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https://www.readbyqxmd.com/read/27910713/sn-38-loading-capacity-of-hydrophobic-polymer-blend-nanoparticles-formulation-optimization-and-efficacy-evaluation
#1
Simona Dimchevska, Nikola Geskovski, Gjorgji Petruševski, Marina Chacorovska, Riste Popeski-Dimovski, Sonja Ugarkovic, Katerina Goracinova
One of the most important problems in nanoencapsulation of extremely hydrophobic drugs is poor drug loading due to rapid drug crystallization outside the polymer core. The effort to use nanoprecipitation, as a simple one-step procedure with good reproducibility and FDA approved polymers like Poly(lactic-co-glycolic acid) (PLGA) and Polycaprolactone (PCL), will only potentiate this issue. Considering that drug loading is one of the key defining characteristics, in this study we attempted to examine whether the nanoparticle core composed of two hydrophobic polymers will provide increased drug loading for 7-Ethyl-10-hydroxy-camptothecin (SN-38), relative to nanoparticles prepared using individual polymers...
December 2, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27908720/preparation-and-characterization-of-polymeric-nanoparticles-surface-modified-with-chitosan-for-target-treatment-of-colorectal-cancer
#2
Mohamed M Badran, Mohsen M Mady, Magdy M Ghannam, Faiyaz Shakeel
5-Fluorouracil (5-FU) loaded chitosan (C) coated polylactic-co-glycolic acid (PLGA) nanoparticles [NPs] (C-5-FU PLGA NPs) and polycaprolactone [PCL] (C-5-FU PCL NPs) were employed as the carriers for cancer treatment. The prepared NPs showed the spherical shape of NPs with the particle size in the range of 188.1-302.2nm with polydispersity index (PDI) of<0.30. C-coated NPs converted zeta potential from negative to positive value with small modification in particle size distribution. The entrapment efficiency of 5-FU was recorded in the range of 32-51%...
November 28, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27905322/synergistic-interactions-between-silver-decorated-graphene-and-carbon-nanotubes-yield-flexible-composites-to-attenuate-electromagnetic-radiation
#3
Shital Patangrao Pawar, Sachin Kumar, Shubham Jain, Mounika Gandi, Kaushik Chatterjee, Suryasarathi Bose
The need of today's highly integrated electronic devices, especially working in the GHz frequencies, is to protect them from unwanted interference from neighbouring devices. Hence, lightweight, flexible, easy to process microwave absorbers were designed here by dispersing conductive multiwall carbon nanotubes (MWNTs) and silver nanoparticles decorated onto two-dimensional graphene sheets (rGO@Ag) in poly(ε-caprolactone) (PCL). In this study, we have shown how dielectric losses can be tuned in the nanocomposites by rGO@Ag nano-hybrid; an essential criterion for energy dissipation within a material resulting in effective shielding of the incoming electromagnetic (EM) radiation...
December 1, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27905320/nanoporous-nanocomposite-membranes-via-hybrid-twin-screw-extrusion-multijet-electrospinning
#4
Semra Senturk-Ozer, Seda Aktas, Jing He, Frank T Fisher, Dilhan M Kalyon
Non-woven nanoporous membranes of poly(caprolactone), PCL, incorporated with multi-walled carbon nanotubes, CNTs, could be fabricated via an industrially-scalable hybrid twin screw extrusion and electrospinning process. The utilization of a spinneret with multiple nozzles allowed the increase of the flow rate beyond what is possible with conventional electrospinning using a single nozzle, albeit at the expense of difficulties in the control of the thickness distributions of the nanofibrous membranes. The thickness and orientation distributions and the resulting mechanical properties of the membranes could be modified via changes in voltage, angular velocity of the collector mandrel and separation distance of the collector from the spinneret...
December 1, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27898014/future-prospects-for-scaffolding-methods-and-biomaterials-in-skin-tissue-engineering-a-review
#5
REVIEW
Atul A Chaudhari, Komal Vig, Dieudonné Radé Baganizi, Rajnish Sahu, Saurabh Dixit, Vida Dennis, Shree Ram Singh, Shreekumar R Pillai
Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvantages. These scaffolds are either made up of highly biocompatible natural biomaterials, such as collagen, chitosan, etc...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27896678/no-clinically-important-difference-in-knee-scores-or-instability-between-transtibial-and-inlay-techniques-for-pcl-reconstruction-a-systematic-review
#6
REVIEW
Young-Soo Shin, Hyun-Jung Kim, Dae-Hee Lee
BACKGROUND: It is unclear whether the biomechanical superiority of the inlay technique over the transtibial technique, arising from avoidance of the killer turn at the graft-tunnel margin of the proximal tibia during posterior cruciate ligament (PCL) reconstruction, leads to better knee scores or greater knee stability. QUESTIONS/PURPOSES: This systematic review was designed to compare Tegner and Lysholm scores, and posterior residual laxity of the knee, between single-bundle PCL reconstruction using transtibial and inlay techniques...
November 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27893032/effect-of-group-vs-individual-cognitive-processing-therapy-in-active-duty-military-seeking-treatment-for-posttraumatic-stress-disorder-a-randomized-clinical-trial
#7
Patricia A Resick, Jennifer Schuster Wachen, Katherine A Dondanville, Kristi E Pruiksma, Jeffrey S Yarvis, Alan L Peterson, Jim Mintz, Elisa V Borah, Antoinette Brundige, Elizabeth A Hembree, Brett T Litz, John D Roache, Stacey Young-McCaughan
Importance: Cognitive processing therapy (CPT), an evidence-based treatment for posttraumatic stress disorder (PTSD), has not been tested as an individual treatment among active-duty military. Group CPT may be an efficient way to deliver treatment. Objective: To determine the effects of CPT on PTSD and co-occurring symptoms and whether they differ when administered in an individual or a group format. Design, Setting, and Participants: In this randomized clinical trial, 268 active-duty servicemembers consented to assessment at an army medical center from March 8, 2012, to September 23, 2014, and were randomized to group or individual CPT...
November 23, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27892655/3d-printed-polycaprolactone-carbon-nanotube-composite-scaffolds-for-cardiac-tissue-engineering
#8
Chee Meng Benjamin Ho, Abhinay Mishra, Pearlyn Teo Pei Lin, Sum Huan Ng, Wai Yee Yeong, Young-Jin Kim, Yong-Jin Yoon
Fabrication of tissue engineering scaffolds with the use of novel 3D printing has gained lot of attention, however systematic investigation of biomaterials for 3D printing have not been widely explored. In this report, well-defined structures of polycaprolactone (PCL) and PCL- carbon nanotube (PCL-CNT) composite scaffolds have been designed and fabricated using a 3D printer. Conditions for 3D printing has been optimized while the effects of varying CNT percentages with PCL matrix on the thermal, mechanical and biological properties of the printed scaffolds are studied...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27889924/dental-ontogeny-of-a-white-shark-embryo
#9
Taketeru Tomita, Kei Miyamoto, Akira Kawaguchi, Minoru Toda, Shin-Ichiro Oka, Ryo Nozu, Keiichi Sato
Unlike most viviparous vertebrates, lamniform sharks develop functional teeth during early gestation. This feature is considered to be related to their unique reproductive mode where the embryo grows to a large size via feeding on nutritive eggs in utero. However, the developmental process of embryonic teeth is largely uninvestigated. We conducted X-ray microcomputed tomography to observe the dentitions of early-, mid-, and full-term embryos of the white shark Carcharodon carcharias (Lamniformes, Lamnidae)...
November 27, 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27886552/three-dimensional-electrospun-pcl-pla-blend-nanofibrous-scaffolds-with-significantly-improved-stem-cells-osteogenic-differentiation-and-cranial-bone-formation
#10
Qingqing Yao, Jaqueline G L Cosme, Tao Xu, Jacob M Miszuk, Paulo H S Picciani, Hao Fong, Hongli Sun
Nanofibrous scaffolds that are morphologically/structurally similar to natural ECM are highly interested for tissue engineering; however, the electrospinning technique has the difficulty in directly producing clinically relevant 3D nanofibrous scaffolds with desired structural properties. To address this challenge, we have developed an innovative technique of thermally induced nanofiber self-agglomeration (TISA) recently. The aim of this work was to prepare (via the TISA technique) and evaluate 3D electrospun PCL/PLA blend (mass ratio: 4/1) nanofibrous scaffolds having high porosity of ∼95...
November 15, 2016: Biomaterials
https://www.readbyqxmd.com/read/27881642/clinoptilolite-pcl-peg-pcl-composite-scaffolds-for-bone-tissue-engineering-applications
#11
Engin Pazarçeviren, Özge Erdemli, Dilek Keskin, Ayşen Tezcaner
The aim of this study was to prepare and characterize highly porous clinoptilolite/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) composite scaffolds. Scaffolds with different clinoptilolite contents (10% and 20%) were fabricated with reproducible solvent-free powder compression/particulate leaching technique. The scaffolds had interconnective porosity in the range of 55-76%. Clinoptilolite/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) scaffolds showed negligible degradation within eight weeks and displayed less water uptake and higher bioactivity than poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) scaffolds...
November 23, 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27880849/loading-patterns-of-the-posterior-cruciate-ligament-in-the-healthy-knee-a-systematic-review
#12
S H Hosseini Nasab, Renate List, Katja Oberhofer, Sandro F Fucentese, Jess G Snedeker, William R Taylor
BACKGROUND: The posterior cruciate ligament (PCL) is the strongest ligament of the knee, serving as one of the major passive stabilizers of the tibio-femoral joint. However, despite a number of experimental and modelling approaches to understand the kinematics and kinetics of the ligament, the normal loading conditions of the PCL and its functional bundles are still controversially discussed. OBJECTIVES: This study aimed to generate science-based evidence for understanding the functional loading of the PCL, including the anterolateral and posteromedial bundles, in the healthy knee joint through systematic review and statistical analysis of the literature...
2016: PloS One
https://www.readbyqxmd.com/read/27879153/polymeric-micelles-of-suberoylanilide-hydroxamic-acid-to-enhance-the-anticancer-potential-in-vitro-and-in-vivo
#13
Sri Vishnu Kiran Rompicharla, Prakruti Trivedi, Preeti Kumari, Pratyusha Ghanta, Balaram Ghosh, Swati Biswas
AIM: To improve the bioavailability and anticancer potential of suberoylanilide hydroxamic acid (SAHA) by developing a drug-loaded polymeric nanomicellar system. METHODS: SAHA-loaded Poly(ethylene glycol)-block-poly(caprolactone) (PEG-PCL) micelles were developed, and physico-chemically characterized. In vitro cellular uptake, viability and apoptosis-inducing ability of the SAHA-PEG-PCL micelles were investigated. In vivo anticancer activity was evaluated in C57BL/6 mice-bearing tumor...
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27874896/unusual-acid-base-properties-of-the-p4-molecule-in-hydrogen-halogen-and-pnicogen-bonded-complexes
#14
Ibon Alkorta, José Elguero, Janet E Del Bene
Ab initio MP2/aug'-cc-pVTZ calculations have been carried out to investigate hydrogen bonding, halogen bonding, and pnicogen bonding involving tetrahedral P4 and the FH, ClH, and FCl molecules. P4 has three unique interaction sites: at a vertex (designated the P1 atom); at an edge (the P2-P3 bond); and at the P2-P3-P4 face. The uniqueness of molecular P4 is its ability to act as an electron donor and an electron acceptor at the same site, except for the P2-P3 bond, which is only an electron donor. FCl and FH form five different complexes with P4, but ClH forms only three...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27872844/fabrication-of-poly-%C3%AE%C2%B5-caprolactone-scaffolds-reinforced-with-cellulose-nanofibers-with-and-without-the-addition-of-hydroxyapatite-nanoparticles
#15
Pedro Morouço, Sara Biscaia, Tânia Viana, Margarida Franco, Cândida Malça, Artur Mateus, Carla Moura, Frederico C Ferreira, Geoffrey Mitchell, Nuno M Alves
Biomaterial properties and controlled architecture of scaffolds are essential features to provide an adequate biological and mechanical support for tissue regeneration, mimicking the ingrowth tissues. In this study, a bioextrusion system was used to produce 3D biodegradable scaffolds with controlled architecture, comprising three types of constructs: (i) poly(ε-caprolactone) (PCL) matrix as reference; (ii) PCL-based matrix reinforced with cellulose nanofibers (CNF); and (iii) PCL-based matrix reinforced with CNF and hydroxyapatite nanoparticles (HANP)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27872126/multiple-ligament-reconstruction-femoral-tunnels-intertunnel-relationships-and-guidelines-to-avoid-convergence
#16
Gilbert Moatshe, Alex W Brady, Erik L Slette, Jorge Chahla, Travis Lee Turnbull, Lars Engebretsen, Robert F LaPrade
BACKGROUND: Knee dislocations often require multiple concurrent ligament reconstructions, which involve creating several tunnels in the distal femur. Therefore, the risk of tunnel convergence is increased because of the limited bone volume within the distal aspect of the femur. PURPOSE: To assess the risk of tunnel convergence and determine the optimal reconstruction tunnel orientations for multiple ligament reconstructions in the femur. STUDY DESIGN: Descriptive laboratory study...
November 21, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27871909/histone-deacetylase-inhibition-enhances-in-vivo-bone-regeneration-induced-by-human-periodontal-ligament-cells
#17
Nam Cong-Nhat Huynh, Vincent Everts, Akira Nifuji, Prasit Pavasant, Ruchanee Salingcarnboriboon Ampornaramveth
: Periodontal ligament cells have the potential to differentiate into bone forming osteoblasts and thus represent a good cellular candidate for bone regeneration. This study aimed to investigate the effect of inhibition of histone deacetylases, using the inhibitor Trichostatin A (TSA), on bone regeneration by human periodontal ligament cells (hPDLCs) in a mouse calvaria bone defect. METHODS: RUNX2 protein and its acetylation was analyzed by immunoprecipitation and western blotting...
November 18, 2016: Bone
https://www.readbyqxmd.com/read/27869464/customized-computer-based-administration-of-the-pcl-5-for-the-efficient-assessment-of-ptsd-a-proof-of-principle-study
#18
Matthew D Finkelman, Sarah R Lowe, Wonsuk Kim, Oliver Gruebner, Niels Smits, Sandro Galea
Objective: To investigate the potential of customized computer-based testing procedures to reduce the mean test length of the Posttraumatic Stress Checklist for DSM-5 (PCL-5). Method: A retrospective analysis was conducted using responses from 942 adults who had completed the full-length (20-item) PCL-5 in the aftermath of Hurricane Sandy. The abilities of 2 testing procedures, curtailment and stochastic curtailment, to lessen the instrument's mean test length while maintaining the same result as the full-length PCL-5 ("positive" or "negative") were evaluated in a post hoc simulation...
November 21, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27865950/lactobacillus-sps-lipase-mediated-poly-%C3%AE%C2%B5-caprolactone-degradation
#19
Imran Khan, Jayati Ray Dutta, Ramakrishnan Ganesan
Polymer degradation through lipase appears to be an enthralling alternative to bulk chemical routes. Poly (ε-caprolactone) (PCL) is an artificial polyester that can be degraded by microbes and enzymes like lipases and esterases. The environmental degradation of PCL is dependent on the activity of bacteria that characterization techniques such as thermogravimetric analysis, differential thermal are widely present in the ecosystem. In this study, three different lipases derived from Lactobacillus brevis, Lactobacillus plantarum and their co-culture have been utilized to explore their efficiency towards PCL enzymatic degradation...
November 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27859544/lateral-soft-tissue-structures-contribute-to-cruciate-retaining-total-knee-arthroplasty-stability
#20
Kiron K Athwal, Hadi El Daou, Breck Lord, Andrew J Davies, William Manning, Ferdinando Rodriguez Y Baena, David J Deehan, Andrew A Amis
Little information is available to surgeons regarding how the lateral structures prevent instability in the replaced knee. The aim of this study was to quantify the lateral soft-tissue contributions to stability following cruciate-retaining total knee arthroplasty (CR TKA). Nine cadaveric knees were tested in a robotic system at full extension, 30°, 60°, and 90° flexion angles. In both native and CR implanted states, ±90 N anterior-posterior force, ±8 Nm varus-valgus, and ±5 Nm internal-external torque were applied...
November 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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