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https://www.readbyqxmd.com/read/29168653/utilizing-biomarkers-in-colorectal-cancer-an-interview-with-ajay-goel
#1
Ajay Goel
Ajay Goel, PhD, is a Professor and Director, Center for Gastrointestinal Research, and Director, Center for Translational Genomics and Oncology, at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. Dr Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 240 scientific articles published in peer-reviewed international journals and several book chapters. He is also a primary inventor on more than 15 international patents aimed at developing various biomarkers for the diagnosis, prognosis and prediction of gastrointestinal cancers...
November 23, 2017: Future Oncology
https://www.readbyqxmd.com/read/29168610/rural-placement-experiences-in-dental-education-and-the-impact-on-professional-intentions-and-employment-outcomes-a-systematic-review
#2
G Johnson, F C Wright, K Foster, A Blinkhorn
CONTEXT/INTRODUCTION: The availability of clinical dental services in rural locations is a major concern for many countries as dental care professionals gravitate to work in metropolitan areas. This systematic review examines the literature on Rural Placement Programs within dentistry and their impact on workforce intentions and employment outcomes. The review provides a detailed analysis of the methodological characteristics of the literature, considers the quality of the evidence and compares the outcomes within an international context...
November 23, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29167877/utility-of-imaging-based-biomarkers-for-glutamate-targeted-drug-development-in-psychotic-disorders-a-randomized-clinical-trial
#3
Daniel C Javitt, Cameron S Carter, John H Krystal, Joshua T Kantrowitz, Ragy R Girgis, Lawrence S Kegeles, John D Ragland, Richard J Maddock, Tyler A Lesh, Costin Tanase, Philip R Corlett, Douglas L Rothman, Graeme Mason, Maolin Qiu, James Robinson, William Z Potter, Marlene Carlson, Melanie M Wall, Tse-Hwei Choo, Jack Grinband, Jeffrey A Lieberman
Importance: Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of target engagement. A key limitation for glutamate-based treatment development is the lack of functional target-engagement biomarkers for translation between preclinical and early-stage clinical studies. We evaluated the utility of 3 potential biomarkers-ketamine-evoked changes in the functional magnetic imaging (fMRI) blood oxygen level-dependent response (pharmacoBOLD), glutamate proton magnetic resonance spectroscopy (1H MRS), and task-based fMRI-for detecting ketamine-related alterations in brain glutamate...
November 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29166917/collaborative-action-for-person-centred-coordinated-care-p3c-an-approach-to-support-the-development-of-a-comprehensive-system-wide-solution-to-fragmented-care
#4
Helen M Lloyd, Mark Pearson, Rod Sheaff, Sheena Asthana, Hannah Wheat, Thava Priya Sugavanam, Nicky Britten, Jose Valderas, Michael Bainbridge, Louise Witts, Debra Westlake, Jane Horrell, Richard Byng
BACKGROUND: Fragmented care results in poor outcomes for individuals with complexity of need. Person-centred coordinated care (P3C) is perceived to be a potential solution, but an absence of accessible evidence and the lack of a scalable 'blue print' mean that services are 'experimenting' with new models of care with little guidance and support. This paper presents an approach to the implementation of P3C using collaborative action, providing examples of early developments across this programme of work, the core aim of which is to accelerate the spread and adoption of P3C in United Kingdom primary care settings...
November 22, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29166894/how-do-public-health-professionals-view-and-engage-with-research-a-qualitative-interview-study-and-stakeholder-workshop-engaging-public-health-professionals-and-researchers
#5
Peter van der Graaf, Lynne F Forrest, Jean Adams, Janet Shucksmith, Martin White
BACKGROUND: With increasing financial pressures on public health in England, the need for evidence of high relevance to policy is now stronger than ever. However, the ways in which public health professionals (PHPs) and researchers relate to one another are not necessarily conducive to effective knowledge translation. This study explores the perspectives of PHPs and researchers when interacting, with a view to identifying barriers to and opportunities for developing practice that is effectively informed by research...
November 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29166434/evidence-hierarchies-relating-to-hand-surgery-current-status-and-improvement-a-bibliometric-analysis-study
#6
Thaís Silva Barroso, Marcelo Cortês Cavalcante, João Baptista Gomes Dos Santos, João Carlos Belloti, Flávio Faloppa, Vinícius Ynoe de Moraes
BACKGROUND: Hierarchy of evidence is an important measurement for assessing quality of literature. Information regarding quality of evidence within the Brazilian hand surgery setting is sparse, especially regarding whether research has improved in either quality or quantity. This study aimed to identify and classify hand surgery studies published in the two most important Brazilian orthopedics journals based on hierarchy of evidence, with comparisons with previously published data. DESIGN AND SETTING: Bibliometric analysis study performed in a federal university...
November 17, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29166141/adherence-to-the-wcrf-aicr-for-women-in-breast-cancer-adjuvant-treatment-submitted-to-educational-nutritional-intervention
#7
Sheyla de Liz, Francilene Gracieli Kunradi Vieira, Maria Alice Altenburg de Assis, Alyne Lizane Cardoso, Clarice Perucchi Lopes Pazini, Patricia Faria Di Pietro
Patients undergoing breast cancer treatment are susceptible to changes in eating behavior and nutrition status, thus making nutrition education relevant. Based on the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guide, with recommendations for cancer prevention released in 2007, the present study aimed to evaluate the effectiveness of educational nutritional intervention for women with breast cancer undergoing treatment while adhering to the 2007 WCRF/AICR guidelines. A nonrandomized clinical trial was conducted with a population composed of female patients, divided in intervention (IG, n = 18) and comparison (CG, n = 68) groups...
November 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29165781/controlling-disasters-local-emergency-management-perceptions-about-federal-emergency-management-and-homeland-security-actions-after-september-11-2001
#8
Sean Hildebrand
This article examines local emergency manager's beliefs regarding control over tasks during various stages of the hazard cycle since federal policies went into effect following the September 11 attacks. The study considers whether a disparity exists between the actions of local officials during each phase of the "hazard cycle" and the policy expectations of the federal government, which call for greater federal control over activities in emergency management and homeland security. To do so, hypothesis testing investigates the jurisdiction's use of comprehensive emergency management (CEM) practices, the perceived "clarity" of the federal policy demands, and if the local actors feel coerced to comply with federal policy demands so that grant funding is not compromised...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29164176/needs-assessment-for-a-medical-home-curriculum-for-pediatric-residents
#9
Renee M Turchi, Aditee Narayan, Michelle Esquivel, Janet R Serwint
Several studies and the Accreditation Council for Graduate Medical Education recommend integration of medical home (MH) concepts into pediatric resident training. There is a paucity of research depicting the current landscape of pediatric resident MH education. We hypothesized formal MH curricula in pediatric residency education are limited and pediatric residency programs desire incorporating MH education into curricula. A national needs assessment of pediatric residency programs was conducted assessing inclusion of MH concepts in training...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29163069/notes-on-the-recent-history-of-neuroscience-in-africa
#10
REVIEW
Vivienne A Russell
Neuroscience began with neuroanatomy and neurosurgery in Egypt more than 5000 years ago. Knowledge grew over time and specialized neurosurgery centers were established in north Africa in the eleventh century. However, it was not until the twentieth century that neuroscience research became established in sub-Saharan Africa. In most African countries, clinical research focused on understanding the rationale and improving treatment of epilepsy, infections, nutritional neuropathies, stroke and tumors. Significant advances were made...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29161680/prediction-of-violent-crime-on-discharge-from-secure-psychiatric-hospitals-a-clinical-prediction-rule-fovox
#11
A Wolf, T R Fanshawe, A Sariaslan, R Cornish, H Larsson, S Fazel
BACKGROUND: Current approaches to assess violence risk in secure hospitals are resource intensive, limited by accuracy and authorship bias and may have reached a performance ceiling. This study seeks to develop scalable predictive models for violent offending following discharge from secure psychiatric hospitals. METHODS: We identified all patients discharged from secure hospitals in Sweden between January 1, 1992 and December 31, 2013. Using multiple Cox regression, pre-specified criminal, sociodemographic, and clinical risk factors were included in a model that was tested for discrimination and calibration in the prediction of violent crime at 12 and 24 months post-discharge...
August 4, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29161403/school-practices-important-for-students-sexual-health-analysis-of-the-school-health-research-network-survey-in-wales
#12
Honor Young, Sara Jayne Long, Britt Hallingberg, Adam Fletcher, Gillian Hewitt, Simon Murphy, Graham F Moore
Background: This study investigates how the sexual health outcomes of a representative sample of students aged 15-16 in Wales vary according to the person delivering Sex and Relationships Education (SRE) in schools, students' access to on-site sexual health services and access to free condoms. Methods: Cross-sectional, self-report survey data were collected from students who participated in the 2015/16 School Health Research Network questionnaire in Wales. Data were analyzed from 59 schools, totalling 3781 students aged 15-16 (M = 15...
November 17, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29161267/sugar-industry-sponsorship-of-germ-free-rodent-studies-linking-sucrose-to-hyperlipidemia-and-cancer-an-historical-analysis-of-internal-documents
#13
Cristin E Kearns, Dorie Apollonio, Stanton A Glantz
In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal of Medicine that discounted evidence linking sucrose consumption to blood lipid levels and hence coronary heart disease (CHD). SRF subsequently funded animal research to evaluate sucrose's CHD risks. The objective of this study was to examine the planning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary Carbohydrate and Blood Lipids in Germ-Free Rats," led by Dr. W...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29160239/education-and-training-in-radioecology-during-the-eu-comet-project-successes-and-suggestions-for-the-future
#14
Clare Bradshaw, Lindis Skipperud, N Beresford, C L Barnett, Miquel Vidal
The 2014 Strategic Research Agenda (SRA) for Radioecology identified that the key challenge in education and training (E&T) was "to maintain and develop a skilled workforce in Europe and world-wide, through university candidates and professionals trained within radioecology" since "scientific research in radioecology and application of that knowledge… requires scientists and workers with adequate competence and appropriate skills." Radioecology is a multidisciplinary science and E&T is needed by both students and professionals within research, industry and radiation protection...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29160234/sustainability-and-integration-of-radioecology-position-paper
#15
Maarit Muikku, N Beresford, Jacqueline Garnier-Laplace, Almudena Real, Liisa Sirkka, Mike C Thorne, Hildegarde Vandenhove, Christine Willrodt
This position paper gives an overview of how the COMET project (COordination and iMplementation of a pan-European instrumenT for radioecology, a combined Collaborative Project and Coordination and Support Action under the EC/Euratom 7th Framework Programme) contributed to the integration and sustainability of radioecology in Europe via its support to and interaction with the European Radioecology ALLIANCE. COMET built upon the foundations laid by the FP7 project STAR (Strategic Network for Integrating Radioecology) Network of Excellence in radioecology...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29160233/comet-strongly-supported-the-development-and-implementation-of-medium-term-topical-research-roadmaps-consistent-with-the-alliance-strategic-research-agenda
#16
Jacqueline Garnier-Laplace, Hildegarde Vandenhove, N Beresford, Maarit Muikku, Almudena Real
The ALLIANCE Strategic Research Agenda (SRA) initiated by the STAR Network of Excellence and integrated in the research strategy implemented by the COMET consortium, defines a long-term vision of the needs for, and implementation of, research in radioecology. This reference document, reflecting views from many stakeholders groups and researchers, serves as an input to those responsible for defining EU research call topics through the ALLIANCE SRA statement delivered each year to the EJP CONCERT (2015-2020)...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29159075/enzyme-replacement-therapy-in-perinatal-hypophosphatasia-case-report-of-a-negative-outcome-and-lessons-for-clinical-practice
#17
Gregory Costain, Aideen M Moore, Lauren Munroe, Alison Williams, Randi Zlotnik Shaul, Cheryl Rockman-Greenberg, Martin Offringa, Peter Kannu
Enzyme replacement therapy (ERT) is a newly approved disease-modifying treatment for hypophosphatasia (HPP), a rare metabolic bone disorder. With an orphan drug and ultra-rare disease, sharing information about responders and non-responders is particularly important, as any one centre's familiarity with its use will be limited. Nearly all published data in infants and very young children with life-threatening HPP are from three small clinical trials that have reported generally positive outcomes. We describe in detail a patient with perinatal HPP for whom treatment with ERT was not successful...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29158660/empowering-one-community-at-a-time-for-policy-system-and-environmental-changes-to-impact-obesity
#18
Katrina Betancourt, Andrea Ridgway, Joy Rockenbach, Sequoya Eady, Joanice Thompson, Lori Brand Bateman, Mona N Fouad, Yu-Mei M Schoenberger
Objective: This article describes Mayors Mentoring Mayors (3M), an initiative of the Arkansas Coalition for Obesity Prevention (ArCOP), which expanded to five states to become the signature community initiative of the Mid-South Transdisciplinary Collaborative Center (Mid-South TCC) for Health Disparities Research. Methods: The 3M program is an extension of the Growing Healthy Communities (GHC) program, which sought to build capacity within communities to reduce obesity by implementing policy, system and environmental (PSE) changes that support healthy living...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29158656/translating-the-birmingham-neighborhood-leaders-survey-into-innovative-action-through-the-community-health-innovation-awards
#19
Shauntice Allen, Alaina Pineda, Anthony C Hood, Jessica F Wakelee
The Carnegie Foundation for the Advancement of Teaching describes community engagement as the collaboration between higher education institutions and their larger communities (local, regional/state, national, global) for the mutually beneficial exchange of knowledge and resources in a context of partnership. This article describes the development, implementation and outcomes of a community-engaged grant-making program, the Community Health Innovation Awards (CHIA). The CHIA program was the by-product of a qualitative study jointly led by researchers at the University of Alabama at Birmingham and neighborhood leaders from the surrounding communities in Birmingham, AL...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29158551/the-international-rare-diseases-research-consortium-policies-and-guidelines-to-maximize-impact
#20
Hanns Lochmüller, Josep Torrent I Farnell, Yann Le Cam, Anneliene H Jonker, Lilian Pl Lau, Gareth Baynam, Petra Kaufmann, Hugh Js Dawkins, Paul Lasko, Christopher P Austin, Kym M Boycott
The International Rare Diseases Research Consortium (IRDiRC) has agreed on IRDiRC Policies and Guidelines, following extensive deliberations and discussions in 2012 and 2013, as a first step towards improving coordination of research efforts worldwide. The 25 funding members and 3 patient umbrella organizations (as of early 2013) of IRDiRC, a consortium of research funders that focuses on improving diagnosis and therapy for rare disease patients, agreed in Dublin, Ireland in April 2013 on the Policies and Guidelines that emphasize collaboration in rare disease research, the involvement of patients and their representatives in all relevant aspects of research, as well as the sharing of data and resources...
November 20, 2017: European Journal of Human Genetics: EJHG
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