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Wei Hung Chang, Kao Chin Chen, I Hui Lee, Mei Hung Chi, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yang
BACKGROUND: Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed after antipsychotic treatment and (ii) whether treatment with different generations of antipsychotics influenced the DAT availability after follow-up for 6 months. METHODS: Twenty-four first-episode, drug-naive patients with schizophrenia were divided into first- and second-generation antipsychotic groups naturalistically...
February 2017: Journal of Clinical Psychopharmacology
Chih-Sung Liang, Pei-Shen Ho, Che-Hung Yen, Chun-Yen Chen, Shin-Chang Kuo, Chang-Chih Huang, Yi-Wei Yeh, Kuo-Hsing Ma, San-Yuan Huang
Novelty seeking (NS) is a core personality trait that primes the susceptibility to drug addiction. Striatal dopamine activity contributes to cognitive flexibility, an important cognitive strategy to inhibit impulsivity and compulsive drug-seeking behavior. Evidence supports the association between dopamine and NS. Opioid-dependent patients show higher levels of NS, and repeated opioid exposure can cause cognitive deficits including poor cognitive flexibility and impaired impulse control. However, in opioid-dependent patients, the link between NS, striatal dopamine activity, and cognitive flexibility is still unclear...
March 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
Sameer Taywade, Madhavi Tripathi, Vivek Tandon, Chandan Jyoti Das, Nishikant Avinash Damle, Shamim Ahmed Shamim, Parul Thukral, Chandrasekhar Bal
Tc-99m TRODAT is cocaine analog and binds to the dopamine transporter in vivo. Tc-99m TRODAT single-photon emission computed tomography/computed tomography. (SPECT/CT) is useful for demonstrating presynaptic dopaminergic dysfunction in patients with Parkinsonism. However, few reports have shown extrastriatal uptake of Tc-99m TRODAT. We present the case of a 67-year-old male who underwent Tc-99m TRODAT SPECT/CT for evaluation of Parkinsonism. In addition to tracer binding in the striatum, tracer uptake was noted in an osteoid tumor of the clivus...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Tian-Sin Fan, Ruey-Meei Wu, Pei-Lung Chen, Ta-Fu Chen, Huei-Ying Li, Yin-Hung Lin, Chien-Yu Chen, Meng-Ling Chen, Chun-Hwei Tai, Hang-I Lin, Chin-Hsien Lin
INTRODUCTION: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS: We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neurodegenerative disorders, to analyze 40 probands with familial PD, and 10 patients with mixed neurodegenerative disorders. Sanger sequencing of the identified mutation in the first set of the study was performed in additional 270 PD patients, including 139 familial PD and 131 early-onset PD (onset age less than 50 years old), and 300 age/gender matched control subjects...
December 2016: Parkinsonism & related Disorders
Wenyan Kang, Fangyi Dong, Dunhui Li, Thomas J Quinn, Shengdi Chen, Jun Liu
BACKGROUND: Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson's disease (PD) from patients with non-Parkinsonian syndromes. Our previous study indicated that the "Sniffin' Sticks" odor identification test (SS-16) acts as a valid instrument for olfactory assessment in Chinese PD patients. The aim of the study was to compare the efficacy of the two methods in diagnosing PD. METHODS: Fifty-two PD patients were involved in this study and underwent single photon emission computed tomography (SPECT) imaging using the labeled dopamine transporter radiotracer (99m)Tc-TRODAT-1 to assess nigrostriatal dopaminergic function...
2016: Translational Neurodegeneration
Che-Hung Yen, Mei-Chen Shih, Cheng-Yi Cheng, Kuo-Hsing Ma, Ru-Band Lu, San-Yuan Huang
The dopamine transporter (DAT) plays a crucial role in the pathogenesis of alcohol dependence (AD) and major depression (MD), and males have more risk factors for the development of AD. However, imaging studies on brain DAT availability in males with AD comorbid with MD (AD/MD) are limited, and the association of DAT availability with cognitive function and depressive scores in patients with AD/MD has not been analyzed. Hence, this study examined the relationship between brain DAT availability, cognitive function, and depressive symptoms in different subgroups of males with AD...
August 2016: Medicine (Baltimore)
Ying Chun Tai, Mei Hung Chi, Ching-Lin Chu, Nan Tsing Chiu, Wei Jen Yao, Po See Chen, Yen Kuang Yang
OBJECTIVE: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. METHOD: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited...
July 7, 2016: Journal of Attention Disorders
Amir Reza Jalilian, Davood Beiki, Arman Hassanzadeh-Rad, Arash Eftekhari, Parham Geramifar, Mohammad Eftekhari
During past 3 decades, nuclear medicine has flourished as vibrant and independent medical specialty in Iran. Since that time, more than 200 nuclear physicians have been trained and now practicing in nearly 158 centers throughout the country. In the same period, Tc-99m generators and variety of cold kits for conventional nuclear medicine were locally produced for the first time. Local production has continued to mature in robust manner while fulfilling international standards. To meet the ever-growing demand at the national level and with international achievements in mind, work for production of other Tc-99m-based peptides such as ubiquicidin, bombesin, octreotide, and more recently a kit formulation for Tc-99m TRODAT-1 for clinical use was introduced...
July 2016: Seminars in Nuclear Medicine
Chiung-Chih Chang, Jung-Lung Hsu, Wen-Neng Chang, Shu-Hua Huang, Chi-Wei Huang, Ya-Ting Chang, Nai-Ching Chen, Chun-Chung Lui, Chen-Chang Lee, Shih-Wei Hsu
Presence of parkinsonian features after carbon monoxide (CO) intoxication is well known and the severity was found to relate to the pre-synaptic dopaminergic deficits. There is no systemic study to analyse the functional network involved in CO-related Parkinsonism. Forty-five CO-related parkinsonism patients and 25 aged-matched controls completed the 3D T1-weighted imaging and (18)F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET). Voxel-based morphometry (VBM) was performed to assess the structural and functional brain differences between the patients and controls...
2016: Frontiers in Neuroscience
Babak Fallahi, Atefe Esmaeili, Davood Beiki, Shahram Oveisgharan, Hamid Noorollahi-Moghaddam, Mostafa Erfani, Abbas Tafakhori, Mohammad Rohani, Armaghan Fard-Esfahani, Alireza Emami-Ardekani, Parham Geramifar, Mohammad Eftekhari
OBJECTIVE: Parkinson disease (PD), parkinsonian syndromes (PS) and essential tremor (ET) are different types of movement disorders which share some symptoms resulting in a difficulty of certain diagnosis. This study was conducted to determine the value of (99m)Tc-TRODAT-1 scan to differentiate PD from ET and other PS cases. METHODS: Totally, 75 patients were studied including 29 PD, 6 possible PD, 22 ET and 18 PS cases. A dual-head SPECT-CT was used to perform basal ganglia (BG) imaging following administration of (99m)Tc-TRODAT-1...
February 2016: Annals of Nuclear Medicine
Yu-Hua Dean Fang, Shao-Chieh Chiu, Chin-Song Lu, Tzu-Chen Yen, Yi-Hsin Weng
PURPOSE: We aimed at improving the existing methods for the fully automatic quantification of striatal uptake of [(99m)Tc]-TRODAT with SPECT imaging. PROCEDURES: A normal [(99m)Tc]-TRODAT template was first formed based on 28 healthy controls. Images from PD patients (n = 365) and nPD subjects (28 healthy controls and 33 essential tremor patients) were spatially normalized to the normal template. We performed an inverse transform on the predefined striatal and reference volumes of interest (VOIs) and applied the transformed VOIs to the original image data to calculate the striatal-to-reference ratio (SRR)...
2015: BioMed Research International
Chun-Chieh Lin, Yu-Ming Fan, Guan-Yu Lin, Fu-Chi Yang, Chun-An Cheng, Kuo-Cheng Lu, Jen-Cheng Lin, Jiunn-Tay Lee
BACKGROUND: Restless legs syndrome (RLS) is a neurological sensory motor disorder of which pathophysiology remains sketchy. The present study was aimed to determine the diagnostic accuracy and potential of SPECT-TRODAT imaging in discriminating patients with RLS from normal individuals. PATIENTS AND METHODS: A total of 34 subjects, 22 diagnosed with RLS and 12 classified as normal, were enrolled. Brain SPECT images were acquired 180 minutes after IV injection of 740 to 925 MBq (20-25 mCi) 99mTc-TRODAT-1 using a double-headed γ-camera equipped with high-resolution fan-beam collimators...
January 2016: Clinical Nuclear Medicine
Che-Hung Yen, Yi-Wei Yeh, Chih-Sung Liang, Pei-Shen Ho, Shin-Chang Kuo, Chang-Chih Huang, Chun-Yen Chen, Mei-Chen Shih, Kuo-Hsing Ma, Giia-Sheun Peng, Ru-Band Lu, San-Yuan Huang
Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers...
2015: PloS One
Shasha Xu, Ying Liu, Yu Li, Yangping Deng, Yiyun Huang, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Zhirui Guo, Mei Han, Xingdang Liu, Daxu Fu
RATIONALE: Chronic exposure to heroin results in decreased dopamine transporter levels. Jitai tablets, a traditional Chinese medicine, have been effective at increasing striatal dopamine transporter availability after 6 months of treatment. However, it remains unknown how long the heroin-induced impairment persists and whether dopamine transporter can be normalized following long-term abstinence or treatment. OBJECTIVES: This study was to evaluate the time course of dopamine transporter changes in heroin users undergoing long-term abstinence and treatment with Jitai tablets for 1 year...
September 2015: Psychopharmacology
Dun-hui Li, Lin-yuan Zhang, Yun-yun Hu, Xu-feng Jiang, Hai-yan Zhou, Qiong Yang, Wen-yan Kang, Jun Liu, Sheng-Di Chen
INTRODUCTIONS: Transcranial sonography (TCS) of the substantia nigra is a new and promising method to diagnose Parkinson's disease (PD) but its effectiveness is controversial. METHODS: All 55 PD patients involved in the study underwent single photon emission computed tomography (SPECT) imaging using the labeled dopamine transporter radiotracer (99m)Tc-TRODAT-1 to assess nigrostriatal dopaminergic function. The echogenicity of the substantia nigra was measured by TCS in all patients who received DAT-SPECT scanning...
August 2015: Parkinsonism & related Disorders
Jie Yuan, Xing Dang Liu, Mei Han, Rong Bin Lv, Yuan Kai Wang, Guang Ming Zhang, Yu Li
To compare the effects of heroin and methamphetamine (METH) addiction on dopamine transporters (DATs) in the same dose and duration, we assessed DAT levels in the striatum by (99m) Tc-TRODAT-1 single-photon emission computed tomography (SPECT) brain images in people with heroin and METH dependence. We recruited 21 healthy human controls, 23 heroin-dependent subjects and 25 METH abusers. The heroin- and METH-dependent subjects exhibited negative urine toxicology after undergoing physiological detoxification...
June 4, 2015: Addiction Biology
Chieh-Sheng Lu, Wei-Yau Kao, Jiann-Chyun Lin, Ping-Ying Chang
Interferon has been used to treat chronic viral hepatitis and several malignancies. However, it may cause various neuropsychiatric adverse effects including parkinsonism. We report a rare case of interferon alpha-2a therapy-related parkinsonism in a 67-year-old man with metastatic papillary renal cell carcinoma and our experience of using Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) as a tool for evaluation of parkinsonism. Physicians should be alert to the possibility of interferon alpha-2a-related parkinsonism...
May 2015: Clinical Neuropharmacology
Cheng-Kai Huang, Jay Wu, Kai-Yuan Cheng, Lung-Kwang Pan
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the basal ganglia. Single photon emission computed tomography (SPECT) scans using [99mTc]TRODAT-1 can image dopamine transporters and provide valuable diagnostic information of PD. In this study, we optimized the scanning parameters for [99mTc]TRODAT-1/SPECT using the Taguchi analysis to improve image quality. SPECT scans were performed on forty-five healthy volunteers according to an L9 orthogonal array...
2015: PloS One
Shih-Hsien Lin, Kao Chin Chen, Sheng-Yu Lee, Nan Tsing Chiu, I Hui Lee, Po See Chen, Tzung Lieh Yeh, Ru-Band Lu, Chia-Chieh Chen, Mei-Hsiu Liao, Yen Kuang Yang
One of the consequences of heroin dependency is a huge expenditure on drugs. This underlying economic expense may be a grave burden for heroin users and may lead to criminal behavior, which is a huge cost to society. The neuropsychological mechanism related to heroin purchase remains unclear. Based on recent findings and the established dopamine hypothesis of addiction, we speculated that expenditure on heroin and central dopamine activity may be associated. A total of 21 heroin users were enrolled in this study...
March 30, 2015: Psychiatry Research
Lan-Ting Lee, Hsin Chun Tsai, Mei Hung Chi, Wei Hung Chang, Kao Chin Chen, I Hui Lee, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yang
Dopamine and serotonin have been indirectly found to be associated with generalized anxiety disorder (GAD). The aims of this study were to examine the availabilities of the striatal dopamine transporter (DAT) and the midbrain serotonin transporter (SERT) in patients with GAD. 12 patients with GAD and 12 sex-matched, age-matched, and smoking status-matched healthy controls were recruited. The availabilities of DAT and SERT were approximated using single-photon emission computed tomography, with [Tc]TRODAT-1 and [I]ADAM as the ligands...
May 2015: International Clinical Psychopharmacology
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