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Cytomegalovirus newborn

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https://www.readbyqxmd.com/read/27882457/cytomegalovirus-vaccines-current-status-and-future-prospects
#1
REVIEW
K M Anderholm, C J Bierle, M R Schleiss
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent neurological injury in newborns, and vaccine development is accordingly a major public health priority. HCMV can also cause disease in solid organ transplant (SOT) and hematopoietic stem-cell transplant (HSCT) recipients, and a vaccine would be valuable in prevention of viremia and end-organ disease in these populations. Currently there is no licensed HCMV vaccine, but progress toward this goal has been made in recent clinical trials...
November 2016: Drugs
https://www.readbyqxmd.com/read/27881652/inhibition-of-human-cytomegalovirus-pul89-terminase-subunit-blocks-virus-replication-and-genome-cleavage
#2
Yan Wang, Lili Mao, Jayakanth Kankanala, Zhengqiang Wang, Robert J Geraghty
: Human cytomegalovirus terminase complex cleaves the concatemeric genomic DNA into unit lengths during genome packaging and particle assembly. This process is an attractive drug target because cleavage of concatemeric DNA is not required in mammalian cell DNA replication, indicating that drugs targeting the terminase complex could be safe and selective. One component of the human cytomegalovirus terminase complex, pUL89, provides the endonucleolytic activity for genome cleavage and the domain responsible is reported to have an RNase H-like fold...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27832434/monitoring-of-venus-transgenic-cell-migration-during-pregnancy-in-non-transgenic-rabbits
#3
N Lipták, O I Hoffmann, A Kerekes, G Iski, D Ernszt, K Kvell, L Hiripi, Z Bősze
Cell transfer between mother and fetus were demonstrated previously in several species which possess haemochorial placenta (e.g. in humans, mice, rats, etc.). Here we report the assessment of fetal and maternal microchimerism in non-transgenic (non-TG) New Zealand white rabbits which were pregnant with transgenic (TG) fetuses and in non-TG newborns of TG does. The TG construct, including the Venus fluorophore cDNA driven by a ubiquitous cytomegalovirus enhancer, chicken ß-actin promoter (CAGGS), was previously integrated into the rabbit genome by Sleeping Beauty transposon system...
November 10, 2016: Transgenic Research
https://www.readbyqxmd.com/read/27816221/congenital-cytomegalovirus-among-children-with-cerebral-palsy
#4
Hayley Smithers-Sheedy, Camille Raynes-Greenow, Nadia Badawi, Marian A Fernandez, Alison Kesson, Sarah McIntyre, Kin-Chuen Leung, Cheryl A Jones
OBJECTIVES: To determine the proportion of children with cerebral palsy (CP) and cytomegalovirus (CMV) DNA detected retrospectively in their newborn screening cards (NBSC), to compare the proportion of children with CMV DNA in their NBSC across spastic subtypes of CP, and to compare the sex and other characteristics of children with CP and CMV detected on their NSBC with those in whom CMV DNA was not detected. STUDY DESIGN: Retrospective observational study. Data were extracted from patient records on children with CP (birth years 1996-2014) from 2 Australian state CP registers and state-wide paediatric rehabilitation services with consent...
November 3, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27783090/dual-intravitreal-injections-with-foscarnet-and-ganciclovir-for-ganciclovir-resistant-recurrent-cytomegalovirus-retinitis-in-a-congenitally-infected-infant
#5
Joseph D Boss, Kevin Rosenberg, Rajiv Shah
Resistant strains of cytomegalovirus can be difficult to treat in cases of congenital cytomegalovirus retinitis. The authors describe a case of recurrent bilateral congenital cytomegalovirus retinitis in an immunocompetent newborn with ganciclovir resistance successfully treated uniquely with dual therapy of intravenous ganciclovir and foscarnet and dual intravitreal injections with ganciclovir and foscarnet. [J Pediatr Ophthalmol Strabismus. 2016;53:e58-e60.].
October 22, 2016: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27781101/cytomegalovirus-vaccines-under-clinical-development
#6
EDITORIAL
Mark R Schleiss
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of disability in newborn infants. CMV also causes serious disease in solid organ (SOT) and haematopoietic stem cell transplant (HSCT) recipients. In otherwise healthy children and adults, primary CMV infection rarely causes illness. However, even asymptomatic CMV infections may predispose an individual towards an increased risk of atherosclerosis, cancer and immune senescence over the life course, although such associations remain controversial...
October 5, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27769314/maternal-and-congenital-cytomegalovirus-infection-and-zero-rubella-igm-prevalence-in-newborns-in-st-paul-s-hospital-millennium-medical-college
#7
Yeshwondm Mamuye, Balkachew Nigatu, Delayehu Bekele, Mekonen Getahun
BACKGROUND: Maternal cytomegalovirus (CMV) and Rubella infections result in adverse neonatal outcomes. Both CMV and Rubella are more widespread in developing countries and in communities with lower socioeconomic status. Thus, the aim of this study was to determine IgM specific to CMV and Rubella among newborns and Maternal CMV-seroprevalence and to identify risk factors. METHOD AND FINDING: Using cross sectional study design a total of 312 (156 newborns and 156 mothers) study participants were recruited by simple random sampling technique from gynecology outpatient department (OPD) and ward, starting from April 1, 2015 to June 30, 2015...
October 21, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27723885/cost-effectiveness-of-universal-and-targeted-newborn-screening-for-congenital-cytomegalovirus-infection
#8
Soren Gantt, Francois Dionne, Fred K Kozak, Oran Goshen, David M Goldfarb, Albert H Park, Suresh B Boppana, Karen Fowler
Importance: Congenital cytomegalovirus (cCMV) infection is a major cause of childhood deafness. Most cCMV infections are not diagnosed without newborn screening, resulting in missed opportunities for directed care. Objective: To estimate the cost-effectiveness of universal and targeted newborn cCMV screening programs compared with no cCMV screening. Design, Setting, and Participants: Models were constructed using rates and outcomes from prospective cohort studies of newborn cCMV screening in US postpartum care and early hearing programs...
December 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27673425/treatment-of-perinatal-viral-infections-to-improve-neurologic-outcomes
#9
REVIEW
William J Muller
Viral infections in the fetus or newborn often involve the central nervous system (CNS) and can lead to significant morbidity and mortality. Substantial progress has been made in identifying interventions decreasing adverse neurodevelopmental outcomes in this population. This review highlights progress in treatment of important viruses affecting the CNS in these susceptible hosts, focusing on herpes simplex virus (HSV), cytomegalovirus (CMV), human immunodeficiency virus (HIV), and enteroviruses. The observation that high-dose acyclovir improves mortality in neonatal HSV disease culminated decades of antiviral research for this disease...
October 26, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27668906/postnatal-cytomegalovirus-infection-in-an-infant-with-congenital-thrombocytopenia-how-it-can-support-or-mislead-the-diagnosis-of-wiskott-aldrich-syndrome
#10
Dimitri Poddighe, Elena Virginia, Marco Nedbal, Annarosa Soresina, Paola Bruni
A male newborn developed a post-natal cytomegalovirus (CMV) infection, arising in the clinical setting of congenital thrombocytopenia, which was diagnosed as being alloimmune. The evidence of active CMV infection in an infant showing slow-resolution lower airways infection, persistent neonatal and low platelet volume thrombocytopenia, and diffuse eczema (associated to very high levels of serum immunoglobulin E) led to the diagnosis of Wiskott-Aldrich syndrome (WAS) before the third month of life, despite the presence of several confounding clinical factors...
September 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27638253/persistent-cytomegalovirus-infection-in-amniotic-membranes-of-the-human-placenta
#11
Takako Tabata, Matthew Petitt, June Fang-Hoover, Martin Zydek, Lenore Pereira
Human cytomegalovirus (HCMV) is the leading viral cause of birth defects, including microcephaly, neurological deficits, hearing impairment, and vision loss. We previously reported that epithelial cells in amniotic membranes of placentas from newborns with intrauterine growth restriction and underlying congenital HCMV infection contain viral proteins in cytoplasmic vesicles. Herein, we immunostained amniotic membranes from 51 placentas from symptomatic and asymptomatic congenital infection with HCMV DNA in amniotic fluid and/or newborn saliva, intrauterine growth restriction, preterm deliveries, and controls...
November 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27623506/transcriptome-altered-by-latent-human-cytomegalovirus-infection-on-thp-1-cells-using-rna-seq
#12
Qi Zhang, Mei-Mei Lai, Yun-Yan Lou, Bin-Han Guo, Hui-Yan Wang, Xiao-Qun Zheng
Human cytomegalovirus (HCMV) has been recognized as a cause of severe, sometimes life-threatening disease in congenitally infected newborns as well as in immunocompromised individuals. However, the molecular mechanisms of the host-virus interaction remain poorly understood. Here, we profiled the expression of mRNAs and long noncoding RNAs (lncRNAs) in THP-1 cells using the emerging RNA-seq to investigate the transcriptional changes during HCMV latent infection. At 4 days post HCMV infection, a total of 169,008,624 sequence reads and 180,616 transcripts were obtained, respectively...
December 5, 2016: Gene
https://www.readbyqxmd.com/read/27622435/cerebral-microcalcifications-in-a-newborn-with-congenital-tuberculosis
#13
Yolanda Cifuentes, Martha Isabel Murcia, Jorge Piar, Patricia Pardo
Tuberculosis is a serious public health problem worldwide. In 2012, the World Health Organization estimated 8.6 million new cases and 1.3 million deaths due to the disease. In 2011, the incidence in Colombia was 24 cases per 100,000 inhabitants. There is little information about tuberculosis in pregnant women, and congenital infection is considered a rare disease that is difficult to diagnose, leads to high mortality, and may be confused with tuberculosis acquired after birth. In addition, it has been associated with HIV infection in mothers and infants...
2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27607910/update-on-treatment-of-cytomegalovirus-infection-in-pregnancy-and-of-the-newborn-with-congenital-cytomegalovirus
#14
William D Rawlinson, Stuart T Hamilton, Wendy J van Zuylen
PURPOSE OF REVIEW: The purpose of this review is to assess the recent studies of therapy of pregnant women and neonates, aimed at preventing the consequences of congenital cytomegalovirus (CMV) infection. RECENT FINDINGS: A recent randomized controlled trial of treatment of CMV during pregnancy with hyperimmune globulin did not show significant efficacy in prevention of foetal infection and morbidity, although there was a trend towards improvement with treatment...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27594857/linking-susceptibility-to-infectious-diseases-to-immune-system-abnormalities-among-hiv-exposed-uninfected-infants
#15
REVIEW
Candice Ruck, Brian A Reikie, Arnaud Marchant, Tobias R Kollmann, Fatima Kakkar
HIV-exposed uninfected (HEU) infants experience increased overall mortality from infectious causes when compared to HIV-unexposed uninfected (HU) infants. This is the case in both the resource-rich and resource-limited settings. Here, we explore the concept that specific types of infectious diseases that are more common among HEU infants could provide clues as to the potential underlying immunological abnormalities. The most commonly reported infections in HEU vs. HU infants are caused by encapsulated bacteria, suggesting the existence of a less effective humoral (antibody, complement) immune response...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27524538/seroprevalence-of-human-cytomegalovirus-hcmv-infection-in-pregnant-women-and-outcomes-of-pregnancies-with-active-infection
#16
Ghulam Mujtaba, Shahzad Shaukat, Mehar Angez, Muhammad Masroor Alam, Fariha Hasan, Syed Sohail Zahoor Zaidi, Aamer Ali Shah
OBJECTIVE: To determine the prevalence of cytomegalovirus in pregnant women and types of overt congenital infection in neonates. METHODS: This cross-sectional study was conducted at the Pakistan Institute of Medical Sciences and Federal Government Services Hospital in Islamabad, Pakistan, from March 2010 to June 2011, and comprised blood samples of pregnant women. Seroprevalence of human cytomegalovirus, immunoglobulin G and immunoglobulin M was determined by enzyme-linked immunosorbent assay while its deoxyribonucleic acid was detected by nested polymerase chain reaction...
August 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27521362/a-phase-1-study-of-4-live-recombinant-human-cytomegalovirus-towne-toledo-chimera-vaccines-in-cytomegalovirus-seronegative-men
#17
Stuart P Adler, Anne-Marie Manganello, Ronzo Lee, Michael A McVoy, Daniel E Nixon, Stanley Plotkin, Edward Mocarski, Josephine H Cox, Patricia E Fast, Pavlo A Nesterenko, Susan E Murray, Ann B Hill, George Kemble
BACKGROUND:  Human cytomegalovirus (HCMV) infection causes disease in newborns and transplant recipients. A HCMV vaccine (Towne) protects transplant recipients. METHODS:  The genomes of Towne and the nonattenuated Toledo strain were recombined, yielding 4 Towne/Toledo chimera vaccines. Each of 36 HCMV-seronegative men received 1 subcutaneous dose of 10, 100, or 1000 plaque-forming units (PFU) in cohorts of 3. Safety and immunogenicity were evaluated over 12 weeks after immunization and for 52 weeks for those who seroconverted...
November 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27518751/newborn-screening-for-congenital-cytomegalovirus-infection-in-iran
#18
Naeme Javid, Fatemeh Cheraghali, Abdolvahab Moradi, Mishar Kelishadi, Alijan Tabarraei
No abstract text is available yet for this article.
September 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27515898/parent-misidentification-leading-to-the-breastfeeding-of-the-wrong-baby-in-a-neonatal-intensive-care-unit
#19
Charles W Sauer, Krishelle L Marc-Aurele
BACKGROUND Because there are clear benefits to breast milk over formula for infants, the goal of the World Health Organization is to increase breastfeeding rates. As more women are breastfeeding and providing breast milk to newborns in hospitals, there is increased risk for administration error. CASE REPORT A hospitalized preterm infant was breastfed by the wrong mother when the Neonatal Intensive Care Unit Nurse failed to properly identify the mother. An infectious disease workup done on the donor mother was negative, but the recipient infant was positive for cytomegalovirus (CMV)...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27334585/a-novel-non-replication-competent-cytomegalovirus-capsid-mutant-vaccine-strategy-is-effective-in-reducing-congenital-infection
#20
K Yeon Choi, Matthew Root, Alistair McGregor
UNLABELLED: Congenital cytomegalovirus (CMV) infection is a leading cause of mental retardation and deafness in newborns. The guinea pig is the only small animal model for congenital CMV infection. A novel CMV vaccine was investigated as an intervention strategy against congenital guinea pig cytomegalovirus (GPCMV) infection. In this disabled infectious single-cycle (DISC) vaccine strategy, a GPCMV mutant virus was used that lacked the ability to express an essential capsid gene (the UL85 homolog GP85) except when grown on a complementing cell line...
September 1, 2016: Journal of Virology
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