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https://www.readbyqxmd.com/read/27936399/gastrodia-elata-attenuates-inflammatory-response-by-inhibiting-the-nf-%C3%AE%C2%BAb-pathway-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#1
Yu Li, Li-Min Wang, Jian-Zhong Xu, Ke Tian, Chen-Xi Gu, Zhi-Fu Li
Gastrodia elata (GE), which belongs to the Orchidaceae family, was found to possess anti-inflammatory activity. However, the effect of GE on inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) remains largely unknown. Thus, the aim of this study was to investigate the effects of GE on tumor necrosis factor-α (TNF-α)-induced inflammatory response in RA-FLS and the underlying molecular mechanism was also explored. Our results demonstrated that GE significantly attenuated TNF-α-induced IL-6 and IL-8 production in RA-FLS...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27936168/transcriptome-analysis-of-ceriops-tagal-in-saline-environments-using-rna-sequencing
#2
Xiaorong Xiao, Yuhui Hong, Wei Xia, Shipeng Feng, Xi Zhou, Xiumei Fu, Jian Zang, Yong Xiao, Xiaolei Niu, Chunxia Li, Yinhua Chen
Identification of genes involved in mangrove species' adaptation to salt stress can provide valuable information for developing salt-tolerant crops and understanding the molecular evolution of salt tolerance in halophiles. Ceriops tagal is a salt-tolerant mangrove tree growing in mudflats and marshes in tropical and subtropical areas, without any prior genome information. In this study, we assessed the biochemical and transcriptional responses of C. tagal to high salt treatment (500 mmol/L NaCl) by hydroponic experiments and RNA-seq...
2016: PloS One
https://www.readbyqxmd.com/read/27935580/second-malignancies-in-the-context-of-lenalidomide-treatment-an-analysis-of-2732-myeloma-patients-enrolled-to-the-myeloma-xi-trial
#3
J R Jones, D A Cairns, W M Gregory, C Collett, C Pawlyn, R Sigsworth, A Striha, R Henderson, M F Kaiser, M Jenner, G Cook, N H Russell, C Williams, G Pratt, B Kishore, J Lindsay, M T Drayson, F E Davies, K D Boyd, R G Owen, G H Jackson, G J Morgan
We have carried out the largest randomised trial to date of newly diagnosed myeloma patients, in which lenalidomide has been used as an induction and maintenance treatment option and here report its impact on second primary malignancy (SPM) incidence and pathology. After review, 104 SPMs were confirmed in 96 of 2732 trial patients. The cumulative incidence of SPM was 0.7% (95% confidence interval (CI) 0.4-1.0%), 2.3% (95% CI 1.6-2.7%) and 3.8% (95% CI 2.9-4.6%) at 1, 2 and 3 years, respectively. Patients receiving maintenance lenalidomide had a significantly higher SPM incidence overall (P=0...
December 9, 2016: Blood Cancer Journal
https://www.readbyqxmd.com/read/27933406/differential-roles-for-the-coagulation-factors-xi-and-xii-in-regulating-the-physical-biology-of-fibrin
#4
Joanna L Sylman, Uranbileg Daalkhaijav, Ying Zhang, Elliot M Gray, Parsa A Farhang, Tiffany T Chu, Jevgenia Zilberman-Rudenko, Cristina Puy, Erik I Tucker, Stephanie A Smith, James H Morrissey, Travis W Walker, Xiaolin L Nan, András Gruber, Owen J T McCarty
In the contact activation pathway of the coagulation, zymogen factor XII (FXII) is converted to FXIIa, which triggers activation of FXI leading to the activation of FIX and subsequent thrombin generation and fibrin formation. Feedback activation of FXI by thrombin has been shown to promote thrombin generation in a FXII-independent manner and FXIIa can bypass FXI to directly activate FX and prothrombin in the presence of highly negatively charged molecules, such as long-chain polyphosphates (LC polyP). We sought to determine whether activation of FXII or FXI differentially regulate the physical biology of fibrin formation...
December 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27933291/endocytosis-and-physiology-insights-from-disabled-2-deficient-mice
#5
REVIEW
Wensi Tao, Robert Moore, Elizabeth R Smith, Xiang-Xi Xu
Disabled-2 (Dab2) is a clathrin and cargo binding endocytic adaptor protein, and cell biology studies revealed that Dab2 plays a role in cellular trafficking of a number of transmembrane receptors and signaling proteins. A PTB/PID domain located in the N-terminus of Dab2 binds the NPXY motif(s) present at the cytoplasmic tails of certain transmembrane proteins/receptors. The membrane receptors reported to bind directly to Dab2 include LDL receptor and its family members LRP1 and LRP2 (megalin), growth factor receptors EGFR and FGFR, and the cell adhesion receptor beta1 integrin...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27929106/channel-morphology-effect-on-water-transport-through-graphene-bilayers
#6
Bo Liu, Renbing Wu, Adrian Wing-Keung Law, Xi-Qiao Feng, Lichun Bai, Kun Zhou
The application of few-layered graphene-derived functional thin films for molecular filtration and separation has recently attracted intensive interests. In practice, the morphology of the nanochannel formed by the graphene (GE) layers is not ideally flat and can be affected by various factors. This work investigates the effect of channel morphology on the water transport behaviors through the GE bilayers via molecular dynamics simulations. The simulation results show that the water flow velocity and transport resistance highly depend on the curvature of the graphene layers, particularly when they are curved in non-synergic patterns...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928921/discovery-of-natural-mouse-serum-derived-hiv-1-entry-inhibitor-s
#7
M Wei, Y Chen, J Xi, S Ru, M Ji, D Zhang, Q Fang, B Tang
Among rationally designed human immunodeficiency virus 1 (HIV-1) inhibitors, diverse natural factors have showed as potent anti-HIV activity in human blood. We have discovered that the boiled supernatant of healthy mouse serum could suppress HIV-1 entry, and exhibited reduced inhibitory activity after trypsin digestion. Further analysis demonstrated that only the fraction containing 10-25 K proteins could inhibit HIV-1 mediated cell-cell fusion. These results suggest that the 10-25 K protein(s) is novel natural HIV-1 entry inhibitor(s)...
2016: Acta Virologica
https://www.readbyqxmd.com/read/27925176/pd-l1-expression-of-the-residual-tumor-serves-as-a-prognostic-marker-in-local-advanced-breast-cancer-after-neoadjuvant-chemotherapy
#8
Sheng Chen, Ruo-Xi Wang, Yin Liu, Wen-Tao Yang, Zhi-Ming Shao
This study sought to investigate the prevalence of programmed death ligand 1 (PD-L1) and its prognostic value in patients with residual tumors after neoadjuvant chemotherapy (NCT) for locally advanced breast cancer (LABC). A total of 309 patients considered as non-pathological complete responders (non-pCR) after NCT followed by mastectomy were selected. The expression of PD-L1 and tumor-infiltrating lymphocytes (TILs) in residual breast cancer cells was assessed by immunohistochemistry in surgical specimens...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27924504/clinical-features-and-prognostic-factors-of-small-cell-lung-cancer-a-retrospective-study-in-148-patients
#9
Qian Cai, Hong-Lan Luo, Xi-Can Gao, Chun-Jin Xiong, Fan Tong, Rui-Guang Zhang, Yu Hu, Gang Wu, Xiao-Rong Dong
To better understand the outcomes of small cell lung cancer (SCLC), we examined the clinical features and prognostic factors of SCLC in this study. A total of 148 patients who were diagnosed as having SCLC between January 2009 and December 2013 in Cancer Center of Union Hospital, Wuhan, China, were enrolled and their clinical features and prognostic factors were retrospectively analyzed. Log-rank test and Cox regression model were employed for analysis of prognostic factors. The 1- and 2-year overall survival (OS) rates were 59...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27922103/hypothalamic-activation-is-essential-for-endotoxemia-induced-acute-muscle-wasting
#10
Kaipeng Duan, Qiyi Chen, Minhua Cheng, Chenyan Zhao, Zhiliang Lin, Shanjun Tan, Fengchan Xi, Tao Gao, Jialiang Shi, Juanhong Shen, Weiqin Li, Wenkui Yu, Jieshou Li, Ning Li
Growing evidence suggests acute skeletal muscle wasting is a key factor affecting nutritional support and prognosis in critical patients. Previously, plenty of studies of muscle wasting focused on the peripheral pathway, little was known about the central role. We tested the hypothesis whether central inflammatory pathway and neuropeptides were involved in the process. In lipopolysaccharide (LPS) treated rats, hypothalamic NF-κB pathway and inflammation were highly activated, which was accompanied with severe muscle wasting...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920736/protective-effect-of-self-compassion-to-emotional-response-among-students-with-chronic-academic-stress
#11
Yonghong Zhang, Xi Luo, Xianwei Che, Wenjie Duan
The literature has shown that self-compassion is a protective factor of an individual's emotional response to chronic stress. However, this stress-buffering effect has not been completely analyzed in individuals who report significantly high academic stress. The present study explored the role of self-compassion in a group of undergraduate students who experience chronic academic stress. A total of 208 undergraduate students who were preparing for the Postgraduate Entrance Examination (PEE) were recruited and completed the Self-Compassion Scale, Adolescent Self-Rating Life Event Check List, and Positive and Negative Affect Schedule...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27919911/in-vitro-activation-of-coagulation-by-human-neutrophil-dna-and-histone-proteins-but-not-neutrophil-extracellular-traps
#12
Denis F Noubouossie, Matthew F Whelihan, Yuan-Bin Yu, Erica Sparkenbaugh, Rafal Pawlinski, Dougald M Monroe, Nigel S Key
NETosis is a physiological process in which neutrophils release their nuclear material in the form of neutrophil extracellular traps (NETs). NETs have been reported to directly promote thrombosis in animal models. Although the effects of purified NET components including DNA, histone proteins and neutrophil enzymes on coagulation have been characterized, the mechanism by which intact NETs promote thrombosis is largely unknown. In this study, human neutrophils were stimulated to produce NETs in platelet-free plasma (PFP) or in buffer using PMA or calcium ionophore...
December 5, 2016: Blood
https://www.readbyqxmd.com/read/27919522/quantitative-assessment-of-healthy-skin-elasticity-reliability-and-feasibility-of-shear-wave-elastography
#13
Xi Xiang, Feng Yan, Yujia Yang, Yuanjiao Tang, Liyun Wang, Jia Zeng, Li Qiu
The goal of this study was to investigate the reliability and feasibility of shear wave elastography by assessing the elasticity of the healthy skin of 40 volunteers. Young's moduli for bilateral fingers, forearms, anterior chest (sternum), and anterior abdomen were determined with both transverse and longitudinal sectional measurements. Reliability of measurements was evaluated using intra- and inter-class correlation coefficients with two observers. Our results revealed that the elastic modulus values of the skin between symmetric parts of fingers and forearms did not statistically different...
December 2, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27919431/immunoreactivities-of-nf-%C3%AE%C2%BAb-il-1%C3%AE-and-il-1r-in-the-skin-of-chinese-brown-frog-rana-dybowskii
#14
Liqin Xi, Ruiqi Hu, Ting Guo, Yuhan Wang, Xia Sheng, Yingying Han, Zhengrong Yuan, Qiang Weng, Meiyu Xu
The cytokine interleukin-1 beta (IL-1β) is an evolutionarily conserved molecule that was originally identified in the immune system. Nuclear factor κB (NF-κB) plays a critical role in the activation of immune cells by upregulating the expression of many cytokines. In this study, we investigated the localization and expression level of IL-1β, its functional membrane receptor type I (IL-1R1) and NF-κB in the skin of Rana dybowskii during the breeding period and pre-hibernation. Histologically, the skin of Rana dybowskii consists of epidermis and dermis, and four kinds of cells were identified in the epidermis during the breeding period and pre-hibernation, while the dermis was composed of homogenous gel, mucous glands and granular glands...
December 2, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27919278/microrna-19b-3p-regulates-nasopharyngeal-carcinoma-radiosensitivity-by-targeting-tnfaip3-nf-%C3%AE%C2%BAb-axis
#15
Teng Huang, Li Yin, Jing Wu, Jia-Jia Gu, Jian-Zhong Wu, Dan Chen, Hong-Liang Yu, Kai Ding, Nan Zhang, Ming-Yu Du, Lu-Xi Qian, Zhi-Wei Lu, Xia He
BACKGROUND: Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant factor that limits the efficacy of radiotherapy for NPC patients. Growing evidence supports that microRNAs (miRNAs) play an important role in radiation response. METHODS: Real-time quantitative PCR was used to analyze the expression of miR-19b-3p in NPC cell lines and NP69...
December 5, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27918244/polymorphisms-of-abat-scn2a-and-aldh5a1-may-affect-valproic-acid-responses-in-the-treatment-of-epilepsy-in-chinese
#16
Xi Li, Jun Zhang, Xi Wu, Han Yan, Yin Zhang, Ruo-Hui He, Yong-Jun Tang, Yi-Jing He, Dan Tan, Xiao-Yuan Mao, Ji-Ye Yin, Zhao-Qian Liu, Hong-Hao Zhou, Jie Liu
AIM: The clinical efficacy of valproic acid (VPA) varies greatly among epileptic patients. To find the potential genetic factors related to VPA responses, the pharmacogenetics study was conducted. METHODS: Two hundred and one Chinese Han epileptic patients who were treated by VPA for at least 1 year were recruited. Up to 24 SNPs in 11 candidate genes that correlate with the metabolism, transport or target of VPA were genotyped. RESULTS: Three SNPs, rs1731017 (ABAT), rs2304016 (SCN2A) and rs1054899 (ALDH5A1) were found associated with VPA responses with the p-values of 0...
December 5, 2016: Pharmacogenomics
https://www.readbyqxmd.com/read/27917896/astragaloside-iv-ameliorates-allergic-inflammation-by-inhibiting-key-initiating-factors-in-the-initial-stage-of-sensitization
#17
Kai-Fan Bao, Xi Yu, Xiao Wei, Li-Li Gui, Hai-Liang Liu, Xiao-Yu Wang, Yu Tao, Guo-Rong Jiang, Min Hong
To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model of allergic contact dermatitis (ACD). AS-IV administered in the sensitization phase, rather than in the elicitation phase, dramatically alleviated the symptoms of allergic inflammation. We hypothesized that AS-IV exerts its anti-allergy effects by regulating the production of key pro-allergic cytokines based on the fact that interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) levels increase significantly in the initial stage of the sensitization phase...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917177/progress-on-optimizing-miscanthus-biomass-production-for-the-european-bioeconomy-results-of-the-eu-fp7-project-optimisc
#18
Iris Lewandowski, John Clifton-Brown, Luisa M Trindade, Gerard C van der Linden, Kai-Uwe Schwarz, Karl Müller-Sämann, Alexander Anisimov, C-L Chen, Oene Dolstra, Iain S Donnison, Kerrie Farrar, Simon Fonteyne, Graham Harding, Astley Hastings, Laurie M Huxley, Yasir Iqbal, Nikolay Khokhlov, Andreas Kiesel, Peter Lootens, Heike Meyer, Michal Mos, Hilde Muylle, Chris Nunn, Mensure Özgüven, Isabel Roldán-Ruiz, Heinrich Schüle, Ivan Tarakanov, Tim van der Weijde, Moritz Wagner, Qingguo Xi, Olena Kalinina
This paper describes the complete findings of the EU-funded research project OPTIMISC, which investigated methods to optimize the production and use of miscanthus biomass. Miscanthus bioenergy and bioproduct chains were investigated by trialing 15 diverse germplasm types in a range of climatic and soil environments across central Europe, Ukraine, Russia, and China. The abiotic stress tolerances of a wider panel of 100 germplasm types to drought, salinity, and low temperatures were measured in the laboratory and a field trial in Belgium...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27914810/transcriptome-analysis-of-resistant-and-susceptible-tobacco-nicotiana-tabacum-in-response-to-root-knot-nematode-meloidogyne-incognita-infection
#19
Xuexia Xing, Xiaohui Li, Mingzhen Zhang, Yuan Wang, Bingyang Liu, Qiliang Xi, Ke Zhao, Yunjie Wu, Tiezhao Yang
The root-knot nematode (RKN) Meloidogyne incognita reproduces on the roots of tobacco (Nicotiana tabacum), damaging crops, reducing crop yield, and causing economic losses annually. The development of resistant genotypes is an alternative strategy to effectively control these losses. However, the molecular mechanism responsible for host pathogenesis and defense responses in tobacco specifically against RKNs remain poorly understood. Here, root transcriptome analysis of resistant (Yuyan12) and susceptible (Changbohuang) tobacco varieties infected with RKNs was performed...
November 30, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27913544/treatment-of-rare-factor-deficiencies-in-2016
#20
Flora Peyvandi, Marzia Menegatti
Rare bleeding disorders (RBDs) are a heterogeneous group of coagulation disorders characterized by fibrinogen, prothrombin, factors V, VII, X, XI, or XIII (FV, FVII, FX, FXI, or FXIII, respectively), and the combined factor V + VIII and vitamin K-dependent proteins deficiencies, representing roughly 5% of all bleeding disorders. They are usually transmitted as autosomal, recessive disorders, and the prevalence of the severe forms could range from 1 case in 500 000 for FVII up to 1 in 2-3 million for FXIII in the general population...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
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