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Werner Kliche, Ingo Krech, Martin C Michel, Nishant V Sangole, Sadhana Sathaye
The bioengineered tissue plasminogen activator tenecteplase is an important treatment modality of acute myocardial infarction recommended by international guidelines. Following introduction of originator tenecteplase (brand names Metalyse(®) and TNKase(®)), a "biosimilar" tenecteplase became available for commercial use in India under the brand name Elaxim(®) in the absence of Indian biosimilar guidelines which came into force from September 15th, 2012. Based on a report of biochemical and fibrinolytical differences between Metalyse and Elaxim, we have systematically compared them in a range of routine quality testing assays...
2014: Frontiers in Pharmacology
James A Johnstone, Paul A Ford, Gerwyn Hughes, Tim Watson, Andrew C S Mitchell, Andrew T Garrett
The Bioharness™ device is designed for monitoring physiological variables in free-living situations but has only been proven to be reliable and valid in a laboratory environment. Therefore, this study aimed to determine the reliability and validity of the Bioharness™ using a field based protocol. Twenty healthy males participated. Heart rate (HR), breathing frequency (BF) and accelerometry (ACC) were assessed by simultaneous measurement of two Bioharness™ devices and a test-retest of a discontinuous incremental walk-jog-run protocol (4 - 11 km·h(-1)) completed in a sports hall...
2012: Journal of Sports Science & Medicine
James A Johnstone, Paul A Ford, Gerwyn Hughes, Tim Watson, Andrew T Garrett
The Bioharness(™) monitoring system may provide physiological information on human performance but there is limited information on its validity. The objective of this study was to assess the validity of all 5 Bioharness(™) variables using a laboratory based treadmill protocol. 22 healthy males participated. Heart rate (HR), Breathing Frequency (BF) and Accelerometry (ACC) precision were assessed during a discontinuous incremental (0-12 km·h(-1)) treadmill protocol. Infra-red skin temperature (ST) was assessed during a 45 min(-1) sub-maximal cycle ergometer test, completed twice, with environmental temperature controlled at 20 ± 0...
2012: Journal of Sports Science & Medicine
Vuk Niković, Anton Laggner, Dejan Kojić
INTRODUCTION: Pulmonary embolism as a possible cause of acute heart failure is a potentially fatal condition that can cause death in all age groups. Patients successfully resuscitated after cardiac arrest have a high risk of increased mortality and their poor long-term outcome is often associated with severe neurological complications. CASE OUTLINE: This is a case report of a 67-year-old man after a successful cardiopulmonary resuscitation (CPR) which was followed by therapeutic hypothermia (TH)...
July 2013: Srpski Arhiv za Celokupno Lekarstvo
Ian L McAllister, Sarojini Vijayasekaran, Dao-Yi Yu
PURPOSE: To determine the ability of an intravitreal injection of tenecteplase (TNK) to penetrate an intraretinal venous thrombus and its effectiveness in thrombolysis in a porcine model of branch retinal vein occlusion (BRVO). METHODS: Six pigs (group 1) were anesthetized, and a BRVO was induced photothrombotically in the left eye; immediately afterward, fluorescence-conjugated TNK (100 μg) was injected into both eyes, with enucleation at 24 hours. Retinal penetration was assessed on frozen sections by epifluorescence microscopy...
July 2013: Investigative Ophthalmology & Visual Science
H Hayes, L Dembo, R Larbalestier, G O'Driscoll
We report a case of intracardiac thrombus in a patient supported by the Jarvik 2000 Flowmaker successfully treated with a single dose of peripherally administered TNK-tissue plasminogen activator (Tenecteplase, Metalyse, Boehringer Ingelheim). This strategy may be considered in the case of life-threatening VAD associated thrombosis to avoid the need for intracardiac drug delivery or VAD replacement. We also discuss the apparent increased thrombotic risk in patients receiving a VAD for chemotherapy induced cardiomyopathy and the implications this may have for the choice of VAD...
June 2008: Heart, Lung & Circulation
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