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https://www.readbyqxmd.com/read/28737954/an-app-a-day-keeps-the-doctor-away-guided-education-and-training-via-smartphones-in-subthreshold-post-traumatic-stress-disorder
#1
Michael J Roy, Michelle E Costanzo, Krista B Highland, Cara Olsen, Denece Clayborne, Wendy Law
Post traumatic stress disorder (PTSD) symptoms are common in military service members (SMs), but stigma can impede treatment initiation. Smartphone applications (apps) are available anywhere, anytime, with the potential to both mitigate the impact of stigma and reduce PTSD symptom severity. We provided 144 SMs or family members, with subthreshold PTSD symptoms (PTSD Checklist [PCL] scores of 28-49), with apps promoting psychoeducation, social engagement, and relaxation and randomized them to 6 weeks of resilience enhancement (brief cognitive-behavioral session, followed by daily text messages directing app use) or a control group (daily text messages of inspirational quotes)...
July 24, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28737465/the-effect-of-ozone-gas-sterilization-on-the-properties-and-cell-compatibility-of-electrospun-polycaprolactone-scaffolds
#2
Carolina Fracalossi Rediguieri, Paul A De Bank, Maria Helena Ambrosio Zanin, Patrícia Leo, Natalia Neto Pereira Cerize, Adriano Marim de Oliveira, Terezinha de Jesus Andreoli Pinto
The growing area of tissue engineering has the potential to alleviate the shortage of tissues and organs for transplantation, and electrospun biomaterial scaffolds are extremely promising devices for translating engineered tissues into a clinical setting. However, to be utilized in this capacity, these medical devices need to be sterile. Traditional methods of sterilization are not always suitable for biomaterials, especially as many commonly used biomedical polymers are sensitive to chemical-, thermal- or radiation-induced damage...
July 24, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28737462/co-delivery-of-hydrophilic-and-hydrophobic-drugs-by-micelles-a-new-approach-using-drug-conjugated-peg-pcl-nanoparticles
#3
H Danafar, K Rostamizadeh, S Davaran, M Hamidi
Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. A conjugate of the antitumor drug, doxorubicin, with diblock methoxy poly (ethylene glycol)-poly caprolactone (mPEG-PCL) copolymer was synthesized by the reaction of mPEG-PCL copolymer with doxorubicin in the presence of p-nitrophenylchloroformate. The conjugated copolymer was characterized in vitro by (1)H NMR, FTIR, DSC and GPC techniques. Then, the doxorubicin conjugated mPEG-PCL(DOX-mPEG-PCL) was self-assembled into micelles in the presence of curcumin in aqueous solution...
July 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28736379/-preparation-of-nanoparticles-for-sustained-insulin-release-using-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-poly-n-n-diethylamino-2-ethylmethaerylate
#4
Lei Wu, Wen-Ting Zhu, Jun Wang, Jie Liu, Qing-Bing Zeng
OBJECTIVE: To prepare an insulin-loaded nanoparticle assembled using pH-sensitive poly(ethylene glycol)-poly(ε-caprolactone)-poly(N,N-diethylamino-2-ethylmethaerylate) (mPEG-PCL-PDEAEMA) and investigate its performance of sustained insulin release in vitro and its hypoglycemic effects in diabetic rats. METHDOS: mPEG-PCL-PDEAEMA triblock copolymers with different hydrophobic lengths were synthesized by ring opening polymerization (ROP) combined with atom transfer radical polymerization (ATRP)...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735544/facile-fabrication-of-composite-electrospun-nano-fibrous-matrices-of-poly-%C3%AE%C2%B5-caprolactone-silica-based-pickering-emulsion
#5
Archana Samanta, Sonam Takkar, Ritu Kulshreshtha, Bhanu Nandan, Rajiv K Srivastava
Functionalized matrices have been sought for their application in sensors, filtration, energy storage, catalysis and tissue engineering. We report formation of an inorganic-organic composite matrix based on poly(ε-caprolactone) (PCL) functionalized with hydrophobically modified silica (m-silica) fabricated with reduced organic solvent usage. The matrix was obtained via electrospinning of a water-in-oil emulsion of PCL that was stabilized by judicious choice of m-silica as a Pickering agent resulting into an emulsifier free matrix...
July 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28735148/mechanically-competent-and-cytocompatible-polycaprolactone-borophosphosilicate-hybrid-biomaterials
#6
Dibakar Mondal, S Jeffrey Dixon, Kibret Mequanint, Amin S Rizkalla
Organic-inorganic class II hybrid materials have domain sizes at the molecular level and chemical bonding between the organic and inorganic phases. We have previously reported the synthesis of class II hybrid biomaterials from alkoxysilane-functionalized polycaprolactone (PCL) and borophosphosilicate (B2O3-P2O5-SiO2) glass (BPSG) through a non-aqueous sol-gel process. In the present study, the mechanical properties and degradability of these PCL/BPSG hybrid biomaterials were studied and compared to those of their conventional composite counterparts...
July 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28733774/a-study-of-anatomy-of-distal-femur-pertaining-to-total-knee-replacement-an-analysis-conclusions-and-recommendations
#7
K Kumar, D Sharma
BACKGROUND: Multiple landmarks including the transepicondylar axis (TEA), posterior condylar axis (PCA) and anterior trochlear line (TL) have been used to set up the femoral component rotation, but each is faced with its own practical obstacle that limits its usage. Also a common practice is to set the femoral component rotation at 3° external rotation to PCA and valgus resection angle at 5°-7° to anatomical axis of femur. For the reason that the anatomy of each knee is different, it may not be justified to practice such a set protocol in all cases...
July 21, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28726926/using-one-halogen-bond-to-change-the-nature-of-a-second-bond-in-ternary-complexes-with-pcl-and-fcl-halogen-bonds
#8
Janet E Del Bene, Ibon Alkorta, José Elguero
Ab initio MP2/aug'-cc-pVTZ calculations have been carried out to determine the effect of the presence of one halogen bond on the nature of the other in ternary complexes H2XP:ClF:ClH and H2XP:ClF:ClF, for X = F, Cl, H, NC, and CN. The PCl bonds remain chlorine-shared halogen bonds in the ternary complexes H2XP:ClF:ClH, although the degree of chlorine sharing increases relative to the corresponding binary complexes. The FCl bonds in the ternary complexes remain traditional halogen bonds. The binding energies of the complexes H2XP:ClF:ClH increase relative to the corresponding binary complexes, and nonadditivities of binding energies are synergistic...
July 20, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28718680/development-of-emu-oil-loaded-pcl-collagen-bioactive-nanofibers-for-proliferation-and-stemness-preservation-of-human-adipose-derived-stem-cell-possible-application-in-regenerative-medicine
#9
Kazem Nejati-Koshki, Younes Pilehvar-Soltanahmadi, Effat Alizadeh, Abbas Ebrahimi-Kalan, Yousef Mortazavi, Nosratollah Zarghami
Adipose tissue-derived stem cells (ASCs) are promising candidate in stem cell therapies, and maintaining their stemness potential is vital to achieve effective treatment. Natural based scaffolds have been recently attracted increasing attention in nanomedicine and drug delivery. In the present study, a polymeric nanofibrous scaffold was developed based on the polycaprolactone/Collagen (PCL/Coll) containing Emu oil as a bioactive material to induce the proliferation of ASCs, while simultaneously preserve the stemness property of those cells...
July 18, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28714045/characterization-drug-loading-and-antibacterial-activity-of-nanohydroxyapatite-polycaprolactone-nha-pcl-electrospun-membrane
#10
Mohd Izzat Hassan, Naznin Sultana
Considering the important factor of bioactive nanohydoxyapatite (nHA) to enhance osteoconductivity or bone-bonding capacity, nHA was incorporated into an electrospun polycaprolactone (PCL) membrane using electrospinning techniques. The viscosity of the PCL and nHA/PCL with different concentrations of nHA was measured and the morphology of the electrospun membranes was compared using a field emission scanning electron microscopy. The water contact angle of the nanofiber determined the wettability of the membranes of different concentrations...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28713016/a-conducive-bioceramic-polymer-composite-biomaterial-for-diabetic-wound-healing
#11
Fang Lv, Jie Wang, Peng Xu, Yiming Han, Hongshi Ma, He Xu, Shijie Chen, Jiang Chang, Qinfei Ke, Mingyao Liu, Zhengfang Yi, Chengtie Wu
Diabetic wound is a common complication of diabetes. Biomaterials offer great promise in inducing tissue regeneration for chronic wound healing. Herein, we reported a conducive Poly (caprolactone) (PCL)/gelatin nanofibrous composite scaffold containing silicate-based bioceramic particles (Nagelschmidtite, NAGEL, Ca7P2Si2O16) for diabetic wound healing. NAGEL bioceramic particles were well distributed in the inner of PCL/gelatin nanofibers via co-electrospinning process and the Si ions maintained a sustained release from the composite scaffolds during the degradation process...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28712026/posterior-cruciate-ligament-is-twisted-and-flat-structure-new-prospective-on-anatomical-morphology
#12
Tomohiro Kato, Robert Śmigielski, Yunshen Ge, Urszula Zdanowicz, Bogdan Ciszek, Mitsuo Ochi
PURPOSE: This cadaveric study aimed to elucidate PCL morphology by observing the anatomical relationship with other structures and the fibre layers of the PCL in cross section for remnant preserving PCL reconstruction. METHODS: Seventeen fresh-frozen cadaveric knees were studied, using the clock-face method to analyse the anatomical relationship between the PCL and Humphrey's ligament. The width and thickness of the PCL, Humphrey's and Wrisberg's ligaments were measured...
July 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28710510/surgical-reconstruction-is-a-cost-efficient-treatment-option-for-isolated-pcl-injuries
#13
Christian Owesen, Eline Aas, Asbjørn Årøen
PURPOSE AND HYPOTHESIS: The main purpose of the study is to put focus on the costs related to treating posterior cruciate ligament (PCL) injuries and the possible implications of chosen treatment strategy to the respective institutions and society. METHODS: Costs of treating PCL injuries nonoperatively and for both single-bundle (SB) and double-bundle (DB) reconstruction were estimated. These costs were translated into equivalent quality-adjusted life years (QALY) given a threshold value of Euro (€) 70,000 per QALY...
July 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28709035/case-study-reinforcement-of-45s5-bioglass-robocast-scaffolds-by-ha-pcl-nanocomposite-coatings
#14
Azadeh Motealleh, Siamak Eqtesadi, Antonia Pajares, Pedro Miranda, David Salamon, Klara Castkova
The purpose of this study is to analyze the mechanical enhancement provided by nanocomposite coatings deposited on robocast 45S5 bioglass (BG) scaffolds for bone tissue regeneration. In particular, a nanocomposite layer consisting of hydroxyapatite (HA) nanoparticles, as reinforcing phase, in a polycaprolactone (PCL) matrix was deposited onto the surface of the BG struts conforming the scaffold. Three different HA nanopowders were used in this study. The effect of particle size and morphology of these HA nanopowders on the mechanical performance of 45S5 BG scaffolds is evaluated...
July 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28706813/all-inside-bicruciate-ligament-reconstruction-technique-a-focus-on-graft-tensioning-sequence
#15
Mathieu Thaunat, Gilles Clowez, Colin G Murphy, Antoine Desseaux, Tales Guimaraes, Jean Marie Fayard, Bertrand Sonnery-Cottet
Bicruciate ligament (BCL) reconstructions are challenging procedures. One of the main operative goals is to stabilize the knee in the correct anterior-posterior position. We present an all-inside arthroscopic BCL reconstruction technique using hamstring tendon grafts. Ipsilateral semitendinosus (ST) and gracilis tendons are used for TriLink (Arthrex, Naples, FL) double-bundle posterior cruciate ligament (PCL) reconstruction and contralateral ST tendon is used for GraftLink (Arthrex) single-bundle anterior cruciate ligament (ACL) reconstruction...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28705112/pcl-tcp-wet-spun-scaffolds-carrying-antibiotic-loaded-microspheres-for-bone-tissue-engineering
#16
Elbay Malikmammadov, Tugba Endogan Tanir, Aysel Kiziltay, Vasif Hasirci, Nesrin Hasirci
Scaffolds produced for tissue engineering applications are proven to be promising alternatives to be used in healing and regeneration of injured tissues and organs. In this study, porous and fibrous poly(ε-caprolactone) (PCL) scaffolds were prepared by wet spinning technique and modified by addition of tricalcium phosphate (TCP) and by immobilizing gelatin onto fibers. Meanwhile, gelatin microspheres carrying Ceftriaxone sodium (CS), a model antibiotic, were added onto the scaffolds and antimicrobial activity of CS was investigated against Escherichia coli (E...
July 14, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28704904/development-of-a-spirulina-extract-alginate-imbedded-pcl-nanofibrous-cosmetic-patch
#17
Seon Yeong Byeon, Myung Kwon Cho, Kyou Hee Shim, Hye Jin Kim, Hyeon Gi Song, Hwa Sung Shin
Cosmetic patches have recently been developed as skin products for personal care due to rapid advances in the technology of delivery of active ingredients, moisture and adhesiveness to skin. Alginate and Spirulina are typical marine resources used in cosmetic products. This research involved the development of a Spirulina extract-impregnated alginate nanofiber cosmetic patch supported by a polycaprolactone (PCL) nanofiber cover (Spi/Alg-PCL NF patch). In addition to the ability of alginate to affect moisture and adhesiveness to skin, the impregnation of Spirulina extract strengthened those abilities as well as its own bioactive effectiveness...
July 14, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28703122/synergistic-effect-of-electrical-conductivity-and-biomolecules-on-human-meniscal-cell-attachment-growth-and-proliferation-in-poly-%C3%AE%C2%B5-caprolactone-nanocomposite-scaffolds
#18
Janarthanan Gopinathan, Mamatha M Pillai, K Santosh Sahanand, B K Dinakar Rai, Rajendran Selvakumar, Amitava Bhattacharyya
Poly-ε-caprolactone (PCL) based nanocomposite scaffolds with different concentrations of carbon nanofillers (carbon nanofibers (CNF), nanographite and exfoliated graphite) have been studied to investigate the effect of electrical conductivity and biomolecules supplementation for enhanced human meniscal cell attachment, growth and proliferation. Incorporation of carbon nanofillers was found to improve mechanical and electrical properties. CNF based nanocomposite scaffolds showed highest electrical conductivity with significant improvements in mechanical properties (more than 50% tensile strength increase than PCL with 10% (w/w) CNF)...
July 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28701742/tissue-engineered-trachea-from-a-3d-printed-scaffold-enhances-whole-segment-tracheal-repair
#19
Manchen Gao, Hengyi Zhang, Wei Dong, Jie Bai, Botao Gao, Dekai Xia, Bei Feng, Maolin Chen, Xiaomin He, Meng Yin, Zhiwei Xu, Nevin Witman, Wei Fu, Jinghao Zheng
Long segmental repair of trachea stenosis is an intractable condition in the clinic. The reconstruction of an artificial substitute by tissue engineering is a promising approach to solve this unmet clinical need. 3D printing technology provides an infinite possibility for engineering a trachea. Here, we 3D printed a biodegradable reticular polycaprolactone (PCL) scaffold with similar morphology to the whole segment of rabbits' native trachea. The 3D-printed scaffold was suspended in culture with chondrocytes for 2 (Group I) or 4 (Group II) weeks, respectively...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699766/assessing-acute-psychological-distress-in-the-immediate-aftermath-of-stroke
#20
Vanessa Juth, Michelle K Chan, Steven C Cramer, E Alison Holman
BACKGROUND AND PURPOSE: High acute stress may presage the development of subsequent cardiovascular ailments. Understanding how best to assess acute stress may inform early interventions seeking to prevent long-term morbidity/mortality following stroke. A mixed methods approach examined early post-stroke acute stress symptoms using the post-traumatic stress disorder checklist-5 (PCL-5) and the acute stress disorder scale (ASDS). METHODS: A focus group of stroke survivors and/or their caregivers ( N=8) evaluated PCL-5/ASDS feasibility, and 20 patients hospitalized for acute stroke were interviewed 2-10 days post-stroke onset, using either the PCL-5 or the ASDS...
July 1, 2017: European Journal of Cardiovascular Nursing
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