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https://www.readbyqxmd.com/read/29350716/three-dimensional-multiscale-fiber-matrices-development-and-characterization-for-increased-hepg2-functional-maintenance-for-bio-artificial-liver-application
#1
Surendra Kumar Verma, Akshay Modi, Jayesh Bellare
The development of a cell-growth substrate that provides a nature-like microenvironment, promotes cell adhesion, and maintains the cells' functional activities is a research focus in the field of tissue engineering. In the present study, three-dimensional micro-nano multiscale fiber-based substrates were developed by depositing biocompatible polycaprolactone (PCL)/PCL-Chitosan (C)/PCL-C-Gelatin (G) electrospun nanofibers (NFs) on the outer surface of hollow fiber membranes (HFMs) in one step. A comparison study with regard to physico-chemical characterization, hemocompatibility, cytotoxicity, and cellular functionality was performed with the developed matrices...
January 19, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29344305/a-tumor-activatable-theranostic-nanomedicine-platform-for-nir-fluorescence-guided-surgery-and-combinatorial-phototherapy
#2
Xiaoning Li, Canan Schumann, Hassan A Albarqi, Christopher J Lee, Adam W G Alani, Shay Bracha, Milan Milovancev, Olena Taratula, Oleh Taratula
Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29343450/paediatric-physeal-sparing-posterior-cruciate-ligament-pcl-reconstruction-with-parental-donation-allograft-rationale-and-operative-approach
#3
R S Khakha, S K Yasen, A J Wilson
BACKGROUND: Paediatric PCL injuries are rare but constitute a significant management challenge. We describe a novel approach to the surgical management of an 11-year-old boy who presented with persisting symptomatic instability following 18months of failed conservative therapy. METHODS: PCL reconstruction was performed using a physeal sparing, all-inside technique under fluoroscopic control. This avoids the potential for iatrogenic growth injury. A parentally donated hamstrings allograft was used to ensure adequate graft size, and reinforced using a non-elastic two millimetre braided suture...
January 14, 2018: Knee
https://www.readbyqxmd.com/read/29343229/the-colombo-twin-and-singleton-follow-up-study-a-population-based-twin-study-of-psychiatric-disorders-and-metabolic-syndrome-in-sri-lanka
#4
Kaushalya Jayaweera, Lisa Aschan, Gayani Pannala, Anushka Adikari, Nicholas Glozier, Khalida Ismail, Carmine M Pariante, Fruhling Rijsdijk, Sisira Siribaddana, Helena M S Zavos, Patricia A Zunszain, Athula Sumathipala, Matthew Hotopf
BACKGROUND: The disease burden related to mental disorders and metabolic syndrome is growing in low-and middle-income countries (LMIC). The Colombo Twin and Singleton Study (COTASS) is a population-based sample of twins and singletons in Colombo, Sri Lanka. Here we present prevalence estimates for metabolic syndrome (metS) and mental disorders from a follow-up (COTASS-2) of the original study (COTASS-1), which was a mental health survey. METHODS: In COTASS-2, participants completed structured interviews, anthropometric measures and provided fasting blood and urine samples...
January 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29342890/polymer-ceramic-composite-scaffolds-the-effect-of-hydroxyapatite-and-%C3%AE-tri-calcium-phosphate
#5
Boyang Huang, Guilherme Caetano, Cian Vyas, Jonny James Blaker, Carl Diver, Paulo Bártolo
The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. The produced scaffolds were physically and chemically assessed, considering mechanical, wettability, scanning electron microscopy and thermal gravimetric tests...
January 14, 2018: Materials
https://www.readbyqxmd.com/read/29338185/injectable-and-thermo-sensitive-hydrogel-and-pdlla-electrospun-nanofiber-membrane-composites-for-guided-spinal-fusion
#6
Ying Qu, BeiYu Wang, Bingyang Chu, Chenlu Liu, Xin Rong, Hua Chen, JinRong Peng, Zhiyong Qian
Spinal fusion is the classic treatment to achieve spinal stability for the treatment of the spinal disease. Generally, spinal fusion still has to combine a certain of bone matrix for promoting bone formation to achieve the desired fusion effect based on the surgery, including the traditional bone matrix, such as the autologous bone, allografts and xenografts. Nevertheless, some problems still existed such as the immunogenic problems, the secondary wound, and pathogenic transfer and so on. Here the injectable thermosensitive hydrogel could substitute to avoid the problems as a potential biological scaffold for tissue engineering...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29337429/co-expression-of-orfcma-with-phb-depolymerase-phazcma-in-escherichia-coli-induces-efficient-whole-cell-biodegradation-of-polyesters
#7
Ming-Chieh Lee, En-Jung Liu, Cheng-Han Yang, Li-Jung Hsiao, Tzong-Ming Wu, Si-Yu Li
Whole-cell degradation of polyesters not only avoids the tedious process of enzyme separation, but also allows the degraded product to be reused as a carbon source. In this study, Escherichia coli BL21(DE3) harboring phaZCma , a gene encoding poly(3-hydroxybutyrate) (PHB) depolymerase from Caldimonas manganoxidans, was constructed. The extra-cellular fraction of E. coli/pPHAZ exhibited a fast PHB degradation rate where it only took 35 h to completely degrade PHB films, while C. manganoxidans took 81 h to do the same...
January 16, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29335199/3-d-mineralized-silk-fibroin-polycaprolactone-composite-scaffold-modified-with-polyglutamate-conjugated-with-bmp-2-peptide-for-bone-tissue-engineering
#8
Jingjing Luo, Haitao Zhang, Jiang Zhu, Xiaokang Cui, Junjiu Gao, Xin Wang, Jie Xiong
In the field of bone tissue engineering, an ideal three-dimensional (3-D) scaffold should not only structurally mimic the extracellular matrix (ECM) in large tissues but also mechanically support the bone healing process and provide biochemical cues to induce osteogenesis. In this study, we investigated the feasibility of functionalisation of scaffolds by coupling polyglutamate acid conjugated with BMP-2 peptide onto silk fibroin (SF)/polycaprolactone (PCL) (SF/PCL) blend nanofibers. The morphology, composition, and mineralisation, were confirmed by FE-SEM, XRD, and FT-IR spectroscopy...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29333859/chromatographic-separation-and-visual-detection-on-wicking-microfluidic-devices-quantitation-of-cu2-in-surface-ground-and-drinking-water
#9
Gayan C Bandara, Christopher Heist, Vincent T Remcho
Copper is widely applied in industrial and technological applications, and is an essential micro nutrient for humans and animals. However, exposure to high environmental levels of copper, especially through drinking water, can lead to copper toxicity, resulting in severe acute and chronic health effects. Therefore, regular monitoring of aqueous copper ions has become necessary as recent anthropogenic activities have led to elevated environmental concentrations of copper. On-site monitoring processes require an inexpensive, simple, and portable analytical approach capable of generating reliable qualitative and quantitative data efficiently...
January 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29330769/comorbid-insomnia-and-sleep-apnea-in-veterans-with-post-traumatic-stress-disorder
#10
Ali A El-Solh, David Adamo, Thomas Kufel
PURPOSE: The purpose of this study was to determine the impact of insomnia in Veterans with post-traumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) on health-related outcomes before and after 12 weeks of continuous positive airway pressure (CPAP) treatment. METHODS: We conducted a prospective cohort study of Veterans with PTSD and documented apnea hypopnea index (AHI) ≥ 5 with and without clinically significant insomnia as determined by the Insomnia Severity Index (ISI)...
January 10, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29330345/a-computational-simulation-study-to-determine-the-biomechanical-influence-of-posterior-condylar-offset-and-tibial-slope-in-cruciate-retaining-total-knee-arthroplasty
#11
K-T Kang, Y-G Koh, J Son, O-R Kwon, J-S Lee, S K Kwon
OBJECTIVES: Posterior condylar offset (PCO) and posterior tibial slope (PTS) are critical factors in total knee arthroplasty (TKA). A computational simulation was performed to evaluate the biomechanical effect of PCO and PTS on cruciate retaining TKA. METHODS: We generated a subject-specific computational model followed by the development of ± 1 mm, ± 2 mm and ± 3 mm PCO models in the posterior direction, and -3°, 0°, 3° and 6° PTS models with each of the PCO models...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29329076/attachment-of-nanoparticulate-drug-release-systems-on-poly-%C3%AE%C2%B5-caprolactone-nanofibers-via-a-graftpolymer-as-interlayer
#12
Dominik de Cassan, Steffen Sydow, Nadeschda Schmidt, Peter Behrens, Yvonne Roger, Andrea Hoffmann, Anna Lena Hoheisel, Birgit Glasmacher, Robert Hänsch, Henning Menzel
Electrospun poly(ε-caprolactone) (PCL) fiber mats are modified using a chitosan grafted with PCL (CS-g-PCL), to improve the biological performance and to enable further modifications. The graft copolymer is immobilized by the crystallization of the PCL grafts on the PCL fiber surface as binding mechanism. In this way, the surface of the fibers is covered with chitosan bearing cationic amino groups, which allow adsorption of oppositely charged nanoparticulate drug-delivery systems. The modification of the fiber mats and the attachment of the drug delivery systems are easy and scalable dip processes...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29328961/vaginal-delivery-related-changes-in-the-pelvic-organ-position-and-vaginal-cross-sectional-area-in-the-general-population
#13
Shotaro Naganawa, Eriko Maeda, Akifumi Hagiwara, Shiori Amemiya, Wataru Gonoi, Shouhei Hanaoka, Takeharu Yoshikawa, Kuni Ohtomo
PURPOSE: Evaluate the effect of vaginal delivery on pelvic organ positions and vaginal cross-sectional areas. METHODS: MRI of 119 premenopausal women were grouped according to the number of deliveries. The distances from the three 3-reference points (bladder, uterus, and rectum) to two 2-lines (pubococcygeal-line (PCL) and midpubic-line (MPL)), length of H- and M-lines and vaginal cross-sectional area were compared between the groups. RESULTS: With increasing parity, distance from the rectum to PCL tended to increase (nullipara vs...
December 15, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29328888/posterior-cruciate-ligament-reconstruction-with-transtibial-or-tibial-inlay-techniques-a-meta-analysis-of-biomechanical-and-clinical-outcomes
#14
Dong-Yeong Lee, Dong-Hee Kim, Hyun-Jung Kim, Hyeong-Sik Ahn, Tae-Ho Lee, Sun-Chul Hwang
BACKGROUND: Transtibial (TT) or tibial inlay (TI) techniques are commonly used for posterior cruciate ligament reconstruction (PCLR). However, the optimum method for PCLR after PCL injury remains debatable. Hypothesis/Purpose: The hypothesis was that TT and TI techniques would not show significant differences for all outcome measures. The purpose was to determine the biomechanical and clinical outcomes of TT and TI surgical techniques for PCLR. STUDY DESIGN: Meta-analysis; Level of evidence, 3...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29327490/fetal-subcutaneous-cells-have-potential-for-autologous-tissue-engineering
#15
Åsa Ekblad, Magnus Westgren, Magdalena Fossum, Cecilia Götherström
BACKGROUND: Major congenital malformations affect up to 3% of newborns. Infants with prenatally diagnosed soft tissue defects should benefit from having autologous tissue readily available for surgical implantation in the perinatal period. In this study, we investigate fetal subcutaneous cells (fSC) as cellular source for tissue engineering. METHODS: Fetal subcutaneous biopsies were collected from elective terminations at gestational week 20-21. Cells were isolated, expanded and characterized in vitro...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29325834/a-computed-tomography-scan-based-template-to-place-the-femoral-component-in-accurate-rotation-with-respect-to-the-surgical-epicondylar-axis-in-total-knee-arthroplasty
#16
Yasushi Oshima, Norishige Iizawa, Tatsunori Kataoka, Tokifumi Majima, Shinro Takai
BACKGROUND: Femoral rotational alignment is considered an essential factor for total knee arthroplasty because malrotation of femoral components results in poor outcomes. To obtain proper alignment, we developed a superimposable computed tomography (CT) scan-based template to intraoperatively determine the accurate surgical epicondylar axis (SEA), and evaluated the effectiveness of this CT template. METHODS: In the experimental group (n=55), three serial slices of CT images, including medial and lateral epicondyles, were merged into a single image, and SEA was overlaid...
January 9, 2018: Knee
https://www.readbyqxmd.com/read/29325446/reduction-of-ptsd-symptoms-with-pre-reactivation-propranolol-therapy-a-randomized-controlled-trial
#17
Alain Brunet, Daniel Saumier, Aihua Liu, David L Streiner, Jacques Tremblay, Roger K Pitman
OBJECTIVE: The authors assessed the efficacy of trauma memory reactivation performed under the influence of propranolol, a noradrenergic beta-receptor blocker, as a putative reconsolidation blocker, in reducing symptoms of posttraumatic stress disorder (PTSD). METHOD: This was a 6-week, double-blind, placebo-controlled, randomized clinical trial in 60 adults diagnosed with long-standing PTSD. Propranolol or placebo was administered 90 minutes before a brief memory reactivation session, once a week for 6 consecutive weeks...
January 12, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29323717/chondrogenic-differentiation-of-human-scalp-adipose-derived-stem-cells-in-polycaprolactone-scafold-and-using-freeze-thaw-freeze-method
#18
Rana Moradian Tehrani, Hamed Mirzaie, Javad Verdi, Amirhossein Sahebkar, Mahdi Noureddini, Rasoul Salehi, Behrang Alani, Mojtaba Kianmehr
Human adipose tissue has been identified as a viable alternative source for mesenchymal stem cells. SADSCs were isolated from human scalp biopsy and then were characterized by Flow cytometry. SADSCS expressed CD90, CD44, and CD105 but did not express CD45 surface marker. Growth factors were used for chondrogenesis induction. Histology and immunohistology methods and gene expression by real-time PCR 14 days after induced cells have shown the feature of chondrocytes in their morphology and extracellular matrix in both inducing patterns of combination and cycling induction...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29322332/evaluation-of-age-dependent-morphometrics-of-the-meniscofemoral-ligaments-in-reference-to-the-posterior-cruciate-ligament-in-routine-mri
#19
Sebastian Röhrich, Franz Kainberger, Lena Hirtler
OBJECTIVES: To quantify the morphological correlation between the posterior cruciate ligament (PCL) and the meniscofemoral ligaments (MFLs), to propose normal ranges for different age populations, and to define guidelines for correct identification and differentiation of MFLs in routine MRI. METHODS: Three hundred forty-two subjects were included retrospectively and subdivided into five age groups. Morphometrics of the PCL and the MFLs were measured on standard MRI in the sagittal, coronal, and axial planes...
January 10, 2018: European Radiology
https://www.readbyqxmd.com/read/29322240/ki-67-more-than-a-proliferation-marker
#20
REVIEW
Xiaoming Sun, Paul D Kaufman
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression. These localizations correlate with distinct functions. For example, during interphase, Ki-67 is required for normal cellular distribution of heterochromatin antigens and for the nucleolar association of heterochromatin...
January 10, 2018: Chromosoma
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