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Antibiofilm activity

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https://www.readbyqxmd.com/read/28636236/assessment-of-silibinin-as-a-potential-antifungal-agent-and-investigation-of-its-mechanism-of-action
#1
Dae Gyu Yun, Dong Gun Lee
Silibinin, which is derived from Silybum marianum (milk thistle), has used as a traditional remedy for liver or biliary disorders and known to have superior antioxidant activity. In addition, silibinin was recently reported to have antifungal effect related to fungal apoptosis against Candida albicans and the interest in the therapeutic effect is increasing. In this study, we found another mode of antifungal action of silibinin and its antibiofilm activity on C. albicans. To investigate influence on fungal plasma membrane, propidium iodide and bis-(1, 3-dibutylbarbituric acid) trimethineoxonol [DiBAC4 (3)] assay were primarily carried out...
June 21, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28634301/microbial-glycoside-hydrolases-as-antibiofilm-agents-with-cross-kingdom-activity
#2
Brendan D Snarr, Perrin Baker, Natalie C Bamford, Yukiko Sato, Hong Liu, Mélanie Lehoux, Fabrice N Gravelat, Hanna Ostapska, Shane R Baistrocchi, Robert P Cerone, Elan E Filler, Matthew R Parsek, Scott G Filler, P Lynne Howell, Donald C Sheppard
Galactosaminogalactan and Pel are cationic heteropolysaccharides produced by the opportunistic pathogens Aspergillus fumigatus and Pseudomonas aeruginosa, respectively. These exopolysaccharides both contain 1,4-linked N-acetyl-d-galactosamine and play an important role in biofilm formation by these organisms. Proteins containing glycoside hydrolase domains have recently been identified within the biosynthetic pathway of each exopolysaccharide. Recombinant hydrolase domains from these proteins (Sph3h from A...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629011/chitosan-nanoparticles-as-alternative-anti-staphylococci-agents-bactericidal-antibiofilm-and-antiadhesive-effects
#3
E M Costa, S Silva, S Vicente, C Neto, P M Castro, M Veiga, R Madureira, F Tavaria, M M Pintado
Chitosan is a biocompatible, bioactive, non-toxic polymer that due to these characteristics has been widely used as a carrier for targeted delivery of bioactive molecules. In recent years, and considering that chitosan has a strong antimicrobial potential, the scientific community's focus has shifted onto the possible antimicrobial activity of chitosan nanoparticles. With this in mind, the aim of this work was to produce low molecular weight chitosan nanoparticles, through the ionic gelation method and characterize their potential biological activity against three staphylococci (MSSA, MRSA and MRSE) in planktonic and sessile environments...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628170/recent-advances-and-perspectives-in-the-design-and-development-of-polymyxins
#4
REVIEW
Francesc Rabanal, Yolanda Cajal
Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considered as a last-line therapy to treat infections caused by multi-drug resistant Gram-negative bacteria. This review surveys the progress in understanding polymyxin structure, and their chemistry, mechanisms of antibacterial activity and nephrotoxicity, biomarkers, synergy and combination with other antimicrobial agents and antibiofilm properties...
June 19, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28610835/antibiofilm-effect-of-ultrasound-combined-with-microbubbles-against-staphylococcus-epidermidis-biofilm
#5
Ying Dong, Yaling Xu, Pan Li, Chuanqing Wang, Yun Cao, Jialin Yu
Biofilms are difficult to eradicate due to their resistance to antibiotics and host immune cells. Ultrasound microbubbles have emerged as a new treatment modality with the underlying mechanisms largely unknown. In this study, we exposed 24-h-old Staphylococcus epidermidis biofilms established in OptiCell™ chambers to ultrasound in combination with microbubbles, and investigated the activities of vancomycin and neutrophils against S. epidermidis biofilms after treatment. The antibiofilm mechanims of ultrasound microbubbles were explored in terms of bacterial permeability and biofilm-associated gene expression...
June 11, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28598149/taking-the-silver-bullet-colloidal-silver-particles-for-the-topical-treatment-of-biofilm-related-infections
#6
Katharina Richter, Paula Facal, Nicky Thomas, Ilse Vandecandelaere, Mahnaz Ramezanpour, Clare Cooksley, Clive A Prestidge, Tom Coenye, Peter-John Wormald, Sarah Vreugde
BACKGROUND: Biofilms are aggregates of bacteria residing in a self-assembled matrix, which protects these sessile cells against external stress, including antibiotic therapies. In light of emerging multidrug-resistant bacteria alternative strategies to antibiotics are emerging. The present study evaluated the activity of colloidal silver nanoparticles (AgNPs) of different shapes against biofilms formed by Staphylococcus aureus (SA), methicillin-resistant SA (MRSA) and Pseudomonas aeruginosa (PA)...
June 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28587762/two-novel-roles-of-buffalo-milk-lactoperoxidase-antibiofilm-agent-and-immunomodulator-against-multidrug-resistant-salmonella-enterica-serovar-typhi-and-listeria-monocytogenes
#7
Likaa Mahdi, Hadeel Musafer, Luma Zwain, Istabreq Salman, Ikbal Al-Joofy, Khetam Rasool, Amal Mussa, Sana'a Al-Kakei, Rasha Al-Oqaili, Shaymaa Al-Alak, Amal Chaloob, Afrah Abdulkareem, Bydaa Hussein, Nada Mahdi, Nehad Taher
The increasing occurrence of multidrug resistant bacteria causing bacteremia infection, constitutes a major health problem, difficult-to-treat bacteremia due to its ability to form biofilm. Buffalo milk lactoperoxidase (BMLpo) is effective and safe to use as bacteriostatic agent. The MIC of BMLpo and amikacin were used to evaluate the antibiofilm activity against resistant L. monocytogenes and S. typhi. Prophylactic effects of BMLpo against L. monocytogenes and S. typhi bacteremia in vivo have been tested and ELISA test used to evaluate serum cytokines...
June 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28586721/antibacterial-and-antibiofilm-activities-of-the-metabolites-isolated-from-the-culture-of-the-mangrove-derived-endophytic-fungus-eurotium-chevalieri-kufa-0006
#8
War War May Zin, Suradet Buttachon, Tida Dethoup, José A Pereira, Luís Gales, Ângela Inácio, Paulo M Costa, Michael Lee, Nazim Sekeroglu, Artur M S Silva, Madalena M M Pinto, Anake Kijjoa
Five previously undescribed metabolites, including acetylquestinol, two prenylated indole 3-carbaldehyde derivatives, an anthranilic acid derivative and an isochromone derivative, were isolated, in addition to eleven known compounds: palmitic acid, ergosterol 5,8-endoperoxide, emodin, physcion, questin, questinol, (11S, 14R)-cyclo(tryptophylvalyl), preechinulin, neoechinulin E, echinulin and eurocristatine, from the culture of the endophytic fungus Eurotium chevalieri KUFA 0006. The structures of the previously undescribed compounds were established based on an extensive 1D and 2D NMR spectral analysis as well as HRMS and IR data...
June 3, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28584159/in-vitro-antibiofilm-activity-of-eucarobustol-e-against-candida-albicans
#9
Rui-Huan Liu, Zhi-Chun Shang, Tian-Xiao Li, Ming-Hua Yang, Ling-Yi Kong
Formyl-phloroglucinol meroterpenoids (FPMs) are an important type of natural products with various bioactivities. Our antifungal susceptibility assay showed that one of the Eucalyptus robusta derived FPMs-Eucarobustol E (EE) exerted strong inhibitory effect against Candida albicans biofilms at a concentration of 16 μg/ml. EE was found to block the yeast-to-hypha transition and reduce the cellular surface hydrophobicity of the biofilm cells. RNA sequencing and real time reverse-transcription PCR analysis showed that exposure to 16 μg/ml of EE resulted in marked reduction of expressions of genes involved in hyphal growth (EFG1, CPH1, TEC1, EED1, UME6, and HGC1) and cell surface proteins (ALS3, HWP1, and SAP5)...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28583888/extracellular-polysaccharide-derived-from-potential-probiotic-strain-with-antioxidant-and-antibacterial-activities-as-a-prebiotic-agent-to-control-pathogenic-bacterial-biofilm-formation
#10
Abdelkarim Mahdhi, Nadia Leban, Ibtissem Chakroun, Mohamed Aymen Chaouch, Jawhar Hafsa, Kais Fdhila, Kacem Mahdouani, Hatem Majdoub
Because of their functional diversity, bioactive compounds are becoming a new biocontrol agent to limit biofilm formation by pathogens. In this study, the physico-chemical characterization of an exopolysaccharide (EPS) isolated from Lactobacillus plantarum (EPLB) was characterized and its in vitro effect on biofilm formation was studied. The EPS had a molecular weight of 36 kDa and polydispersity index estimated to be 1.2. The tested EPLB had an antibacterial activity, with a Minimal Inhibition Concentration (MIC) values ranging between 1 mg/ml and 10 mg/ml, displayed an antibiofilm effect concentration dependent on Gram positive and negative strains...
June 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28567627/endophytic-nocardiopsis-sp-from-zingiber-officinale-with-both-antiphytopathogenic-mechanisms-and-antibiofilm-activity-against-clinical-isolates
#11
Rohini Sabu, K R Soumya, E K Radhakrishnan
Novel and potential antimicrobial compounds are essential to tackle the frequently emerging multidrug-resistant pathogens and also to develop environment friendly agricultural practices. In the current study, endophytic actinomycetes from rhizome of Zingiber officinale were explored in terms of its diversity and bioactive properties. Fourteen different organisms were isolated, identified and screened for activity against Pythium myriotylum and human clinical pathogens. Among these, Nocardiopsis sp. ZoA1 was found to have highest inhibition with excellent antibacterial effects compared to standard antibiotics...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28567419/shin-iseihaito-xinyiqingfeitang-suppresses-the-biofilm-formation-of-streptococcus-pneumoniae-in-vitro
#12
Masaaki Minami, Toru Konishi, Hiroshi Takase, Toshiaki Makino
Streptococcus pneumoniae (S. pneumoniae) is the important pathogen that causes otolaryngeal diseases such as sinusitis. S. pneumoniae frequently forms the biofilm to prevent severe circumstances such as antimicrobial agents. Shin'iseihaito (xinyiqingfeitang) is a formula of Japanese traditional Kampo medicine that has 9 crude drugs and provides the medicinal usage for sinusitis. The objective of the present study is to reveal the mechanism of antibiofilm activity by Shin'iseihaito extract (SSHT). SSHT significantly inhibited the formation of biofilm from S...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28562631/synergistic-antibiofilm-efficacy-of-a-gallotannin-1-2-6-tri-o-galloyl-%C3%AE-d-glucopyranose-from-terminalia-chebula-fruit-in-combination-with-gentamicin-and-trimethoprim-against-multidrug-resistant-uropathogenic-escherichia-coli-biofilms
#13
Anwesa Bag, Rabi Ranjan Chattopadhyay
In recent years the emergence of multiple drug resistance microbes has become a global public health problem. The aim of the present investigation was to evaluate possible antibiofilm efficacy of a gallotannin 1,2,6-tri-O-galloyl-β-D-glucopyranose from Terminalia chebula fruits alone and in combination with gentamicin and trimethoprim against preformed biofilms of multidrug-resistant (MDR) uropathogenic E. coli isolates using microbroth dilution, checkerboard titration and kill kinetics methods. Test gallotannin showed > 50% antibiofilm efficacy after 24 h when administered alone whereas gentamicin and trimethoprim failed to do so...
2017: PloS One
https://www.readbyqxmd.com/read/28561790/himatanthus-drasticus-leaves-chemical-characterization-and-evaluation-of-their-antimicrobial-antibiofilm-antiproliferative-activities
#14
Cristiane Santos Silva E Silva Figueiredo, Joice Castelo Branco Santos, José Artur de Aguiar Castro Junior, Vinícius Galvão Wakui, João F S Rodrigues, Mariana Oliveira Arruda, Andrea de Souza Monteiro, Valério Monteiro-Neto, Maria Rosa Quaresma Bomfim, Lucília Kato, Luís Cláudio Nascimento da Silva, Marcos Augusto Grigolin Grisotto
Plant-derived products have played a fundamental role in the development of new therapeutic agents. This study aimed to analyze antimicrobial, antibiofilm, cytotoxicity and antiproliferative potentials of the extract and fractions from leaves of Himatanthusdrasticus, a plant from the Apocynaceae family. After harvesting, H. drasticus leaves were macerated and a hydroalcoholic extract (HDHE) and fractions were prepared. Antimicrobial tests, such as agar-diffusion, Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) were carried out against several bacterial species...
May 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28552808/phytochemical-composition-anti-biofilm-and-anti-quorum-sensing-potential-of-fruit-stem-and-leaves-of-salvadora-persica-l-methanolic-extracts
#15
Emira Noumi, Mejdi Snoussi, Abderrahmen Merghni, Filomena Nazzaro, Guillermo Quindós, Gültekin Akdamar, Maha Mastouri, Abdulbasset Al-Sieni, Ozgur Ceylan
Emergence of antibiotic resistance among pathogenic bacteria encourages us to search for new molecules as an alternative treatment. The aim of this study was to evaluate the antiquorum sensing (anti-QS) and antibiofilm potential of Salvadora persica L. methanolic extracts to prevent the infections due to Staphylococcus as an alternate to antibiotics. The methanolic extracts of S. persica L. fruit, leaves and stems was assessed for their activity in inhibiting QS-depedent phenomenon such as violacein pigment production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1 and biofilm formation in oral Staphylococcus strains on polymethylmetacrylate (PMMA)...
May 26, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28548699/cytocompatibility-physical-properties-and-antibiofilm-activity-of-endodontic-sealers-with-amoxicillin
#16
Carolina Andolfatto, Idomeo Bonetti-Filho, Iracilda Zeppone Carlos, Juliane Maria Guerreiro-Tanomaru, Milton Carlos Kuga, Fernanda Borges Cunha Tormin, Gisele Faria
The aim was to evaluate the cytocompatibility of the AH Plus and Sealapex associated with amoxicillin (AA) in a quantity of 10% by total weight of the sealers, the flow and setting time of these sealers with 10%-0.25% AA and antibiofilm activity of these sealers associated with AA in a concentration that does not alter their physical properties (1%). Cytocompatibility was assessed by MTT, neutral red and cytoskeletal fluorescence assays. Setting time and flow was evaluated using the specifications of ISO 6876/2012...
May 26, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28544960/anti-biofilm-effect-of-dihydromyricetin-loaded-nanocapsules-on-urinary-catheter-infected-by-pseudomonas-aeruginosa
#17
A J F Dalcin, C G Santos, S S Gündel, I Roggia, R P Raffin, A F Ourique, R C V Santos, P Gomes
Nosocomial infections associated with biofilm formation on urinary catheters are among the leading causes of complications due to biofilm characteristics and high antimicrobial resistance. An interesting alternative are natural products, such as Dihydromyricetin (DMY), a flavonoid which presents several pharmacological properties, including strong antimicrobial activity against various microorganisms. However, DMY, has low aqueous solubility and consequently low bioavailability. Nanoencapsulation can contribute to the improvement of characteristics of some drugs, by increasing the apparent solubility and sustained release has been reported among other advantages...
May 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28540585/antibiofilm-activity-and-mode-of-action-of-dmso-alone-and-its-combination-with-afatinib-against-gram-negative-pathogens
#18
Mohd Fakharul Zaman Raja Yahya, Zazali Alias, Saiful Anuar Karsani
Biofilms are complex microbial communities that tend to attach to either biotic or abiotic surface. Enclosed in a self-produced extracellular polymeric substance (EPS) matrix, the biofilms often cause persistent infections. The objective of this study was to investigate the antibiofilm activity of dimethyl sulfoxide (DMSO) and afatinib against Gram-negative pathogens. Test microorganisms used in this study were Escherichia coli ATCC 1299, Pseudomonas aeruginosa ATCC 10145, and Salmonella typhimurium ATCC 14028...
May 24, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28533236/antibacterial-and-antibiofilm-activities-of-a-novel-synthetic-cyclic-lipopeptide-against-cariogenic-streptococcus-mutans-ua159
#19
Kyung R Min, Adriana Galvis, Brandon Williams, Ramanjaneyulu Rayala, Predrag Cudic, Dragana Ajdic
Despite continuous efforts to control cariogenic dental biofilms, very few effective antimicrobial treatments exist. In this study, we characterized the activity of a novel synthetic cyclic lipopeptide 4 (CLP-4), derived from fusaricidin, against the cariogenic pathogen Streptococcus mutans UA159. We determined CLP-4's minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), spontaneous resistance frequency, and we performed time-kill assays. Additionally, we assessed CLP-4's potential to inhibit biofilm formation (MBIC) and eradicate pre-formed biofilms (MBEC)...
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28529865/hyaluronic-acid-and-its-composites-as-a-local-antimicrobial-antiadhesive-barrier
#20
REVIEW
C L Romanò, E De Vecchi, M Bortolin, I Morelli, L Drago
Living in biofilms is probably the most common condition for bacteria and fungi and biofilm-related infections account for the majority of bacterial infectious diseases worldwide. Among others biofilm-related infections, those associated with implanted biomaterials have an enormous and still largely underestimated impact in orthopaedics and trauma, cardio-surgery and several other surgical disciplines. Given the limited efficacy of existing antibiotics in the prevention and treatment of bacterial biofilms, new strategies are needed to protect implants and host tissues, overcoming the striking ability of the microorganisms to adhere on different surfaces and to immediately protect themselves by forming the biofilm matrix...
2017: Journal of bone and joint infection
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