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https://www.readbyqxmd.com/read/29161037/biodegradation-of-carbon-nanotube-polymer-nanocomposites-using-a-monoculture
#1
David G Goodwin, Iruhany Boyer, Thomas Devahif, Cong Gao, Benjamin Frank, Xier Lu, Leo Kuwama, Tucker B Gordon, JingJing Wang, James F Ranville, Edward J Bouwer, D Howard Fairbrother
The biodegradation rates of carbon nanotube (CNT)/ polymer nanocomposites (PNCs) containing poly-ɛ-caprolactone (PCL) were investigated using Pseudomonas aeruginosa, a microorganism commonly found in the environment. CNT/PCL nanocomposite mass loss profiles revealed that the rate of PCL matrix biodegradation decreased systematically as the CNT loading increased from 0.1 to 10% w/w. Addition of even a low CNT loading (< 1% w/w) caused the CNT/PCL biodegradation rate constant to decrease by more than 50%...
November 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29160940/morphological-transformation-of-hbmsc-from-2d-monolayer-to-3d-microtissue-on-low-crystallinity-sf-pcl-patch-with-promotion-of-cardiomyogenesis
#2
Hsin-Yu Lo, An-Li Huang, Pei-Chi Lee, Tze-Wen Chung, Shoei-Shen Wang
The effects of the stiffness of substrates on the cell behaviors of hBMSC have been investigated but the effects of the secondary structures of proteins in the substrates on the morphological transformation and differentiation of hBMSC have yet been elucidated. To investigate these issues, SP cardiac patches of poly(ε-caprolactone) (P), on which is grafted by silk (SF) with various β-sheet contents (or crystallinity) to provide various degrees of stiffness, were produced to examine the in-vitro behaviors of hBMSC during proliferation, and cardiomyogenesis on the SP patches...
November 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29160080/adjuvant-activity-of-poly-%C3%AE%C2%B5-caprolactone-chitosan-nanoparticles-characterized-by-mast-cell-activation-and-ifn-%C3%AE-and-il-17-production
#3
Sandra Jesus, Edna Soares, Gerrit Borchard, Olga Borges
Polymeric nanoparticles (NPs) are extremely attractive vaccine adjuvants, able to promote antigen delivery and in some instances, exert intrinsic immunostimulatory properties that enhance antigen specific humoral and cellular immune responses. The poly-ε-caprolactone (PCL)/chitosan NPs were designed with the aim of being able to combine the properties of the 2 polymers in the preparation of an adjuvant for the hepatitis B surface antigen (HBsAg). This manuscript reports important results of an in vitro mechanistic study and immunization studies with HBsAg associated with different concentrations of the nanoparticles...
November 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29159350/mucopenetrating-micelles-with-a-peg-corona
#4
Essi M Taipaleenmäki, Sidsel A Mouritzen, Philipp S Schattling, Yan Zhang, Brigitte Städler
Crossing the intestinal mucus layer is a long-standing challenge for orally delivered nanoparticles carrying therapeutic cargo. We report the assembly of mucopenetrating cargo-loaded micelles using block copolymers consisting of either linear poly(ethylene glycol) (PEG) or bottle-brush poly(oligo(ethylene glycol)methacrylate) (PEGb) as the hydrophilic block and poly(caprolactone) (PCL) or poly(cholesteryl methacrylate) (PCMA) as the hydrophobic extension. The micelles were shown to preserve their stability and retain ∼50% of their cargo in simulated gastric fluid...
November 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29158834/rational-design-of-polymeric-hybrid-micelles-to-overcome-lymphatic-and-intracellular-delivery-barriers-in-cancer-immunotherapy
#5
Hanmei Li, Yanping Li, Xue Wang, Yingying Hou, Xiaoyu Hong, Tao Gong, Zhirong Zhang, Xun Sun
Poor distribution of antigen/adjuvant to target sites and inadequate induction of T cell responses remain major challenges in cancer immunotherapy because of the lack of appropriate delivery systems. Nanocarrier-based antigen delivery systems have emerged as an innovative strategy to improve vaccine efficacy. Here we present polymeric hybrid micelles (PHMs) as a simple and potent antigen/adjuvant co-delivery system with highly tunable properties. PHMs consist of two amphiphilic diblock copolymers, polycaprolactone-polyethylenimine (PCL-PEI) and polycaprolactone-polyethyleneglycol (PCL-PEG)...
2017: Theranostics
https://www.readbyqxmd.com/read/29158646/management-of-comminuted-tibial-end-bony-avulsion-of-posterior-cruciate-ligament-by-open-posterior-approach-using-suture-bridge-technique-a-case-series
#6
Vivek Pandey, Naveen Mathai, A Varshini, Kiran Acharya
Background: Comminuted tibial end bony avulsion of posterior cruciate ligament (PCL) is a challenging problem in terms of accurate reduction, fixation and union to provide a stable knee. Arthroscopic reduction or a screw fixation is good option for a large fragment but comminuted fragment reduction remains a challenge. Suture bridge technique using two anchors can provide an accurate reduction and stable fixation. Method: 10 patients of isolated comminuted PCL avulsion with a mean age of 30 years were fixed by standard posterior approach using suture bridge technique...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29155411/porosity-effect-of-3d-printed-polycaprolactone-membranes-on-calvarial-defect-model-for-guided-bone-regeneration
#7
Jin-Hyung Shim, Jae-Hyang Jeong, Joo-Yun Won, Ji-Hyeon Bae, Geunseon Ahn, Hojun Jeon, Won-Soo Yun, Eun-Bin Bae, Jae-Won Choi, So-Hyoun Lee, Chang-Mo Jeong, Hoyun Chung, Jung-Bo Huh
The appropriate porosity and pore size of barrier membrane were associated with the transportation of biomolecules required for new bone formation and angiogenesis. In this study, we fabricated 3D-printed resorbable polycaprolactone (PCL) membranes with different porosities (30%, 50%, and 70%) to evaluate the effective pore size for guided bone regeneration (GBR) membranes. To analyze mechanical properties and cytocompatibility, PCL membranes prepared using extrusion-based 3D printing technology were compared in dry and wet conditions and tested in vitro...
November 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29154809/facilitated-acquisition-of-the-classically-conditioned-eyeblink-response-in-active-duty-military-expressing-posttraumatic-stress-disorder-symptoms
#8
Justin D Handy, Pelin Avcu, Nora Ko, Alejandro Ortiz, Michael J Doria, Richard J Servatius
OBJECTIVE: Learning diathesis models underscore the role of hyper-conditioning in the development of PTSD following trauma exposure. Eyeblink classical conditioning is one method of examining associative learning biases independent of fear and threat produced by trauma. Facilitated learning is apparent in individuals self-expressing PTSD symptoms, as well as behaviorally inhibited (BI) temperament, a vulnerability factor for PTSD. Here, we examine eyeblink conditioning in active duty military personnel and relate learning with PTSD symptomology...
November 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29148548/acrylate-based-materials-for-heart-valve-scaffold-engineering
#9
Rosaria Santoro, Seshasailam Venkateswaran, Francesco Amadeo, Rong Zhang, Maura Brioschi, Anthony Callanan, Marco Agrifoglio, Cristina Banfi, Mark Bradley, Maurizio Pesce
Calcific aortic valve disease (CAVD) is the most frequent cardiac valve pathology. Its standard treatment consists of surgical replacement either with mechanical (metal made) or biological (animal tissue made) valve prostheses, both of which have glaring deficiencies. In the search for novel materials to manufacture artificial valve tissue, we have conducted a high-throughput screening with subsequent up-scaling to identify non-degradable polymer substrates that promote valve interstitial cells (VICs) adherence/growth and, at the same time, prevent their evolution toward a pro-calcific phenotype...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29145963/functional-results-and-isokinetic-muscle-strength-in-patients-with-fraser-type-i-floating-knee-treated-with-internal-fixation
#10
Fernando Brandao Andrade-Silva, Adriana Carvalho, Caio Mansano, Aline Giese, Marcos de Camargo Leonhardt, Dennis Barbosa, Kodi Edson Kojima, Jorge Santos Silva
INTRODUCTION: According to Fraser's description, ipsilateral femoral and tibial diaphyseal fractures are characterised as type I floating knee and have a better prognosis than fractures with joint involvement (type II). There are few reports of functional and muscle strength in these patients. The objective of this study was to evaluate the functional and isokinetic muscle strength of patients with type I floating knee undergoing femoral and tibial internal fixation. METHODS: Patients with type I floating knee undergoing concomitant femoral and tibial internal fixation were invited for clinical evaluation...
October 2017: Injury
https://www.readbyqxmd.com/read/29143785/waterborne-polyurethane-coatings-with-covalently-linked-black-dye-sudan-black-b
#11
Tao Wang, Wei Sun, Xingyuan Zhang, Haiyan Xu, Fei Xu
Colored waterborne polyurethanes have been widely used in paintings, leathers, textiles, and coatings. Here, a series of black waterborne polyurethanes (WPUs) with different ratios of black dye, Sudan Black B (SDB), were prepared by step-growth polymerization. WPU emulsions as obtained exhibit low particle sizes and remarkable storage stability at the same time. At different dye loadings, essential structural, statistical and thermal properties are characterized. FTIR (fourier transform infrared) spectra indicate that SDB is covalently linked into waterborne polyurethane chains...
October 28, 2017: Materials
https://www.readbyqxmd.com/read/29142416/protective-effect-of-pluchea-lanceolata-against-aluminum-chloride-induced-neurotoxicity-in-swiss-albino-mice
#12
Ravi Mundugaru, Senthilkumar Sivanesan, Padmaja Udaykumar, Niranjan Rao, Naveen Chandra
Background: Aluminum chloride (AlCl3) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in the brain. The herb Pluchea lanceolata is commonly known as "Rasana" and used as a nerve tonic in neuroinflammatory conditions in Indian system of medicine. Objective: To evaluate the neuroprotective activity of hydroalcoholic extract of P. lanceolata in chronic AlCl3-induced neurotoxicity in Swiss albino mice. Materials and Methods: Albino mice were categorized into four different groups; Group 1served as vehicle control, Group 2 mice were administered with AlCl3, 40 mg/kg body weight by intraperitoneal route for 45 consecutive days...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137784/surface-modified-sio2-nanoparticles-by-thiamine-and-ultrasonication-synthesis-of-pcl-sio2-vb1-ncs-morphology-thermal-mechanical-and-bioactivity-investigations
#13
Shadpour Mallakpour, Zahra Khani
The influence of silica (SiO2) nanoparticles (NPs) on the properties of polycaprolactone (PCL) was investigated. Due to the intense tendency of SiO2 NPs to aggregation and their high surface energy, the surface of SiO2 NPs was treatment via Vitamin B1 (VB1) as a biosafe coupling agent. Novel PCL/SiO2-VB1 nanocomposites (NC) films by variety of percentage of SiO2-VB1 NPs were prepared under ultrasonic irradiation as an eco-friendly and fast procedure following by casting method. Fourier transform infrared spectroscopy and energy dispersive X-ray analysis exposed the presence of SiO2 NPs into the polymer matrix...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29134783/electrospun-titania-fiber-mats-spin-coated-with-thin-polymer-films-as-nanofibrous-scaffolds-for-enhanced-cell-proliferation
#14
Alfin Kurniawan, Chintya Effendi, Meng-Jiy Wang
The incorporation of inorganic materials into electrospun nanofibers has recently gained considerable attention for the development of ECM-like scaffolds with improved mechanical properties and enhanced biological functions for tissue engineering applications. In this study, polymer-inorganic composite fibers consisting of poly(2-ethyl-2-oxazoline) (PEOXA) and tetrabutyl titanate (TBT) as the titanium precursor were successfully fabricated through a combined sol-gel/electrospinning approach. PEOXA/Ti(OR)n composite fibers were obtained with varying amounts of polymer and titanium precursors...
November 14, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29133635/is-the-distance-from-punctum-a-factor-in-the-anatomical-and-functional-success-of-canalicular-laceration-repairs
#15
Manpreet Singh, Natasha Gautam, Nitasha Ahir, Manpreet Kaur
PURPOSE: The aim is to analyze the influence of the location of lacrimal canalicular laceration over the eventual anatomical and functional success after surgery. METHODS: Retrospective, observational study of proximal canalicular laceration (PCL) and distal canalicular laceration (DCL) repairs by a single surgeon (MS). The distance between lacrimal punctum and the lateral canalicular lacerated end was defined as proximal (<6 mm) and distal (≥6 mm). The operation theater setup, microscopic magnified view, local adrenaline, and pigtail probe were used to locate the medial canalicular lacerated end...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133120/enhanced-oral-absorption-and-anticancer-efficacy-of-cabazitaxel-by-overcoming-intestinal-mucus-and-epithelium-barriers-using-surface-polyethylene-oxide-peo-decorated-positively-charged-polymer-lipid-hybrid-nanoparticles
#16
Tianyang Ren, Qian Wang, Ying Xu, Lin Cong, Jingxin Gou, Xiaoguang Tao, Yu Zhang, Haibing He, Tian Yin, Haotian Zhang, Yan Zhang, Xing Tang
Polymer-lipid hybrid nanoparticles, PMONPs, were developed to improve the oral absorption of cabazitaxel (CTX), a semi-synthetic taxane derivative, by overcoming multiple gastrointestinal barriers. The nano-carrier is comprised of a poly(ε-caprolactone) (PCL) and chain triglyceride (MCT) hybrid core for drug loading, and a positively charged surface while slightly concealed with a polyethylene oxide (PEO) shell by insertion of poloxamer 188, with the aim of improving the intestinal mucus permeation and epithelial cell uptake...
November 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29131407/posttraumatic-stress-disorder-gender-and-risk-factors-world-trade-center-tower-survivors-10-to-11-years-after-the-september-11-2001-attacks
#17
Rosemarie M Bowler, Shane W Adams, Vihra V Gocheva, Jiehui Li, Donna Mergler, Robert Brackbill, James E Cone
Ten to eleven years after the September 11, 2001 terrorist attacks, probable posttraumatic stress disorder (PTSD) was evaluated in 1,755 World Trade Center (WTC) evacuees based on data from the WTC Health Registry. Characteristics of men and women were compared and factors associated with PTSD symptom severity were examined using the PTSD Checklist (PCL). Compared with men (n = 1,015, 57.8%), women (n = 740, 42.2%) were younger and of lower socioeconomic status. Ten to eleven years after September 11, 2001, 13...
November 13, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29130548/reliability-and-validity-of-the-arabic-ptsd-checklist-civilian-version-pcl-c-in-women-survivors-of-intimate-partner-violence
#18
Eman Alhalal, Marilyn Ford-Gilboe, Carol Wong, Fadia AlBuhairan
Although intimate partner violence (IPV) survivors are at high risk for developing posttraumatic stress disorder (PTSD), PTSD has been considered a disorder specific to Western culture. There is a lack of reliable and valid measures of PTSD symptomology available in the Arab world, and there is still no clear evidence about the underlying factor structure of PTSD symptomology in the context of IPV. Thus, in the present study we investigated the construct validity (factor structure), internal consistency, and concurrent validity of a translated version of the PTSD Checklist Civilian Version (PCL-C) in a sample of 299 Saudi women who had experienced IPV...
November 11, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/29130147/callous-unemotional-traits-modulate-brain-drug-craving-response-in-high-risk-young-offenders
#19
Gina M Vincent, Lora M Cope, Jean King, Prashanth Nyalakanti, Kent A Kiehl
Adults with psychopathy have a high propensity for substance abuse, generally starting from a young age. This investigation tested hypotheses about differences in the neural responses associated with drug craving among high-risk young offenders with histories of abuse of stimulants and other drugs as a function of psychopathic traits. Fifty-four male adolescents (44 with a history of stimulant abuse and 10 controls) incarcerated at a maximum-security facility (M age = 17.08 years) completed a drug-cue exposure task while brain hemodynamic activity was monitored using functional magnetic resonance imaging (fMRI) with a mobile MRI scanner stationed at the facility...
November 13, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29128835/star-poly-%C3%AE%C2%B5-caprolactone-based-electrospun-fibers-as-biocompatible-scaffold-for-doxorubicin-with-prolonged-drug-release-activity
#20
Preethi Balakrishnan, Lorenza Gardella, Mahdi Forouharshad, Teresa Pellegrino, Orietta Monticelli
In this work, a novel drug delivery system consisting of poly(ε-caprolactone) (PCL) electrospun fibers containing an ad-hoc-synthesized star polymer made up of a poly(amido-amine) (PAMAM) core and PCL branches (PAMAM-PCL) was developed. The latter system which was synthesized via the ring opening polymerization of ε-caprolactone, starting from a hydroxyl-terminated PAMAM dendrimer and characterized by means of (1)H NMR, IR and DSC, was found to be compatible with both the polymer matrix and a hydrophilic chemotherapeutic drug, doxorubicin (DOXO), the model drug used in this work...
November 7, 2017: Colloids and Surfaces. B, Biointerfaces
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