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Lung CT image genome

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https://www.readbyqxmd.com/read/27856720/non-destructive-cryo-micro-ct-imaging-enables-structural-and-molecular-analysis-of-human-lung-tissue
#1
Dragos Mihai Vasilescu, André B Phillion, Naoya Tanabe, Daisuke Kinose, David F Paige, Jacob J Kantrowitz, Gang Liu, Hanqiao Liu, Nick Fishbane, Stijn E Verleden, Bart M Vanaudenaerde, Marc E Lenburg, Christopher S Stevenson, Avrum Spira, Joel D Cooper, Tillie-Louise Hackett, James C Hogg
Micro Computed Tomography (CT) enables 3-dimensional (3D) imaging of complex soft tissue structures, but current protocols used to achieve this goal preclude cellular and molecular phenotyping of the tissue. Here we describe a radiolucent cryo stage that permits micro CT imaging of unfixed frozen human lung samples at a spatial resolution of 11 µm under conditions where the sample is maintained frozen at -30°C during imaging. The cryo stage was tested for thermal stability to maintain samples frozen up to 8 hours...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27755912/genomic-adequacy-from-solid-tumor-core-needle-biopsies-of-ex-vivo-tissue-and-in-vivo-lung-masses-prospective-study
#2
Neema Jamshidi, Danshan Huang, Fereidoun G Abtin, Christopher T Loh, Stephen T Kee, Robert D Suh, Shota Yamamoto, Kingshuk Das, Sarah Dry, Scott Binder, Dieter R Enzmann, Michael D Kuo
Purpose To identify the variables and factors that affect the quantity and quality of nucleic acid yields from imaging-guided core needle biopsy. Materials and Methods This study was approved by the institutional review board and compliant with HIPAA. The authors prospectively obtained 232 biopsy specimens from 74 patients (177 ex vivo biopsy samples from surgically resected masses were obtained from 49 patients and 55 in vivo lung biopsy samples from computed tomographic [CT]-guided lung biopsies were obtained from 25 patients) and quantitatively measured DNA and RNA yields with respect to needle gauge, number of needle passes, and percentage of the needle core...
October 18, 2016: Radiology
https://www.readbyqxmd.com/read/27753752/percutaneous-lung-biopsy-in-the-molecular-profiling-era-a-survey-of-current-practices
#3
Christopher Lee, Phillip L Guichet, Fereidoun Abtin
PURPOSE: This study aimed to assess the current practice patterns of radiologists performing percutaneous lung biopsies. MATERIALS AND METHODS: This cross-sectional study used a web-based survey sent to the Society of Thoracic Radiology membership from August to October 2015. Responses were collected anonymously, and results were tallied. RESULTS: A total of 244 Society of Thoracic Radiology members responded to the survey. One hundred thirty-seven radiologists regularly perform percutaneous lung biopsies, of whom 102 (74%) practice at an academic teaching hospital...
October 6, 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27739898/visual-assessment-of-chest-ct-images-is-independently-useful-for-genetic-association-analysis-in-studies-of-chronic-obstructive-pulmonary-disease
#4
Eitan Halper-Stromberg, Michael H Cho, Carla Wilson, Dipti Nevrekar, James D Crapo, George Washko, Raúl San José Estépar, David A Lynch, Edwin K Silverman, Sonia Leach, Peter J Castaldi
RATIONALE: Automated analysis of computed tomographic (CT) lung images for epidemiologic nand genetic association studies is increasingly common, but little is known about the utility of visual versus semi-automated emphysema and airway assessments for genetic association studies. OBJECTIVES: Assess the relative utility of visual versus semi-automated emphysema and airway assessments for genetic association studies. METHODS: A standardized inspection protocol was used to visually assess chest CTs for 1540 non-Hispanic white subjects within the COPDGene Study for the presence and severity of radiographic features representing airway wall thickness and emphysema...
October 14, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/26703805/personalized-radiation-therapy-prt-for-lung-cancer
#5
REVIEW
Jian-Yue Jin, Feng-Ming Spring Kong
This chapter reviews and discusses approaches and strategies of personalized radiation therapy (PRT) for lung cancers at four different levels: (1) clinically established PRT based on a patient's histology, stage, tumor volume and tumor locations; (2) personalized adaptive radiation therapy (RT) based on image response during treatment; (3) PRT based on biomarkers; (4) personalized fractionation schedule. The current RT practice for lung cancer is partially individualized according to tumor histology, stage, size/location, and combination with use of systemic therapy...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26056507/genetics-of-interstitial-lung-disease-vol-de-nuit-night-flight
#6
REVIEW
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Naoyuki Tsuchiya, Shigeto Tohma
Interstitial lung disease (ILD) is a chronic, progressive fibrotic lung disease with a dismal prognosis. ILD of unknown etiology is referred to as idiopathic interstitial pneumonia (IIP), which is sporadic in the majority of cases. ILD is frequently accompanied by rheumatoid arthritis (RA), systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), and other autoimmune diseases, and is referred to as collagen vascular disease-associated ILD (CVD-ILD). Susceptibility to ILD is influenced by genetic and environmental factors...
2015: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/24386367/structural-stabilization-of-tissue-for-embryo-phenotyping-using-micro-ct-with-iodine-staining
#7
Michael D Wong, Shoshana Spring, R Mark Henkelman
The International Mouse Phenotyping Consortium has been established to conduct large-scale phenotyping of the approximately 23,000 single-gene knockout mice generated by the International Knockout Mouse Consortium to investigate the role of each gene in the mouse genome. Of the generated mouse lines, 30% are predicted to be embryonic lethal, requiring the implementation of imaging techniques and analysis tools specific to late gestation mouse embryo phenotyping. A well-adopted technique combines the use of iodinated contrast solutions and micro-computed tomography imaging...
2013: PloS One
https://www.readbyqxmd.com/read/23934142/development-of-quantitative-computed-tomography-lung-protocols
#8
REVIEW
John D Newell, Jered Sieren, Eric A Hoffman
The purpose of this review article is to review the process of developing optimal computed tomography (CT) protocols for quantitative lung CT (QCT). In this review, we discuss the following important topics: QCT-derived metrics of lung disease; QCT scanning protocols; quality control; and QCT image processing software. We will briefly discuss several QCT-derived metrics of lung disease that have been developed for the assessment of emphysema, small airway disease, and large airway disease. The CT scanning protocol is one of the most important elements in a successful QCT...
September 2013: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/22208315/intraventricular-twin-fetuses-in-fetu
#9
Lauren N Huddle, Christine Fuller, Tiffany Powell, Judith A Hiemenga, Jia Yan, Brian Deuell, Eric M Lyders, Joann N Bodurtha, Peter R Papenhausen, Colleen K Jackson-Cook, Arti Pandya, Margie Jaworski, Gary W Tye, Ann M Ritter
The authors report a rare case of multiple intracranial fetuses in fetu, fulfilling Willis' traditional criteria, which include an axial and appendicular skeleton with surrounding organized tissue. This case was ascertained from studies of a full-term female neonate who presented with ventriculomegaly. A CT scan showed intracranial calcifications that were suggestive of an axial skeleton. Her birth weight was 3.176 kg (50th-75th percentile), length was 52 cm (90th percentile), head circumference was 35 cm (50th-75th percentile), and Apgar scores were 7 and 8 at 1 and 5 minutes, respectively...
January 2012: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/20964199/longitudinal-assessment-of-lung-cancer-progression-in-the-mouse-using-in-vivo-micro-ct-imaging
#10
Eman Namati, Jacqueline Thiesse, Jessica C Sieren, Alan Ross, Eric A Hoffman, Geoffrey McLennan
PURPOSE: Small animal micro-CT imaging is being used increasingly in preclinical biomedical research to provide phenotypic descriptions of genomic models. Most of this imaging is coincident with animal death and is used to show the extent of disease as an end point. Longitudinal imaging overcomes the limitation of single time-point imaging because it enables tracking of the natural history of disease and provides qualitative and, where possible, quantitative assessments of the effects of an intervention...
September 2010: Medical Physics
https://www.readbyqxmd.com/read/18287264/canine-anatomic-phantom-for-preclinical-dosimetry-in-internal-emitter-therapy
#11
Laura Padilla, Choonsik Lee, Rowan Milner, Amir Shahlaee, Wesley E Bolch
UNLABELLED: The majority of investigational studies of new diagnostic and therapeutic radiopharmaceuticals use murine animal models for preclinical assessments of pharmacokinetics and organ radiation dosimetry. Although mice and rats are widely available and relatively inexpensive, their smaller organ anatomy relative to that of humans can lead to considerable differences in organ dosimetry, thus complicating extrapolations of dose-response relationships to human patients. Nonhuman primates circumvent these problems in many respects but are increasingly becoming expensive and limited because of ethical considerations...
March 2008: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/16720848/lung-cancer-screening
#12
REVIEW
Apar Kishor Ganti, James L Mulshine
Advances in imaging technology have ushered in a new era for lung cancer screening in high-risk individuals using computed tomographic (CT) scans. Although most published studies are nonrandomized observational cohorts of volunteers, the ability of CT scans to detect early stage lung cancer is undisputable. What is unresolved is the ability of spiral CT screening to affect lung cancer-related mortality. A large randomized trial sponsored by the National Cancer Institute to address this question is currently under way...
May 2006: Oncologist
https://www.readbyqxmd.com/read/15988680/novel-strategies-for-the-early-detection-and-prevention-of-lung-cancer
#13
REVIEW
Noel R Wardwell, Pierre P Massion
Lung cancer is the leading cause of cancer death in the United States. Despite evidence of molecular abnormalities in biological specimens, progress in this disease is hampered by the lack of diagnostic markers useful for clinical practice. The majority of patients with lung cancer are still diagnosed at an advanced stage, when prognosis is poor. This article reviews new strategies being studied for the early detection of lung cancer. These strategies involve new methods of imaging (including low-dose computed tomography [CT] scanning), DNA analysis, and proteomic-based techniques...
June 2005: Seminars in Oncology
https://www.readbyqxmd.com/read/15382310/fluorescent-bronchoscopy
#14
REVIEW
Sebastien Gilbert, James D Luketich, Neil A Christie
Detection of clinically occult lung neoplasms may represent an opportunity for early curative intervention. Fluorescent bronchoscopy is a sensitive technique for detecting early endobronchial tumors that may be combined with CT scanning as part of a comprehensive lung cancer screening program. Identification and longitudinal follow-up of dysplastic endobronchial changes with fluorescent bronchoscopy should facilitate studies of chemoprevention and further knowledge regarding the natural history of these lesions...
February 2004: Thoracic Surgery Clinics
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