keyword
https://read.qxmd.com/read/38540999/genome-sequencing-of-multiple-primary-lung-cancers-harbouring-mixed-histology-and-spontaneously-regressing-small-cell-lung-cancer
#1
Valentina Thomas, Ahmed Rashed, Clare Faul, Siobhan Nicholson, Vincent Young, John Hanson, Bryan T Hennessy, Sinead Toomey, Simon J Furney
Up to 15% of lung cancer patients present two or more anatomically separate primary lung lesions, known as multiple primary lung cancers (MPLCs). While surgical resection or stereotactic body radiation therapy (SBRT) is the standard of care for most early-stage lung cancer cases, this may not be an option for patients with widespread tumours, highlighting the need for the improved targeted management of MPLC patients, which remains challenging. Moreover, the spontaneous regression (SR) of small-cell lung cancer (SCLC) is rare, with only four cases accounted for between 1988 and 2018...
February 28, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38538102/vexas-syndrome-presenting-as-diffuse-alveolar-haemorrhage
#2
JOURNAL ARTICLE
Fayaz Ahmad Sofi, Shaariq Mehraj Naqati, Mushtaq Ahmad, Muzaffar Bindroo
We report the case of a man in his late 30s who presented with a history of breathlessness and cough with haemoptysis. Complete blood counts revealed pancytopenia. High-resolution CT showed diffuse bilateral ground glass opacities. Sequential bronchoalveolar lavage confirmed alveolar haemorrhage. Bone marrow aspiration showed vacuoles in erythroid and myeloid precursor cells. The genome was sequenced, and the UBA1 gene revealed a c.121 A>G mutation (p.Met41Val), confirming vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome...
March 27, 2024: BMJ Case Reports
https://read.qxmd.com/read/38462073/the-first-reported-pulmonary-nocardiosis-caused-by-nocardia-gipuzkoensis-resisted-to-tmp-smz-in-an-immunocompetent-patient
#3
JOURNAL ARTICLE
Yishan Duan, Xiaoxia Zhang, Wen Deng, Suyan Wang, Jinrui Hu, Xiaohui Wang, Weimin Li, Bojiang Chen
BACKGROUND: . Nocardia gipuzkoensis was first described as a novel and distinct species in 2020 by Imen Nouioui and pulmonary nocardiosis associated with Nocardia gipuzkoensis was once reported in two bronchiectasis patients. Noteworthy, both reported Nocardia gipuzkoensis cases showed sensitivity to Trimethoprim/Sulfamethoxazol (TMP-SMZ), which are usually recommended for empirical therapy. METHODS: We reported the third case of Nocardia gipuzkoensis infection in a 16-year-old girl with chief complaints of cough, persistent chest and back pain...
March 8, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38455501/brca2-positive-lung-adenocarcinoma-treated-with-olaparib-a-case-report
#4
Takumi Motohashi, Kazutoshi Isobe, Takahiro Yoshizawa, Yusuke Usui, Hiroshige Shimizu, Muneyuki Sekiya, Shion Miyoshi, Yasuhiko Nakamura, Naohisa Urabe, Susumu Sakamoto, Sakae Homma, Sota Sadamoto, Naobumi Tochigi, Kazuma Kishi
A 66-year-old woman was found to have abnormal shadows on a chest radiograph at a previous hospital 4 years ago, which led to a diagnosis of lung adenocarcinoma, cT2aN1M1b stage IVA. First-line treatment included carboplatin and paclitaxel plus thoracic radiotherapy and stereotactic radiation therapy for brain metastases. The patient later underwent second-line pemetrexed treatment, followed by third-line nivolumab, fourth-line docetaxel and bevacizumab, fifth-line tegafur-gimeracil-oteracil, and sixth-line gemcitabine...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38422915/spontaneous-regression-of-acute-fibrinous-organizing-pneumonia-induced-by-covid-19-vaccination-a-case-report
#5
Sanshiro Haga, Ryota Otoshi, Akimasa Sekine, Taichi Kaneko, Chieri Yamada, Tomohisa Baba, Shigeru Komatsu, Tomoe Sawazumi, Tamiko Takemura, Takashi Ogura
A 42-year-old woman visited our hospital with complaints of fever, muscle pain, and dyspnea one week after receiving the coronavirus disease 2019 (COVID-19) vaccine. Chest high-resolution computed tomography showed a patchy consolidation and ground-glass attenuation in the both lungs, consistent with acute interstitial pneumonia. Transbronchial lung cryobiopsy revealed organizing pneumonia with marked intra-alveolar fibrin, and pathologically diagnosed as acute fibrinous organizing pneumonia (AFOP). Other causative diseases such as dermatomyositis was clinically ruled out, and COVID-19 vaccine-induced AFOP was diagnosed...
February 28, 2024: Respiratory Investigation
https://read.qxmd.com/read/38415484/disease-course-and-pulmonary-involvement-of-covid-19-during-the-delta-variant-period-in-germany-a-comparative-study-of-vaccinated-and-unvaccinated-patients-at-a-tertiary-hospital
#6
JOURNAL ARTICLE
Andrea Steuwe, Alexandra Ljimani, Marcel Andree, Tobias Wienemann, Nadine Lübke, Andreas Walker, Björn-Erik Ole Jensen, The Racoon Study Group, Karl Ludger Radke, Gerald Antoch, Birte Valentin
UNLABELLED: <p>Background: Despite the availability of vaccines, there is an increasing number of SARS-CoV-2-breakthrough-infections. OBJECTIVE: The aim of this study was to determine whether there is a radiological difference in lung parenchymal involvement between infected vaccinated and unvaccinated patients. Additionally, we aimed to investigate whether vaccination has an impact on the course of illness and the need for intensive care. METHODS: This study includes all patients undergoing chest computed tomography (CT) or x-ray imaging in case of a proven SARS-CoV-2 infection between September and November 2021...
February 26, 2024: Current medical imaging
https://read.qxmd.com/read/38404269/-investigation-on-the-signaling-pathways-in-the-mechanism-of-hyperoxia-induced-acute-lung-injury-based-on-transcriptomics-sequencing
#7
JOURNAL ARTICLE
Song Qin, Xiaoqin Wang, Yingcong Ren, Banghai Feng, Junya Liu, Hong Yu, Jie Zheng, Huajun Chen, Zhouxiong Xing, Hong Mei
OBJECTIVE: To observe and verify the changes of transcriptome in hyperoxia-induced acute lung injury (HALI), and to further clarify the changes of pathways in HALI. METHODS: Twelve healthy male C57BL/6J mice were randomly divided into normoxia group and HALI group according to the random number table, with 6 mice in each group. The mice in the normoxia group were fed normally in the room, and the mice in the HALI group was exposed to 95% oxygen to reproduce the HALI animal model...
January 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38400087/generation-of-high-quality-african-swine-fever-virus-complete-genome-from-field-samples-by-next-generation-sequencing
#8
JOURNAL ARTICLE
Chuan Shi, Qinghua Wang, Yutian Liu, Shujuan Wang, Yongqiang Zhang, Chunju Liu, Yongxin Hu, Dongxia Zheng, Chengyou Sun, Fangfang Song, Xiaojing Yu, Yunling Zhao, Jingyue Bao, Zhiliang Wang
African swine fever (ASF) is a lethal contagious viral disease of domestic pigs and wild boars caused by the African swine fever virus (ASFV). The pandemic spread of ASF has caused severe effects on the global pig industry. Whole-genome sequencing provides crucial information for virus strain characterization, epidemiology analysis and vaccine development. Here, we evaluated the performance of next-generation sequencing (NGS) in generating ASFV genome sequences from clinical samples. Thirty-four ASFV-positive field samples including spleen, lymph node, lung, liver and blood with a range of Ct values from 14...
February 18, 2024: Viruses
https://read.qxmd.com/read/38387831/pathologic-assessment-and-staging-of-multiple-non-small-cell-lung-carcinomas-a-paradigm-shift-with-the-emerging-role-of-molecular-methods
#9
REVIEW
Jason Chang, Natasha Rekhtman
Non-small cell lung carcinomas (NSCLC) commonly present as two or more separate tumors. Biologically, this encompasses two distinct processes: separate primary lung carcinomas (SPLCs), representing independently arising tumors, and intrapulmonary metastases (IPMs), representing intrapulmonary spread of a single tumor. The advent of computed tomography imaging has substantially increased the detection of multifocal NSCLC. The strategies and approaches for distinguishing between SPLCs and IPMs have evolved significantly over the years...
February 20, 2024: Modern Pathology
https://read.qxmd.com/read/38383258/contrast-enhanced-ct-radiogenomics-in-a-retrospective-nsclc-cohort-models-attempted-validation-of-a-published-model-and-the-relevance-of-the-clinical-context
#10
JOURNAL ARTICLE
A Kohan, R Hinzpeter, R Kulanthaivelu, S A Mirshahvalad, L Avery, M Tsao, Q Li, C Ortega, U Metser, A Hope, P Veit-Haibach
RATIONALE AND OBJECTIVE: To develop a radiogenomic predictive model for non-small cell lung cancer (NSCLC) patients studied through contrast enhanced chest computed tomography (CE-CT) targeting the most frequent gene alterations. M&M: A retrospective study of patients with NSCLC imaged with CE-CT before treatment and had their tumor genomics sequenced at our institution was performed. Data was gathered from their imaging studies, their electronic medical records and a web-based database search (cBioPortal...
February 20, 2024: Academic Radiology
https://read.qxmd.com/read/38361006/efficientnet-based-system-for-detecting-egfr-mutant-status-and-predicting-prognosis-of-tyrosine-kinase-inhibitors-in-patients-with-nsclc
#11
JOURNAL ARTICLE
Nan Xu, Jiajun Wang, Gang Dai, Tao Lu, Shu Li, Kexue Deng, Jiangdian Song
We aimed to develop and validate a deep learning-based system using pre-therapy computed tomography (CT) images to detect epidermal growth factor receptor (EGFR)-mutant status in patients with non-small cell lung cancer (NSCLC) and predict the prognosis of advanced-stage patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors (TKI). This retrospective, multicenter study included 485 patients with NSCLC from four hospitals. Of them, 339 patients from three centers were included in the training dataset to develop an EfficientNetV2-L-based model (EME) for predicting EGFR-mutant status, and the remaining patients were assigned to an independent test dataset...
February 15, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38313385/response-to-savolitinib-in-a-patient-with-advanced-poorly-differentiated-lung-carcinoma-positive-for-a-novel-eml4-met-gene-fusion
#12
Ganlu Ouyang, Pei Shu, Yinyin Xue, Feng Luo, Yan Li
BACKGROUND: Cellular-mesenchymal to epithelial transition factor (c-MET) alterations have significant therapeutic implications in non-small cell lung cancer (NSCLC). Although MET fusion is a rare genomic event, advances in detection technologies have enabled the identification of various MET fusion partner genes. However, standard therapeutic options for MET fusion in NSCLC cases remain undefined. This report presents a novel fusion variant, EML4-MET, encompassing exons 1 to 13 of EML4 and exons 15 to 21 of MET, including the entire MET kinase domain, and discusses the response of this case to savolitinib treatment...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38289233/idiopathic-pulmonary-fibrosis-from-common-microscopy-to-single-cell-biology-and-precision-medicine
#13
JOURNAL ARTICLE
Moisés Selman, Annie Pardo
Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disease of unknown etiology and is included in the large, complex, and heterogeneous group of interstitial lung diseases (ILD). IPF is characterized by an aberrant activation of epithelial cells and fibroblasts and excessive accumulation of extracellular matrix, resulting in the progressive destruction of the lung architecture. Here we approach the fascinating historical evolution of our knowledge about this disorder from the past century, when most efforts were focused on ILD classification and terminology, until the current century, when the explosive progress in molecular genetics, epigenetics, and multiomics, as well as the development of complex computational tools, resulted in a huge advance in unveiling the pathogenic mechanisms of the disease...
January 30, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38255770/graph-neural-network-model-for-prediction-of-non-small-cell-lung-cancer-lymph-node-metastasis-using-protein-protein-interaction-network-and-18-f-fdg-pet-ct-radiomics
#14
JOURNAL ARTICLE
Hyemin Ju, Kangsan Kim, Byung Il Kim, Sang-Keun Woo
The image texture features obtained from 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) images of non-small cell lung cancer (NSCLC) have revealed tumor heterogeneity. A combination of genomic data and radiomics may improve the prediction of tumor prognosis. This study aimed to predict NSCLC metastasis using a graph neural network (GNN) obtained by combining a protein-protein interaction (PPI) network based on gene expression data and image texture features. 18 F-FDG PET/CT images and RNA sequencing data of 93 patients with NSCLC were acquired from The Cancer Imaging Archive...
January 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38244306/could-the-underlying-biological-basis-of-prognostic-radiomics-and-deep-learning-signatures-be-explored-in-patients-with-lung-cancer-a-systematic-review
#15
REVIEW
Lujie Qian, Ting Wu, Shuaihang Kong, Xinjing Lou, Yixiao Jiang, Zhengxin Tan, Linyu Wu, Chen Gao
OBJECTIVES: To summarize the underlying biological correlation of prognostic radiomics and deep learning signatures in patients with lung cancer and evaluate the quality of available studies. METHODS: This study examined databases including the PubMed, Embase, Web of Science Core Collection, and Cochrane Library, for studies that elaborated on the underlying biological correlation with prognostic radiomics and deep learning signatures based on CT or PET/CT for predicting the prognosis in patients with lung cancer...
January 12, 2024: European Journal of Radiology
https://read.qxmd.com/read/38241959/body-positioning-related-laryngeal-narrowing-pattern-and-expiratory-mechanical-constraints-in-advanced-chronic-obstructive-pulmonary-disease-a-case-report
#16
Yuka Nagata, Keisuke Miki, Ryo Kijima, Yasuhiro Mihashi, Satoshi Miyamoto, Hisako Hashimoto, Takuro Nii, Takanori Matsuki, Kazuyuki Tsujino, Hiroshi Kida
We previously reported that laryngeal widening led to improved exercise tolerance in COPD. However, it is not clear whether laryngeal narrowing occurs as a compensatory response to tracheal movement or is affected by posture. Here, we report the case of an advanced COPD patient whose more prolonged expiration in a head-forward leaning position compared with that in a neck-extended position occurred with an excessive duration of severe laryngeal narrowing without tracheal obstruction, which led to exercise intolerance with expiratory mechanical constraints...
January 18, 2024: Respiratory Investigation
https://read.qxmd.com/read/38241957/leukemic-pulmonary-infiltrates-in-chronic-lymphocytic-leukemia-clinical-and-imaging-features
#17
JOURNAL ARTICLE
Vasilios Tzilas, Thomas E Hartman, Jay H Ryu
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries. Although various patterns of lung involvement with CLL have been reported, data on clinicoradiologic presentation are sparse. METHODS: A computer-assisted search was conducted to identify patients encountered at Mayo Clinic from 1998 to 2022 and had leukemic pulmonary infiltrates (LPI) with CLL demonstrated on lung biopsy. Medical records and chest imaging studies were reviewed to identify clinical and radiologic features...
January 18, 2024: Respiratory Investigation
https://read.qxmd.com/read/38225543/novel-model-integrating-computed-tomography-based-image-markers-with-genetic-markers-for-discriminating-radiation-pneumonitis-in-patients-with-unresectable-stage-iii-non-small-cell-lung-cancer-receiving-radiotherapy-a-retrospective-multi-center-radiogenomics
#18
JOURNAL ARTICLE
Jiaran Li, Li Li, Shanshan Tang, Qingxi Yu, Wenju Liu, Ning Liu, Fengchang Yang, Dexian Zhang, Shuanghu Yuan
BACKGROUND: Chemoradiotherapy is a critical treatment for patients with locally advanced and unresectable non-small cell lung cancer (NSCLC), and it is essential to identify high-risk patients as early as possible owing to the high incidence of radiation pneumonitis (RP). Increasing attention is being paid to the effects of endogenous factors for RP. This study aimed to investigate the value of computed tomography (CT)-based radiomics combined with genomics in analyzing the risk of grade ≥ 2 RP in unresectable stage III NSCLC...
January 15, 2024: BMC Cancer
https://read.qxmd.com/read/38203236/different-transcriptome-features-of-peripheral-blood-mononuclear-cells-in-non-emphysematous-chronic-obstructive-pulmonary-disease
#19
JOURNAL ARTICLE
Takuro Imamoto, Takeshi Kawasaki, Hironori Sato, Koichiro Tatsumi, Daisuke Ishii, Keiichiro Yoshioka, Yoshinori Hasegawa, Osamu Ohara, Takuji Suzuki
Non-emphysematous chronic obstructive pulmonary disease (COPD), which is defined based on chest computed tomography findings, presented different transcriptome features of peripheral blood mononuclear cells (PBMCs) compared with emphysematous COPD. Enrichment analysis of transcriptomic data in COPD demonstrated that the "Hematopoietic cell lineage" pathway in Kyoto Encyclopedia of Genes and Genomes pathway analysis was highly upregulated, suggesting that cellular dynamic dysregulation in COPD lungs is affected by pathologically modified PBMCs...
December 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38184958/sfxn1-as-a-potential-diagnostic-and-prognostic-biomarker-of-luad-is-associated-with-18-f-fdg-metabolic-parameters
#20
JOURNAL ARTICLE
Yao-Hua Zhang, Xu-Sheng Liu, Yan Gao, Ling-Ling Yuan, Zhong-Min Huang, Yu Zhang, Zi-Yue Liu, Yi Yang, Xiao-Yu Liu, Chang-Bin Ke, Zhi-Jun Pei
BACKGROUND: Sideroflexin 1 (SFXN1) has been discovered as a novel tumor marker for lung adenocarcinoma, but data on its importance in the development of lung adenocarcinoma is still limited. This study evaluated the correlation between SFXN1 and parameters related to 18 F-flurodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT), and further explored the role of SFXN1 in the value-added and glycolytic processes of LUAD. METHOD: The expression and prognostic value of SFXN1 mRNA in LUAD were analyzed using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data base...
December 27, 2023: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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