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https://www.readbyqxmd.com/read/27907840/clinical-68-ga-pet-is-radiosynthesis-module-an-absolute-necessity
#1
Rubel Chakravarty, Sudipta Chakraborty, E R Radhakrishnan, Koramadai Kamaleshwaran, Ajit Shinto, Ashutosh Dash
INTRODUCTION: The commercially available (68)Ge/(68)Ga generators are generally used in clinical context in conjunction with automated or semi-automated modules for the syntheses of (68)Ga radiopharmaceuticals. It is desirable to develop strategies for the formulation of (68)Ga-radiopharmaceuticals without use of such expensive modules in order to make (68)Ga-based clinical positron emission tomography (PET) more popular and affordable worldwide. METHODS: An organic matrix based (68)Ge/(68)Ga generator was used for preparation of clinically relevant doses of four different (68)Ga-based radiopharmaceuticals, namely (68)Ga-DOTA-NOC, (68)Ga-NODAGA-RGD2, (68)Ga-PSMA-11 and (68)Ga-BPAMD...
November 16, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27904871/in-vivo-measurement-and-characterization-of-a-novel-formulation-of-177-lu-dota-octreotate
#2
Dale L Bailey, Thomas M Hennessy, Kathy P Willowson, E Courtney Henry, David Lh Chan, Alireza Aslani, Paul J Roach
OBJECTIVES: Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as "No Carrier Added" (NCA) (177)Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr(3))-octreotate with NCA (177)Lu ("NCA-LuTATE") and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) (177)Lu imaging...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904870/preclinical-study-of-68-ga-dotatoc-biodistribution-assessment-in-syrian-rats-and-evaluation-of-absorbed-dose-in-human-organs
#3
Mojdeh Naderi, Samaneh Zolghadri, Hassan Yousefnia, Ali Ramazani, Amir Reza Jalilian
OBJECTIVES: Gallium-68 DOTA-DPhe(1)-Tyr(3)-Octreotide ((68)Ga-DOTATOC) has been applied by several European centers for the treatment of a variety of human malignancies. Nevertheless, definitive dosimetric data are yet unavailable. According to the Society of Nuclear Medicine and Molecular Imaging, researchers are investigating the safety and efficacy of this radiotracer to meet Food and Drug Administration requirements. The aim of this study was to introduce the optimized procedure for (68)Ga-DOTATOC preparation, using a novel germanium-68 ((68)Ge)/(68)Ga generator in Iran and evaluate the absorbed doses in numerous organs with high accuracy...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27887852/morphological-and-functional-imaging-of-neck-paragangliomas
#4
J-P Guichard, N Fakhry, J Franc, P Herman, C-A Righini, D Taieb
OBJECTIVE: To review the optimal techniques for localization and characterization of neck paragangliomas (PGL). MATERIAL AND METHODS: Systematic review of the literature from the PubMed/Medline database. RESULTS: Neck PGL are hypervascular tumours essentially arising from paraganglionic tissue situated at the carotid bifurcation (carotid body) and along the vagus nerve. Morphological and functional imaging are indicated to confirm the diagnosis, identify multifocal disease and for local and regional staging...
November 22, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27882120/lutetium-177-dota-tate-therapy-for-esthesioneuroblastoma-a-case-report
#5
Juliano Guerra Sabongi, Mônica Carboni Pereira Gonçalves, Cira Danielle Casado Alves, João Alves, Cristovam Scapulatempo-Neto, Sonia Marta Moriguchi
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27879373/novel-molecular-add-on-based-on-evans-blue-confers-superior-pharmacokinetics-and-transforms-drugs-to-theranostic-agents
#6
Haojun Chen, Orit Jacobson, Gang Niu, Ido Weiss, Dale O Kiesewetter, Yi Liu, Ying Ma, Hua Wu, Xiaoyuan Chen
: One of the major design considerations for a drug is its pharmacokinetics in the blood. A drug with short half-life in the blood is less available at a target organ. Such a limitation dictates treatment with either high doses or more frequent doses, both of which may increase the likelihood of undesirable side effects. To address the need for additional methods to improve the blood half-life of drugs and molecular imaging agents, we developed an "add-on" molecule that contains three groups: (i) truncated Evans Blue (EB) dye molecule that binds to albumin with low micromolar affinity and provides prolonged half-life in the blood; (ii) a metal chelate that allows radiolabeling for imaging and radiotherapy; and (iii) a maleimide for easy conjugation to drug molecules...
November 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27875420/molecular-imaging-in-neuroendocrine-tumors-recent-advances-controversies-unresolved-issues-and-roles-in-management
#7
Tetsuhide Ito, Robert T Jensen
PURPOSE OF REVIEW: The purpose is to review recent advances in molecular imaging of neuroendocrine tumors (NETs), discuss unresolved issues, and review how these advances are affecting clinical management. RECENT FINDINGS: Molecular imaging of NETs underwent a number of important changes in the last few years, leading to some controversies, unresolved issues, and significant changes in clinical management. The most recent changes are reviewed in this article. Particularly important is the rapid replacement in somatostatin receptor scintigraphy of In-diethylenetriamine penta-acetic acid-single-photon emission computed tomography/computed tomography (CT) by Ga-fluorodopa(F-D)PA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptide-PET/CT imaging, which is now approved in many countries including the USA...
November 21, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27865999/approaches-to-improve-metabolic-stability-of-a-statine-based-grp-receptor-antagonist
#8
Ilinca Popp, Luigi Del Pozzo, Beatrice Waser, Jean Claude Reubi, Philipp T Meyer, Helmut R Maecke, Eleni Gourni
: The bombesin receptor family, in particular the gastrin-releasing peptide receptor (GRPr), is an attractive target in the field of nuclear oncology due to the high density of these receptors on the cell surface of several human tumors. The successful clinical implementation of (64)Cu-CB-TE2A-AR06, (68)Ga-RM2 and (68)Ga-NODAGA-MJ9, prompted us to continue the development of GRPr-antagonists. The aim of the present study was to assess if N-terminal modulations of the statine-based GRPr-antagonist influence the binding affinity, the pharmacokinetic performance and the in vivo metabolic stability...
November 4, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27863564/designing-and-developing-pet-based-precision-model-in-thyroid-carcinoma-the-potential-avenues-for-a-personalized-clinical-care
#9
REVIEW
Sandip Basu, Rahul Vithalrao Parghane
This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG, (68)Ga-DOTA-NOC/TATE, FDOPA)...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27862624/gadolinium-containing-telechelic-peg-polymers-end-capped-by-di-phenylalanine-motives-as-potential-supramolecular-mri-contrast-agents
#10
Carlo Diaferia, Eliana Gianolio, Antonella Accardo, Giancarlo Morelli
Telechelic PEG-polymers end-capped by diphenylalanine (FF) motives and containing a DOTA-Gd complex, bound on a lysine side chain at the centre of peptide moiety, are studied for their assembling properties and for the relaxometric behavior. The observed variations in terms of relaxivity are correlated to the assembling properties of the aggregates by using several techniques: fluorescence, Circular Dichroism (CD) and Fourier Transform Infrared (FTIR) for aggregation tendency and secondary structure determination; Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) for morphological definition...
November 15, 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/27833311/preparation-and-preclinical-evaluation-of-68-ga-dota-amlodipine-for-l-type-calcium-channel-imaging
#11
Tahereh Firuzyar, Amir Reza Jalilian, Mohammad Reza Aboudzadeh, Hossein Sadeghpour, Mahdi Shafiee-Ardestani, Ali Khalaj
AIM: In order to develop a possible tracer for L-type calcium channel imaging, we here report the development of a Ga-68 amlodipine derivative for possible PET imaging. MATERIALS AND METHODS: Amlodipine DOTA conjugate was synthesized, characterized and went through calcium channel blockade, toxicity, apoptosis/necrosis tests. [(68)Ga] DOTA AMLO was prepared at optimized conditions followed by stability tests, partition coefficient determination and biodistribution studies using tissue counting and co incidence imaging up to 2 h...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27824725/68ga-vacuum-elution-approach-for-direct-radiolabelling-of-dota-conjugated-and-nodaga-conjugated-peptides
#12
Rana Ben Azzouna, Sébastien Leygnac, Faisal Al-Shoukr, François Rouzet, Denis Guilloteau, Dominique Le Guludec
BACKGROUND/OBJECTIVES: The Ge/Ga generator is of increasing interest for clinical PET. The arrival on the market of the pharmaceutical-grade generator, which provides an eluate with chemical and radiochemical purities in conformity with the European Pharmacopeia specifications, makes the direct labelling of vectors possible. The kit formulation strategies using single vial productions can improve the access of hospitals and imaging centres that are not equipped with costly automated synthesis modules to the Ga-radiopharmaceutical production...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27824238/breath-hold-68ga-dota-toc-pet-ct-in-neuroendocrine-tumors-detection-of-additional-lesions-and-effects-on-quantitative-parameters
#13
Mariana Zirnsak, Robert Bärwolf, Martin Freesmeyer
BACKGROUND: Respiratory motion during PET/CT acquisition generates artifacts in the form of breath-related blurring, which influences the lesion detectability and diagnostic accuracy. The goal of this study was to verify whether breath-hold [68Ga]DOTA-TOC PET/CT (bhPET) allows detection of additional foci compared to free-breathing PET/CT (fbPET), and to assess the impact of breath-holding on standard uptake values (SUV) and isocontoured volume (Vic40) in patients with neuroendocrine tumors (NET)...
November 8, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27820832/quantitative-multi-parametric-magnetic-resonance-imaging-of-tumor-response-to-photodynamic-therapy
#14
Tom J L Schreurs, Stefanie J Hectors, Igor Jacobs, Holger Grüll, Klaas Nicolay, Gustav J Strijkers
OBJECTIVE: The aim of this study was to characterize response to photodynamic therapy (PDT) in a mouse cancer model using a multi-parametric quantitative MRI protocol and to identify MR parameters as potential biomarkers for early assessment of treatment outcome. METHODS: CT26.WT colon carcinoma tumors were grown subcutaneously in the hind limb of BALB/c mice. Therapy consisted of intravenous injection of the photosensitizer Bremachlorin, followed by 10 min laser illumination (200 mW/cm2) of the tumor 6 h post injection...
2016: PloS One
https://www.readbyqxmd.com/read/27813061/development-of-lu-177-trastuzumab-for-radioimmunotherapy-of-her2-expressing-breast-cancer-and-its-feasibility-assessment-in-breast-cancer-patients
#15
Priya Bhusari, Rakhee Vatsa, Gurpreet Singh, Madan Parmar, Amanjit Bal, Devinder K Dhawan, Bhagwant R Mittal, Jaya Shukla
HER2/neu is over expressed in 20-25% of breast cancers. HER2 breast cancers are aggressive and are associated with poor prognosis. The aim of this study was to develop the clinical grade Lu-177-trastuzumab and its preliminary evaluation for specific tumor targeting in HER2 positive breast cancer patients. Trastuzumab was conjugated to bifunctional chelator, DOTA, and characterized for integrity and the number of molecules conjugated. Radiolabeling of DOTA-conjugated trastuzumab was optimized using Lu-177. Quality control parameters including radiochemical purity, stability, sterility, pyrogenicity and immunoreactivity were assessed...
November 3, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27801444/ridme-spectroscopy-on-high-spin-mn-2-centers
#16
D Akhmetzyanov, H Y V Ching, V Denysenkov, P Demay-Drouhard, H C Bertrand, L C Tabares, C Policar, T F Prisner, S Un
Pulsed EPR dipolar spectroscopy is a powerful tool for determining the structure and conformational dynamics of biological macromolecules, as it allows precise measurements of distances in the range of 1.5-10 nm. Utilization of high-spin Mn(2+) species as spin probes for distance measurements is of significant interest, because they are biologically compatible and endogenous in numerous biological systems. However, to date dipolar spectroscopy experiments with this kind of species have been underexplored. Here we present pulsed electron electron double resonance (PELDOR also called DEER) and relaxation-induced dipolar modulation enhancement (RIDME) experiments, which have been performed at W-band (94 GHz) and J-band frequencies (263 GHz) on a bis-MnDOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) model system...
November 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27791281/macrocyclic-paramagnetic-agents-for-mri-determinants-of-relaxivity-and-strategies-for-their-improvement
#17
Alberto Fringuello Mingo, Sonia Colombo Serra, Simona Baroni, Claudia Cabella, Roberta Napolitano, Ivan Hawala, Irene Maria Carnovale, Luciano Lattuada, Fabio Tedoldi, Silvio Aime
PURPOSE: To dissect the contributions to the longitudinal relaxivity (r1 ) of two commercial contrast agents (CAs), Gd-DOTA and Gd-HP-DO3A, and to synthesize/characterize a novel macrocyclic agent (Gd-Phen-DO3A) having superior r1 . METHODS: Longitudinal relaxation rates R1 of the CAs in saline with/without human serum albumin (HSA), ionized simulated body fluid (i-SBF), viscous simulated body fluid (v-SBF), and human plasma were measured. Results have been interpreted to evince the main determinants to the observed r1 values...
October 28, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27780640/cu-2-labeled-dansyl-compounds-as-fluorescent-and-pet-probes-for-imaging-apoptosis
#18
Junyan Han, Xukui Wang, MeiXiang Yu
Compound DNSTT-Cu(2+), a novel chelate of Cu(2+) with DOTA conjugated to a fluorescent dansyl fragment, is developed for imaging cell apoptosis. Apoptotic U-87MG cells could be selectively visualized by the fluorescence of DNSTT-Cu(2+) from cytoplasm of cells, confirmed by the fluorescence of apoptosis cells co-labeled with Alexa Fluor 568-labeled annexin V, a conventional probe for selectively labeling membranes of apoptosis cells. A radioactive (64)Cu(2)(+) analog, DNSTT-(64)Cu(2+), was easily synthesized, providing a potential PET probe for imaging apoptosis in vivo...
September 29, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27776176/evaluation-of-cd146-as-target-for-radioimmunotherapy-against-osteosarcoma
#19
Sara Westrøm, Tina B Bønsdorff, Nasir Abbas, Øyvind S Bruland, Thora J Jonasdottir, Gunhild M Mælandsmo, Roy H Larsen
BACKGROUND: Osteosarcoma is a rare form of cancer but with a substantial need for new active drugs. There is a particular need for targeted therapies to combat metastatic disease. One possible approach is to use an antibody drug conjugate or an antibody radionuclide conjugate to target the osteosarcoma metastases and circulating tumor cells. Herein we have evaluated a radiolabeled monoclonal antibody targeting CD146 both in vitro and in vivo. METHODS AND RESULTS: A murine monoclonal anti-CD146 IgG1 isotype antibody, named OI-3, was developed along with recombinant chimeric versions with human IgG1 or human IgG3 Fc sequences...
2016: PloS One
https://www.readbyqxmd.com/read/27775994/the-role-of-68ga-dota-tate-pet-ct-scanning-in-the-evaluation-of-patients-with-multiple-myeloma-preliminary-results
#20
Kerim Sonmezoglu, Betul Vatankulu, Tugrul Elverdi, Resit Akyel, Melih E Erkan, Metin Halac, Meltem Ocak, Emre Demirci, Yildiz Aydin
OBJECTIVE: In this observational pilot study, we aimed to evaluate the role of gallium-68-labelled DOTA-TATE (Ga-TATE) PET/computed tomography (CT) scanning in patients with multiple myeloma (MM), considering previous promising results obtained from conventional somatostatin receptor scintigraphy with In pentetreotide. MATERIALS AND METHODS: Twenty-one patients with a diagnosis of MM were prospectively included in this study: eight patients were referred for initial staging and 13 patients for restaging purpose...
January 2017: Nuclear Medicine Communications
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