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Pulmonary Emphysema subtype

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https://www.readbyqxmd.com/read/29725304/coupled-immunological-and-biomechanical-model-of-emphysema-progression
#1
Mario Ceresa, Andy L Olivares, Jérôme Noailly, Miguel A González Ballester
Chronic Obstructive Pulmonary Disease (COPD) is a disabling respiratory pathology, with a high prevalence and a significant economic and social cost. It is characterized by different clinical phenotypes with different risk profiles. Detecting the correct phenotype, especially for the emphysema subtype, and predicting the risk of major exacerbations are key elements in order to deliver more effective treatments. However, emphysema onset and progression are influenced by a complex interaction between the immune system and the mechanical properties of biological tissue...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29695900/the-link-between-chronic-obstructive-pulmonary-disease-phenotypes-and-histological-subtypes-of-lung-cancer-a-case-control-study
#2
Wei Wang, Mengshuang Xie, Shuang Dou, Liwei Cui, Chunyan Zheng, Wei Xiao
Background: COPD is considered an independent risk factor for lung cancer. COPD and lung cancer are both very heterogeneous diseases, and the study herein investigates the link between COPD phenotypes and specific histological subtypes of lung cancer. Methods: This case-control study comprised 2,283 patients with newly diagnosed pathological lung cancer and 2,323 non-lung cancer controls. All participants underwent pulmonary function tests. The diagnosis of COPD was based on Global Initiative for Chronic Obstructive Lung Disease criteria...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29522352/early-endotyping-a-chance-for-intervention-in-copd
#3
Hans Petersen, Rodrigo Vazquez Guillamet, Paula Meek, Akshay Sood, Yohannes Tesfaigzi
Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but subphenotyping the various disease subtypes has been difficult. One reason may be that current efforts which are focused on studying COPD once it has occurred do not allow to trace back the different origins of disease. This prespective proposes that emphysema originates when susceptible airway, endothelial, and/or hematopoietic cells are exposed to environmental toxins, such as cigarette smoke, biomass fuel, or traffic emissions...
March 9, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29413504/several-high-resolution-computed-tomography-findings-associate-with-survival-and-clinical-features-in-rheumatoid-arthritis-associated-interstitial-lung-disease
#4
Hanna M Nurmi, Hannu-Pekka Kettunen, Sanna-Katja Suoranta, Minna K Purokivi, Miia S Kärkkäinen, Tuomas A Selander, Riitta L Kaarteenaho
OBJECTIVE: To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. MATERIALS AND METHODS: HRCTs from 60 RA-ILD patients were independently evaluated and re-categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and unclassified subtypes by two radiologists...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29361243/emphysematous-and-nonemphysematous-gas-trapping-in-chronic-obstructive-pulmonary-disease-quantitative-ct-findings-and-pulmonary-function
#5
Mariaelena Occhipinti, Matteo Paoletti, Francesca Bigazzi, Gianna Camiciottoli, Riccardo Inchingolo, Anna Rita Larici, Massimo Pistolesi
Purpose To identify a prevalent computed tomography (CT) subtype in patients with chronic obstructive pulmonary disease (COPD) by separating emphysematous from nonemphysematous contributions to total gas trapping and to attempt to predict and grade the emphysematous gas trapping by using clinical and functional data. Materials and Methods Two-hundred and two consecutive eligible patients (159 men and 43 women; mean age, 70 years [age range, 41-85 years]) were prospectively studied. Pulmonary function and CT data were acquired by pulmonologists and radiologists...
May 2018: Radiology
https://www.readbyqxmd.com/read/29354811/unsupervised-discovery-of-spatially-informed-lung-texture-patterns-for-pulmonary-emphysema-the-mesa-copd-study
#6
Jie Yang, Elsa D Angelini, Pallavi P Balte, Eric A Hoffman, John H M Austin, Benjamin M Smith, Jingkuan Song, R Graham Barr, Andrew F Laine
Unsupervised discovery of pulmonary emphysema subtypes offers the potential for new definitions of emphysema on lung computed tomography (CT) that go beyond the standard subtypes identified on autopsy. Emphysema subtypes can be defined on CT as a variety of textures with certain spatial prevalence. However, most existing approaches for learning emphysema subtypes on CT are limited to texture features, which are sub-optimal due to the lack of spatial information. In this work, we exploit a standardized spatial mapping of the lung and propose a novel framework for combining spatial and texture information to discover spatially-informed lung texture patterns (sLTPs)...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29202136/explaining-radiological-emphysema-subtypes-with-unsupervised-texture-prototypes-mesa-copd-study
#7
Jie Yang, Elsa D Angelini, Benjamin M Smith, John H M Austin, Eric A Hoffman, David A Bluemke, R Graham Barr, Andrew F Laine
Pulmonary emphysema is traditionally subcategorized into three subtypes, which have distinct radiological appearances on computed tomography (CT) and can help with the diagnosis of chronic obstructive pulmonary disease (COPD). Automated texture-based quantification of emphysema subtypes has been successfully implemented via supervised learning of these three emphysema subtypes. In this work, we demonstrate that unsupervised learning on a large heterogeneous database of CT scans can generate texture prototypes that are visually homogeneous and distinct, reproducible across subjects, and capable of predicting accurately the three standard radiological subtypes...
2017: Medical Computer Vision and Bayesian and Graphical Models for Biomedical Imaging: MICCAI 2016 International Workshops, MCV and BAMBI, Athens, Greece, October 21, 2016, Revised Selected Papers
https://www.readbyqxmd.com/read/28989563/generative-method-to-discover-emphysema-subtypes-with-unsupervised-learning-using-lung-macroscopic-patterns-lmps-the-mesa-copd-study
#8
Jingkuan Song, Jie Yang, Benjamin Smith, Pallavi Balte, Eric A Hoffman, R Graham Barr, Andrew F Laine, Elsa D Angelini
Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes: centrilobular emphysema (CLE), panlobular emphysema (PLE) and paraseptal emphysema (PSE). Automated classification methods based on supervised learning are generally based upon the current definition of emphysema subtypes, while unsupervised learning of texture patterns enables the objective discovery of possible new radiological emphysema subtypes. In this work, we use a variant of the Latent Dirichlet Allocation (LDA) model to discover lung macroscopic patterns (LMPs) in an unsupervised way from lung regions that encode emphysematous areas...
April 2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28801407/the-boundaries-of-mild-chronic-obstructive-pulmonary-disease-copd-design-of-the-searching-clinical-copd-onset-soon-study
#9
Gonzalo Labarca, Andrea Bustamante, Gonzalo Valdivia, Rodrigo Díaz, Álvaro Huete, Paul Mac Nab, Laura Mendoza, Jaime Leppe, Carmen Lisboa, Fernando Saldías, Orlando Díaz
INTRODUCTION: Clinical onset of chronic obstructive pulmonary disease (COPD) is the point at which the disease is first identifiable by physicians. It is a poorly defined stage which seems to include both mild spirometric and non-spirometric disease, and could be described as early grade COPD, for practical purposes. While dyspnoea; chronic bronchitis and CT imaging evidence of emphysema and airway disease may be present very early, the lone significance of dyspnoea, the most relevant symptom in COPD in identifying these individuals, has been scarcely assessed...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28765242/pulmonary-involvement-in-antineutrophil-cytoplasmic-antibodies-anca-associated-vasculitis-the-influence-of-anca-subtype
#10
Aladdin J Mohammad, Kristian H Mortensen, Judith Babar, Rona Smith, Rachel B Jones, Daiki Nakagomi, Pasupathy Sivasothy, David R W Jayne
OBJECTIVE: To describe pulmonary involvement at time of diagnosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), as defined by computed tomography (CT). METHODS: Patients with thoracic CT performed on or after the onset of AAV (n = 140; 75 women; granulomatosis with polyangiitis, n = 79; microscopic polyangiitis MPA, n = 61) followed at a tertiary referral center vasculitis clinic were studied. Radiological patterns of pulmonary involvement were evaluated from the CT studies using a predefined protocol, and compared to proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA specificity...
October 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28704452/influence-of-lung-ct-changes-in-chronic-obstructive-pulmonary-disease-copd-on-the-human-lung-microbiome
#11
Marion Engel, David Endesfelder, Brigitte Schloter-Hai, Susanne Kublik, Michael S Granitsiotis, Piera Boschetto, Mariarita Stendardo, Imre Barta, Balazs Dome, Jean-François Deleuze, Anne Boland, Joachim Müller-Quernheim, Antje Prasse, Tobias Welte, Jens Hohlfeld, Deepak Subramanian, David Parr, Ivo Glynne Gut, Timm Greulich, Andreas Rembert Koczulla, Adam Nowinski, Dorota Gorecka, Dave Singh, Sumit Gupta, Christopher E Brightling, Harald Hoffmann, Marion Frankenberger, Thomas P Hofer, Dorothe Burggraf, Marion Heiss-Neumann, Loems Ziegler-Heitbrock, Michael Schloter, Wolfgang Zu Castell
BACKGROUND: Changes in microbial community composition in the lung of patients suffering from moderate to severe COPD have been well documented. However, knowledge about specific microbiome structures in the human lung associated with CT defined abnormalities is limited. METHODS: Bacterial community composition derived from brush samples from lungs of 16 patients suffering from different CT defined subtypes of COPD and 9 healthy subjects was analyzed using a cultivation independent barcoding approach applying 454-pyrosequencing of 16S rRNA gene fragment amplicons...
2017: PloS One
https://www.readbyqxmd.com/read/28610627/multiple-biomarkers-predict-disease-severity-progression-and-mortality-in-copd
#12
MULTICENTER STUDY
Rachel L Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E Miller, Ruth Tal-Singer, Russell P Bowler
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by multiple subtypes and variable disease progression. Blood biomarkers have been variably associated with subtype, severity, and disease progression. Just as combined clinical variables are more highly predictive of outcomes than individual clinical variables, we hypothesized that multiple biomarkers may be more informative than individual biomarkers to predict subtypes, disease severity, disease progression, and mortality...
June 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28268558/texton-and-sparse-representation-based-texture-classification-of-lung-parenchyma-in-ct-images
#13
Jie Yang, Xinyang Feng, Elsa D Angelini, Andrew F Laine
Automated texture analysis of lung computed tomography (CT) images is a critical tool in subtyping pulmonary emphysema and diagnosing chronic obstructive pulmonary disease (COPD). Texton-based methods encode lung textures with nearest-texton frequency histograms, and have achieved high performance for supervised classification of emphysema subtypes from annotated lung CT images. In this work, we first explore characterizing lung textures with sparse decomposition from texton dictionaries, using different regularization strategies, and then extend the sparsity-inducing constraint to the construction of the dictionaries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226735/texton-and-sparse-representation-based-texture-classification-of-lung-parenchyma-in-ct-images
#14
Jie Yang, Xinyang Feng, Elsa D Angelini, Andrew F Laine, Jie Yang, Xinyang Feng, Elsa D Angelini, Andrew F Laine, Xinyang Feng, Jie Yang, Elsa D Angelini, Andrew F Laine
Automated texture analysis of lung computed tomography (CT) images is a critical tool in subtyping pulmonary emphysema and diagnosing chronic obstructive pulmonary disease (COPD). Texton-based methods encode lung textures with nearest-texton frequency histograms, and have achieved high performance for supervised classification of emphysema subtypes from annotated lung CT images. In this work, we first explore characterizing lung textures with sparse decomposition from texton dictionaries, using different regularization strategies, and then extend the sparsity-inducing constraint to the construction of the dictionaries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28164246/immune-mediated-inflammation-in-the-pathogenesis-of-emphysema-insights-from-mouse-models
#15
REVIEW
John M Craig, Alan L Scott, Wayne Mitzner
The cellular mechanisms that result in the initiation and progression of emphysema are clearly complex. A growing body of human data combined with discoveries from mouse models utilizing cigarette smoke exposure or protease administration have improved our understanding of emphysema development by implicating specific cell types that may be important for the pathophysiology of chronic obstructive pulmonary disease. The most important aspects of emphysematous damage appear to be oxidative or protease stress and sustained macrophage activation and infiltration of other immune cells leading to epithelial damage and cell death...
March 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28122034/a-low-peripheral-blood-cd4-cd8-ratio-is-associated-with-pulmonary-emphysema-in-hiv
#16
Matthew Triplette, Engi F Attia, Kathleen M Akgün, Guy W Soo Hoo, Matthew S Freiberg, Adeel A Butt, Cherry Wongtrakool, Matthew Bidwell Goetz, Sheldon T Brown, Christopher J Graber, Laurence Huang, Kristina Crothers
OBJECTIVES: The prevalence of emphysema is higher among HIV-infected (HIV+) individuals compared to HIV-uninfected persons. While greater tobacco use contributes, HIV-related effects on immunity likely confer additional risk. Low peripheral blood CD4+ to CD8+ T-lymphocyte (CD4/CD8) ratio may reflect chronic inflammation in HIV and may be a marker of chronic lung disease in this population. Therefore, we sought to determine whether the CD4/CD8 ratio was associated with chronic obstructive pulmonary disease (COPD), particularly the emphysema subtype, in a cohort of HIV+ subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28113658/a-bayesian-nonparametric-model-for-disease-subtyping-application-to-emphysema-phenotypes
#17
James C Ross, Peter J Castaldi, Michael H Cho, Junxiang Chen, Yale Chang, Jennifer G Dy, Edwin K Silverman, George R Washko, Raul San Jose Estepar
We introduce a novel Bayesian nonparametric model that uses the concept of disease trajectories for disease subtype identification. Although our model is general, we demonstrate that by treating fractions of tissue patterns derived from medical images as compositional data, our model can be applied to study distinct progression trends between population subgroups. Specifically, we apply our algorithm to quantitative emphysema measurements obtained from chest CT scans in the COPDGene Study and show several distinct progression patterns...
September 13, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28060702/a-bayesian-nonparametric-model-for-disease-subtyping-application-to-emphysema-phenotypes
#18
James C Ross, Peter J Castaldi, Michael H Cho, Junxiang Chen, Yale Chang, Jennifer G Dy, Edwin K Silverman, George R Washko, Raul San Jose Estepar
We introduce a novel Bayesian nonparametric model that uses the concept of disease trajectories for disease subtype identification. Although our model is general, we demonstrate that by treating fractions of tissue patterns derived from medical images as compositional data, our model can be applied to study distinct progression trends between population subgroups. Specifically, we apply our algorithm to quantitative emphysema measurements obtained from chest CT scans in the COPDGene Study and show several distinct progression patterns...
January 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27768836/lung-cancer-in-patients-with-combined-pulmonary-fibrosis-and-emphysema-revisited-with-the-2015-world-health-organization-classification-of-lung-tumors
#19
Li Gao, Sheng Xie, Hui Liu, Pingping Liu, Yan Xiong, Jiping Da, Chengli Que, Huaping Dai, Chen Wang
OBJECTIVE: Combined pulmonary fibrosis and emphysema (CPFE) is a newly defined entity that comprises upper lobe emphysema and lower lobe fibrosis. Patients with CPFE are at high risk for lung cancer and have poor prognoses. To investigate the clinical and pathological characteristics of lung cancer with CPFE, lung cancers with CPFE and non-CPFE interstitial lung disease (ILD) were reevaluated by 2015 WHO classification and compared. METHODS: A total of 60 patients with histologically proven lung cancer were selected from the database of two institutional medical centers...
February 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27460105/distinct-emphysema-subtypes-defined-by-quantitative-ct-analysis-are-associated-with-specific-pulmonary-matrix-metalloproteinases
#20
Kristoffer Ostridge, Nicholas Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Ngaire A Coombs, Paul T Elkington, Raul San Jose Estepar, George Washko, Karl J Staples, Tom M A Wilkinson
BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been identified as potentially important in the development of emphysema. However, the relationship between MMPs and emphysema sub-type is unknown. We investigated the role of MMPs and their inhibitors in the development of emphysema sub-types by quantifying levels and determining relationships with these sub-types in mild-moderate COPD patients and ex/current smokers with preserved lung function...
July 26, 2016: Respiratory Research
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