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https://www.readbyqxmd.com/read/29793034/a-case-control-study-about-foetal-trauma-during-cesarean-delivery
#1
Enora Dolivet, Cécile Delesalle, Rémi Morello, Marie Blouet, Corinne Bronfen, Michel Dreyfus, Guillaume Benoist
OBJECTIVE: The caesarean section rate is gradually increasing in most countries. The frequency of occurrence of foetal injury per birth is estimated to 1%. The majority of these injuries presents a low functional impact, but remains responsible for a significant neonatal morbidity. Even though the foetal risk factors are well documented in cases of vaginal birth, they have not been accurately identified for cesarean section. The aim of this study is to identify the risk factors for neonatal fracture during caesarean section...
May 21, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29792994/lumbar-spinal-stenosis-comparison-of-surgical-practice-variation-and-clinical-outcome-in-three-national-spine-registries
#2
Greger Lønne, Peter Fritzell, Olle Hägg, Dennis Nordvall, Paul Gerdhem, Tobias Lagerbäck, Mikkel Andersen, Søren Eiskjaer, Martin Gehrchen, Wilco Jacobs, Miranda L van Hooff, Tore K Solberg
BACKGROUND: Decompression surgery for lumbar spinal stenosis (LSS) is the most common spinal procedure in the elderly. To avoid persisting low back pain, adding arthrodesis has been recommended, especially if there is a coexisting degenerative spondylolisthesis. However, this strategy remains controversial, resulting in practice-based variation. PURPOSE: To evaluate in a pragmatic study if surgical selection criteria and variation in use of arthrodesis in three Scandinavian countries can be linked to variation in treatment effectiveness...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792993/responsiveness-of-the-japanese-orthopaedic-association-back-pain-evaluation-questionnaire-in-lumbar-surgery-and-its-threshold-for-indicating-clinically-important-differences
#3
Takahito Fujimori, Toshitada Miwa, Takenori Oda
BACKGROUND CONTEXT: Introduced in 2007, the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) has been widely used, but its psychometric properties have not been well studied. PURPOSE: To assess the responsiveness and the clinically important differences of JOABPEQ for lumbar surgery. STUDY DESIGN: Prospective study. PATIENT SAMPLE: Two hundreds and three consecutive patients underwent lumbar surgeries between July 2013 and November 2015 in a single hospital...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792992/frailty-status-as-a-predictor-of-three-month-cognitive-and-functional-recovery-following-spinal-surgery-a-prospective-pilot-study
#4
Robert J Rothrock, Jeremy M Steinberger, Henry Badgery, Andrew C Hecht, Samuel K Cho, John M Caridi, Stacie Deiner
Background Context As increasing numbers of elderly Americans undergo spinal surgery, it is important to identify which patients are at highest risk for poor cognitive and functional recovery. Frailty is a geriatric syndrome which has been closely linked to poor outcomes, and short form screening may be a helpful tool for preoperative identification of at risk patients. Purpose To conduct a pilot study on the usefulness of a short-form screening tool to identify elderly patients at increased risk for prolonged cognitive and functional recovery following elective spine surgery...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792982/portuguese-children-dietary-exposure-to-multiple-mycotoxins-an-overview-of-risk-assessment-under-mycomix-project
#5
Ricardo Assunção, Carla Martins, Elsa Vasco, Alessandra Jager, Carlos Oliveira, Sara Cunha, José Fernandes, Baltazar Nunes, Susana Loureiro, Paula Alvito
Mycotoxins are secondary fungi metabolites that induce acute and chronic toxic effects in humans and animals. Simultaneous contamination of cereal-based products by multiple mycotoxins has been increasingly reported, including in food products usually consumed by children. Although some previous authors assessed the health risk of children exposed to multiple mycotoxins, scarce data are available on the risk associated with the ingestion of multiple mycotoxins through different food products. MYCOMIX, a national funded project, intended to contribute to fill this gap...
May 21, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29792542/defining-bladder-health-in-women-and-girls-implications-for-research-clinical-practice-and-public-health-promotion
#6
Emily S Lukacz, Tamara G Bavendam, Amanda Berry, Cynthia S Fok, Sheila Gahagan, Patricia S Goode, Cecilia T Hardacker, Jeni Hebert-Beirne, Cora E Lewis, Jessica Lewis, Lisa Kane Low, Jerry L Lowder, Mary H Palmer, Ariana L Smith, Sonya S Brady
BACKGROUND: Bladder health in women and girls is poorly understood, in part, due to absence of a definition for clinical or research purposes. This article describes the process used by a National Institutes of Health funded transdisciplinary research team (The Prevention of Lower Urinary Tract Symptoms [PLUS] Consortium) to develop a definition of bladder health. METHODS: The PLUS Consortium identified currently accepted lower urinary tract symptoms (LUTS) and outlined elements of storage and emptying functions of the bladder...
May 24, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29792466/the-science-of-team-science-a-review-of-the-empirical-evidence-and-research-gaps-on-collaboration-in-science
#7
Kara L Hall, Amanda L Vogel, Grace C Huang, Katrina J Serrano, Elise L Rice, Sophia P Tsakraklides, Stephen M Fiore
Collaborations among researchers and across disciplinary, organizational, and cultural boundaries are vital to address increasingly complex challenges and opportunities in science and society. In addition, unprecedented technological advances create new opportunities to capitalize on a broader range of expertise and information in scientific collaborations. Yet rapid increases in the demand for scientific collaborations have outpaced changes in the factors needed to support teams in science, such as institutional structures and policies, scientific culture, and funding opportunities...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792074/lessons-learned-conducting-a-multi-center-trial-with-a-military-population-the-tinnitus-retraining-therapy-trial
#8
Roberta W Scherer, Leonora D Sensinger, Benigno Sierra-Irizarry, Craig Formby
Background The Tinnitus Retraining Therapy Trial (TRTT), a randomized, placebo-controlled, multi-center trial, evaluated the efficacy of tinnitus retraining therapy and its individual components, tinnitus-specific educational counseling and sound therapy versus the standard of care, in military practice to improve study participants' quality of life. The trial was conducted at six US military hospitals to take advantage of the greater prevalence of tinnitus in the military population. Methods During the trial, various challenges arose that were uniquely related to the military setting...
May 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29791940/global-neurology-navigating-career-possibilities
#9
Nicoline Schiess, Deanna Saylor, Joseph Zunt
Neurology has not typically been associated with international relief work; however, with the growth of chronic cardiovascular disease and stroke associated with unhealthy eating and sedentary ways, the appearance of "new" neurologic diseases, such as the Zika and West Nile viruses, and the high numbers of seizure disorders resulting from neuroinfectious diseases, more opportunities are arising for international and globally oriented neurologists. Multiple opportunities exist for developing a global clinician-educator career pathway, including private institutions, nongovernmental organizations, government-funded opportunities such as Medical Education Partnership Initiative, Fogarty and Fulbright Scholarships, and the American Academy of Neurology's Global Health Section...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791829/burosumab-therapy-in-children-with-x-linked-hypophosphatemia
#10
Thomas O Carpenter, Michael P Whyte, Erik A Imel, Annemieke M Boot, Wolfgang Högler, Agnès Linglart, Raja Padidela, William Van't Hoff, Meng Mao, Chao-Yin Chen, Alison Skrinar, Emil Kakkis, Javier San Martin, Anthony A Portale
BACKGROUND: X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities. We investigated burosumab, a monoclonal antibody that targets FGF-23, in patients with X-linked hypophosphatemia. METHODS: In an open-label, phase 2 trial, we randomly assigned 52 children with X-linked hypophosphatemia, in a 1:1 ratio, to receive subcutaneous burosumab either every 2 weeks or every 4 weeks; the dose was adjusted to achieve a serum phosphorus level at the low end of the normal range...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791822/extracorporeal-membrane-oxygenation-for-severe-acute-respiratory-distress-syndrome
#11
Alain Combes, David Hajage, Gilles Capellier, Alexandre Demoule, Sylvain Lavoué, Christophe Guervilly, Daniel Da Silva, Lara Zafrani, Patrice Tirot, Benoit Veber, Eric Maury, Bruno Levy, Yves Cohen, Christian Richard, Pierre Kalfon, Lila Bouadma, Hossein Mehdaoui, Gaëtan Beduneau, Guillaume Lebreton, Laurent Brochard, Niall D Ferguson, Eddy Fan, Arthur S Slutsky, Daniel Brodie, Alain Mercat
BACKGROUND: The efficacy of venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) remains controversial. METHODS: In an international clinical trial, we randomly assigned patients with very severe ARDS, as indicated by one of three criteria - a ratio of partial pressure of arterial oxygen (Pao2 ) to the fraction of inspired oxygen (Fio2 ) of less than 50 mm Hg for more than 3 hours; a Pao2 :Fio2 of less than 80 mm Hg for more than 6 hours; or an arterial blood pH of less than 7...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791813/higher-lung-cancer-incidence-in-young-women-than-young-men-in-the-united-states
#12
Ahmedin Jemal, Kimberly D Miller, Jiemin Ma, Rebecca L Siegel, Stacey A Fedewa, Farhad Islami, Susan S Devesa, Michael J Thun
BACKGROUND: Previous studies showed a higher incidence of lung cancer among young women than among young men in the United States. Whether this pattern has continued in contemporary birth cohorts and, if so, whether it can be fully explained by sex differences in smoking behaviors are unknown. METHODS: We examined the nationwide population-based incidence of lung cancer according to sex, race or ethnic group, age group (30 to 34, 35 to 39, 40 to 44, 45 to 49, and 50 to 54 years), year of birth (1945 to 1980), and calendar period of diagnosis (1995-1999, 2000-2004, 2005-2009, and 2010-2014), and we calculated female-to-male incidence rate ratios...
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791726/building-capacity-in-health-and-education-systems-to-deliver-interventions-that-strengthen-early-child-development
#13
Milagros Nores, Camila Fernandez
Building capacity within health and education systems of low- and middle-income countries in order to deliver high-quality early childhood services requires coordinated efforts across sectors, effective governance, sufficient funding, an adequate workforce, reliable data systems, and continuous monitoring, evaluation, and improvement cycles; it also requires partnerships with the private sector, communities, and parents. In addition, building capacity requires leadership, innovation of strategies to fit into existing structures, evidence-based intervention models, and effective partnerships that help make interventions more culturally relevant, help finance them, and help create institutional long-term support and sustainability for them...
May 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29791259/a-pragmatic-trial-of-e-cigarettes-incentives-and-drugs-for-smoking-cessation
#14
Scott D Halpern, Michael O Harhay, Kathryn Saulsgiver, Christine Brophy, Andrea B Troxel, Kevin G Volpp
Background Whether financial incentives, pharmacologic therapies, and electronic cigarettes (e-cigarettes) promote smoking cessation among unselected smokers is unknown. Methods We randomly assigned smokers employed by 54 companies to one of four smoking-cessation interventions or to usual care. Usual care consisted of access to information regarding the benefits of smoking cessation and to a motivational text-messaging service. The four interventions consisted of usual care plus one of the following: free cessation aids (nicotine-replacement therapy or pharmacotherapy, with e-cigarettes if standard therapies failed); free e-cigarettes, without a requirement that standard therapies had been tried; free cessation aids plus $600 in rewards for sustained abstinence; or free cessation aids plus $600 in redeemable funds, deposited in a separate account for each participant, with money removed from the account if cessation milestones were not met...
May 23, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791247/a-randomized-trial-of-a-family-support-intervention-in-intensive-care-units
#15
Douglas B White, Derek C Angus, Anne-Marie Shields, Praewpannarai Buddadhumaruk, Caroline Pidro, Cynthia Paner, Elizabeth Chaitin, Chung-Chou H Chang, Francis Pike, Lisa Weissfeld, Jeremy M Kahn, Joseph M Darby, Amy Kowinsky, Susan Martin, Robert M Arnold
Background Surrogate decision makers for incapacitated, critically ill patients often struggle with decisions related to goals of care. Such decisions cause psychological distress in surrogates and may lead to treatment that does not align with patients' preferences. Methods We conducted a stepped-wedge, cluster-randomized trial involving patients with a high risk of death and their surrogates in five intensive care units (ICUs) to compare a multicomponent family-support intervention delivered by the interprofessional ICU team with usual care...
May 23, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791017/addressing-the-vexed-issue-of-authorship-and-author-order-a-discussion-paper
#16
Terence V McCann, Meg Polacsek
AIMS: To review and discuss authorship and author order in the context of nursing and midwifery publications and to present a set of principles to guide and justify author order. BACKGROUND: Variation in author order trends is evident across different authors, disciplines and countries. Confusion and conflict between authors give rise to important issues concerning ethics and collaboration and may delay publication. Lack of transparency in authorship practices also impedes judgements when individual contributions are used in support of employment, promotion, tenure and/or research funding applications...
May 23, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29790824/addressing-the-challenges-of-ecmo-simulation
#17
Guillaume Alinier, Ibrahim Fawzy Hassan, Abdullah Alsalemi, Mohammed Al Disi, Ali Ait Hssain, Ahmed Labib, Yahya Alhomsi, Fayçal Bensaali, Abbes Amira, Abdulsalam Saif Ibrahim
INTRODUCTION/AIM: The patient's condition and high-risk nature of extracorporeal membrane oxygenation (ECMO) therapy force clinical services to ensure clinicians are properly trained and always ready to deal effectively with critical situations. Simulation-based education (SBE), from the simplest approaches to the most immersive modalities, helps promote optimum individual and team performance. The risks of SBE are negative learning, inauthenticity in learning and over-reliance on the participants' suspension of disbelief...
May 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29790631/allied-health-clinicians-using-translational-research-in-action-to-develop-a-reliable-stroke-audit-tool
#18
Philip Abery, Suzanne Kuys, Mary Lynch, Nancy Low Choy
OBJECTIVE: To design and establish reliability of a local stroke audit tool by engaging allied health clinicians within a privately funded hospital. METHODS: Design: Two-stage study involving a modified Delphi process to inform stroke audit tool development and inter-tester reliability. PARTICIPANTS: Allied health clinicians. INTERVENTIONS: A modified Delphi process to select stroke guideline recommendations for inclusion in the audit tool...
May 23, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29790174/an-update-of-nih-research-funding-of-aapm-members-from-1985-to-2017
#19
Brendan Whelan
Excellence in scientific research is one of the three pillars of the AAPMs mission to advance medicine, along with excellence in education and professional practice. The primary funder of medical research in the USA is the National Institutes of Health (NIH), which in 2017 had a budget of $33 billion USD. The Working Group for a Research Database (WGRD) previously published a special report into the development and testing of an algorithm to create a database of NIH funding of AAPM members [1]. The published data covered the years 1985 to 2015...
May 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29789878/nuts-as-a-replacement-for-carbohydrates-in-the-diabetic-diet-a-reanalysis-of-a-randomised-controlled-trial
#20
David J A Jenkins, Cyril W C Kendall, Benoît Lamarche, Monica S Banach, Korbua Srichaikul, Edward Vidgen, Sandy Mitchell, Tina Parker, Stephanie Nishi, Balachandran Bashyam, Russell J de Souza, Christopher Ireland, Sathish C Pichika, Joseph Beyene, John L Sievenpiper, Robert G Josse
AIMS/HYPOTHESIS: In line with current advice, we assessed the effect of replacing carbohydrate consumption with mixed nut consumption, as a source of unsaturated fat, on cardiovascular risk factors and HbA1c in type 2 diabetes. The data presented here are from a paper that was retracted at the authors' request ( https://doi.org/10.2337/dc16-rt02 ) owing to lack of adjustment for repeated measures in the same individual. Our aim, therefore, was to fix the error and add new complementary data of interest, including information on clotting factors and LDL particle size...
May 23, 2018: Diabetologia
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