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https://www.readbyqxmd.com/read/27846139/the-accessory-spleen-is-an-important-pitfall-of-68ga-dotanoc-pet-ct-in-the-workup-for-pancreatic-neuroendocrine-neoplasm
#1
Vittoria Rufini, Frediano Inzani, Antonella Stefanelli, Paola Castaldi, Germano Perotti, Annarita Cinquino, Luca Indovina, Guido Rindi
OBJECTIVE: The aim of the study was to assess the value and potential pitfalls of Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). METHODS: Consecutive patients referred for Ga-DOTANOC PET/CT for suspected pNEN between May 1, 2011, and October 31, 2014, were retrospectively assessed. Scan data were compared with cytological/histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27843513/bilateral-choroidal-metastases-from-endobronchial-carcinoid-treated-with-somatostatin-analogues
#2
Deborah De Bruyn, Jan Lamont, Erik Vanderstraeten, Simon Van Belle, Elise Platteau, Julie De Zaeytijd, Kristien P Hoornaert
OBJECTIVE: To describe a patient with bilateral multifocal choroidal metastases from an endobronchial carcinoid treated with a somatostatin analogue. METHOD: A 60-year-old woman presenting with photopsia in the left eye underwent an extensive ophthalmic examination, including fluorescein angiography, OCT and ultrasound. RESULTS: Fundoscopy revealed a small retinal tear in the left eye, for which she received laser treatment. In addition, choroidal masses were detected in both eyes...
2016: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/27824322/68ga-dotanoc-focal-pulmonary-activity-with-no-corresponding-ct-abnormality
#3
Emmanouil Panagiotidis, Nagabhushan Seshadri, Rashika Fernando, Priya Healey, Sobhan Vinjamuri
A 28-year-old woman with medullary thyroid cancer treated with total thyroidectomy and bilateral central and right lateral neck nodal resection postoperatively had increasing calcitonin and carcinoembryonic antigen values. A Ga-DOTANOC PET/CT study performed showed tracer-avid disease in the neck, mediastinal, and hilar lymph nodes. However, there were 3 tracer-avid foci in the lungs bilaterally, suggestive of lung metastases but with no corresponding abnormalities on low-dose CT. A negative contrast-enhanced CT of the lungs along with clinical and radiological follow-up confirmed that the lung activity was artifactual, demonstrating the possibility of Ga-DOTANOC-avid iatrogenic pulmonary microembolism...
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27811124/molecular-imaging-of-gastroenteropancreatic-neuroendocrine-tumors-current-status-and-future-directions
#4
REVIEW
Christophe M Deroose, Elif Hindié, Electron Kebebew, Bernard Goichot, Karel Pacak, David Taïeb, Alessio Imperiale
Through diagnostic imaging and peptide receptor radionuclide therapy, nuclear medicine has earned a major role in gastroenteropancreatic neuroendocrine tumors (GEP NETs). GEP NETs are diagnosed fortuitously or on the basis of symptoms or hormonal syndrome. The functional tumor characteristics shown by radionuclide imaging allow for more accurate staging and treatment selection. Tumor grade helps determine which tracer should be selected. In the past, (111)In-pentetreotide has been successful in well-differentiated (G1 and G2) tumors...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27749422/fdg-dotanoc-mismatch-in-in-vivo-characterization-and-grading-of-neuroendocrine-tumor
#5
Anirban Mukherjee, Krishan Kant Agarwal, Chandrasekhar Bal, Rakesh Kumar
Neuroendocrine tumors (NETs) are rare heterogeneous neoplasm of variable aggressiveness. A 55-year-old woman underwent Ga-DOTANOC PET-CT for suspected NET, which revealed DOTANOC-avid soft tissue mass in the second part of the duodenum with multiple hepatic metastases. Another non-DOTANOC-avid abdominal mass and hypodense lesion in segment VI of the liver were noted. For further evaluation, FDG PET-CT was performed, which revealed increased uptake in the abdominal mass and lesion in segment VI of the liver...
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27612032/comparison-of-renal-uptake-of-68ga-dotanoc-pet-ct-and-estimated-glomerular-filtration-rate-before-and-after-peptide-receptor-radionuclide-therapy-in-patients-with-metastatic-neuroendocrine-tumours
#6
Chalermrat Kaewput, Sobhan Vinjamuri
BACKGROUND: Ga-DOTA-conjugated peptide PET/CT is used widely for diagnosis and treatment planning in patients with neuroendocrine tumours. As nephrotoxicity is a major limiting factor during peptide receptor radionuclide therapy (PRRT), it is important to evaluate renal function before, during and after treatment. The aim of our study is to compare renal uptake of Ga-DOTANOC and estimated glomerular filtration rate (eGFR) before and after PRRT and to identify any surrogate indicators of renal toxicity...
September 8, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27479886/influence-of-pet-ct-68ga-somatostatin-receptor-imaging-on-proceeding-with-patients-who-were-previously-diagnosed-with-99mtc-edda-hynic-toc-spect
#7
Dorota Madrzak, Renata Mikołajczak, Grzegorz Kamiński
BACKGROUND: The aim of this study was the assessment of utility of somatostatin receptor scintigraphy (SRS) by SPECT imaging using 99mTc-EDDA/HYNIC-Tyr3-octreotide (99mTc-EDDA/HYNIC-TOC) in patients with neuroendocrine neoplasm (NEN) or suspected NEN, referred to Nuclear Medicine Dept. of Voivodship Specialty Center in Rzeszow. The selected group of patients was referred also to 68Ga PET/CT. The posed question was the ratio of patients for whom PET/CT with 68Ga would change their management...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27467882/revisiting-the-robustness-of-pet-based-textural-features-in-the-context-of-multi-centric-trials
#8
Clément Bailly, Caroline Bodet-Milin, Solène Couespel, Hatem Necib, Françoise Kraeber-Bodéré, Catherine Ansquer, Thomas Carlier
PURPOSE: This study aimed to investigate the variability of textural features (TF) as a function of acquisition and reconstruction parameters within the context of multi-centric trials. METHODS: The robustness of 15 selected TFs were studied as a function of the number of iterations, the post-filtering level, input data noise, the reconstruction algorithm and the matrix size. A combination of several reconstruction and acquisition settings was devised to mimic multi-centric conditions...
2016: PloS One
https://www.readbyqxmd.com/read/27440185/pet-radiopharmaceuticals-for-personalized-medicine
#9
Sushil K Sharma
Recent advances in the self-shielded cyclotrons, improved targets, video-monitored hot cells design, and automated PET radiopharmaceutical (RPs) synthesis modules, utilizing computer-controlled graphic user interphase (GUI) has revolutionized PET molecular imaging technology for basic biomedical research and theranostics to accomplish the ultimate goal of evidence-based personalized medicine. Particularly, [18F]HX4: (3-[18F]fluoro-2-(4-((2-nitro-1Himidazol-1-yl)methyl)-1H-1,2,3,-triazol-1-yl)-propan-1-ol), 18F-FAZA: 1-(5-[18F]Fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole, and 18F-FMSIO: 18F-Ffluoromisonidazole to assess tumor hypoxia, [18F]FB-VAD-FMK: [18F]4-fluorobenzylcarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone to determine in vivo apoptosis, 64Cu-PTSM: 64Cu-Pyrualdehyde Bis-N-Methylthiosemicarbazone for brain and myocardial perfusion imaging, and 68Ga-DOTATOC: 68Ga-DOTAD-Phy1-Tyr3-octreotide and 68Ga-DOTANOC: 68Ga-(1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid)-1-NaI3-octreotide for neuroendocrine and neural crest tumors have demonstrated great promise in personalized theranostics...
July 19, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27321028/pet-based-molecular-imaging-in-designing-personalized-management-strategy-in-gastroenteropancreatic-neuroendocrine-tumors
#10
REVIEW
Sandip Basu, Rohit Ranade, Vikas Ostwal, Shailesh V Shrikhande
In recent years, PET-based molecular functional imaging has been increasingly used in neuroendocrine tumors for tailoring of treatment strategies to the individual characteristics of each patient. For each particular patient, the relative tracer uptake by the dual-tracer PET imaging approach (with 68Ga-DOTANOC/TATE and 18F-FDG) frequently plays an important role along with the histopathologic tumor grades for selecting the optimal treatment approach for advanced/metastatic cases. Various tumor-specific parameters have resulted in development of such precision-medicine type model in this biologically heterogeneous group of tumors...
July 2016: PET Clinics
https://www.readbyqxmd.com/read/27316444/a-dual-tracer-68-ga-dotanoc-pet-ct-and-18-f-fdg-pet-ct-pilot-study-for-detection-of-cardiac-sarcoidosis
#11
Lars C Gormsen, Ate Haraldsen, Stine Kramer, Andre H Dias, Won Yong Kim, Per Borghammer
BACKGROUND: Cardiac sarcoidosis (CS) is a potentially fatal condition lacking a single test with acceptable diagnostic accuracy. (18)F-FDG PET/CT has emerged as a promising imaging modality, but is challenged by physiological myocardial glucose uptake. An alternative tracer, (68)Ga-DOTANOC, binds to somatostatin receptors on inflammatory cells in sarcoid granulomas. We therefore aimed to conduct a proof-of-concept study using (68)Ga-DOTANOC to diagnose CS. In addition, we compared diagnostic accuracy and inter-observer variability of (68)Ga-DOTANOC vs...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27284479/ga-68-dotanoc-pet-ct-imaging-in-detection-of-primary-site-in-patients-with-metastatic-neuroendocrine-tumours-of-unknown-origin-and-its-impact-on-clinical-decision-making-experience-from-a-tertiary-care-centre-in-india
#12
Ankur Pruthi, Promila Pankaj, Ritu Verma, Anjali Jain, Ethel S Belho, Harsh Mahajan
BACKGROUND: Neuroendocrine tumours (NETs) are rare, heterogeneous group of tumours which usually originate from small, occult primary sites and are characterized by over-expression of somatostatin receptors (SSTRs). Positron emission tomography/computed tomography (PET/CT) using Ga-68-labeled-somatostatin-analogues have shown superiority over other modalities for imaging of NETs. The objective of the study was to retrospectively evaluate the efficacy of Ga-68 DOTANOC PET/CT imaging in detecting the primary site in patients with metastatic NETs of unknown origin and its impact on clinical decision making in such patients...
June 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27239005/primary-neuroendocrine-tumor-of-seminal-vesicle-an-extremely-rare-clinical-entity-emphasizing-diagnostic-role-of-68-ga-dotanoc-pet-ct-scan-and-therapeutic-potential-of-long-acting-depot-octreotide-injection-in-maintenance
#13
Narayan Adhikari, Dodul Mondal, Manisha Jana, Kalpana Kumari, Kalpa Jyoti Das, Pramod K Julka
No abstract text is available yet for this article.
May 2, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27108447/preclinical-in-vivo-application-of-152-tb-dotanoc-a-radiolanthanide-for-pet-imaging
#14
Cristina Müller, Christiaan Vermeulen, Karl Johnston, Ulli Köster, Raffaella Schmid, Andreas Türler, Nicholas P van der Meulen
BACKGROUND: Terbium has attracted the attention of researchers and physicians due to the existence of four medically interesting radionuclides, potentially useful for SPECT and PET imaging, as well as for α- and β(-)-radionuclide therapy. The aim of this study was to produce (152)Tb (T 1/2 = 17.5 h, Eβ+av = 1140 keV) and evaluate it in a preclinical setting in order to demonstrate its potential for PET imaging. For this purpose, DOTANOC was used for targeting the somatostatin receptor in AR42J tumor-bearing mice...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27100499/radionuclide-imaging-and-treatment-of-thyroid-cancer
#15
Xiu Juan Wang, XianFeng Li, Yuan Ren
Over the past decades, the diagnostic methods and therapeutic tools for thyroid cancer (TC) have been greatly improved. In addition to the classical method of ingestion of radioactive iodine-131 (I131) and subsequent I123 and I124 positron emission tomography (PET) in therapy and examination, I124 PET-based 3-dimensional imaging, Ga68-labeled [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid]-1-NaI(3)-octreotide (DOTANOC) PET/computed tomography (CT), Tc99m tetrofosmin, pre-targeted radioimmunotherapy, and peptide receptor radionuclide therapy have all been used clinically...
2016: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27006371/comparison-of-68ga-dotanoc-pet-ct-and-contrast-enhanced-ct-in-localisation-of-tumours-in-ectopic-acth-syndrome
#16
Majunath R Goroshi, Swati S Jadhav, Anurag R Lila, Rajeev Kasaliwal, Shruti Khare, Chaitanya G Yerawar, Priya Hira, Uday Phadke, Hina Shah, Vikram R Lele, Gaurav Malhotra, Tushar Bandgar, Nalini S Shah
BACKGROUND: Localising ectopic adrenocorticotrophic hormone (ACTH) syndrome (EAS) tumour source is challenging. Somatostatin receptor-based PET imaging has shown promising results, but the data is limited to case reports and small case series. We reviewed here the performance of (68)Ga-DOTANOC positron emission tomography (PET)/computed tomography (CT) and contrast-enhanced CT (CECT) in our cohort of 12 consecutive EAS patients. MATERIALS AND METHODS: Retrospective data analysis of 12 consecutive patients of EAS presenting to a single tertiary care centre in a period between January 2013 and December 2014 was done...
March 2016: Endocrine Connections
https://www.readbyqxmd.com/read/26917888/diagnostic-importance-of-contrast-enhanced-18-f-fluorodeoxyglucose-positron-emission-computed-tomography-in-patients-with-tumor-induced-osteomalacia-our-experience
#17
Avani S Jain, Simon Shelley, Indirani Muthukrishnan, Shilpa Kalal, Jaykanth Amalachandran, Sureshkumar Chandran
AIMS AND OBJECTIVES: To assess the diagnostic utility of contrast-enhanced (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-ceCT) in localization of tumors in patients with clinical diagnosis of tumor-induced osteomalacia (TIO), in correlation with histopathological results. MATERIALS AND METHODS: Eight patients (five male and three female) aged 24-60 (mean 42) years with a clinical diagnosis of TIO were included in this prospective study...
January 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/26912984/unusual-presentation-of-bladder-paraganglioma-comparison-of-131-i-mibg-spect-ct-and-68-ga-dotanoc-pet-ct
#18
Tarun Kumar Jain, Rajender Kumar Basher, Nitin Gupta, Jaya Shukla, Shrawan Kumar Singh, Bhagwant Rai Mittal
Extraadrenal chromaffin cell-related tumors or paragangliomas are rare, especially in the bladder, accounting for less than 1% of cases. We report a 16-year-old boy who presented with hematuria and paroxysmal headache and was found to have a prostatic growth infiltrating the urinary bladder on anatomical imaging. Iodine-131 ((131)I) metaiodobenzylguanidine (MIBG) whole-body scanning and subsequently gallium-68 ((68)Ga) DOTANOC positron emission tomography/computed tomography (PET/CT) were performed. The MIBG scan revealed a non-tracer-avid soft-tissue mass, while DOTANOC PET/CT revealed a tracer-avid primary soft-tissue mass involving the urinary bladder and prostate with metastasis to the iliac lymph nodes...
January 2016: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26912977/metastatic-neuroendocrine-tumor-with-extensive-bone-marrow-involvement-at-diagnosis-evaluation-of-response-and-hematological-toxicity-profile-of-prrt-with-177-lu-dotatate
#19
Sandip Basu, Rohit Ranade, Pradeep Thapa
The aim of this study was to evaluate the response and hematological toxicity in peptide receptor radionuclide therapy (PRRT) with lutetium ((177)Lu)-DOTA-octreotate (DOTATATE) in metastatic neuroendocrine tumor (NET) with extensive bone marrow metastasis at the initial diagnosis. A retrospective evaluation was undertaken for this purpose: Patients with NET with extensive diffuse bone marrow involvement at diagnosis who had received at least three cycles of PRRT with (177)Lu-DOTATATE were considered for the analysis...
January 2016: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26905068/multiple-endocrine-neoplasia-type-1-syndrome-single-centre-experience-from-western-india
#20
Manjunath Goroshi, Tushar Bandgar, Anurag R Lila, Swati Sachin Jadhav, Shruti Khare, Shailesh V Shrikhande, Shinya Uchino, Abhay N Dalvi, Nalini S Shah
Multiple endocrine neoplasia type 1 syndrome (MEN1) is a rare autosomal dominant familial cancer syndrome affecting multiple endocrine glands. Published literature on MEN1 from Indian subcontinent is scarce. We report here a case series of MEN1 patients (n = 18) from 14 unrelated families. Retrospective study describing the clinical profile of MEN1 patients from endocrine unit of a tertiary care hospital from western India. Additionally clinical profile of primary hyperparathyroidism (PHPT) in MEN1 patients was compared with that of apparently sporadic PHPT cohort from our centre...
October 2016: Familial Cancer
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