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https://www.readbyqxmd.com/read/29609141/exploring-the-novel-heterocyclic-derivatives-as-lead-molecules-for-design-and-development-of-potent-anticancer-agents
#1
Iqbal Azad, Malik Nasibullah, Tahmeena Khan, Firoj Hassan, Yusuf Akhter
This paper deals with in silico evaluation of newly proposed heterocyclic derivatives in search of potential anticancer activity. Best possible drug candidates have been proposed using a rational approach employing a pipeline of computational techniques namely MetaPrint2D prediction, molinspiration, cheminformatics, Osiris Data warrior, AutoDock and iGEMDOCK. Lazar toxicity prediction, AdmetSAR predictions, and targeted docking studies were also performed. 27 heterocyclic derivatives were selected for bioactivity prediction and drug likeness score on the basis of Lipinski's rule, Viber rule, Ghose filter, leadlikeness and Pan Assay Interference Compounds (PAINS) rule...
March 9, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29572865/hippocampal-subfield-segmentation-in-temporal-lobe-epilepsy-relation-to-outcomes
#2
B A K Kreilkamp, B Weber, S B Elkommos, M P Richardson, S S Keller
OBJECTIVE: To investigate the clinical and surgical outcome correlates of preoperative hippocampal subfield volumes in patients with refractory temporal lobe epilepsy (TLE) using a new magnetic resonance imaging (MRI) multisequence segmentation technique. METHODS: We recruited 106 patients with TLE and hippocampal sclerosis (HS) who underwent conventional T1-weighted and T2 short TI inversion recovery MRI. An automated hippocampal segmentation algorithm was used to identify twelve subfields in each hippocampus...
March 23, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29570227/the-effect-of-polyploidization-on-tree-hydraulic-functioning
#3
Niels J F De Baerdemaeker, Niek Hias, Jan Van den Bulcke, Wannes Keulemans, Kathy Steppe
PREMISE OF THE STUDY: Recent research has highlighted the importance of living tissue in wood. Polyploidization can impact amounts and arrangements of living cells in wood, potentially leading to increased drought tolerance. Tetraploid variants were created from the apple cultivar Malus ×domestica 'Gala' (Gala-4x), and their vulnerability to drought-induced cavitation and their hydraulic capacitance were compared to those of their diploid predecessors (Gala-2x). Assuming a positive correlation between polyploidy and drought tolerance, we hypothesized lower vulnerability and higher capacitance for the tetraploid...
March 9, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29565147/adolescents-with-high-intellectual-ability-differences-in-body-composition-and-physical-activity-by-sex
#4
Alonso Hormazábal-Peralta, Javier Espinoza, Pablo Cáceres, Pablo A Lizana
OBJECTIVES: Physical activity (PA) has been shown to have multiple health and wellness benefits, but there is no such information for adolescents with high intellectual ability (HIA). Thus, the aim of this study is to assess body composition and PA in HIA Chilean adolescents. METHODS: Weight and body composition were measured by bioelectrical impedance in 73 adolescents (39 female) aged 14-18 years from the Valparaíso region of Chile. HIA was assessed via Raven's Progressive Matrices (> 75th percentile) and PA, via questionnaire...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29563095/king-devick-concussion-test-performs-poorly-as-a-screening-tool-in-elite-rugby-union-players-a-prospective-cohort-study-of-two-screening-tests-versus-a-clinical-reference-standard
#5
Gordon Ward Fuller, Matthew J Cross, Keith A Stokes, Simon P T Kemp
BACKGROUND: The King-Devick (KD) test is an objective clinical test of eye movements that has been used to screen for concussion. We characterised the accuracy of the KD test and the World Rugby Head Injury Assessment (HIA-1) screening tools as methods of off-field evaluation for concussion after a suspicious head impact event. METHODS: A prospective cohort study was performed in elite English rugby union competitions between September 2016 and May 2017. The study population comprised consecutive players identified with a head impact event with the potential to result in concussion...
March 21, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29543211/-preoperative-and-postoperative-endocrine-disorders-associated-with-pituitary-stalk-injuries-caused-by-suprasellar-growing-tumors
#6
B A Kadashev, A N Konovalov, L I Astaf'eva, P L Kalinin, M A Kutin, I S Klochkova, D V Fomichev, O I Sharipov, D N Andreev
The pituitary stalk (PS) is a relatively thin bundle connecting the hypophyseal stalk to the pituitary gland; it consists of both axons of the hypothalamic nuclei (terminating in the neurohypophysis) and the system of portal vessels. Compression of the PS by a space-occupying lesion or its transection (forced or intended) during surgery may lead to the development of endocrine disorders: hypopituitarism, diabetes insipidus, and hyperprolactinemia. The modern literature lacks studies evaluating the severity of endocrine disorders depending on the PS condition before and after surgery...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29528510/2-hydroxyimino-aldehydes-photochemical-and-physico-chemical-properties-of-a-versatile-functional-group-for-monomer-design
#7
Patrizia Gentili, Martina Nardi, Irene Antignano, Paolo Cambise, Marco D'Abramo, Francesca D'Acunzo, Alessandro Pinna, Emanuele Ussia
In the context of our research on stimuli-responsive polymers bearing the 2-(hydroxyimino)aldehyde (HIA) group, we explore the photochemical behavior and physico-chemical properties of a number of HIAs. Interpretation of experimental data is supported by quantum mechanical calculations. HIAs are expected to undergo photoisomerization, chelate metal ions, yield hydrogen-bonded dimers or oligomers, exhibit relatively low pKas, and form >C=NO* radicals through OH hydrogen abstraction or oxidation of the oximate ion...
March 12, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29506358/-residential-cohort-study-on-mortality-and-hospitalization-in-viggiano-and-grumento-nova-municipalities-in-the-framework-of-hia-in-val-d-agri-basilicata-region-southern-italy
#8
Fabrizio Minichilli, Fabrizio Bianchi, Carla Ancona, Marco Cervino, Gianluigi De Gennaro, Cristina Mangia, Michele Santoro, Elisa Bustaffa
OBJECTIVES: to evaluate the associations among the emissions produced by "Centro olio Val d'Agri" (COVA), with mortality and hospitalization of residents in the Viggiano and Grumento Nova Municipalities, located in Val d'Agri (Basilicata Region, Southern Italy). DESIGN: residential cohort study. SETTINGS AND PARTICIPANTS: Lagrangians dispersion models to estimate the level of exposure at the address of residence to NOX concentrations as tracers of COVA emissions...
January 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29506357/-recommendations-from-a-health-impact-assessment-in-viggiano-and-grumento-nova-basilicata-region-southern-italy
#9
Nunzia Linzalone, Fabrizio Bianchi, Marco Cervino, Liliana Cori, Gianluigi De Gennaro, Cristina Mangia, Elisa Bustaffa
In Europe, Health Impact Assessment (HIA) is a consolidated practice aimed at predicting health impacts supporting the predisposition of plans and projects subjected to authorization procedures. In Italy, further developments are needed to harmonize the practice and consolidate methodologies in order to extend the HIA application in different fields. The recent HIA conducted in Val d'Agri (Basilicata) on the impacts of a first crude oil treatment plant represents an opportunity to illustrate its tools, methods and fields of application...
January 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29459062/cost-effectiveness-of-a-potential-vaccine-candidate-for-haemophilus-influenzae-serotype-a
#10
Affan Shoukat, Robert Van Exan, Seyed M Moghadas
The preceding decade has witnessed the emergence of severe community-acquired acute infections caused by Haemophilus influenzae serotype a (Hia), with alarming incidence rates in North America, particularly among indigenous populations. The remarkable success of Hib conjugate vaccine over the past 20 years signify the development of an Hia vaccine candidate as a prevention measure to reduce the incidence of invasive Hia disease. However, quantifications of the long-term epidemiologic and economic impacts of vaccination are needed to inform decision on investment in Hia vaccine development and immunization programs...
February 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29445635/implementing-health-impact-assessment-at-national-level-an-experience-in-iran
#11
Behzad Damari, Abbas Vosoogh-Moghaddam, Sahand Riazi-Isfahani
Background: According to the general health policies issued in 2014, Health Impact Assessment (HIA) or Health Annex should be implemented in Iran. The present study provided a model for executing HIA in the Iranian context as a developing country. Methods: This is a system design study with the qualitative approach. The data on the system components were gathered via reviews of the literature, in-depth interviews and focused group discussions (FGDs) with experts...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29430073/n-heterocycle-ligated-borocations-as-highly-tunable-carbon-lewis-acids
#12
James E Radcliffe, Jay J Dunsford, Jessica Cid, Valerio Fasano, Michael J Ingleson
The relative (to BEt3) hydride ion affinity (HIA) of a series of acridine borenium salts has been calculated, with some HIAs found to be similar to that for [Ph3C]+. The HIA at the acridine C9 position is controlled by both acridine and the boron substituents, the latter presumably affecting the strength of the B=N bond in the acridane-BY2 products from hydride transfer. Through a range of hydride abstraction benchmarking reactions against organic hydride donors the experimental HIA of [F5acr-BCat]+ (cat = catechol, F5acr = 1,2,3,4,7-pentafluoroacridine) has been confirmed to be extremely high and closely comparable to that of [Ph3C]+...
December 26, 2017: Organometallics
https://www.readbyqxmd.com/read/29415042/comparing-autotransporter-%C3%AE-domain-configurations-for-their-capacity-to-secrete-heterologous-proteins-to-the-cell-surface
#13
Wouter S P Jong, Maaike Schillemans, Corinne M Ten Hagen-Jongman, Joen Luirink, Peter van Ulsen
Monomeric autotransporters have been extensively used for export of recombinant proteins to the cell surface of Gram-negative bacteria. A bottleneck in the biosynthesis of such constructs is the passage of the outer membrane, which is facilitated by the β-domain at the C terminus of an autotransporter in conjunction with the Bam complex in the outer membrane. We have evaluated eight β-domain constructs for their capacity to secrete fused proteins to the cell surface. These constructs derive from the monomeric autotransporters Hbp, IgA protease, Ag43 and EstA and the trimeric autotransporter Hia, which all were selected because they have been previously used for secretion of recombinant proteins...
2018: PloS One
https://www.readbyqxmd.com/read/29410284/coronary-angiographic-findings-and-outcomes-in-patients-with-sudden-cardiac-arrest-without-st-elevation-myocardial-infarction-a-swedeheart-study
#14
Axel Wester, Moman A Mohammad, Pontus Andell, Rebecca Rylance, Josef Dankiewicz, Hans Friberg, Stefan James, Elmir Omerovic, David Erlinge, Sasha Koul
BACKGROUND/AIM: Sudden cardiac arrest (SCA) has a substantial mortality rate and the acute coronary syndrome constitutes the major cause. Post-resuscitation electrocardiogram ST-elevation SCA (STE-SCA) is a strong indication for emergency coronary angiography, but the role of early angiography and PCI in patients without ST-elevation (NSTE-SCA) remains to be established. This paper aimed to describe this patient group and evaluate the prognostic effect of early PCI in a large nationwide cohort of NSTE-SCA patients undergoing coronary angiography...
February 1, 2018: Resuscitation
https://www.readbyqxmd.com/read/29404862/choices-behind-numbers-a-review-of-the-major-air-pollution-health-impact-assessments-in-europe
#15
REVIEW
E Malmqvist, A Oudin, M Pascal, S Medina
PURPOSE OF REVIEW: The aim of this review is to identify the key contextual and methodological differences in health impact assessments (HIA) of ambient air pollution performed for Europe. We limited our review to multi-country reviews. An additional aim is to quantify some of these differences by applying them in a HIA template in three European cities. RECENT FINDINGS: Several HIAs of ambient air pollution have been performed for Europe, and their key results have been largely disseminated...
February 5, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29391000/computational-investigations-of-physicochemical-pharmacokinetic-toxicological-properties-and-molecular-docking-of-betulinic-acid-a-constituent-of-corypha-taliera-roxb-with-phospholipase-a2-pla2
#16
Mohammad Firoz Khan, Nusrat Nahar, Ridwan Bin Rashid, Akhtaruzzaman Chowdhury, Mohammad A Rashid
BACKGROUND: Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide range of biological and medicinal properties including anti-inflammatory activity. Therefore, this theoretical investigation is performed to evaluate (a) physicochemical properties such as acid dissociation constant (pKa), distribution coefficient (logD), partition coefficient (logP), aqueous solubility (logS), solvation free energy, dipole moment, polarizability, hyperpolarizability and different reactivity descriptors, (b) pharmacokinetic properties like human intestinal absorption (HIA), cellular permeability, skin permeability (PSkin), plasma protein binding (PPB), penetration of the blood brain barrier (BBB), (c) toxicological properties including mutagenicity, carcinogenicity, risk of inhibition of hERG gene and (d) molecular mechanism of anti-inflammatory action which will aid the development of analytical method and the synthesis of BA derivatives...
February 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29387334/hypersensitivity-reactions-to-human-insulin-analogs-in-insulin-na%C3%A3-ve-patients-a-systematic-review
#17
REVIEW
Andrew S Bzowyckyj, Amanda M Stahnke
Objective: The objective of this study was to raise awareness of hypersensitivity reactions to human insulin analogs (HIAs) in insulin-naïve patients and encourage consistent and detailed reporting of HIA reactions. Data sources: A search of PubMed, MEDLINE and International Pharmaceutical Abstracts using the terms 'insulin' and 'hypersensitivity' was completed with English language, humans, and publication date after 1 January 1990 as limits. Study selection and data extraction: The initial search identified 598 articles...
February 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29369952/running-performance-in-brazilian-professional-football-players-during-a-congested-match-schedule
#18
Luiz H Palucci Vieira, Rodrigo Aquino, Carlos Lago-Peñas, Guilherme H Munhoz Martins, Enrico F Puggina, Fabio A Barbieri
Palucci Vieira, LH, Aquino, R, Lago-Peñas, C, Munhoz Martins, GH, Puggina, EF, and Barbieri, FA. Running performance in Brazilian professional football players during a congested match schedule. J Strength Cond Res 32(2): 313-325, 2018-The purpose of the study was to examine the influence of playing congested fixtures (2 matches a week) on running performance of Brazilian professional football players, pooled (all performance files regardless players' rotation between games) or individualized data treatment (including only files of athletes' who played pair(s) of noncongested-congested matches which occurred on the same week)...
February 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29330030/health-impact-assessment-of-cycling-network-expansions-in-european-cities
#19
Natalie Mueller, David Rojas-Rueda, Maëlle Salmon, David Martinez, Albert Ambros, Christian Brand, Audrey de Nazelle, Evi Dons, Mailin Gaupp-Berghausen, Regine Gerike, Thomas Götschi, Francesco Iacorossi, Luc Int Panis, Sonja Kahlmeier, Elisabeth Raser, Mark Nieuwenhuijsen
We conducted a health impact assessment (HIA) of cycling network expansions in seven European cities. We modeled the association between cycling network length and cycling mode share and estimated health impacts of the expansion of cycling networks. First, we performed a non-linear least square regression to assess the relationship between cycling network length and cycling mode share for 167 European cities. Second, we conducted a quantitative HIA for the seven cities of different scenarios (S) assessing how an expansion of the cycling network [i...
April 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29204727/economic-evaluation-of-2014-cholera-outbreak-in-ghana-a-household-cost-analysis
#20
Dziedzom Kwesi Awalime, Bernard Bright K Davies-Teye, Linda A Vanotoo, Nkechi S Owoo, Edward Nketiah-Amponsah
INTRODUCTION: Ghana experienced its worst cholera outbreak in three decades in 2014. Evidence of cholera economic costs on affected households has been limited. This study aimed at determining economic costs on households affected by the  cholera outbreak in a Coastal Region of Ghana. METHODS: Two districts; High and Low Incidence Areas (HIA and LIA) were selected in comparative cost analysis and disease impact on affected households assessed based on scientifically documented economic indicators...
December 4, 2017: Health Economics Review
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