Geoffrey R Oxnard, Ruthia Chen, Jennifer C Pharr, Diane R Koeller, Arrien A Bertram, Suzanne E Dahlberg, Irene Rainville, Kate Shane-Carson, Kelly A Taylor, Alicia Sable-Hunt, Lynette M Sholl, Craig C Teerlink, Alun Thomas, Lisa A Cannon-Albright, André P Fay, Patrícia Ashton-Prolla, Hao Yang, Mary M Salvatore, Bonnie J Addario, Pasi A Jänne, David P Carbone, Georgia L Wiesner, Judy E Garber
PURPOSE: The genomic underpinnings of inherited lung cancer risk are poorly understood. This prospective study characterized the clinical phenotype of patients and families with germline EGFR pathogenic variants (PVs). METHODS: The Investigating Hereditary Risk from T790M study (ClinicalTrials.gov identifier: NCT01754025) enrolled patients with lung cancer whose tumor profiling harbored possible germline EGFR PVs and their relatives, either in person or remotely, providing germline testing and follow-up...
December 1, 2023: Journal of Clinical Oncology