Soheila Ali Akbari Ghavimi, Matthew R Aronson, Daniel D Ghaderi, Ryan M Friedman, Neil Patel, Terri Giordano, Ryan C Borek, Conor M Devine, Lin Han, Ian N Jacobs, Riccardo Gottardi
OBJECTIVE: Subglottic stenosis (SGS) may result from prolonged intubation where fibrotic scar tissue narrows the airway. The scar forms by differentiated myofibroblasts secreting excessive extracellular matrix (ECM). TGF-β1 is widely accepted as a regulator of fibrosis; however, it is unclear how biomechanical pathways co-regulate fibrosis. Therefore, we phenotyped fibroblasts from pediatric patients with SGS to explore how key signaling pathways, TGF-β and Hippo, impact scarring and assess the impact of inhibiting these pathways with potential therapeutic small molecules SB525334 and DRD1 agonist dihydrexidine hydrochloride (DHX)...
July 17, 2023: Laryngoscope