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REVIEW
Francesca Lusetti, Annalisa Schiepatti, Davide Scalvini, Stiliano Maimaris, Federico Biagi
Background: Persistent symptoms in coeliac disease (CD) can be due to not only poor gluten-free diet (GFD) adherence and complications of CD, but also functional gastrointestinal disorders such as irritable bowel syndrome (IBS). Although the role of a low fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) diet is well-established in IBS, little data are available on its role in coeliac patients with persistent IBS-like symptoms despite a GFD. Methods: We systematically reviewed the literature in accordance with the PRISMA guidelines for studies evaluating the role of FODMAPs and/or a low-FODMAP diet in coeliac patients with persistent symptoms...
April 8, 2024: Nutrients
#22
JOURNAL ARTICLE
Larissa Caetano Silva, Eduardo Yoshio Nakano, Renata Puppin Zandonadi
The objective of this cross-sectional study was to assess eating competence (EC) and the adherence to the division of responsibility in child feeding (sDOR) of Brazilian caregivers of children with celiac disease (CD). It also examined the association between EC and sDOR, children's adherence to a gluten-free diet, and sociodemographic data. This study administered a survey set that included sociodemographic data, health-related data, eating habits, and the instruments ecSI2.0TM BR and sDOR.2-6yTM BR, validated for a Brazilian population...
April 4, 2024: Nutrients
#23
REVIEW
Anna Maria Mazzola, Irene Zammarchi, Maria Chiara Valerii, Enzo Spisni, Ilaria Maria Saracino, Francesco Lanzarotto, Chiara Ricci
A lifelong gluten-free diet (GFD) is the only treatment for celiac disease and other gluten-related disorders. Nevertheless, strict adherence to the GFD is often challenging due to concerns about social isolation, risk of gluten contaminations, high cost, poor quality and the taste of gluten-free products. Moreover, although the GFD is effective in achieving mucosal healing, it may lead to dietary imbalances due to nutrient deficiencies over a long period of time. To overcome these issues, several gluten-free wheat flours have been developed to create products that closely resemble their gluten-containing counterparts...
March 29, 2024: Nutrients
#24
JOURNAL ARTICLE
Joanna Leszczyńska, Agnieszka K Szczepankowska, Iwona Majak, Dorota Mańkowska, Beata Smolińska, Sylwia Ścieszka, Anna Diowksz, Bożena Cukrowska, Tamara Aleksandrzak-Piekarczyk
Immunoreactive gluten peptides that are not digested by peptidases produced by humans can trigger celiac disease, allergy and non-celiac gluten hypersensitivity. The aim of this study was to evaluate the ability of selected probiotic strains to hydrolyze immunoreactive gliadin peptides and to identify peptidase-encoding genes in the genomes of the most efficient strains. Residual gliadin immunoreactivity was measured after one- or two-step hydrolysis using commercial enzymes and bacterial peptidase preparations by G12 and R5 immunoenzymatic assays...
March 27, 2024: Nutrients
#25
REVIEW
Effat Noori, Nader Hashemi, Delsuz Rezaee, Reza Maleki, Forough Shams, Bahram Kazemi, Mojgan Bandepour, Fardin Rahimi
Celiac disease (CD) is a chronic autoimmune enteropathy and multifactorial disease caused by inappropriate immune responses to gluten in the small intestine. Weight loss, anemia, osteoporosis, arthritis, and hepatitis are among the extraintestinal manifestations of active CD. Currently, a strict lifelong gluten-free diet (GFD) is the only safe, effective, and available treatment. Despite the social burden, high expenses, and challenges of following a GFD, 2 to 5 percent of patients do not demonstrate clinical or pathophysiological improvement...
April 11, 2024: International Immunopharmacology
#26
JOURNAL ARTICLE
Zhangbing Zhou, Yunfeng Chen, Liu Wang
Observational research shows a link between celiac disease (CeD) and sarcoidosis, but the causal link between CeD and sarcoidosis is still unknown. A two-sample Mendelian randomization (MR) study was conducted to ascertain the causal connection between the 2 disorders. In our two-sample MR analysis, we identified independent genetic variants associated with CeD using publicly accessible GWAS data from people of European ancestry. Summary data for sarcoidosis were obtained from the FinnGen Consortium, the UK-Biobank, and a large GWAS dataset...
April 12, 2024: Medicine (Baltimore)
#27
JOURNAL ARTICLE
Valentina Discepolo, Ciarán P Kelly, Frits Koning, Detlef Schuppan
The only proven treatment for celiac disease is adherence to a strict, lifelong, gluten free diet. However, complete dietary gluten avoidance is challenging and a substantial number of patients do not respond fully, clinically or histologically, despite their best efforts. As celiac disease is common and its central pathophysiology is well elucidated, it has become attractive for drug development to address the limitations of dietary treatment. Most efforts address non-responsive celiac disease, defined as continued symptoms and/or signs of disease activity despite a gluten free diet, including the more severe forms of refractory celiac disease type 1 and 2...
April 9, 2024: Gastroenterology
#28
JOURNAL ARTICLE
Carlo Catassi, Olimpia Vincentini, Flavia Pricci, Umberto Agrimi, Marco Silano, Emanuele Bosi
No abstract text is available yet for this article.
April 10, 2024: Minerva pediatrics
#29
Carrie Arnold
No abstract text is available yet for this article.
April 10, 2024: Nature Medicine
#30
JOURNAL ARTICLE
M Ines Pinto-Sanchez, Jedid-Jah Blom, Peter R Gibson, David Armstrong
CeD is the most common immune condition affecting the gastrointestinal tract; it is triggered by gluten and the only available treatment is a strict gluten-free diet (GFD). Therefore, for patients with CeD, adopting a GFD is not a lifestyle choice. The major problem is that a GFD is restrictive, and like all restrictive diets, it has the potential for adverse nutritional outcomes, especially if adopted for a long-term. It is well known that GFD can be nutritionally inadequate and is frequently associated with vitamin and mineral deficiencies; it is, also, associated with excessive sugar and fat intake, particularly when gluten-free substitutes are consumed...
April 7, 2024: Gastroenterology
#31
MULTICENTER STUDY
Paola Ilaria Bianchi, Marco Vincenzo Lenti, Clarissa Petrucci, Giulia Gambini, Nicola Aronico, Matteo Varallo, Carlo Maria Rossi, Elena Pozzi, Elena Groppali, Francesca Siccardo, Giulia Franchino, Gian Vincenzo Zuccotti, Grazia Di Leo, Chiara Zanchi, Fernanda Cristofori, Ruggiero Francavilla, Marina Aloi, Giulia Gagliostro, Monica Montuori, Sara Romaggioli, Caterina Strisciuglio, Marco Crocco, Noemi Zampatti, Angela Calvi, Renata Auricchio, Costantino De Giacomo, Silvia Maria Elena Caimmi, Carolina Carraro, Annamaria Staiano, Sabrina Cenni, Mauro Congia, Enrico Schirru, Francesca Ferretti, Carolina Ciacci, Nicoletta Vecchione, Mario Andrea Latorre, Semela Resuli, Giusy Cinzia Moltisanti, Giulia Maria Abruzzese, Andrea Quadrelli, Simone Saglio, Pietro Canu, Damiano Ruggeri, Annalisa De Silvestri, Catherine Klersy, Gian Luigi Marseglia, Gino Roberto Corazza, Antonio Di Sabatino
IMPORTANCE: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood. OBJECTIVES: To investigate the diagnostic delay of CD in childhood, and to assess factors associated with this delay. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective, cross-sectional study (2010-2019) of pediatric (aged 0-18 years) patients with CD from 13 pediatric tertiary referral centers in Italy...
April 1, 2024: JAMA Network Open
#32
REVIEW
Alessio Danilo Inchingolo, Gianna Dipalma, Fabio Viapiano, Anna Netti, Irene Ferrara, Anna Maria Ciocia, Antonio Mancini, Daniela Di Venere, Andrea Palermo, Angelo Michele Inchingolo, Francesco Inchingolo
INTRODUCTION: This systematic review aims to elucidate the intricate correlation between celiac disease (CD) and dental enamel defects (DED), exploring pathophysiological mechanisms, oral health implications, and a dentist's role in early diagnosis. MATERIALS AND METHODS: Following PRISMA guidelines, a comprehensive search from 1 January 2013 to 1 January 2024 across PubMed, Cochrane Library, Scopus, and Web of Science identified 153 publications. After exclusions, 18 studies met the inclusion criteria for qualitative analysis...
February 28, 2024: Journal of Clinical Medicine
#33
Megan Elizabeth Moore, Fawad Talat, Michael Talanian, Harmony Allison
Celiac disease (CD) is associated with several neurological diseases. We report a case of a 25-year-old man with CD that was discovered during hospitalization for acute transverse myelitis. The diagnosis of CD was suspected after positive serological tests and was confirmed with duodenal biopsy. Steroid pulse therapy and plasma exchange stabilized the patient's condition. The patient started a gluten-free diet and rituximab therapy before discharge. Although the association of CD with various neurological diseases is well established, this case report describes a less explored association between CD and transverse myelitis...
April 2024: ACG Case Reports Journal
#34
JOURNAL ARTICLE
Rasha Alradadi, Daliah M Alharbi, Maram S Alrehely, Samah F Alraddadi, May Almouteri, Muna Mohammad AlSuhaimi, Maram Abdullah Alaofi, Noha Farouk Tashkandi, Fatimah A Aljohani
BACKGROUND: Type 1 diabetes mellitus (T1DM) in children, a significant public health concern, often leads to diabetic ketoacidosis (DKA). The prevalence of T1DM is increasing globally, with Saudi Arabia recording high rates of DKA at T1DM onset. This study aimed to evaluate the characteristics and risk factors of pediatric T1DM patients presenting with DKA in the emergency room in Saudi Arabia and quantify intensive care unit (ICU) admission incidences reflecting DKA severity. METHODS: This retrospective chart review, conducted at Medina Maternity and Children's Hospital, Saudi Arabia, analyzed data from 2017 to 2022...
March 2024: Curēus
#35
JOURNAL ARTICLE
Weichen Yuan, Xiangrui Li, Guan Wang, Bo Qu, Fangkun Zhao
BACKGROUND: Many observational studies have been reported that patients with autoimmune or allergic diseases seem to have a higher risk of developing senile cataract, but the views are not consistent. In order to minimize the influence of reverse causality and potential confounding factors, we performed Mendelian Randomization (MR) analysis to investigate the genetic causal associations between autoimmune, allergic diseases and senile cataract. METHODS: Single nucleotide polymorphisms associated with ten common autoimmune and allergic diseases were obtained from the IEU Open genome-wide association studies (GWAS) database...
2024: Frontiers in Immunology
#36
JOURNAL ARTICLE
Sho Fujiwara, Keiichiro Kawamura, Yoshiyuki Nakano, Tetsuo Watanabe, Hiroshi Yamashita
BACKGROUND: Pancreaticoduodenal artery aneurysm (PDAA) is a rare, but fatal disease. However, the association between aneurysm size and the risk of rupture remains unclear. There are many options for therapeutic strategies that should be discussed well because the treatment options are often complicated and highly invasive. However, it remains unclear whether additional endovascular therapy is essential for all patients undergoing bypass surgery. Here, we present a case of triple PDAAs with celiac axis occlusion and spontaneous complete regression of inferior PDAAs (IPDAA) after aneurysmectomy of superior PDAA (SPDAA) and aorto-splenic bypass...
April 8, 2024: Surgical Case Reports
#37
REVIEW
Renato Beas, Euler Altamirano-Farfan, Diego Izquierdo-Veraza, Dalton A Norwood, Adrian Riva-Moscoso, Ambar Godoy, Eleazar E Montalvan-Sanchez, Mirian Ramirez, Daniel A Guifarro, Emily Kitchin, Monika Fischer, Satya Kurada
BACKGROUND: Celiac disease (CeD) is an immune-mediated disorder affecting the small bowel, associated with genetic factors and increasing global prevalence. AIM: This study explores the association between CeD, Systemic Lupus Erythematosus (SLE), primary Sjogren syndrome (pSS), and Systemic Sclerosis (SSc). METHODS: A systematic review and meta-analysis were conducted following PRISMA guidelines. Searches across multiple databases yielded 2728 articles, with 15 studies selected...
April 6, 2024: Digestive and Liver Disease
#38
JOURNAL ARTICLE
Philippe Tresson, Maria Tawdi, Emeraude Rivoire, Antoine Million, Guillaume Passot, Olivier Rouvière, Anne Long
OBJECTIVE: The purpose of this study was to assess whether the presence of an aneurysmal or dissecting arterial disease was a risk factor of poor prognosis in patients presenting a dissection of the celiac trunk (CT). METHODS: All patients presenting a CT dissection between January 1, 2014 and June 30, 2022 were included. Patients with a CT dissection due to the extension of an aortic dissection were excluded. Les antécédents familiaux de dissection, de maladie anévrysmale, de maladie athéromateuse ou du tissu conjonctif, la pratique d'une activité physique ou sportive, un effort inhabituel les jours précédant la dissection ainsi qu'un traumatisme étaient recherchés...
April 5, 2024: Annals of Vascular Surgery
#39
JOURNAL ARTICLE
Ida Lindeman, Lene S Høydahl, Asbjørn Christophersen, Louise F Risnes, Jørgen Jahnsen, Knut E A Lundin, Ludvig M Sollid, Rasmus Iversen
Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific immunoglobulin (Ig) A plasma cells are abundant in gut biopsies of patients. Here, we describe the corresponding population of autoreactive B cells in blood. Circulating TG2-specific IgA cells are present in untreated patients on a gluten-containing diet but not in controls. They are clonally related to TG2-specific small intestinal plasma cells, and they express gut-homing molecules, indicating that they are plasma cell precursors...
April 4, 2024: Cell Reports
#40
JOURNAL ARTICLE
Morad Guennouni, Nysrine Mannani, Ider Oujamaa, Mohamed Echchakery, Abdelaziz Ait Melloul, Nabila Soraa, Aicha Bourrahouat, Abderraouaf Hilali, Asmae Hanchi Lamrani, Brahim Admou
BACKGROUND: The rising prevalence of gluten-related disorders such as celiac disease explains the increased consumption of gluten-free foods (GFF). However, these foods must be safe in terms of both gluten content and contamination by pathogenic microorganisms in order to avoid food poisoning. OBJECTIVE: The objective of this study was to assess the microbiological quality of gluten-free meals, naturally gluten free foods, and gluten free-labelled products. MATERIAL AND METHODS: We collected 62 GFF samples including 20 meals (M-GF), 22 naturally gluten free (N-GFF) and 20 labelled (L-GFF) products, which were investigated for microbiological contamination according to Moroccan regulations guidelines, issued by the International Organization for Standardization (ISO)...
2024: Roczniki Państwowego Zakładu Higieny
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