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https://www.readbyqxmd.com/read/29116340/18f-dopa-pet-ct-and-68ga-dotanoc-pet-ct-scans-as-diagnostic-tools-in-focal-congenital-hyperinsulinism-a-blinded-evaluation
#1
Charlotte Dahl Christiansen, Henrik Petersen, Anne Lerberg Nielsen, Sönke Detlefsen, Klaus Brusgaard, Lars Rasmussen, Maria Melikyan, Klas Ekström, Evgenia Globa, Annett Helleskov Rasmussen, Claus Hovendal, Henrik Thybo Christesen
PURPOSE: Focal congenital hyperinsulinism (CHI) is curable by surgery, which is why identification of the focal lesion is crucial. We aimed to determine the use of 18F-fluoro-dihydroxyphenylalanine (18F-DOPA) PET/CT vs. 68Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic-acid-1-Nal3-octreotide (68Ga-DOTANOC) PET/CT as diagnostic tools in focal CHI. METHODS: PET/CT scans of children with CHI admitted to Odense University Hospital between August 2005 and June 2016 were retrospectively evaluated visually and by their maximal standardized uptake values (SUVmax) by two independent examiners, blinded for clinical, surgical and pathological data...
November 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29072093/the-utility-of-68-ga-dotatate-positron-emission-tomography-computed-tomography-in-the-diagnosis-management-follow-up-and-prognosis-of-neuroendocrine-tumors
#2
Amit Tirosh, Electron Kebebew
Neuroendocrine tumors (NETs) are rare neoplasms that emerge mainly from the GI tract, pancreas and respiratory tract. The incidence of NETs has increased more than sixfold in the last decades. NETs typically express somatostatin receptors on their cell surface, which can be targeted by 'cold' somatostatin analogs for therapy or by 'hot' radiolabeled somatostatin analogs for tumor localization and treatment. 68-Gallium-DOTA peptides (DOTATATE, DOTATOC, DOTANOC) positron emission tomography/computed tomography is a highly accurate imaging modality for NETs that has been found to be more sensitive for NET detection than other imaging modalities...
October 26, 2017: Future Oncology
https://www.readbyqxmd.com/read/29034744/correction-to-oncogenic-osteomalacia-role-of-ga-68-dotanoc-pet-ct-scan-in-identifying-the-culprit-lesion-and-its-management
#3
Deepa Singh, Aditi Chopra, Mudalsha Ravina, Srikant Kongara, Eesh Bhatia, Narvesh Kumar, Sushil Gupta, Subhash Yadav, Preeti Dabadghao, Rajnikant Yadav, Veeresh Dube, Utham Kumar, Manish Dixit, Sanjay Gambhir
No abstract text is available yet for this article.
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28890865/functional-imaging-of-paragangliomas-with-an-emphasis-on-von-hippel-lindau-associated-disease-a-mini-review
#4
REVIEW
Ioannis Ilias, Georgios Meristoudis
Few reports have presented data and results on functional (i.e., nuclear medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von Hippel-Lindau (VHL) patients. Nuclear medicine localization modalities for chromaffin tumors can be specific or nonspecific. Specific methods make use of the expression of the human norepinephrine transporter (hNET) and vesicular monoamine transporters (VMATs) by these tumors. These permit the use of radiolabeled ligands that enter the synthesis and storage pathway of catecholamines...
2017: Journal of Kidney Cancer and VHL
https://www.readbyqxmd.com/read/28872545/concomitant-177lu-dotatate-and-capecitabine-therapy-in-patients-with-advanced-neuroendocrine-tumors-a-long-term-outcome-toxicity-survival-and-quality-of-life-study
#5
Sanjana Ballal, Madhav P Yadav, Nishikant A Damle, Ranjit K Sahoo, Chandrasekhar Bal
PURPOSE: The purpose of this study was to evaluate the outcome, toxicity, survival, and quality of life in patients with advanced neuroendocrine tumors. METHODS: One hundred sixty-seven patients were enrolled in the study. All patients underwent baseline Ga-DOTANOC PET/CT scans. Lu-DOTATATE therapy was administered quarterly along with oral capecitabine therapy in group 1 patients (n = 88), whereas group 2 patients (n = 79) were treated only with Lu-DOTATATE. Hematologic, kidney function, liver function tests and chromogranin A levels were recorded before and after therapy at 2-week, 4-week, and 3-month intervals...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28864614/somatostatin-receptor-antagonists-for-imaging-and-therapy
#6
REVIEW
Melpomeni Fani, Guillaume P Nicolas, Damian Wild
Somatostatin receptor (sstr) scintigraphy for imaging and sstr analogs for treatment have been used for more than 20 y. An important improvement in recent years was the introduction of peptide receptor radionuclide therapy with radiolabeled sstr agonists, such as [(90)Y-DOTA(0),Tyr(3)]octreotide or [(177)Lu-DOTA(0),Tyr(3)]octreotide ((90)Y- or (177)Lu-DOTATOC, respectively) and [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE). PET/CT with (68)Ga-labeled sstr agonists, such as (68)Ga-DOTATOC, (68)Ga-DOTATATE, and [(68)Ga-DOTA,1-Nal(3)]octreotide ((68)Ga-DOTANOC), plays an important role in staging and restaging neuroendocrine tumors...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28782321/insulinoma-presenting-with-neuropsychiatric-symptoms
#7
S Aggarwal, N Nand, N Damle, R Godara, R Kumar
An insulinoma is a rare pancreatic endocrine tumor which is typically a hypervascular, solitary small tumour. 90 % of tumors are benign and less than 2 cm in size. Some insulinomas are associated with MEN-1 syndrome. Some cases of insulinoma may present with neuropsychiatric symptoms and may be wrongly diagnosed as psychosis. We report a case of insulinoma in a 55 years old female who presented with episodes of abnormal behavior and altered sensorium. On detailed investigations she was diagnosed as a case of hyperinsulinemic hypoglycemia due to insulinoma (in her case MRI abdomen was normal) DOTANOC PET CT confirmed the insulinoma in body/tail of pancreas...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28776139/catching-the-zebra-clinical-pearls-and-pitfalls-for-the-successful-diagnosis-of-zollinger-ellison-syndrome
#8
REVIEW
Aaron H Mendelson, Mark Donowitz
Zollinger-Ellison syndrome (ZES) results from an ectopic gastrin-secreting tumor leading to peptic ulcer disease, reflux, and chronic diarrhea. While early recognition portends an excellent prognosis with >80% survival at 15 years, symptoms are often nonspecific making the diagnosis difficult to establish. Diagnosis involves a series of tests, including fasting gastrin, gastric pH, chromogranin A, and secretin stimulation. Performing these tests in the correct sequence and at the proper time is essential to avoid inaccurate results...
August 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28713755/tumor-induced-osteomalacia-a-sherlock-holmes-approach-to-diagnosis-and-management
#9
G V Chanukya, Manoj Mengade, Jagadishwar Goud, I Satish Rao, Anuj Jain
Tumor-induced osteomalacia (TIO) is a subtype of paraneoplastic syndrome associated with hypophosphatemia due to renal phosphate wasting in adults. The humoral factor responsible for clinical picture known as fibroblast growth factor 23 (FGF23) is most often secreted by benign yet elusive mesenchymal tumors, difficult to localize, access, and excise completely; rarely, they are multiple and malignant. Paradoxical inappropriately normal or low levels of 1,25-dihydroxyvitamin D in the setting of hypophosphatemia is due to suppressive effect of FGF23...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28686510/somatostatin-receptor-expression-in-lymphomas-a-source-of-false-diagnosis-of-neuroendocrine-tumor-at-68-ga-dotanoc-pet-ct-imaging
#10
Tiina Ruuska, Yadith Ramírez Escalante, Samuli Vaittinen, Maria Gardberg, Aida Kiviniemi, Päivi Marjamäki, Jukka Kemppainen, Sirkku Jyrkkiö, Heikki Minn
BACKGROUND: (68)Ga-DOTANOC PET/CT is routinely used to image neuroendocrine tumors (NETs). A case of lymphoma initially thought to be NET based on a positive (68)Ga-DOTANOC PET/CT was recently seen at our institution. This prompted us to determine prospectively somatostatin receptor (SSTR) status in patients with lymphoma by immunohistochemical analysis of SSTR subtypes 2, 3 and 5 (SSTR2,3,5) and (68)Ga-DOTANOC PET/CT imaging. MATERIAL AND METHODS: Twenty-one patients with newly diagnosed lymphoma were referred to (68)Ga-DOTANOC and FDG PET/CT prior to any treatment...
July 7, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28682847/metastatic-neuroblastoma-in-adult-patient-presenting-as-a-super-scan-on-68ga-dotanoc-pet-ct-imaging
#11
Dharmender Malik, Abhiram Jois, Harmandeep Singh, Girdhar S Bora, Rajender Kumar Basher, Bhagwant Rai Mittal
We report a case of 23-year-old man who presented with complaints of progressive abdominal distension for the past 3 months along with the loss of appetite and weight and had a large solid cystic mass in the left half of the abdominal cavity revealed on ultrasonography and contrast-enhanced CT of the abdomen. Subsequent biopsy and histopathology revealed it to be neuroblastoma. Ga-DOTANOC PET/CT scan performed to rule out distant metastasis showed intense radiotracer uptake distributed throughout the skeleton, mimicking a super scan...
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28682844/whole-body-68ga-dotanoc-pet-mri-versus-68ga-dotanoc-pet-ct-in-patients-with-neuroendocrine-tumors-a-prospective-study-in-28-patients
#12
Dominik Berzaczy, Chiara Giraudo, Alexander R Haug, Markus Raderer, Daniela Senn, Georgios Karanikas, Michael Weber, Marius E Mayerhoefer
PURPOSE: The aim of this study was to assess the diagnostic performance of simultaneous whole-body Ga-DOTANOC PET/MRI compared with Ga-DOTANOC PET/CT for detection of distant metastatic disease in patients with well-differentiated neuroendocrine tumors (NETs). METHODS: Patients with histologically proven, well-differentiated NET (G1 or G2) were included in this prospective, institutional review board-approved study. Patients underwent Ga-DOTANOC PET/CT and subsequent Ga-DOTANOC PET/MRI after a single tracer injection on the same day for staging or restaging purposes...
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28680217/glomus-tumor-of-the-larynx-a-rare-synchronous-paraganglioma-in-a-patient-with-bilateral-carotid-body-tumor-detected-on-68-ga-dotanoc-pet-ct
#13
Sarthak Tripathy, Anirban Mukherjee, Chirom A Singh, Bhinyaram Jat, Chandrasekhar Bal, Shamim Ahmed Shamim
Paragangliomas are neoplasms arising from extra-adrenal chromaffin tissue. They frequently cause symptoms by overproduction of catecholamines with known predilection to multicentricity. We describe the case of a patient with bilateral carotid body tumor who underwent a baseline 68 Gallium labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-Octreotide.
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28533641/image-findings-of-a-rare-case-of-neuroendocrine-tumor-metastatic-to-orbital-extraocular-muscle-in-gallium-68-dotanoc-positron-emission-tomography-computed-tomography-and-therapy-with-lutetium-177-dotatate
#14
Koramadai Karuppusamy Kamaleshwaran, Jephy Joseph, Indra Upadhya, Ajit Sugunan Shinto
Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1-13% of all orbital masses. In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit, followed by metastasis from the lung, prostate, and gastrointestinal tract. Carcinoid tumors are rare neuroendocrine neoplasms derived from enterochromaffin cells, which are found primarily in the gastrointestinal tract and bronchial tree. Liver metastases are the classic presentation of distant disease...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28399530/68gallium-dotanoc-pet-imaging-in-lung-carcinoids-impact-on-patients-management
#15
Angela Lamarca, D Mark Pritchard, Thomas Westwood, Georgios Papaxoinis, Daisuke Nonaka, Sobhan Vinjamuri, Juan W Valle, Prakash Manoharan, Wasat Mansoor
No abstract text is available yet for this article.
April 12, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28341976/development-and-evaluation-of-user-friendly-single-vial-dota-peptide-kit-formulations-specifically-designed-for-radiolabelling-with-68-ga-from-a-tin-dioxide-68-ge-68-ga-generator
#16
Deidré Prince, Daniel Rossouw, Claudia Davids, Sietske Rubow
PURPOSE: This study was aimed to develop single vial 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptide kits to be used with fractionated eluates from a SnO2-based (68)Ge/(68)Ga generator. PROCEDURES: Kits were formulated with 35 μg DOTA-Tyr(3)-Thre(8)-octreotide, DOTA-[Tyr(3)]-octreotide and DOTA-[NaI(3)]-octreotide (DOTATATE, DOTATOC and DOTANOC) and sodium acetate powder, vacuum-dried and stored at -20 °C for up to 12 months. Labelling of the kits was carried out with 2 ml (68)Ga eluate...
December 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28315919/a-rare-adult-renal-neuroblastoma-better-imaged-by-18-f-fdg-than-by-68-ga-dotanoc-in-the-pet-ct-scan
#17
COMPARATIVE STUDY
Tarun Kumar Jain, Sharwan Kumar Singh, Ashwani Sood, Abhiram Gj Ashwathanarayama, Rajender Kumar Basher, Jaya Shukla, Bhagwant Rai Mittal
Primary renal neuroblastoma is an uncommon tumor in children and extremely rare in adults. We present a case of a middle aged female having a large retroperitoneal mass involving the right kidney with features of neuroblastoma on pre-operative histopathology. Whole-body fluorine-18-fluoro-deoxyglucose positron emission tomography ((18)F-FDG PET/CT) and (68)Ga-dotanoc PET/CT scans performed for staging and therapeutic potential revealed a tracer avid mass replacing the right kidney and also pelvic lymph nodes...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28263209/the-wandering-mesenteric-lymph-node-delayed-68ga-dotanoc-pet-ct-imaging-to-overcome-a-potential-pitfall
#18
Lucia Zanoni, Maurizio Zompatori, Federica Scalorbi, Stefano Fanti, Valentina Ambrosini
A patient multiple endocrine neoplasia type 1 presenting with radiological suspicion of pancreatic neuroendocrine tumor relapse after surgical and somatostatin analog treatment underwent restaging Ga-DOTANOC PET/CT. Standard and delayed images detected an area of focal intense uptake moving from the left para-aortic to the paracaval region. The lesion was identified at previous imaging in different abdominal locations (eg, adjacent to the duodenal wall at presurgical PET and in the aortocaval region at restaging contrast-enhanced CT)...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28254872/pet-mri-for-oncologic-brain-imaging-a-comparison-of-standard-mr-based-attenuation-corrections-with-a-model-based-approach-for-the-siemens-mmr-pet-mr-system
#19
COMPARATIVE STUDY
Ivo Rausch, Lucas Rischka, Claes N Ladefoged, Julia Furtner, Matthias Fenchel, Andreas Hahn, Rupert Lanzenberger, Marius E Mayerhoefer, Tatjana Traub-Weidinger, Thomas Beyer
The aim of this study was to compare attenuation-correction (AC) approaches for PET/MRI in clinical neurooncology. Methods: Forty-nine PET/MRI brain scans were included: brain tumor studies using (18)F-fluoro-ethyl-tyrosine ((18)F-FET) (n = 31) and (68)Ga-DOTANOC (n = 7) and studies of healthy subjects using (18)F-FDG (n = 11). For each subject, MR-based AC maps (MR-AC) were acquired using the standard DIXON- and ultrashort echo time (UTE)-based approaches. A third MR-AC was calculated using a model-based, postprocessing approach to account for bone attenuation values (BD, noncommercial prototype software by Siemens Healthcare)...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28181822/oncogenic-osteomalacia-role-of-ga-68-dotanoc-pet-ct-scan-in-identifying-the-culprit-lesion-and-its-management
#20
Deepa Singh, Aditi Chopra, Mudalsha Ravina, Srikant Kongara, Eesh Bhatia, Narvesh Kumar, Sushil Gupta, Subhash Yadav, Preeti Dabadghao, Rajnikant Yadav, Veeresh Dube, Utham Kumar, Manish Dixit, Sanjay Gambhir
OBJECTIVE: The aim of this study was to evaluate the role of (68)Ga-DOTANOC positron emission tomography (PET)/CT scan in localization of culprit lesion for biopsy and required intervention [surgical excision/radiofrequency ablation (RFA)] in patients with long-standing oncogenic osteomalacia (OOM)/tumour-induced osteomalacia. METHODS: 17 patients (8 males and 9 females) underwent (68)Ga-DOTANOC PET/CT scan. The patients referred with clinical and biochemical evidence of hypophosphatemia and raised fibroblast growth factor-23...
April 2017: British Journal of Radiology
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