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Antibiofilm activity

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https://www.readbyqxmd.com/read/29772735/antibiofilm-peptides-and-peptidomimetics-with-focus-on-surface-immobilization
#1
REVIEW
Athina Andrea, Natalia Molchanova, Håvard Jenssen
Bacterial biofilms pose a major threat to public health, as they are associated with at least two thirds of all infections. They are highly resilient and render conventional antibiotics inefficient. As a part of the innate immune system, antimicrobial peptides have drawn attention within the last decades, as some of them are able to eradicate biofilms at sub-minimum inhibitory concentration (MIC) levels. However, peptides possess a number of disadvantages, such as susceptibility to proteolytic degradation, pH and/or salinity-dependent activity and loss of activity due to binding to serum proteins...
May 16, 2018: Biomolecules
https://www.readbyqxmd.com/read/29767946/highly-stable-graphene-based-nanocomposite-go-pei-ag-with-broad-spectrum-long-term-antimicrobial-activity-and-antibiofilm-effects
#2
Rongtao Zhao, Wen Kong, Mingxuan Sun, Yi Yang, Wanying Liu, Min Lv, Shiping Song, Lihua Wang, Hongbin Song, Rongzhang Hao
Various silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites (GO-Ag) have received increasing attention owing to their antimicrobial activity and biocompatibility; however, their aggregation in physiological solutions and the generally complex synthesis methods warrant improvement. This study aimed to synthesize a polyethyleneimine (PEI)-modified and AgNP-decorated GO nanocomposite (GO-PEI-Ag) through a facile approach through microwave irradiation without any extra reductants and surfactants; its antimicrobial activity was investigated on Gram-negative/-positive bacteria (including drug-resistant bacteria) and fungi...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29760099/hydrogel-delivery-of-lysostaphin-eliminates-orthopedic-implant-infection-by-staphylococcus-aureus-and-supports-fracture-healing
#3
Christopher T Johnson, James A Wroe, Rachit Agarwal, Karen E Martin, Robert E Guldberg, Rodney M Donlan, Lars F Westblade, Andrés J García
Orthopedic implant infections are a significant clinical problem, with current therapies limited to surgical debridement and systemic antibiotic regimens. Lysostaphin is a bacteriolytic enzyme with high antistaphylococcal activity. We engineered a lysostaphin-delivering injectable PEG hydrogel to treat Staphylococcus aureus infections in bone fractures. The injectable hydrogel formulation adheres to exposed tissue and fracture surfaces, ensuring efficient, local delivery of lysostaphin. Lysostaphin encapsulation within this synthetic hydrogel maintained enzyme stability and activity...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29754050/sargassum-wightii-synthesized-zno-nanoparticles-from-antibacterial-and-insecticidal-activity-to-immunostimulatory-effects-on-the-green-tiger-shrimp-penaeus-semisulcatus
#4
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Suganya Subbaiah, Abdul Khudus Nazar, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Mohammed N Al-Anbr
The green synthesis of metal nanoparticles using phytochemical from marine seaweeds is a fast-growing research field in nanotechnology. Here, the biosynthesis of zinc oxide nanoparticles was achieved using the hot water extract of Sargassum wightii. The hot water extract prepared from S. wightii (H Sw) and ZnO NPs were studied by UV-visible and FTIR spectroscopy, SEM and XRD. Then, both products were evaluated for antibiofilm activity towards aquatic pathogens. The nanoparticles' immunostimulating potential on green tiger prawns, Penaeus semisulcatus was studied through immersion and dietary administration...
May 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29746950/candida-periprosthetic-joint-infection-a-rare-and-difficult-to-treat-infection
#5
Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Jaime Lora-Tamayo, Laura Morata, Oscar Murillo, Helem Vilchez, Luisa Sorli, Laura Guío Carrión, José Mª Barbero, Julián Palomino-Nicás, Alberto Bahamonde, Alfredo Jover-Sáenz, Natividad Benito, Rosa Escudero, Marta Fernandez- Sampedro, Rafael Pérez Vidal, Lucía Gómez, Pablo S Corona, Benito Almirante, Javier Ariza, Carles Pigrau
BACKGROUND: Candida periprosthetic joint infection (CPJI) is a rare, difficult-to-treat disease. The purpose of this study was to evaluate the clinical characteristics and outcomes of CPJI treated with various surgical and antifungal strategies. METHODS: We conducted a multicenter retrospective study of all CPJI diagnosed between 2003 and 2015 in 16 Spanish hospitals. RESULTS: Forty-three patients included: median age, 75 years, and median Charlson Comorbidity Index score, 4...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29740028/novel-antibiofilm-chemotherapies-target-nitrogen-from-glutamate-and-glutamine
#6
Tal Hassanov, Iris Karunker, Nitai Steinberg, Ayelet Erez, Ilana Kolodkin-Gal
Bacteria in nature often reside in differentiated communities termed biofilms, which are an active interphase between uni-cellular and multicellular life states for bacteria. Here we demonstrate that the development of B. subtilis biofilms is dependent on the use of glutamine or glutamate as a nitrogen source. We show a differential metabolic requirement within the biofilm; while glutamine is necessary for the dividing cells at the edges, the inner cell mass utilizes lactic acid. Our results indicate that biofilm cells preserve a short-term memory of glutamate metabolism...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737589/ll-37-fragments-have-antimicrobial-activity-against-staphylococcus-epidermidis-biofilms-and-wound-healing-potential-in-hacat-cell-line
#7
Paola Saporito, Michelle Vang Mouritzen, Anders Løbner-Olesen, Håvard Jenssen
Staphylococcus epidermidis is a common nosocomial pathogen able to form biofilms in indwelling devices, resulting in chronic infections, which are refractory to antibiotics treatment. Staphylococcal biofilms are also associated with the delayed reepithelization and healing of chronic wounds. The human cathelicidin peptide LL-37 has been proven active against S. epidermidis biofilms in vitro and to promote wound healing. As previous studies have demonstrated that fragments of LL-37 could possess an equal antibacterial activity as the parent peptide, we tested whether shorter (12-mer) synthetic fragments of LL-37 maintained the antibiofilm and/or immune modulating activity, aiming at the identification of essential regions within the LL-37 parent sequence...
May 8, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29727856/bactericidal-and-antibiofilm-activity-of-bactenecin-derivative-peptides-against-the-food-pathogen-listeria-monocytogenes-new-perspectives-for-food-processing-industry
#8
Gianna Palmieri, Marco Balestrieri, Federico Capuano, Yolande T R Proroga, Francesco Pomilio, Patrizia Centorame, Alessia Riccio, Raffaele Marrone, Aniello Anastasio
Antimicrobial peptides have received great attention for their potential benefits to extend the shelf-life of food-products. Innate defense regulator peptide-1018 (IDR-1018) represents a promising candidate for such applications, due to its broad-spectrum antimicrobial activity, although food-isolated pathogens have been poorly investigated. Herein, we describe the design and the structural-functional characterization of a new 1018-derivative peptide named 1018-K6, in which the alanine in position 6 was replaced with a lysine...
April 27, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29727653/chitosan-nanoparticles-and-povidone-iodine-containing-alginate-gel-for-prevention-and-treatment-of-orthopedic-implant-associated-infections
#9
Vaishali Pawar, Harshad Topkar, Rohit Srivastava
Implant associated infections are the most serious complications in the orthopedic surgery. Such complications are of major concern unless encountered during initial stages of contamination due to the bacterial biofilm formation. Thus, our aim is to eradicate bacteria at the early stages of infection. Herein, we develop a vancomycin-loaded chitosan nanoparticles (CNPs) and povidone-iodine (PI) containing in situ alginate (CNPs-PI-Alg) gel for antibacterial and antibiofilm activity, respectively. The CNPs were synthesized by ionic gelation method and the processing parameters were optimized to attain nanoparticles of 200-250 nm size and 37...
May 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29719996/antibiofilm-activity-of-an-edta-containing-nanoemulsion-on-multidrug-resistant-acinetobacter-baumannii
#10
Karthikeyan Ramalingam, Valerie A Lee
Acinetobacter baumannii have evolved as an exceedingly troublesome pathogenic microorganisms and prevention and controlling this pathogen is considered to be a public health problem. Nanoemulsions (NE) are a distinctive type of decontaminator produced by integration of immiscible oil phase with aqueous phase under extreme shear forces. The effectiveness of NEs and their components was determined against four stains of A. baumannii by MBC, adherence assay, biofilm assay and SEM studies. NE dilutions ranging from 125 to 225 reduced adhesion by from 61...
May 2, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29718664/recent-progress-in-polymer-research-to-tackle-infections-and-antimicrobial-resistance
#11
Mohini Mohan Konai, Brinta Bhattacharjee, Sreyan Ghosh, Jayanta Haldar
Global health is increasingly threatened by the rapid emergence of drug-resistant microbes. The ability of these microbes to form biofilm has further exacerbated the scenario leading to notorious infections which are almost impossible to treat. To address this clinical threat, various antimicrobial polymers, polymer-based antimicrobial hydrogels and polymer-coated antimicrobial surfaces have been developed in the recent past. This review aims to discuss such polymer-based antimicrobial strategies, with a focus on their current advancement in the field...
May 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29718248/antibacterial-activity-and-mechanism-of-action-of-analogues-derived-from-the-antimicrobial-peptide-mbjamp1-isolated-from-branchiostoma-japonicum
#12
Jonggwan Park, Hee Kyoung Kang, Moon-Chang Choi, Jeong Don Chae, Byoung Kwan Son, Yong Pil Chong, Chang Ho Seo, Yoonkyung Park
Objectives: The worldwide increase in antibiotic-resistant bacteria is a growing threat to public health. Antimicrobial peptides (AMPs) are potentially effective alternatives to conventional antibiotics. We therefore tested analogues of the AMP mBjAMP1 from Branchiostoma japonicum, which we produced by adding and/or replacing amino acids to increase antimicrobial activity against Gram-negative bacteria. Methods: We compared the antimicrobial activities of mBjAMP1 analogues against Gram-negative bacteria reference strains and 52 strains of Klebsiella pneumoniae isolated from patients...
April 30, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29706943/antibacterial-and-antibiofilm-activities-of-psychorubrin-a-pyranonaphthoquinone-isolated-from-mitracarpus-frigidus-rubiaceae
#13
Ari S O Lemos, Lara M Campos, Lívia Melo, Maria C M R Guedes, Luiz G Oliveira, Thiago P Silva, Rossana C N Melo, Vinícius N Rocha, Jair A K Aguiar, Ana C M Apolônio, Elita Scio, Rodrigo L Fabri
Psychorubrin, a natural pyranonaphthoquinone found in different plants, has become an interesting compound in the search for new antimicrobial therapeutic agents. Here, we investigated the potential antagonistic activity of psychorubrin against planktonic and biofilm bacteria. First, psychorubrin was tested against several Gram-positive and Gram-negative bacteria strains by a broth microdilution susceptibility method. Second, bacterial killing assay, bacterial abundance, and membrane viability were evaluated...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29704178/structural-characterization-of-bacillus-licheniformis-dahb1-exopolysaccharide-antimicrobial-potential-and-larvicidal-activity-on-malaria-and-zika-virus-mosquito-vectors
#14
Muthukumar Abinaya, Baskaralingam Vaseeharan, Mani Divya, Sekar Vijayakumar, Marimuthu Govindarajan, Naiyf S Alharbi, Jamal M Khaled, Mohammed N Al-Anbr, Giovanni Benelli
Microbial polysaccharides produced by marine species play a key role in food and cosmetic industry, as they are nontoxic and biodegradable polymers. This investigation reports the isolation of exopolysaccharide from Bacillus licheniformis Dahb1 and its biomedical applications. Bacillus licheniformis Dahb1 exopolysaccharide (Bl-EPS) was extracted using the ethanol precipitation method and structurally characterized. FTIR and 1 H-NMR pointed out the presence of various functional groups and primary aromatic compounds, respectively...
April 27, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29698774/biofilm-inhibition-mechanism-from-extract-of-hymenocallis-littoralis-leaves
#15
Naiem H Nadaf, Rishikesh S Parulekar, Rahul S Patil, Trupti K Gade, Anjum A Momin, Shailesh R Waghmare, Maruti J Dhanavade, Akalpita U Arvindekar, Kailas D Sonawane
ETHNOPHARMACOLOGICAL RELEVANCE: Hymenocallis littoralis (Jacq.) Salisb. has been referred as beach spider lily and commonly known for its rich phytochemical diversity. Phytochemicals such as alkaloids, volatile constituents, phenols, flavonoids, flavonols extracted from different parts of these plants like bulbs, flowers, leaf, stem and root had been used in folk medicines from ancient times because of their excellent antimicrobial and antioxidant properties. The leaf and bulb extract of H...
April 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29696011/topical-colloidal-silver-for-the-treatment-of-recalcitrant-chronic-rhinosinusitis
#16
Mian L Ooi, Katharina Richter, Catherine Bennett, Luis Macias-Valle, Sarah Vreugde, Alkis J Psaltis, Peter-John Wormald
Background: The management of recalcitrant chronic rhinosinusitis (CRS) is challenged by difficult-to-treat polymicrobial biofilms and multidrug resistant bacteria. This has led to the search for broad-spectrum non-antibiotic antimicrobial therapies. Colloidal silver (CS) has significant antibiofilm activity in vitro and in vivo against S. aureus, MRSA , and P. aeruginosa . However, due to the lack of scientific efficacy, it is only currently used as an alternative medicine. This is the first study looking at the safety and efficacy of CS in recalcitrant CRS...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29687885/antimicrobial-peptides-an-effective-approach-to-prevent-bacterial-biofilm-formation-in-platelet-concentrates
#17
Meshari Alabdullatif, Chintamani D Atreya, Sandra Ramirez-Arcos
BACKGROUND: The safety of platelet concentrates (PCs) is a major concern in transfusion medicine due to contamination mainly with skin Gram-positive bacteria. The predominant contaminant, Staphylococcus epidermidis, forms bacterial cell aggregates (biofilms) in PCs posing a safety risk for transfusion patients. Combinations of synthetic antimicrobial peptides (AMPs) have demonstrated bactericidal activity in PCs. Herein, we have evaluated the ability of a mix of AMPs to inhibit biofilm formation and/or eradicate S...
April 24, 2018: Transfusion
https://www.readbyqxmd.com/read/29685351/coculture-induced-improved-production-of-biosurfactant-by-staphylococcus-lentus-sz2-role-in-protecting-artemia-salina-against-vibrio-harveyi
#18
Faseela Hamza, Ameeta Ravi Kumar, Smita Zinjarde
Coculturing microorganisms can lead to enhanced production of bioactive compounds as a result of cross-species or cross-genera interactions. In this study, we demonstrate improved production of the biosurfactant (BS-SLSZ2 with antibiofilm properties) by the marine epibiotic bacterium Staphylococcus lentus SZ2 after cross-genera interactions with an aquaculture pathogen Vibrio harveyi. In cocultures, growth of V. harveyi was completely inhibited and resultant biofilms were exclusively composed of S. lentus. The cell free supernatant (CFS) derived from cocultures displayed improved antibiofilm activity with enhanced contents of BS-SLSZ2 compared to monocultured S...
July 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29684540/chemical-composition-antioxidant-anticholinesterase-antimicrobial-and-antibiofilm-activities-of-essential-oil-and-methanolic-extract-of-anthemis-stiparum-subsp-sabulicola-pomel-oberpr
#19
Ahmed Elkhalifa Chemsa, Amar Zellagui, Mehmet Öztürk, Ebru Erol, Ozgür Ceylan, Mehmet Emin Duru, Mesbah Lahouel
Anthemis species are traditionally used to treat infectious and inflammatory processes, among others clinical disturbances. In the current study, the chemical composition, the total phenolic and flavonoid contents, the antioxidant, anticholinesterase, antimicrobial, and antibiofilm activities of Anthemis stiparum subsp. sabulicola aerial parts methanolic extract (As-ME) and essential oil (As-EO) were investigated. The chemical composition of As-EO was established by GC-MS and GC-FID. Total phenolic and flavonoid contents of As-ME were spectrophotometrically determined...
April 20, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29682545/curcumin-as-a-promising-antibacterial-agent-effects-on-metabolism-and-biofilm-formation-in-s-mutans
#20
Bingchun Li, Xinlong Li, Huancai Lin, Yan Zhou
Streptococcus mutans (S. mutans) has been proved to be the main aetiological factor in dental caries. Curcumin, a natural product, has been shown to exhibit therapeutic antibacterial activity, suggesting that curcumin may be of clinical interest. The objective of this study is to evaluate the inhibitory effects of curcumin on metabolism and biofilm formation in S. mutans using a vitro biofilm model in an artificial oral environment. S. mutans biofilms were treated with varying concentrations of curcumin. The biofilm metabolism and biofilm biomass were assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and the crystal violet assay...
2018: BioMed Research International
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