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https://www.readbyqxmd.com/read/29459062/cost-effectiveness-of-a-potential-vaccine-candidate-for-haemophilus-influenzae-serotype-a
#1
Affan Shoukat, Robert Van Exan, Seyed M Moghadas
The preceding decade has witnessed the emergence of severe community-acquired acute infections caused by Haemophilus influenzae serotype a (Hia), with alarming incidence rates in North America, particularly among indigenous populations. The remarkable success of Hib conjugate vaccine over the past 20 years signify the development of an Hia vaccine candidate as a prevention measure to reduce the incidence of invasive Hia disease. However, quantifications of the long-term epidemiologic and economic impacts of vaccination are needed to inform decision on investment in Hia vaccine development and immunization programs...
February 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29445635/implementing-health-impact-assessment-at-national-level-an-experience-in-iran
#2
Behzad Damari, Abbas Vosoogh-Moghaddam, Sahand Riazi-Isfahani
Background: According to the general health policies issued in 2014, Health Impact Assessment (HIA) or Health Annex should be implemented in Iran. The present study provided a model for executing HIA in the Iranian context as a developing country. Methods: This is a system design study with the qualitative approach. The data on the system components were gathered via reviews of the literature, in-depth interviews and focused group discussions (FGDs) with experts...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29430073/n-heterocycle-ligated-borocations-as-highly-tunable-carbon-lewis-acids
#3
James E Radcliffe, Jay J Dunsford, Jessica Cid, Valerio Fasano, Michael J Ingleson
The relative (to BEt3) hydride ion affinity (HIA) of a series of acridine borenium salts has been calculated, with some HIAs found to be similar to that for [Ph3C]+. The HIA at the acridine C9 position is controlled by both acridine and the boron substituents, the latter presumably affecting the strength of the B=N bond in the acridane-BY2 products from hydride transfer. Through a range of hydride abstraction benchmarking reactions against organic hydride donors the experimental HIA of [F5acr-BCat]+ (cat = catechol, F5acr = 1,2,3,4,7-pentafluoroacridine) has been confirmed to be extremely high and closely comparable to that of [Ph3C]+...
December 26, 2017: Organometallics
https://www.readbyqxmd.com/read/29415042/comparing-autotransporter-%C3%AE-domain-configurations-for-their-capacity-to-secrete-heterologous-proteins-to-the-cell-surface
#4
Wouter S P Jong, Maaike Schillemans, Corinne M Ten Hagen-Jongman, Joen Luirink, Peter van Ulsen
Monomeric autotransporters have been extensively used for export of recombinant proteins to the cell surface of Gram-negative bacteria. A bottleneck in the biosynthesis of such constructs is the passage of the outer membrane, which is facilitated by the β-domain at the C terminus of an autotransporter in conjunction with the Bam complex in the outer membrane. We have evaluated eight β-domain constructs for their capacity to secrete fused proteins to the cell surface. These constructs derive from the monomeric autotransporters Hbp, IgA protease, Ag43 and EstA and the trimeric autotransporter Hia, which all were selected because they have been previously used for secretion of recombinant proteins...
2018: PloS One
https://www.readbyqxmd.com/read/29410284/coronary-angiographic-findings-and-outcomes-in-patients-with-sudden-cardiac-arrest-without-st-elevation-myocardial-infarction-a-swedeheart-study
#5
Axel Wester, Moman A Mohammad, Pontus Andell, Rebecca Rylance, Josef Dankiewicz, Hans Friberg, Stefan James, Elmir Omerovic, David Erlinge, Sasha Koul
BACKGROUND/AIM: Sudden cardiac arrest (SCA) has a substantial mortality rate and the acute coronary syndrome constitutes the major cause. Post-resuscitation electrocardiogram ST-elevation SCA (STE-SCA) is a strong indication for emergency coronary angiography, but the role of early angiography and PCI in patients without ST-elevation (NSTE-SCA) remains to be established. This paper aimed to describe this patient group and evaluate the prognostic effect of early PCI in a large nationwide cohort of NSTE-SCA patients undergoing coronary angiography...
February 1, 2018: Resuscitation
https://www.readbyqxmd.com/read/29404862/choices-behind-numbers-a-review-of-the-major-air-pollution-health-impact-assessments-in-europe
#6
REVIEW
E Malmqvist, A Oudin, M Pascal, S Medina
PURPOSE OF REVIEW: The aim of this review is to identify the key contextual and methodological differences in health impact assessments (HIA) of ambient air pollution performed for Europe. We limited our review to multi-country reviews. An additional aim is to quantify some of these differences by applying them in a HIA template in three European cities. RECENT FINDINGS: Several HIAs of ambient air pollution have been performed for Europe, and their key results have been largely disseminated...
February 5, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29391000/computational-investigations-of-physicochemical-pharmacokinetic-toxicological-properties-and-molecular-docking-of-betulinic-acid-a-constituent-of-corypha-taliera-roxb-with-phospholipase-a2-pla2
#7
Mohammad Firoz Khan, Nusrat Nahar, Ridwan Bin Rashid, Akhtaruzzaman Chowdhury, Mohammad A Rashid
BACKGROUND: Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide range of biological and medicinal properties including anti-inflammatory activity. Therefore, this theoretical investigation is performed to evaluate (a) physicochemical properties such as acid dissociation constant (pKa), distribution coefficient (logD), partition coefficient (logP), aqueous solubility (logS), solvation free energy, dipole moment, polarizability, hyperpolarizability and different reactivity descriptors, (b) pharmacokinetic properties like human intestinal absorption (HIA), cellular permeability, skin permeability (PSkin), plasma protein binding (PPB), penetration of the blood brain barrier (BBB), (c) toxicological properties including mutagenicity, carcinogenicity, risk of inhibition of hERG gene and (d) molecular mechanism of anti-inflammatory action which will aid the development of analytical method and the synthesis of BA derivatives...
February 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29387334/hypersensitivity-reactions-to-human-insulin-analogs-in-insulin-na%C3%A3-ve-patients-a-systematic-review
#8
REVIEW
Andrew S Bzowyckyj, Amanda M Stahnke
Objective: The objective of this study was to raise awareness of hypersensitivity reactions to human insulin analogs (HIAs) in insulin-naïve patients and encourage consistent and detailed reporting of HIA reactions. Data sources: A search of PubMed, MEDLINE and International Pharmaceutical Abstracts using the terms 'insulin' and 'hypersensitivity' was completed with English language, humans, and publication date after 1 January 1990 as limits. Study selection and data extraction: The initial search identified 598 articles...
February 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29369952/running-performance-in-brazilian-professional-football-players-during-a-congested-match-schedule
#9
Luiz H Palucci Vieira, Rodrigo Aquino, Carlos Lago-Peñas, Guilherme H Munhoz Martins, Enrico F Puggina, Fabio A Barbieri
Palucci Vieira, LH, Aquino, R, Lago-Peñas, C, Munhoz Martins, GH, Puggina, EF, and Barbieri, FA. Running performance in Brazilian professional football players during a congested match schedule. J Strength Cond Res 32(2): 313-325, 2018-The purpose of the study was to examine the influence of playing congested fixtures (2 matches a week) on running performance of Brazilian professional football players, pooled (all performance files regardless players' rotation between games) or individualized data treatment (including only files of athletes' who played pair(s) of noncongested-congested matches which occurred on the same week)...
February 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29330030/health-impact-assessment-of-cycling-network-expansions-in-european-cities
#10
Natalie Mueller, David Rojas-Rueda, Maëlle Salmon, David Martinez, Albert Ambros, Christian Brand, Audrey de Nazelle, Evi Dons, Mailin Gaupp-Berghausen, Regine Gerike, Thomas Götschi, Francesco Iacorossi, Luc Int Panis, Sonja Kahlmeier, Elisabeth Raser, Mark Nieuwenhuijsen
We conducted a health impact assessment (HIA) of cycling network expansions in seven European cities. We modeled the association between cycling network length and cycling mode share and estimated health impacts of the expansion of cycling networks. First, we performed a non-linear least square regression to assess the relationship between cycling network length and cycling mode share for 167 European cities. Second, we conducted a quantitative HIA for the seven cities of different scenarios (S) assessing how an expansion of the cycling network [i...
January 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29204727/economic-evaluation-of-2014-cholera-outbreak-in-ghana-a-household-cost-analysis
#11
Dziedzom Kwesi Awalime, Bernard Bright K Davies-Teye, Linda A Vanotoo, Nkechi S Owoo, Edward Nketiah-Amponsah
INTRODUCTION: Ghana experienced its worst cholera outbreak in three decades in 2014. Evidence of cholera economic costs on affected households has been limited. This study aimed at determining economic costs on households affected by the  cholera outbreak in a Coastal Region of Ghana. METHODS: Two districts; High and Low Incidence Areas (HIA and LIA) were selected in comparative cost analysis and disease impact on affected households assessed based on scientifically documented economic indicators...
December 4, 2017: Health Economics Review
https://www.readbyqxmd.com/read/29189672/invasive-haemophilus-influenzae-serotype-a-infection-in-children-clinical-description-of-an-emerging-pathogen-alaska-2002-2014
#12
Ian D Plumb, Danielle Lecy, Rosalyn Singleton, Michael C Engel, Matthew Hirschfeld, James W Keck, Joseph Klejka, Karen M Rudolph, Thomas W Hennessy, Michael G Bruce
BACKGROUND: Invasive infections from Haemophilus influenzae serotype a (Hia) have been reported with increasing frequency, especially among indigenous populations. However there are limited population-based-studies of clinical severity. We studied invasive Hia infections in Alaska to determine clinical characteristics, mortality, and sequelae. METHODS: We defined an invasive Hia infection as the first detection of Hia from a usually sterile site in a child <10 years of age from Alaska...
November 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29182636/identification-of-differences-in-health-impact-modelling-of-salt-reduction
#13
Marieke A H Hendriksen, Johanna M Geleijnse, Joop M A van Raaij, Francesco P Cappuccio, Linda C Cobiac, Peter Scarborough, Wilma J Nusselder, Abbygail Jaccard, Hendriek C Boshuizen
We examined whether specific input data and assumptions explain outcome differences in otherwise comparable health impact assessment models. Seven population health models estimating the impact of salt reduction on morbidity and mortality in western populations were compared on four sets of key features, their underlying assumptions and input data. Next, assumptions and input data were varied one by one in a default approach (the DYNAMO-HIA model) to examine how it influences the estimated health impact. Major differences in outcome were related to the size and shape of the dose-response relation between salt and blood pressure and blood pressure and disease...
2017: PloS One
https://www.readbyqxmd.com/read/29127149/regnase-1-and-roquin-nonredundantly-regulate-th1-differentiation-causing-cardiac-inflammation-and-fibrosis
#14
Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi
Regnase-1 and Roquin are RNA binding proteins that are essential for degradation of inflammatory mRNAs and maintenance of immune homeostasis. Although deficiency of either of the proteins leads to enhanced T cell activation, their functional relationship in T cells has yet to be clarified because of lethality upon mutation of both Regnase-1 and Roquin. By using a Regnase-1 conditional allele, we show that mutations of both Regnase-1 and Roquin in T cells leads to massive lymphocyte activation. In contrast, mutation of either Regnase-1 or Roquin affected T cell activation to a lesser extent than the double mutation, indicating that Regnase-1 and Roquin function nonredundantly in T cells...
December 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29104762/safety-and-efficacy-of-intra-arterial-hepatic-chemotherapy-with-doxorubicin-loaded-nanoparticles-in-hepatocellular-carcinoma
#15
Philippe Merle, Philippe Camus, Armand Abergel, Georges Philippe Pageaux, Claude Masliah, Jean Pierre Bronowicki, Jean Pierre Zarski, Gilles Pelletier, Mohamed Bouattour, Laetitia Farloux, Etienne Dorval, Gilles Verset, Si-Nafa Si-Ahmed, Michel Doffoel, Patrice Couzigou, Julien Taieb, Bérangère Vasseur, Pierre Attali
Background: Doxorubicin Transdrug (DT), a nanoformulation of doxorubicin, was demonstrated to overcome the chemoresistance of hepatocellular carcinoma (HCC) in preclinical models. Its efficacy and safety were thus investigated in phase I and randomised phase II trials in unresectable HCC. Patients and methods: Phase I was a single dose of DT through the hepatic intra-arterial (HIA) route, dose-escalating 3+3 trial, evaluating five-dose levels from 10 to 40 mg/m(2) with maximal tolerated dose (MTD) as primary endpoint...
2017: ESMO Open
https://www.readbyqxmd.com/read/29096410/review-of-education-focused-health-impact-assessments-conducted-in-the-united-states
#16
Lauren N Gase, Amelia R DeFosset, Maxim Gakh, Celia Harris, Susan R Weisman, Andrew L Dannenberg
BACKGROUND: Health impact assessment (HIA) provides a structured process for examining the potential health impacts of proposed policies, plans, programs, and projects. This study systematically reviewed HIAs conducted in the United States on prekindergarten, primary, and secondary education-focused decisions. METHODS: Relevant HIA reports were identified from web sources in late 2015. Key data elements were abstracted from each report. Four case studies were selected to highlight diversity of topics, methods, and impacts of the assessment process...
December 2017: Journal of School Health
https://www.readbyqxmd.com/read/29069177/health-impact-assessment-hia-analyses-and-challenges-to-brazilian-health-surveillance
#17
Missifany Silveira, André Luiz Dutra Fenner
This study aims to discuss the Health Impact Assessment (HIA), pointing out the main initiatives of the health sector, challenges and perspectives for its implementation in Brazil. HIA is a methodology recommended by the WHO and is widely used in several countries, but with few initiatives in Brazil. Health issues in the context of large projects are commonly conducted on a timely basis within the environmental licensing processes, unlike HIA, which proposes an integrated approach, with the involvement of social stakeholders in the territory since the beginning of the project...
October 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29049096/the-effect-of-tackler-technique-on-head-injury-assessment-risk-in-elite-rugby-union
#18
Gregory J Tierney, Karl Denvir, Garreth Farrell, Ciaran K Simms
PURPOSE: To use match video evidence of tackles in elite level rugby union in order to identify tackler proficiency characteristics, for both Lower Body and Upper Body Tackles, that result in Head Injury Assessments (HIA) for the tackler. METHODS: A review of international rugby union matches (2013-2016) and Pro 12/ERC Champions Cup matches (2014-2016) from a professional rugby union club was conducted. HIA (n=53) and non-HIA tackles (n=233) were categorised as either front-on or side-on Upper Body or Lower Body Tackles and scored for tackling proficiency characteristics...
October 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28964149/heavy-ion-acoustic-rogue-waves-in-electron-positron-multi-ion-plasmas
#19
N A Chowdhury, A Mannan, M M Hasan, A A Mamun
The nonlinear propagation of heavy-ion-acoustic (HIA) waves (HIAWs) in a four-component multi-ion plasma (containing inertial heavy negative ions and light positive ions, as well as inertialess nonextensive electrons and positrons) has been theoretically investigated. The nonlinear Schrödinger (NLS) equation is derived by employing the reductive perturbation method. It is found that the NLS equation leads to the modulational instability (MI) of HIAWs, and to the formation of HIA rogue waves (HIARWs), which are due to the effects of nonlinearity and dispersion in the propagation of HIAWs...
September 2017: Chaos
https://www.readbyqxmd.com/read/28951105/epidemiology-of-invasive-pneumococcal-and-haemophilus-influenzae-diseases-in-northwestern-ontario-canada-2010-2015
#20
Vic Eton, Annette Schroeter, Len Kelly, Michael Kirlew, Raymond S W Tsang, Marina Ulanova
INTRODUCTION: North American indigenous populations experience a high burden of invasive bacterial infections. Because Streptococcus pneumoniae and Haemophilus influenzae have multiple antigenic variants, the existing vaccines cannot prevent all cases. This study addresses the current epidemiology of invasive H. influenzae and pneumococcal disease (IPD) in a region of Northwestern Ontario, Canada with a relatively high (82%) indigenous population. METHODS: Data were retrieved from a retrospective chart review at a hospital servicing a population of 29000 (82% indigenous), during January 2010-July 2015...
September 22, 2017: International Journal of Infectious Diseases: IJID
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