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Antibiofilm activity

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https://www.readbyqxmd.com/read/28330321/antimicrobial-antibiofilm-and-microbial-barrier-properties-of-poly-%C3%AE%C2%B5-caprolactone-cloisite-30b-thin-films
#1
Snigdha Sajeendra Babu, Shiji Mathew, Nandakumar Kalarikkal, Sabu Thomas, Radhakrishnan E K
Development of antibacterial and antibiofilm surfaces is in high demand. In this study, nanocomposite of Poly (ε-caprolactone)/Cloisite 30B was prepared by the solvent casting method. The membranes were characterised by SEM, AFM, and FTIR. Evaluation of water uptake, antimicrobial, antibiofilm, and microbial barrier properties demonstrated a significant antimicrobial and antibiofilm activity against MTCC strain of Staphylococcus haemolyticus and strong biofilm positive Staphylococcus epidermidis of clinical origin at low clay concentrations...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330096/characterization-of-pyocyanin-with-radical-scavenging-and-antibiofilm-properties-isolated-from-pseudomonas-aeruginosa-strain-btry1
#2
M Laxmi, Sarita G Bhat
A biomolecule namely pyocyanin was isolated from Pseudomonas aeruginosa (BTRY1). It was confirmed by UV-Vis spectrum with absorption maxima at 270 nm and was further characterized using Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR). Spectroscopy analyses showed the presence of relevant bonds in their respective structures. Although pyocyanin had antihemolytic, antioxidant and antibiofilm activities against food pathogens, it showed no observable cytotoxicity, and thus proposed for potential use in the preservation of food...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28319869/biofilm-inhibition-formation-of-clinical-strains-of-pseudomonas-aeruginosa-mutans-photocatalytic-activity-of-azo-dye-and-gc-ms-analysis-of-leaves-of-lagerstroemia-speciosa
#3
V Sai Saraswathi, Neethu Kamarudheen, K V Bhaskara Rao, K Santhakumar
The investigation was conducted to analyse the bioactive compounds from the leaf extracts of L. speciosa by GC-MS. The extracts were screened for antibacterial and antibiofilm activities against potential clinical strains. The bioactive compounds from the leaves of L. speciosa were extracted by soxhlet continuous extraction method and their chemical composition was analysed by Gas Chromatography-Mass Spectroscopy (GC-MS). The antibacterial activity was evaluated against clinical strain like Staphylococcus aureus, Escherichia coli, P...
March 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28303128/a-high-throughput-screening-platform-of-microbial-natural-products-for-the-discovery-of-molecules-with-antibiofilm-properties-against-salmonella
#4
Sonia Paytubi, Mercedes de La Cruz, Jose R Tormo, Jesús Martín, Ignacio González, Victor González-Menendez, Olga Genilloud, Fernando Reyes, Francisca Vicente, Cristina Madrid, Carlos Balsalobre
In this report, we describe a High-Throughput Screening (HTS) to identify compounds that inhibit biofilm formation or cause the disintegration of an already formed biofilm using the Salmonella Enteritidis 3934 strain. Initially, we developed a new methodology for growing Salmonella biofilms suitable for HTS platforms. The biomass associated with biofilm at the solid-liquid interface was quantified by staining both with resazurin and crystal violet, to detect living cells and total biofilm mass, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28297055/any-use-for-alternative-lock-solutions-in-the-prevention-of-catheter-related-blood-stream-infections
#5
Laura Labriola, Jean-Michel Pochet
The prevention of catheter-related blood stream infections (CRBSI) in hemodialysis (HD) patients remains a challenge because of high morbidity and mortality associated to CRBSI. Alternative locking solutions (ALS) containing an antithrombotic substance with additional antimicrobial or antibiofilm properties (citrate, ethylenediaminetetraacetic acid [EDTA], 70% ethanol, thrombolytics) with or without the addition of molecules with specific antimicrobial activity (antibiotics, taurolidine, paraben-methylene-blue) has been proposed with the aim to prevent or eradicate intraluminal biofilm colonization and subsequent CRBSI...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28296935/peptide-modification-results-in-the-formation-of-a-dimer-with-a-60-fold-enhanced-antimicrobial-activity
#6
Amal Thamri, Myriam Létourneau, Alex Djoboulian, David Chatenet, Eric Déziel, Annie Castonguay, Jonathan Perreault
Cationic antimicrobial peptides (CAMPs) occur naturally in numerous organisms and are considered as a class of antibiotics with promising potential against multi-resistant bacteria. Herein, we report a strategy that can lead to the discovery of novel small CAMPs with greatly enhanced antimicrobial activity and retained antibiofilm potential. We geared our efforts towards i) the N-terminal cysteine functionalization of a previously reported small synthetic cationic peptide (peptide 1037, KRFRIRVRV-NH2), ii) its dimerization through a disulfide bond, and iii) a preliminary antimicrobial activity assessment of the newly prepared dimer against Pseudomonas aeruginosa and Burkholderia cenocepacia, pathogens responsible for the formation of biofilms in lungs of individuals with cystic fibrosis...
2017: PloS One
https://www.readbyqxmd.com/read/28287299/effect-of-serine-protease-kex2-on-candida-albicans-virulence-under-halogenated-methyl-sulfones
#7
Monika Staniszewska, Małgorzata Bondaryk, Michalina Kazek, Aleksandra Gliniewicz, Christina Braunsdorf, Martin Schaller, Hector M Mora-Montes, Zbigniew Ochal
AIM: The effect of KEX2 mutations on C. albicans virulence and resistance to halogenated methyl sulfones was assessed. MATERIALS & METHODS: The mechanism of action of sulfones was studied using flow cytometry and microscopy. Expression of KEX2 and SAP5 was assessed using quantitative Real-Time-PCR. 2,3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide and lactate dehydrogenase assays were elaborated to study, respectively, metabolism of Candida treated with sulfones and their cytotoxicity against tissues...
March 2017: Future Microbiology
https://www.readbyqxmd.com/read/28281851/antibacterial-activity-and-biofilm-inhibition-by-surface-modified-titanium-alloy-medical-implants-following-application-of-silver-titanium-dioxide-and-hydroxyapatite-nanocoatings
#8
A Besinis, S D Hadi, H R Le, C Tredwin, R D Handy
One of the most common causes of implant failure is peri-implantitis, which is caused by bacterial biofilm formation on the surfaces of dental implants. Modification of the surface nanotopography has been suggested to affect bacterial adherence to implants. Silver nanoparticles are also known for their antibacterial properties. In this study, titanium alloy implants were surface modified following silver plating, anodisation and sintering techniques to create a combination of silver, titanium dioxide and hydroxyapatite (HA) nanocoatings...
March 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28281322/chemical-composition-antibacterial-antibiofilm-and-synergistic-properties-of-essential-oils-from-eucalyptus-globulus-labill-and-seven-mediterranean-aromatic-plants
#9
Maria Vieira, Lucinda J Bessa, M Rosário Martins, Sílvia Arantes, António P S Teixeira, Ângelo Mendes, Paulo Martins da Costa, Anabela D F Belo
Essential oils (EOs) from Eucalyptus globulus Labill. ssp. globulus and from Mediterranean autochthonous aromatic plants - Thymus mastichina L., Mentha pulegium L., Rosmarinus officinalis L., Calamintha nepeta (L.) Savi ssp. nepeta, Cistus ladanifer L., Foeniculum vulgare L., Dittrichia viscosa (L.) Greuter ssp. viscosa - were extracted by hydrodistillation and characterized by GC-FID and NMR spectroscopy. EOs were evaluated for antimicrobial properties against several bacterial strains, using diverse methods, namely, the agar disc-diffusion method, the microdilution method, the crystal violet assay and the Live/Dead staining for assessment of biofilm formation...
March 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28263055/dual-functional-polyethylene-glycol-b-polyhexanide-surface-coating-with-in-vitro-and-in-vivo-antimicrobial-and-antifouling-activities
#10
Zelun Zhi, Yajuan Su, Yuewei Xi, Liang Tian, Miao Xu, Qianqian Wang, Sara Padidan, Peng Li, Wei Huang
In recent years, microbial colonization on the surface of biomedical implants/devices has become a severe threat to human health. Herein, surface-immobilized guanidine derivative block copolymers create an antimicrobial and antifouling dual-functional coating. We report the preparation of an antimicrobial and antifouling block copolymer by the conjugation of polyhexanide (PHMB) with either allyl glycidyl ether or allyloxy polyethylene glycol (APEG; MW 1200 and 2400). The allyl glycidyl ether modified PHMB (A-PHMB) and allyloxy polyethylene glycol1200/2400 modified PHMB (APEG1200/2400-PHMB) copolymers were grafted onto a silicone rubber surface as a bottlebrush-like coating, respectively, using a plasma-UV-assisted surface-initiated polymerization...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28260589/improved-effect-of-amikacin-loaded-poly-d-l-lactide-co-glycolide-nanoparticles-against-planktonic-and-biofilm-cells-of-pseudomonas-aeruginosa
#11
Parastoo Sabaeifard, Ahya Abdi-Ali, Carlos Gamazo, Juan Manuel Irache, Mohammad Reza Soudi
PURPOSE: Amikacin is one of the most effective antibiotics against Pseudomonas aeruginosa infections, but because of its high toxicity, the use of this antibiotic has been clinically limited. In the present study, amikacin was successfully loaded into a new formulation of nanoparticles (NPs) based on poly(d,l-lactide-co-glycolide) 50 : 50 in order to enhance the treatment efficacy. The synthetized amikacin-loaded PLGA nanoparticles with high drug loading and stability were used to eliminate P...
March 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28259673/unexplored-endemic-fruit-species-from-brazil-antibiofilm-properties-insights-into-mode-of-action-and-systemic-toxicity-of-four-eugenia-spp
#12
Janaina de Cássia Orlandi Sardi, Irlan Almeida Freires, Josy Goldoni Lazarini, Juliana Infante, Severino Matias de Alencar, Pedro Luiz Rosalen
Brazilian endemic fruit species have aroused attention due to their highly valuable, yet unexplored, agro-industrial, food and therapeutic potential. Herein, we describe the antifungal activity of four Eugenia spp. against Candida albicans biofilms, and further demonstrate insights into their potential mode(s) of action and toxicity in vitro and in vivo. Extracts from different parts (seeds, pulps, leaves) of E. leitonii (EL), E. brasiliensis (EB), E. myrcianthes (EM) and E. involucrata (EI) were obtained (S23°23',W45°39') and chemically characterized by GC/MS...
March 1, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28258230/innovative-approaches-to-treat-staphylococcus-aureus-biofilm-related-infections
#13
REVIEW
Katharina Richter, Freija Van den Driessche, Tom Coenye
Many bacterial infections in humans and animals are caused by bacteria residing in biofilms, complex communities of attached organisms embedded in an extracellular matrix. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. This decreased susceptibility, together with conventional mechanisms leading to antimicrobial resistance, makes biofilm-related infections increasingly difficult to treat and alternative antibiofilm strategies are urgently required...
February 28, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28242548/new-azole-derivatives-showing-antimicrobial-effects-and-their-mechanism-of-antifungal-activity-by-molecular-modeling-studies
#14
İnci Selin Doğan, Selma Saraç, Suat Sari, Didem Kart, Şebnem Eşsiz Gökhan, İmran Vural, Sevim Dalkara
Azole antifungals are potent inhibitors of fungal lanosterol 14α demethylase (CYP51) and have been used for eradication of systemic candidiasis clinically. Herein we report the design, synthesis, and biological evaluation of a series of 1-phenyl/1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethanol esters. Many of these derivatives showed fungal growth inhibition at very low concentrations. Minimal inhibition concentration (MIC) value of 15 was 0.125 μg/mL against Candida albicans. Additionally, some of our compounds, such as 19 (MIC: 0...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28223377/exopolysaccharide-repressing-small-molecules-with-antibiofilm-and-antivirulence-activity-against-pseudomonas-aeruginosa
#15
Erik van Tilburg Bernardes, Laetitia Charron-Mazenod, David J Reading, Shauna L Reckseidler-Zenteno, Shawn Lewenza
Biofilm formation is a universal virulence strategy in which bacteria grow in dense microbial communities enmeshed within a polymeric extracellular matrix that protects them from antibiotic exposure and the immune system. Pseudomonas aeruginosa is an archetypal biofilm-forming organism that utilizes a biofilm growth strategy to cause chronic lung infections in Cystic Fibrosis (CF) patients. The extracellular matrix of P. aeruginosa biofilms is comprised mainly of exopolysaccharides (EPS) and DNA. Both mucoid and non-mucoid isolates of P...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28213334/reactive-oxygen-a-novel-antimicrobial-mechanism-for-targeting-biofilm-associated-infection
#16
REVIEW
Matthew S Dryden, Jonathan Cooke, Rami J Salib, Rebecca E Holding, Timothy Biggs, Ali A Salamat, Raymond N Allan, Rachel S Newby, Fenella Halstead, Beryl Oppenheim, Thomas Hall, Sophie C Cox, Liam M Grover, Zain Al-Hindi, Lilyann Novak-Frazer, Malcolm D Richardson
Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. Bacterial biofilms are a significant problem in clinical settings owing to their increased tolerance towards conventionally prescribed antibiotics and their propensity for selection of further antibacterial resistance. There is therefore a pressing need for the development of alternative therapeutic strategies that can improve antibiotic efficacy towards biofilms...
February 14, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28211475/biofilm-formation-of-the-black-yeast-like-fungus-exophiala-dermatitidis-and-its-susceptibility-to-antiinfective-agents
#17
Lisa Kirchhoff, Maike Olsowski, Katrin Zilmans, Silke Dittmer, Gerhard Haase, Ludwig Sedlacek, Eike Steinmann, Jan Buer, Peter-Michael Rath, Joerg Steinmann
Various fungi have the ability to colonize surfaces and to form biofilms. Fungal biofilm-associated infections are frequently refractory to targeted treatment because of resistance to antifungal drugs. One fungus that frequently colonises the respiratory tract of cystic fibrosis (CF) patients is the opportunistic black yeast-like fungus Exophiala dermatitidis. We investigated the biofilm-forming ability of E. dermatitidis and its susceptibility to various antiinfective agents and natural compounds. We tested 58 E...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196974/the-efficacy-of-different-anti-microbial-metals-at-preventing-the-formation-of-and-eradicating-bacterial-biofilms-of-pathogenic-indicator-strains
#18
Natalie Gugala, Joe A Lemire, Raymond J Turner
The emergence of multidrug-resistant pathogens and the prevalence of biofilm-related infections have generated a demand for alternative anti-microbial therapies. Metals have not been explored in adequate detail for their capacity to combat infectious disease. Metal compounds can now be found in textiles, medical devices and disinfectants-yet, we know little about their efficacy against specific pathogens. To help fill this knowledge gap, we report on the anti-microbial and antibiofilm activity of seven metals: silver, copper, titanium, gallium, nickel, aluminum and zinc against three bacterial strains, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28192138/isolation-biochemical-characterization-and-antibiofilm-effect-of-a-lectin-from-the-marine-sponge-aplysina-lactuca
#19
Rômulo Farias Carneiro, Paulo Henrique Pinheiro de Lima, Renata Pinheiro Chaves, Rafael Pereira, Anna Luísa Pereira, Mayron Alves de Vasconcelos, Ulisses Pinheiro, Edson Holanda Teixeira, Celso Shiniti Nagano, Alexandre Holanda Sampaio
A new lectin was isolated from the marine sponge Aplysina lactuca (ALL) by combining ammonium sulfate precipitation and affinity chromatography on guar gum matrix. ALL showed affinity for the disaccharides α-lactose, β-lactose and lactulose (Ka=12.5, 31.9 and 145.5M(-1), respectively), as well as the glycoprotein porcine stomach mucin. Its hemagglutinating activity was stable in neutral acid pH values and temperatures below 60°C. ALL is a dimeric protein formed by two covalently linked polypeptide chains...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28184157/silver-loaded-nanotubular-structures-enhanced-bactericidal-efficiency-of-antibiotics-with-synergistic-effect-in-vitro-and-in-vivo
#20
Na Xu, Hao Cheng, Jiangwen Xu, Feng Li, Biao Gao, Zi Li, Chenghao Gao, Kaifu Huo, Jijiang Fu, Wei Xiong
Antibiotic-resistant bacteria have become a major issue due to the long-term use and abuse of antibiotics in treatments in clinics. The combination therapy of antibiotics and silver (Ag) nanoparticles is an effective way of both enhancing the antibacterial effect and decreasing the usage of antibiotics. Although the method has been proved to be effective in vitro, no in vivo tests have been carried out at present. Herein, we described a combination therapy of local delivery of Ag and systemic antibiotics treatment in vitro in an infection model of rat...
2017: International Journal of Nanomedicine
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