other-congenital-infections
#1
Ana Laura Tellechea, Victoria Luppo, María Alejandra Morales, Boris Groisman, Agustin Baricalla, Cintia Fabbri, Anabel Sinchi, Alicia Alonso, Cecilia Gonzalez, Bibiana Ledesma, Patricia Masi, María Silva, Adriana Israilev, Marcela Rocha, Marcela Quaglia, María Paz Bidondo, Rosa Liascovich, Pablo Barbero
BACKGROUND: Zika virus (ZIKV) vertical transmission may lead to microcephaly and other congenital anomalies. In March and April 2016, the first outbreak of ZIKV occurred in Argentina. The objective was to describe the surveillance of newborns with microcephaly and other selected brain anomalies in Argentina, and evaluation different etiologies. METHODS: Participants were enrolled between April 2016 and March 2017. CASES: newborns from the National Network of Congenital Abnormalities of Argentina (RENAC) with head circumference lower than the 3rd percentile according to gestational age and sex, or selected brain anomalies...
June 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29912824/the-natural-history-and-rehabilitative-outcomes-of-hearing-loss-in-congenital-cytomegalovirus-a-systematic-review
#2
Kyle T Fletcher, Erin M Wolf Horrell, John Ayugi, Catherine Irungu, Maria Muthoka, Liza M Creel, Cathy Lester, Matthew L Bush
OBJECTIVE: The purpose of this study was to examine the literature regarding the natural history and rehabilitative outcomes of sensorineural hearing loss from congenital cytomegalovirus infections. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: A systematic search was performed in PubMed, PsychINFO, CINAHL, and Web of Science to identify peer-reviewed research. Eligible studies were those containing original peer-reviewed research in English addressing either the natural history or rehabilitative outcomes of sensorineural hearing loss (SNHL) in congenital cytomegalovirus (cCMV)...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29894555/clinical-characteristics-audiological-and-neurodevelopmental-outcomes-of-newborns-with-congenital-cytomegalovirus-infection
#3
Manuela Kobas, Myriam Bickle Graz, Anita Carmen Truttmann, Eric Giannoni, Pascal Meylan, Sandra Andrea Asner
BACKGROUND: Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. AIMS OF THE STUDY: (1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection...
June 12, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29889809/nonprimary-maternal-cytomegalovirus-infection-after-viral-shedding-in-infants
#4
Isabelle Boucoiran, Bryan T Mayer, Elizabeth M Krantz, Arnaud Marchant, Sunil Pati, Suresh Boppana, Anna Wald, Larry Corey, Corey Casper, Joshua T Schiffer, Soren Gantt
BACKGROUND: Most infants with congenital Cytomegalovirus (CMV) infection are born to seropositive women as a result of maternal CMV nonprimary infection (reinfection or reactivation). Although infected children are known to transmit CMV to their seronegative mothers, the frequency and magnitude of nonprimary maternal CMV infection after exposure to viral shedding by children in their household have not been characterized. METHODS: A cohort of Ugandan newborns and their mothers were tested weekly for CMV by quantitative polymerase chain reaction of oral swabs...
July 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29867968/murine-cmv-expressing-the-high-affinity-nkg2d-ligand-mult-1-a-model-for-the-development-of-cytomegalovirus-based-vaccines
#5
Lea Hiršl, Ilija Brizić, Tina Jenuš, Vanda Juranić Lisnić, Johanna Julia Reichel, Slaven Jurković, Astrid Krmpotić, Stipan Jonjić
The development of a vaccine against human cytomegalovirus (CMV) has been a subject of long-term medical interest. The research during recent years identified CMV as an attractive vaccine vector against infectious diseases and tumors. The immune response to CMV persists over a lifetime and its unique feature is the inflationary T cell response to certain viral epitopes. CMV encodes numerous genes involved in immunoevasion, which are non-essential for virus growth in vitro . The deletion of those genes results in virus attenuation in vivo , which enables us to dramatically manipulate its virulence and the immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29860410/viral-loads-in-congenital-cytomegalovirus-infection-from-a-highly-immune-population
#6
Aiqiang Xu, Shiwen Wang, Wenqiang Zhang, Xiaofang Wang, Tongzhan Wang, Xiaolin Liu, Haiyan Wang, Wei Ma, Minal Amin, Sheila Dollard, Chengbin Wang
Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P = .02).
June 1, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29847359/newborn-glaucoma-don-t-forget-infections
#7
Sushmita Kaushik, Pankaj Kataria, Gunjan Joshi, Mini P Singh, Jagat Ram
Intrauterine infections can affect various structures of the developing fetal eye. Rubella infection results in congenital cataracts, keratopathy, retinopathy and less commonly, glaucoma. Ophthalmic manifestations of Intrauterine cytomegalovirus (CMV) infection have been reported to be chorioretinitis, optic nerve colobomas and corneal opacities, but has not been implicated in congenital cataract or congenital glaucoma. Concurrent infection with both Rubella and CMV virus has not been reported. We report concurrent Rubella and CMV infection in a baby born with corneal opacification, severe congenital glaucoma and congenital cataract...
May 29, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29843259/unusual-complication-of-fulminant-congenital-cytomegalovirus-infection
#8
T Arun Babu, Y Soliman, K Mohammad
Persistent pulmonary hypertension of newborn (PPHN) is a very rare manifestation of congenital cytomegalovirus (CMV) infection. PPHN associated with CMV can be severe but is usually transient and responds well to antiviral therapy. We report a rare case of PPHN that occurred in the setting of fulminant congenital CMV infection and successful treatment with antiviral therapy along with review of the very few cases reported in literature. A male appropriate for gestational Age (AGA) newborn developed rapidly progressive respiratory distress starting at 11 hours of life requiring ventilatory support and 100% oxygen...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29784513/racial-and-ethnic-differences-in-the-prevalence-of-congenital-cytomegalovirus-infection
#9
Karen B Fowler, Shannon A Ross, Masako Shimamura, Amina Ahmed, April L Palmer, Marian G Michaels, David I Bernstein, Pablo J Sánchez, Kristina N Feja, Audra Stewart, Suresh Boppana
OBJECTIVE: To evaluate the impact of race and ethnicity upon the prevalence and clinical spectrum of congenital cytomegalovirus infection (cCMV). STUDY DESIGN: From 2007 to 2012, 100 332 infants from 7 medical centers were screened for cCMV while in the hospital. Ethnicity and race were collected and cCMV prevalence rates were calculated. RESULTS: The overall prevalence of cCMV in the cohort was 4.5 per 1000 live births (95% CI, 4.1-4.9)...
May 18, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29769344/efficient-delivery-of-hcmv-t-cell-antigens-by-attenuated-sendai-virus-vectors
#10
Richard Kiener, Markus Fleischmann, Marian Alexander Wiegand, Niels A W Lemmermann, Christiane Schwegler, Christine Kaufmann, Angelique Renzaho, Simone Thomas, Eva Felder, Hans Helmut Niller, Benedikt Asbach, Ralf Wagner
Human Cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression and the licensing of a protective HCMV vaccine remains an unmet global need. Herein, we designed and validated novel Sendai virus (SeV) vectors delivering T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a non-productive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus strain Modified Vaccinia Ankara (MVA)...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29767504/motion-based-immunological-detection-of-zika-virus-using-pt-nanomotors-and-a-cellphone
#11
Mohamed Shehata Draz, Nivethitha Kota Lakshminaraasimulu, Sanchana Krishnakumar, Dheerendranath Battalapalli, Anish Vasan, Manoj Kumar Kanakasabapathy, Aparna Sreeram, Shantanu Kallakuri, Prudhvi Thirumalaraju, Yudong Li, Stephane Hua, Xu G Yu, Daniel R Kuritzkes, Hadi Shafiee
Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2 O2 solution...
May 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29761033/diagnosis-and-treatment-of-congenital-sensorineural-hearing-loss
#12
Divya A Chari, Dylan K Chan
Purpose of Review: The aim of this report is to review current literature regarding the work-up and management of congenital sensorineural hearing loss. Recent Findings: Diagnostic evaluation of a newborn with sensorineural hearing loss begins with a complete audiologic evaluation and comprehensive history and physical exam. This review presents a diagnostic algorithm for the work-up of congenital hearing loss, focusing on the three following modalities: cytomegalovirus testing, genetic evaluation, and imaging...
December 2017: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29753934/recovery-of-cytomegalovirus-dna-from-newborn-saliva-samples-by-different-methods
#13
Oran Goshen, David M Goldfarb, Laura Book, Peter Tilley, Soren Gantt
BACKGROUND: Polymerase chain reaction (PCR) testing of saliva swabs has been shown to be an attractive method to screen for congenital cytomegalovirus (CMV) infection. However, few data are available regarding the impact of pre-analytic methods on CMV DNA recovery from saliva samples under various conditions. OBJECTIVES: The purpose of this study was to evaluate the impact of various transport media and transport conditions on the recovery of CMV DNA from spiked and clinical saliva samples from newborns using PCR testing...
May 5, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29746374/direct-saliva-real-time-polymerase-chain-reaction-assay-shows-low-birth-prevalence-of-congenital-cmv-infection-in-urban-western-india
#14
Rajlakshmi Viswanathan, Sanjay Bafna, Ravikanth Mergu, Gururajrao Deshpande, Rashmi Gunjikar, Shivshankar Gaikwad, Jayati Mullick
BACKGROUND: Congenital cytomegalovirus infection is the leading infectious cause of mental retardation, developmental delay and sensorineural deafness. Non primary infection plays a major role in transmission of this infection in countries with high maternal seroprevalence. Non invasive sampling and testing is a useful alternative to traditional methods of laboratory detection of congenital CMV infection. The present study was conducted to understand birth prevalence of congenital cytomegalovirus (cCMV) infection using molecular techniques, in an urban setting of a developing country with evidence of high maternal seroprevalence...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29735300/clinical-factor-associated-with-congenital-cytomegalovirus-infection-in-pregnant-women-with-non-primary-infection
#15
Hideto Yamada, Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Masashi Deguchi, Mayumi Morizane, Satoshi Nagamata, Kana Ozaki, Yasuhiko Ebina, Toshio Minematsu
The aim of this nested case-control study was to evaluate clinical factors associated with the occurrence of congenital cytomegalovirus (CMV) infection in pregnant women with non-primary CMV infection. In a cohort study of CMV screening for 2193 pregnant women and their newborns, seven newborns with congenital CMV infection were identified among 1287 pregnant women with non-primary CMV infection that was defined as negative IgM and positive IgG with IgG avidity index >45%. In the 1287 women with non-primary CMV infection, clinical findings and complications were compared between pregnancies with and without congenital CMV infection...
May 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29705727/does-screening-for-congenital-cytomegalovirus-at-birth-improve-longer-term-hearing-outcomes
#16
REVIEW
Cathie Hilditch, Bianca Liersch, Nicola Spurrier, Emily J Callander, Celia Cooper, Amy K Keir
Currently, the diagnosis of congenital cytomegalovirus (cCMV) infection in most highly resourced countries is based on clinical suspicion alone. This means only a small proportion of cCMV infections are diagnosed. Identification, through either universal or targeted screening of asymptomatic newborns with cCMV, who would previously have gone undiagnosed, would allow for potential early treatment with antiviral therapy, ongoing audiological surveillance and early intervention if sensorineural hearing loss (SNHL) is identified...
April 28, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29703574/closer-to-universal-newborn-screening-for-congenital-cytomegalovirus-infection-but-far-away-from-antiviral-therapy-in-all-infected-infants
#17
EDITORIAL
Shannon Ross, Sarah S Long, David W Kimberlin
No abstract text is available yet for this article.
April 24, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29684915/histological-analysis-of-term-placentas-from-hyperimmune-globulin-treated-and-untreated-mothers-with-primary-cytomegalovirus-infection
#18
Liliana Gabrielli, Maria Paola Bonasoni, Maria Pia Foschini, Enrico Maria Silini, Arsenio Spinillo, Maria Grazia Revello, Angela Chiereghin, Giulia Piccirilli, Evangelia Petrisli, Gabriele Turello, Giuliana Simonazzi, Dino Gibertoni, Tiziana Lazzarotto
BACKGROUND: The Congenital Human Cytomegalovirus Infection Prevention (CHIP) study, a randomized, blinded, placebo-controlled trial, demonstrated that the efficacy of hyperimmune globulin (HIG) was not different from that of placebo regarding transmission of cytomegalovirus (CMV) from mothers to newborns. Our aim was to analyze histologically HIG effects on placentas collected for the CHIP study. MATERIALS AND METHODS: Virological and histological analyses were performed on 40 placentas from transmitter and nontransmitter HIG-treated and untreated mothers by assessing the number of CMV-positive cells, tissue viral load, tissue damage, and compensatory mechanisms...
April 23, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29681450/concurrent-hearing-genetic-and-cytomegalovirus-screening-in-newborns-taiwan
#19
Chun-Yi Lu, Po-Nien Tsao, Ying-Ying Ke, Yi-Hsin Lin, Yin-Hung Lin, Chia-Cheng Hung, Yi-Ning Su, Wei-Chung Hsu, Wu-Shiun Hsieh, Li-Min Huang, Chen-Chi Wu, Chuan-Jen Hsu
OBJECTIVE: To evaluate the feasibility and potential benefits of incorporating genetic and cytomegalovirus (CMV) screenings into the current newborn hearing screening (NHS) programs. STUDY DESIGN: Newborns were recruited prospectively from a tertiary hospital and a maternity clinic between May 2016 and December 2016 and were subjected to hearing screening, CMV screening, and genetic screening for 4 common mutations in deafness genes (p.V37I and c.235delC of GJB2 gene, c...
April 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29613974/fatal-p-jirovecii-and-cytomegalovirus-infections-in-an-infant-with-normal-trecs-count-pitfalls-of-newborn-screening-for-severe-combined-immunodeficiency
#20
Ana Mendez-Echevarria, Gonzalez-Granado Luis Ignacio, Luis M Allende, De Felipe Beatriz, Del Rosal Teresa, Calvo Cristina, Perez-Martinez Antonio, Ruiz Garcia Raquel, Neth Olaf
Newborn screening (NBS) for severe combined immunodeficiency (SCID) using T-cell receptor-excision circles (TRECs) allows prompt diagnosis and initiation of supportive and curative therapy thereby reducing morbidity and mortality. However, profound combined immunodeficiencies with normal numbers of non-functional T cells will go undetected. We present a patient with ORAI1 deficiency and normal TREC numbers observed after diagnosis at the age of 14 months who suffered from disseminated fatal cytomegalovirus and Pneumocystis jirovecii infection, demonstrating a potential pitfall of the current NBS program...
April 2, 2018: Pediatric Infectious Disease Journal
keyword
keyword
90778
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"