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https://www.readbyqxmd.com/read/28550734/pterostilbene-alleviates-polymicrobial-sepsis-induced-liver-injury-possible-role-of-sirt1-signaling
#1
Xiaojing Liu, Xueliang Yang, Lingna Han, Feng Ye, Min Liu, Wanhu Fan, Kai Zhang, Ying Kong, Jian Zhang, Lei Shi, Yunru Chen, Xi Zhang, Shumei Lin
Liver injury occurs frequently during sepsis. Pterostilbene (Pte), a natural dimethylated analog of resveratrol from blueberries, exerts anti-inflammatory and anti-apoptotic effects in various diseases. However, the role of Pte in sepsis-induced liver injury and its underlying mechanisms remain unknown. The current study aimed to evaluate the protective effects of Pte on sepsis-induced liver injury and its potential mechanisms. Sepsis was induced using cecal ligation and puncture (CLP) in C57BL/6 mice. Mice were administered Pte (5, 10, 15mg/kg, i...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28549969/the-dth8-hd1-module-mediates-day-length-dependent-regulation-of-rice-flowering
#2
Anping Du, Wei Tian, Menghao Wei, Wei Yan, Hang He, Da Zhou, Xi Huang, Shigui Li, Xinhao Ouyang
Photoperiodic flowering is one of the most important pathways to govern flowering in rice (Oryza sativa), in which Heading date 1 (Hd1), an ortholog of the Arabidopsis CONSTANS gene, encodes a pivotal regulator. Hd1 promotes flowering under short-day conditions but represses flowering under long-day conditions by regulating the expression of Heading date 3a (Hd3a), the rice FLOWERING LOCUS T (FT) ortholog. However, the molecular mechanism by which Hd1 reverses its activity in response to day length is largely unknown...
May 23, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28549966/lentivirus-mediated-inhibition-of-aqp4-accelerates-motor-function-recovery-associated-with-ngf-in-spinal-cord-contusion-rats
#3
Jianmin Chen, Xi Zeng, Shengnan Li, Zhanqiong Zhong, Xi Hu, Hongyu Xiang, Ying Rao, Lixin Zhang, Xiuya Zhou, Qingjie Xia, Tinghua Wang, Xiao Zhang
Aquaporin-4 (AQP4) is a water channel protein in spinal cord and plays a critical role in the pathophysiological process of spinal cord injury (SCI). However, little is known about the molecular mechanism of AQP4 involved in SCI. The present study was performed to investigate the possible molecules regulated by AQP4 after SCI by use of lentiviral-mediated RNA interference (RNAi). First, the motor function was evaluated by Basso, Beattie, Bresnahan (BBB) scale and the expression of AQP4 was measured by western blot, immunohistochemical staining and immunofluorescence in rats after contusion spinal cord injury (cSCI)...
May 23, 2017: Brain Research
https://www.readbyqxmd.com/read/28548853/a-series-of-fluorescent-and-colorimetric-chemodosimeters-for-selective-recognition-of-cyanide-based-on-fret-mechanism
#4
Ying-Xi Hua, Yongliang Shao, Ya-Wen Wang, Yu Peng
A series of fluorescence "turn-on" probes (PY, AN, NA, B1 and B2) have been developed and successfully applied to detect cyanide anions based on Michael-addition reaction and FRET mechanism. These probes demonstrated good selectivity, high sensitivity and very fast recognition for CN-. Especially, the fluorescence response of probe NA finished within 3 seconds. Low LODs (down to 63 nM) are also obtained in these probes with remarkable fluorescence enhancement factors. In addition, fluorescence colors of these probes turned to blue, yellow or orange upon sensing CN-...
May 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28548819/tuning-the-properties-of-polymer-capsules-for-cellular-interactions
#5
Huanli Sun, Jiwei Cui, Yi Ju, Xi Chen, Edgar H H Wong, Jenny Tran, Greg G Qiao, Frank Caruso
Particle-cell interactions are governed by, among other factors, the composition and surface properties of the particles. Herein, we report the preparation of various polymer capsules with different compositions and properties via atom transfer radical polymerization mediated continuous assembly of polymers (CAPATRP), where the cellular interactions of these capsules, particularly fouling and specific targeting, are examined by flow cytometry and deconvolution microscopy. Acrylated eight-arm poly(ethylene glycol) (8-PEG) and poly(N-(2-hydroxypropyl)-methacrylamide) (PHPMA) as well as methacrylated hyaluronic acid (HA), poly(glutamic acid) (PGA), and poly(methacrylic acid) (PMA) are used as macro-cross-linkers to obtain a range of polymer capsules with different compositions (PEG, PHPMA, HA, PGA, and PMA)...
May 26, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28542282/expression-patterns-of-members-of-the-ethylene-signaling-related-gene-families-in-response-to-dehydration-stresses-in-cassava
#6
Meng Yun Ren, Ren Jun Feng, Hou Rui Shi, Li Fang Lu, Tian Yan Yun, Ming Peng, Xiao Guan, Heng Zhang, Jing Yi Wang, Xi Yan Zhang, Cheng Liang Li, Yan Jun Chen, Peng He, Yin Dong Zhang, Jiang Hui Xie
Drought is the one of the most important environment stresses that restricts crop yield worldwide. Cassava (Manihot esculenta Crantz) is an important food and energy crop that has many desirable traits such as drought, heat and low nutrients tolerance. However, the mechanisms underlying drought tolerance in cassava are unclear. Ethylene signaling pathway, from the upstream receptors to the downstream transcription factors, plays important roles in environmental stress responses during plant growth and development...
2017: PloS One
https://www.readbyqxmd.com/read/28542174/specification-and-spatial-arrangement-of-cells-in-the-germline-stem-cell-niche-of-the-drosophila-ovary-depend-on-the-maf-transcription-factor-traffic-jam
#7
Trupti Panchal, Xi Chen, Ekaterina Alchits, Youjin Oh, James Poon, Jane Kouptsova, Frank A Laski, Dorothea Godt
Germline stem cells in the Drosophila ovary are maintained by a somatic niche. The niche is structurally and functionally complex and contains four cell types, the escort, cap, and terminal filament cells and the newly identified transition cell. We find that the large Maf transcription factor Traffic jam (Tj) is essential for determining niche cell fates and architecture, enabling each niche in the ovary to support a normal complement of 2-3 germline stem cells. In particular, we focused on the question of how cap cells form...
May 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28536099/repression-of-mir156-by-mir159-regulates-the-timing-of-the-juvenile-to-adult-transition-in-arabidopsis
#8
Changkui Guo, Yunmin Xu, Min Shi, Yongmin Lai, Xi Wu, Huasen Wang, Zhujun Zhu, R Scott Poethig, Gang Wu
Temporally-regulated miRNAs have been identified as master regulators of developmental timing in both animals and plants. In plants, vegetative development is regulated by a temporal decrease in miR156 level, but how this decreased expression is initiated and then maintained during shoot development remains elusive. Here we show that miR159 is required for the correct timing of vegetative development in Arabidopsis thaliana. Loss of miR159 increases miR156 level throughout shoot development and delays vegetative development, whereas overexpression of miR159 slightly accelerated vegetative development...
May 23, 2017: Plant Cell
https://www.readbyqxmd.com/read/28535482/multiple-metal-exposures-and-their-correlation-with-monoamine-neurotransmitter-metabolism-in-chinese-electroplating-workers
#9
Lin-Lin Wu, Wei Gong, Si-Peng Shen, Zhong-He Wang, Jia-Xi Yao, Jun Wang, Jing Yu, Rong Gao, Gang Wu
Excessive metal exposure has been recognized as one of the detrimental factors for brain damage. However, the potential adverse effects induced by heavy metals on monoamine neurotransmitter pathways remains poorly understood. Our study aimed to investigate the possible association between metal exposure and neurotransmitter metabolism. By a cross-sectional investigation, 224 electroplating workers and 213 non-electroplating exposure workers were recruited in the exposure and control groups. Metal exposure levels were analyzed using inductively-coupled plasma mass spectrometry and monoamine neurotransmitter pathway metabolites were measured by ultra-performance liquid chromatography tandem mass spectrometry in human urine samples...
April 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28535426/new-role-of-pcsk9-in-atherosclerotic-inflammation-promotion-involving-the-tlr4-nf-%C3%AE%C2%BAb-pathway
#10
Zhi-Han Tang, Juan Peng, Zhong Ren, Jing Yang, Ting-Ting Li, Tao-Hua Li, Zuo Wang, Dang-Heng Wei, Lu-Shan Liu, Xi-Long Zheng, Zhi-Sheng Jiang
BACKGROUND AND AIMS: Proprotein convertase subtilisin/kexin 9 (PCSK9) has emerged as a popular target in the development of new cholesterol-lowering drugs and therapeutic interventions for atherosclerosis. PCSK9 could accelerate atherosclerosis through mechanisms beyond the degradation of the hepatic low-density lipoprotein receptor. Several clinical studies suggested that PCSK9 is involved in atherosclerotic inflammation. Accordingly, this study aimed to explore the role of PCSK9 in vascular inflammation that promotes atherosclerotic progression...
April 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28534992/hif-1%C3%AE-inhibits-idh-1-expression-in-osteosarcoma
#11
Deng-Cheng Liu, Xun Zheng, Yong Zho, Wan-Rong Yi, Zong-Huan Li, Xiang Hu, Ai-Xi Yu
Recently, hypoxia inducible factor-1 (HIF-1) was reported to be correlated with isocitrate dehydrogenase 1 (IDH-1) in several types of tumors. However, the expression and significance of HIF-1 and IDH-1 in osteosarcoma is still unknown. In the present study, the expression levels of IDH-1 and HIF-1α in 35 formalin-fixed paraffin-embedded sections from osteosarcoma patients were investigated by immunohistochemistry. The expression levels of IDH-1 and HIF-1α in human osteosarcoma cell lines (MG-63 and 143B) were further detected by western blotting under normal and hypoxic conditions...
May 22, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28534690/decreased-left-atrial-myocardial-strain-in-patients-with-suboptimal-blood-pressure-control
#12
Xiao-Jing Chen, Chen Chen, Yu-Jia Liang, Xi-Lian Gao, Jing Jiang, Yu Kang, Yu-Cheng Chen, Qing Zhang, Zhi Zeng
BACKGROUND: Suboptimal blood pressure (BP) control is commonly observed in patients receiving antihypertensive agents, but the relationship between uncontrolled BP and left atrial (LA) impairment remains unknown. METHODS: This study enrolled 279 hypertensive patients who had been medicated, as well as 85 matched normal controls. The BP of systolic <140 mmHg and diastolic<90 mmHg was defined as optimal (HT1 group, n=146), otherwise as suboptimal BP control (HT2 group, n = 133)...
May 23, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28534657/body-mass-index-is-inversely-associated-with-arterial-stiffness-in-chinese-adults-with-primary-hypertension-results-from-the-china-stroke-primary-prevention-trial-csppt
#13
Mohetaboer Momin, Jian-Ping Li, Yan Zhang, Fang-Fang Fan, Xi-Ping Xu, Xin Xu, Bin-Yan Wang, Wen-Bin Yang, Li-Ling Xie, Yong Huo
BACKGROUND: This study aimed to elucidate the relationship between body mass index (BMI) and the presence of arterial stiffness in rural-dwelling Chinese adults with primary hypertension. METHODS: Primary hypertension patients (n = 19,375) receiving an average of 4.5 years of antihypertension therapy were selected from the Chinese Stroke Primary Prevention Trial (mean age: 64.7 ± 7.4 years, male: 37.8%). Anthropometric, demographic, hemodynamic, and biochemical data were obtained...
May 23, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28532338/design-of-amphiphilic-pcl-peg-pcl-block-copolymers-as-vehicles-of-ginkgolide-b-and-their-brain-targeting-studies
#14
Xi-Qing Yan, Yong-Li Shi, Qing-Feng Jiang, Guan-Fang Ping, Zhi-Jian Deng
The amphiphilic PEG-b-PCL block copolymers were synthesized by ring-opening polymerization. The specific and selective antagonists of platelet activating factor, Ginkgolide B (GB), was successfully encapsulated in the synthesized PEG-PCL nanoparticles (NPs) with high Encapsulation Efficiency and Drug Loading. The synthesis of different PEG-PCL copolymers were confirmed with FTIR and (1)H NMR spectra. The morphology and particles size distribution of cargo-free PEG-PCL NPs were studied by transmission electron microscope (TEM) analysis and Malvern laser particle analyzer...
May 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28531759/interferon-regulatory-factors-a-key-to-tumour-immunity
#15
REVIEW
Yan-Jie Chen, Jing Li, Nan Lu, Xi-Zhong Shen
Interferon regulatory factors (IRFs), which have 10 members, belong to the transcription factor family and were named because of the regulation of interferon expression. They play important roles in the immune regulation, cell differentiation, cell apoptosis, and cell cycle regulation. This article will review the functional characteristics and immune activity of the family members, especially in the role of cell differentiation and autoimmune diseases. Intensive studies will help uncover the pathogenesis of the disease in a more comprehensive view, and provide novel targets for disease treatment...
May 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28526870/time-course-responses-of-circulating-micrornas-to-three-resistance-training-protocols-in-healthy-young-men
#16
Shufang Cui, Biao Sun, Xin Yin, Xia Guo, Dingming Chao, Chunni Zhang, Chen-Yu Zhang, Xi Chen, Jizheng Ma
Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three groups: muscular strength endurance (SE), muscular hypertrophy (MH) and maximum strength (MS). Venous blood samples were obtained before exercise and immediately, 1 h and 24 h after each RT protocol to assess the following biological parameters: c-miRNAs, anabolic and catabolic hormones, inflammatory cytokines and muscle damage markers...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526077/the-optimal-extent-of-gastrectomy-for-middle-third-gastric-cancer-distal-subtotal-gastrectomy-is-superior-to-total-gastrectomy-in-short-term-effect-without-sacrificing-long-term-survival
#17
Xin Ji, Yan Yan, Zhao-De Bu, Zi-Yu Li, Ai-Wen Wu, Lian-Hai Zhang, Xiao-Jiang Wu, Xiang-Long Zong, Shuang-Xi Li, Fei Shan, Zi-Yu Jia, Jia-Fu Ji
BACKGROUND: The optimal extent of gastrectomy for middle-third gastric cancer remains controversial. In our study, the short-term effects and longer-term survival outcomes of distal subtotal gastrectomy and total gastrectomy are analysed to determine the optimal extent of gastrectomy for middle-third gastric cancer. METHODS: We retrospectively collect and analyse clinicopathologic data and follow-up outcomes from a prospectively collected database at the Peking University Cancer Hospital...
May 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28524833/promoting-vasa-vasorum-neovascularization-of-vein-grafts-extenuates-hypoxia-of-the-wall-and-its-subsequent-influence-on-intimal-hyperplasia
#18
Rong-Jiang Zou, Zheng-Hua Wang, Chen-Xi Wang, Song Xue
BACKGROUND: The autologous saphenous vein is the most common conduit for coronary artery bypass grafting, but the vein graft disease will occur. This study used Matrigel basement membrane matrix with many different growth factors to promote vasa vasorum neovascularization and extenuate the hypoxia to improve remodeling. METHODS: This study observed the hypoxia and thickness of the vein grafts at different times. Normal veins and vein grafts with 15 min of ischemia one day postoperatively were harvested in the neck of rabbits...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28524175/modulators-of-microglial-activation-and-polarization-after-intracerebral-haemorrhage
#19
REVIEW
Xi Lan, Xiaoning Han, Qian Li, Qing-Wu Yang, Jian Wang
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and developing classic M1-like (proinflammatory) or alternative M2-like (anti-inflammatory) phenotypes. This polarization implies as yet unrecognized actions of microglia in ICH pathology and recovery, perhaps involving microglial production of proinflammatory or anti-inflammatory cytokines and chemokines...
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28522613/dehydration-stress-extends-mrna-3-untranslated-regions-with-noncoding-rna-functions-in-arabidopsis
#20
Hai-Xi Sun, Yan Li, Qi-Wen Niu, Nam-Hai Chua
The 3' untranslated regions (3' UTRs) of mRNAs play important roles in the regulation of mRNA localization, translation and stability. Alternative cleavage and polyadenylation (APA) generates mRNAs with different 3' UTRs, but the involvement of this process in stress response has not yet been clarified. Here, we report that a subset of stress-related genes exhibits 3' UTR extensions of their mRNAs during dehydration stress. These extended 3' UTRs have characteristics of long noncoding RNAs and likely do not interact with miRNAs...
May 18, 2017: Genome Research
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