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Celiacs disease

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https://www.readbyqxmd.com/read/29785564/helicobacter-pylori-infection-in-pediatric-patients-update-on-diagnosis-and-eradication-strategies
#1
REVIEW
Kallirroi Kotilea, Nicolas Kalach, Matjaž Homan, Patrick Bontems
Helicobacter pylori infection is acquired mainly in childhood and remains an essential cause of peptic ulcer disease and gastric cancer. This article provides commentary on the last ESPGHAN/NASPGHAN guidelines and on publications made after the consensus conference of 2015. The majority of infected children are asymptomatic and pediatric studies do not support a role for H. pylori in functional disorders such as recurrent abdominal pain. The role of H. pylori infection in failure to thrive, children's growth, type I diabetes mellitus (T1DM), and celiac disease remains controversial...
May 22, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29782665/dietitian-visits-were-a-safe-and-cost-effective-form-of-follow-up-care-for-children-with-celiac-disease
#2
Karolina Johansson, Elin Malmberg Hård Af Segerstad, Helena Mårtensson, Daniel Agardh
AIM: This study compared follow-up protocols for paediatric celiac disease led by either paediatricians or dieticians at Swedish university hospitals. METHODS: We followed 363 celiac disease patients under 18 years at the university hospitals in Malmö (n=140) and Lund (n=79) between 2011-2013 and after they merged to become Skåne (n=144) between 2014-2016. Both Lund and Malmö provided regular paediatrician follow-up visits, while Skåne provided mainly dietitian-led visits...
May 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29782465/gamma-delta-t-lymphocytes-in-the-diagnostic-approach-of-coeliac-disease
#3
Petula Nijeboer, Tom van Gils, Martine Reijm, Rogier Ooijevaar, Birgit I Lissenberg-Witte, Hetty J Bontkes, Chris J J Mulder, Gerd Bouma
GOALS: To validate cut-off values of CD3 T-cell receptor gamma-delta chain (TCRγδ) intraepithelial lymphocyte (IEL) in the (differential) diagnosis of celiac disease (CD). BACKGROUND: CD is characterized by an increase in gamma-delta IEL (CD3TCRγδ IEL). STUDY: Percentages were determined by flow cytometric analysis of IELs from small bowel biopsies in 213 CD and 13 potential CD (PCD) patients and in total 112 controls. A cut-off value for percentages of CD3TCRγδ IEL to differentiate active CD and controls was obtained from a receiver operating characteristic curve and implemented in controls and PCD patients...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29776388/contributions-of-hla-haplotypes-il8-level-and-toxoplasma-gondii-infection-in-defining-celiac-disease-s-phenotypes
#4
Mohammad Rostami-Nejad, Seyed Hossein Hejazi, Amado Salvador Peña, Hamid Asadzadeh-Aghdaei, Kamran Rostami, Umberto Volta, Mohammad Reza Zali
BACKGROUND: It is not clear why some patients with coeliac disease (CD) present with severe symptoms and small intestinal mucosal damages while others present with milder symptoms and no frank enteropathy. There is no study to assess the associated factors with mild/severe symptoms and enteropathy. The terminologies like latent, silent and potential are difficult to use and are unrepresentative. In the present study we describe coeliac disease's phenotypes based on HLA haplotypes, IL8 production and past infection with Toxoplasma gondii (T...
May 18, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29772313/treatment-of-the-median-arcuate-ligament-syndrome-in-a-patient-with-behcet-s-disease-median-arcuate-ligament-syndrome-accompanying-to-behcet-s-disease
#5
Serkan Burç Deşer, Savas Yuruker, Mustafa Kemal Demirag
Compression of the celiac artery by the median arcuate ligament (MAL) and neurofibrous tissue is called MAL syndrome or Dunbar's syndrome. Postprandial abdominal pain, weight loss are the main symptoms. Surgical treatment still remains the gold standard therapy. Here, we present the first case to our knowledge that accompanying Behcet's disease to Median Arcuate Ligament Syndrome.
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29769033/case-report-on-pathogenetic-link-between-gluten-and-iga-nephropathy
#6
Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù, Domenico Santoro
BACKGROUND: A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time. CASE PRESENTATION: A 39-year-old man with cystic fibrosis (CF) and CF-related diabetes started to present gross hematuria, back pain and headache. At admission, laboratory analysis showed increase in serum creatinine of 1.5 mg/dl, together with hematuria and mild proteinuria (1 g/24 h). He underwent a renal biopsy to investigate the cause of hematuria and renal failure...
May 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29768449/children-with-type-1-diabetes-who-experienced-a-honeymoon-phase-had-significantly-lower-ldl-cholesterol-5-years-after-diagnosis
#7
Benjamin Udoka Nwosu, Bo Zhang, Sanaa S Ayyoub, Stephanie Choi, Tony R Villalobos-Ortiz, Laura C Alonso, Bruce A Barton
IMPORTANCE: Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized. AIM: To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status...
2018: PloS One
https://www.readbyqxmd.com/read/29766709/two-sisters-with-neurofibromatosis-type-1-and-celiac-disease
#8
Teresa Lopez, Emanuele Miraglia, Stefano Calvieri, Sandra Giustini
No abstract text is available yet for this article.
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29765436/anti-thyroid-antibodies-parietal-cell-antibodies-and-tissue-transglutaminase-antibodies-in-patients-with-autoimmune-thyroid-disease
#9
Orit Twito, Yonatan Shapiro, Aviva Golan-Cohen, Yoav Dickstein, Rosane Ness-Abramof, Menachem Shapiro
Introduction: The co-existence of tissue-specific autoantibodies in autoimmune thyroid disease (ATD) is well established. The published prevalence of anti-parietal cell antibodies (PC-Ab) is 20-25%, and that of celiac antibodies is 2-5%. The goal of this study was to determine the prevalence of PC-Ab and anti-tissue transglutaminase antibodies (tTG-Ab) in patients with ATD and to evaluate the correlation between anti-thyroid antibodies and the other antibodies. Material and methods: The files of 120 Israeli Jews and Arabs with ATD were evaluated for anti-thyroglobulin antibodies (Tg-Ab), anti-thyroid peroxidase antibodies (TPO-Ab), PC-Ab and tTG-Ab...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764224/hemolysis-may-cause-false-negative-results-and-underdiagnosis-of-celiac-disease-when-measuring-anti-tissue-transglutaminase-antibodies-in-serum-by-immunoassays
#10
Freja Eriksen, Jutarat Charoenpatrawut, Sumbul Zaman, Isa Neimann Thomasen, Lise Bathum
No abstract text is available yet for this article.
May 15, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29763907/beyond-irritable-bowel-syndrome-the-efficacy-of-the-low-fodmap-diet-for-improving-symptoms-in-inflammatory-bowel-diseases-and-celiac-disease
#11
Anna Testa, Nicola Imperatore, Antonio Rispo, Matilde Rea, Raffaella Tortora, Olga Maria Nardone, Lucia Lucci, Grazia Accarino, Nicola Caporaso, Fabiana Castiglione
BACKGROUND AND AIM: To evaluate the usefulness of a low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols) diet on patients with irritable bowel syndrome (IBS), non-active inflammatory bowel diseases (IBD), and celiac disease (CD) on a gluten-free diet (GFD). METHODS: Dietetic interventional prospective study. IBS, IBD, and CD subjects were evaluated to check if they fulfilled the Rome III criteria. Each subject was educated to follow a low FODMAP diet after being evaluated by filling out questionnaires that assessed the quality of life (QoL) and symptoms experienced (IBS-SSS and SF-36), and was reevaluated after 1 and 3 months...
May 15, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29762265/link-between-celiac-disease-and-inflammatory-bowel-disease
#12
Ayesha Shah, Marjorie Walker, Daniel Burger, Neal Martin, Moritz von Wulffen, Natasha Koloski, Mike Jones, Nicholas J Talley, Gerald J Holtmann
GOAL: The aim of this analysis was to assess in patients with inflammatory bowel disease (IBD) the risk of celiac disease and in celiac disease patients the risk of IBD. BACKGROUND: Previous studies report a possible association between IBD and celiac disease; however, this link is controversial. STUDY: Using the search terms "inflammatory bowel disease" and "celiac disease," we identified initially 1525 publications. In total 27 studies met inclusion criteria...
May 14, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29760697/hookworm-secreted-extracellular-vesicles-interact-with-host-cells-and-prevent-inducible-colitis-in-mice
#13
Ramon M Eichenberger, Stephanie Ryan, Linda Jones, Geraldine Buitrago, Ramona Polster, Marcela Montes de Oca, Jennifer Zuvelek, Paul R Giacomin, Lindsay A Dent, Christian R Engwerda, Matthew A Field, Javier Sotillo, Alex Loukas
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such potent suppressors of inflammation that they have been used in clinical trials to treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description of helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from different helminths have been characterized and their salient roles in parasite-host interactions have been highlighted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29757191/disease-driving-cd4-t-cell-clonotypes-persist-for-decades-in-celiac-disease
#14
Louise F Risnes, Asbjørn Christophersen, Shiva Dahal-Koirala, Ralf S Neumann, Geir K Sandve, Vikas K Sarna, Knut Ea Lundin, Shuo-Wang Qiao, Ludvig M Sollid
Little is known about the repertoire dynamics and persistence of pathogenic T cells in HLA-associated disorders. In celiac disease, a disorder with a strong association with certain HLA-DQ allotypes, presumed pathogenic T cells can be visualized and isolated with HLA-DQ:gluten tetramers, thereby enabling further characterization. Single and bulk populations of HLA-DQ:gluten tetramer-sorted CD4+ T cells were analyzed by high-throughput DNA sequencing of rearranged TCR-α and -β genes. Blood and gut biopsy samples from 21 celiac disease patients, taken at various stages of disease and in intervals of weeks to decades apart, were examined...
May 14, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29753760/gluten-free-living-in-china-the-characteristics-food-choices-and-difficulties-in-following-a-gluten-free-diet-an-online-survey
#15
Zhenxing Lu, Haoyang Zhang, Sanna Luoto, Xiang Ren
BACKGROUND: Individuals adhering to a gluten-free diet (GFD) have been scarcely researched within a Chinese population. This present study was conducted to assess the characteristics, food choices, shopping preferences, and emotions and attitudes of individuals following a GFD. METHODS: Individuals following a GFD were invited to complete an online questionnaire about their demography and geography characteristics, gluten-free food choices, shopping preferences, GFD management and subjective difficulty towards the diet...
May 15, 2018: Appetite
https://www.readbyqxmd.com/read/29753576/is-celiac-disease-better-identified-through-hla-dq8-than-through-hla-dq2-in-mexican-subjects
#16
E Cerda-Contreras, K L Ramírez-Cervantes, J Granados, L Mena, C Núñez-Álvarez, L Uscanga
INTRODUCTION AND AIMS: A strong genetic association between celiac disease (CD) and the human leukocyte antigen (HLA) has been widely demonstrated. In Europe, the HLA-DQ2 allele is predominant. However, studies in Latin America indicate that HLA-DQ8 could be more frequent. In Mexico, the frequency of those alleles has not been reported in subjects with CD. Therefore, the aim of the present study was to evaluate the distribution of HLA-DQ2 and HLA-DQ8 in Mexican individuals with CD. MATERIAL AND METHODS: An exploratory study was conducted on a cohort of 49 subjects with chronic diarrhea...
May 9, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29752820/elevated-anti-tissue-transglutaminase-antibodies-in-children-newly-diagnosed-with-type-1-diabetes-do-not-always-indicate-celiac-disease
#17
Firas Rinawi, Basel Badarneh, Osama Tanous, Husam Bashir, Yardena Tennenbaum-Rakover, Sarit Peleg
AIM: Elevated levels of anti-tissue transglutaminase (anti-tTG) antibody may spontaneously normalise in children with newly diagnosed type 1 diabetes, even if they eat gluten. The prevalence of this phenomenon, and predictors of a subsequent celiac disease (CD) diagnosis, were determined. METHODS: The medical records of children diagnosed with type 1 diabetes at Ha'Emek Medical Centre, Israel, from 2007-2015, were retrospectively reviewed for elevated anti-tTG antibody levels...
May 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29752728/a-retrospective-study-of-dermatitis-herpetiformis-from-an-immunobullous-disease-clinic-in-north-india
#18
Sanjeev Handa, Garima Dabas, Dipankar De, Rahul Mahajan, Debajyoti Chatterjee, Uma N Saika, Bishan D Radotra
BACKGROUND: Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases. METHODS: All data were collected from case record forms of patients registered in immunobullous disease clinic of our institute. The diagnosis was based on characteristic clinical and immuno/histopathological features...
May 11, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29750882/occurrence-of-serum-antibodies-against-wheat-alpha-amylase-inhibitor-0-19-in-celiac-disease
#19
D Sánchez, S Štěpánová-Honzová, M Hospodková, I Hoffmanová, V Hábová, P Halada, H Tlaskalová-Hogenová, L Tučková
The alcohol-soluble fraction of wheat gluten (gliadins) induces in genetically susceptible individuals immunologically mediated celiac disease (CLD). However, gliadins and related cereal proteins are not unique foodstuff targets of CLD patients´ immune system. Non-gluten wheat alpha-amylase inhibitor 0.19 (AAI 0.19) has been found to be capable of activating human monocyte-derived dendritic cells and inducing pro-inflammatory status in intestinal mucosa of patients with celiac disease (CLD). The possible contribution of this reactivity in incomplete remission of CLD patients on a gluten-free diet (GFD) is matter of contention...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29749330/bone-mineral-density-and-vitamin-k-status-in-children-with-celiac-disease-is-there-a-relation
#20
Burcu Volkan, Ali Fettah, Ali İşlek, Soner Sertan Kara, Nezahat Kurt, Atilla Çayır
BACKGROUND/AIMS: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels and osteoporosis. MATERIALS AND METHODS: Children with CD and age- and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
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