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Cytomegalovirus newborn

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https://www.readbyqxmd.com/read/29613974/fatal-p-jirovecii-and-cytomegalovirus-infections-in-an-infant-with-normal-trecs-count-pitfalls-of-newborn-screening-for-severe-combined-immunodeficiency
#1
Ana Mendez-Echevarria, Gonzalez-Granado Luis Ignacio, Luis M Allende, De Felipe Beatriz, Del Rosal Teresa, Calvo Cristina, Perez-Martinez Antonio, Ruiz Garcia Raquel, Neth Olaf
Newborn screening (NBS) for severe combined immunodeficiency (SCID) using T-cell receptor-excision circles (TRECs) allows prompt diagnosis and initiation of supportive and curative therapy thereby reducing morbidity and mortality. However, profound combined immunodeficiencies with normal numbers of non-functional T cells will go undetected. We present a patient with ORAI1 deficiency and normal TREC numbers observed after diagnosis at the age of 14 months who suffered from disseminated fatal cytomegalovirus and Pneumocystis jirovecii infection, demonstrating a potential pitfall of the current NBS program...
April 2, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29571077/neonates-with-congenital-cytomegalovirus-and-hearing-loss-identified-via-the-universal-newborn-hearing-screening-program
#2
William D Rawlinson, Pamela Palasanthiran, Beverly Hall, Laila Al Yazidi, Michael J Cannon, Carolyn Cottier, Wendy J van Zuylen, Monica Wilkinson
BACKGROUND: Congenital cytomegalovirus (CMV) is the most common non-genetic cause of sensorineural hearing loss. Currently, there are no universal CMV screening programs for newborns or routine CMV testing of neonates with hearing loss in Australia, or elsewhere. OBJECTIVES: This study was undertaken to determine the prevalence of congenital CMV infection in infants with hearing loss identified using routine resources via the Australian universal neonatal hearing screening (UNHS) program...
March 15, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29557247/hearing-trajectory-in-children-with-congenital-cytomegalovirus-infection
#3
Tatiana M Lanzieri, Winnie Chung, Jessica Leung, A Chantal Caviness, Jason L Baumgardner, Peggy Blum, Stephanie R Bialek, Gail Demmler-Harrison
Objectives To compare hearing trajectories among children with symptomatic and asymptomatic congenital cytomegalovirus infection through age 18 years and to identify brain abnormalities associated with sensorineural hearing loss (SNHL) in asymptomatic case patients. Study Design Longitudinal prospective cohort study. Setting Tertiary medical center. Subjects and Methods The study included 96 case patients (4 symptomatic and 92 asymptomatic) identified through hospital-based newborn cytomegalovirus screening from 1982 to 1992 and 72 symptomatic case patients identified through referrals from 1993 to 2005...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29554325/the-burden-of-congenital-cytomegalovirus-infection-a-prospective-cohort-study-of-20-000-infants-in-finland
#4
Laura Puhakka, Maija Lappalainen, Tuula Lönnqvist, Riina Niemensivu, Päivi Lindahl, Tea Nieminen, Raija Seuri, Irmeli Nupponen, Sunil Pati, Suresh Boppana, Harri Saxen
Background: Congenital cytomegalovirus (cCMV) infection is the most common congenital infection and causes significant morbidity. This study was undertaken to evaluate the benefits of screening newborns for cCMV and to understand the cCMV disease burden in Finland. Methods: Infants born in Helsinki area hospitals were screened for CMV by testing their saliva with a real-time polymerase chain reaction assay. The CMV-positive infants and matched controls were monitored to determine their neurodevelopmental, audiological, and ophthalmological outcomes at 18 months of age...
March 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29538464/congenital-cytomegalovirus-parvovirus-and-enterovirus-infection-in-mozambican-newborns-at-birth-a-cross-sectional-survey
#5
Lola Madrid, Rosauro Varo, Sonia Maculuve, Tacilta Nhampossa, Carmen Muñoz-Almagro, Enrique J Calderón, Cristina Esteva, Carla Carrilho, Mamudo Ismail, Begoña Vieites, Vicente Friaza, María Del Carmen Lozano-Dominguez, Clara Menéndez, Quique Bassat
BACKGROUND: Congenital cytomegalovirus (cCMV) infection is the most prevalent congenital infection acquired worldwide, with higher incidence in developing countries and among HIV-exposed children. Less is known regarding vertical transmission of parvovirus B19 (B19V) and enterovirus (EV). We aimed to assess the prevalence of CMV, B19V and EV vertical transmission and compare results of screening of congenital CMV obtained from two different specimens in a semirural Mozambican maternity...
2018: PloS One
https://www.readbyqxmd.com/read/29534259/sonographic-diagnosis-of-meningoencephalitis-in-newborns-and-infants
#6
Karl-Heinz Deeg
Prenatal, neonatal meningoencephalitis and infections of the brain in older infants are often associated with serious complications which can be diagnosed by sonography through the open fontanelles. Most frequently postmeningitic hydrocephalus and subdural effusions occur. Rarer complications are brain abscesses and ventriculitis which are caused by gram negative bacteria such as E. coli, Serratia marcescens, Proteus and Enterobacter. A serious complication after ventriculitis is the development of compartment hydrocephalus...
March 13, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29531245/using-massively-parallel-shotgun-sequencing-of-maternal-plasmatic-cell-free-dna-for-cytomegalovirus-dna-detection-during-pregnancy-a-proof-of-concept-study
#7
Virginie Chesnais, Alban Ott, Emmanuel Chaplais, Samuel Gabillard, Diego Pallares, Christelle Vauloup-Fellous, Alexandra Benachi, Jean-Marc Costa, Eric Ginoux
Human cytomegalovirus (HCMV) primary infections of pregnant women can lead to congenital infections of the fetus that could have severe impacts on the health of the newborn. Recent studies have shown that 10-100 billion DNA fragments per milliliter of plasma are circulating cell-free. The study of this DNA has rapidly expanding applications to non-invasive prenatal testing (NIPT). In this study, we have shown that we can detect viral specific reads in the massively parallel shotgun sequencing (MPSS) NIPT data...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29513124/a-rational-approach-to-identifying-newborns-with-hearing-loss-caused-by-congenital-cytomegalovirus-infection-by-dried-blood-spot-screening
#8
Hideaki Moteki, Yuichi Isaka, Yuji Inaba, Mitsuo Motobayashi, Shin-Ya Nishio, Satoshi Ohira, Takuya Yano, Satoshi Iwasaki, Tanri Shiozawa, Kenichi Koike, Shin-Ichi Usami
OBJECTIVE: Congenital cytomegalovirus (cCMV) infection is the most common congenital infection, with the majority of infected newborns having no detectable signs. The aim of this study was to examine the accuracy of our newly developed DBS-based assay as an appropriate mass screening method for cCMV infection. METHODS: Between May 2011 and October 2016, newborns delivered at six hospitals in Nagano Prefecture, Japan were enrolled prospectively. We employed dried blood spot (DBS)-based assays with real-time quantitative PCR (qPCR)...
March 7, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29512778/mcmv-triggers-ros-nlrp3-associated-inflammasome-activation-in-the-inner-ear-of-mice-and-cultured-spiral-ganglion-neurons-contributing-to-sensorineural-hearing-loss
#9
Wei Zhuang, Caiji Wang, Xi Shi, Shiwei Qiu, Shili Zhang, Bing Xu, Min Chen, Wen Jiang, Hongyan Dong, Yuehua Qiao
Congenital cytomegalovirus (CMV) infection is the most common infectious cause of sensorineural hearing loss in children. While the importance of CMV‑induced SNHL has been described, the mechanisms underlying its pathogenesis and the role of inflammatory responses remain elusive. The present study established an experimental model of hearing loss after systemic infection with murine CMV (MCMV) in newborn mice. Auditory brainstem responses were tested to evaluate hearing at 3 weeks, expression of inflammasome‑-associated factors was assessed by immunofluorescence, western blot analysis, reverse transcription‑quantitative polymerase chain reaction and ELISA...
March 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29507070/model-based-dosage-individualization-of-ganciclovir-in-neonates-and-young-infants-with-congenital-cytomegalovirus-infection-a-pilot-study
#10
Qian Dong, Stephanie Leroux, Hai-Yan Shi, Hai-Yan Xu, Chen Kou, Muhammad Wasim Khan, Evelyne Jacqz-Aigrain, Wei Zhao
Background: Newborns with congenital cytomegalovirus (CMV) infection are at high risk for developing permanent sequelae. Intravenous ganciclovir therapy is frequently used for the treatment of congenital CMV infection. Target area under the concentration versus time curve (AUC0-24 ) of 40-50 μg·h/mL is recommended. The standard dose resulted in a large variability in ganciclovir exposure in newborns, indicating the unmet need of dosage individualization in this vulnerable population, but the implementation of this strategy remains challenging in clinical practice...
March 5, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29503274/cytomegalovirus-enterocolitis-in-a-term-neonate
#11
Siva Prasad Vyasam, Thangaraj Abiramalatha, Nalapalu Srinivasan Hema, Niranjan Thomas
BACKGROUND: Cytomegalovirus (CMV) enterocolitis is rare in term neonates. CASE CHARACTERISTICS: A term newborn with persistent pneumonia from birth developed enterocolitis on day 18 of life. OUTCOME: Polymerase chain reaction (PCR) for CMV DNA was positive in urine sample. Antiviral therapy for six weeks resulted in successful treatment without any stricture formation. MESSAGE: CMV enterocolitis should be considered as a differential diagnosis in atypical cases of necrotizing enterocolitis in neonates...
February 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29503048/congenital-cytomegalovirus-infection
#12
REVIEW
Karen B Fowler, Suresh B Boppana
Each year, thousands of children are born with or develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits from congenital CMV infection (cCMV). However, awareness of cCMV and its associated sequelae is very low in pregnant women and healthcare providers. Both targeted and universal approaches to screen newborns for CMV infection are now achievable due to recent scientific advances including the development of a rapid, high-throughput method for detecting CMV in saliva, the efficacy of antiviral treatment in symptomatic infants, and the demonstration of cost effectiveness of CMV screening...
March 1, 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29490704/what-family-doctors-know-about-congenital-cmv-a-regional-survey-in-iran
#13
Ahmad Hosseinzadeh Adli, Chiman Karami, Sanaz Baghban Rahimi, Azam Mirarab, Alijan Tabarraei
BACKGROUND: Since there is no effective treatment or vaccine against the congenital cytomegalovirus (cCMV) infection, knowledge and awareness of medical doctor's (MDs) especially family doctors are essential for preventive strategies and it also seems to be usually ignored by healthcare providers. Aim of this study was to investigate awareness of MDs about cCMV infection in Iran. METHODS: A single page questionnaire was randomly distributed among 450 MDs including general practitioners, pediatricians, gynecologists, internal and other medical specialists concerning of their knowledge in clinical presentation, diagnosis, prevention, prognosis, epidemiology, transmission, and management of cCMV infection...
March 1, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29486386/long-term-stability-of-cmv-dna-in-human-breast-milk
#14
Soya S Sam, Jessica Ingersoll, Lori D Racsa, Angela M Caliendo, Patrick N Racsa, Doris Igwe, Deborah Abdul-Ali, Cassandra Josephson, Colleen S Kraft
BACKGROUND: Human cytomegalovirus (CMV) is the leading cause of intrauterine and perinatal viral infection. The most common route of CMV transmission in newborns is through breastmilk and this can lead to infant morbidity and mortality. Breast milk that has been frozen for an extended period may need to be tested for CMV DNA to determine the source of infection. It has been a challenge for clinical laboratories to ensure the stability of CMV DNA in frozen breast milk for accurate viral load measurement...
May 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29479184/diagnosis-and-management-of-infants-with-congenital-cytomegalovirus-infection
#15
Soren Gantt, Ari Bitnun, Christian Renaud, Fatima Kakkar, Wendy Vaudry
Congenital cytomegalovirus infection (cCMV) is the most common congenital infection, occurring in approximately 0.5% of live births. Most infected newborns are asymptomatic, but up to 20% develop sensorineural hearing loss or other permanent neurologic sequelae. The presentation of newborns with symptomatic cCMV is highly variable, and the infection is usually not diagnosed in the absence of a screening program. Newborn cCMV screening programs are estimated to be beneficial and cost-effective, and are increasingly being implemented...
May 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29467314/a-prominent-role-of-the-human-cytomegalovirus-ul8-glycoprotein-restraining-pro-inflammatory-cytokine-production-by-myeloid-cells-at-late-times-during-infection
#16
Natàlia Pérez-Carmona, Pablo Martínez-Vicente, Domènec Farré, Ildar Gabaev, Martin Messerle, Pablo Engel, Ana Angulo
Human cytomegalovirus (HCMV) persistence in infected individuals relies on a plethora of mechanisms to efficiently reduce host immune responses. To that end, HCMV commits a variety of gene products, some of which have not been identified yet. Here we characterized the UL8 gene, which consists of two exons, sharing the first with the HCMV RL11 family member UL7 UL8 is a transmembrane protein with an N-terminal immunoglobulin (Ig)-like domain in common with UL7 but with an extended stalk and a distinctive cytoplasmic tail...
February 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29456230/isolated-renal-involvement-of-cytomegalovirus-inclusion-disease-in-an-infant
#17
Subramaniam Murugananth, Rajendran Padmaraj, Natarajan Gopalakrishnan, Rajendran Manorajan, Anila Abraham Kurien, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan
Cytomegalovirus (CMV) is the most common cause of congenital infections in humans occurring in 1% of all liveborns. Symptomatic congenital CMV infection involves multiple systems and causes significant morbidity and mortality in newborns. Isolated CMV infection of the kidneys in a living infant has not been reported in literature. Here, we report an infant who presented only with renomegaly and renal biopsy showed extensive CMV inclusions. Serum and urine polymerase chain reaction for CMV were positive, and CMV involvement of other organs was ruled out...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29401303/contribution-of-breastfeeding-to-false-positive-saliva-pcr-for-newborn-congenital-cytomegalovirus-screening
#18
Shannon A Ross, Marian G Michaels, Amina Ahmed, April L Palmer, Pablo J Sánchez, David I Bernstein, Kristina Feja, Audra Stewart, Suresh B Boppana, Karen B Fowler
Real time PCR of saliva is highly sensitive for newborn congenital CMV screening. This study utilizes nationally published CMV seroprevalence and breastfeeding rates to estimate the contribution of CMV DNA in breast milk to false-positive saliva PCR results. The false positive rates adjusted for breast feeding ranged from 0.03% in white Hispanics to 0.14% in white non-Hispanics. Saliva CMV PCR for newborn screening is highly sensitive and the low false positive rates in this study suggest that saliva PCR results are unlikely to be significantly influenced by breastfeeding or other perinatal exposures...
February 1, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29373759/results-of-a-targeted-screening-program-for-congenital-cytomegalovirus-infection-in-infants-who-fail-newborn-hearing-screening
#19
Emily Vancor, Eugene D Shapiro, Jaspreet Loyal
Background: Congenital cytomegalovirus (CMV) infection is a major cause of sensorineural hearing loss. By law, newborns in Connecticut who fail newborn hearing screening are tested for infection with CMV. This targeted screening is controversial, because most children with congenital CMV infection are asymptomatic, and CMV-related hearing loss can have a delayed onset. Our hospital uses a saliva polymerase chain reaction (PCR) assay (confirmed by a urine PCR assay) to detect CMV. Here, we report the results of the first year of our screening program...
January 24, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29359492/cost-effectiveness-of-universal-and-targeted-newborn-screening-for-congenital-cytomegalovirus-infection
#20
Cathie Hilditch, Amy K Keir
No abstract text is available yet for this article.
January 23, 2018: Acta Paediatrica
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