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Stenotic airway

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https://www.readbyqxmd.com/read/28990664/hormone-receptors-analysis-in-idiopathic-progressive-subglottic-stenosis
#1
Ivana Fiz, Zeid Bittar, Cesare Piazza, Jan Constantin Koelmel, Federico Gatto, Diego Ferone, Francesco Fiz, Diana Di Dio, Alexander Bosse, Giorgio Peretti, Christian Sittel
OBJECTIVE: Idiopathic subglottic stenosis predominantly affects fertile and perimenopausal women. Estrogens and/or progesterone have been proposed as mediators of its pathogenesis by stimulating collagen deposition within the upper airway. We evaluated the presence and expression of estrogen-alpha (ER-α), estrogen-beta (ER-β), and progesterone receptors (PR) in idiopathic stenotic patients. STUDY DESIGN: A retrospective analysis on 42 surgical specimens from idiopathic stenosis female patients (mean age, 52...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988443/effects-of-supramaximal-balloon-dilatation-pressures-on-adult-cricoid-and-tracheal-cartilage-a-cadaveric-study
#2
Venkata S P B Durvasula, Sara C Shalin, Ozlem E Tulunay-Ugur, James Y Suen, Gresham T Richter
OBJECTIVES/HYPOTHESIS: Cricoid fracture is a serious concern for balloon dilatation in airway stenosis. Furthermore, there are no studies examining tracheal rupture in balloon dilatation of stenotic segments. The aim of this study was to evaluate the effect of supramaximal pressures of balloons on the cricoid and tracheal rings. STUDY DESIGN: Prospective cadaveric study. METHODS: Seven cadaveric laryngotracheal complexes of normal adults with intact cricothyroid membranes were acquired...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28766977/surgical-management-of-supraglottic-stenosis-using-intubationless-optiflow
#3
Kenric Tam, Caroline Jeffery, C Kwang Sung
OBJECTIVE: Airway management during endoscopic surgical treatment of supraglottic and pharyngeal stenosis is often challenging and can be accomplished by various means, including tracheostomy, jet ventilation, or direct laryngoscopy. We describe CO2 laser excision of supraglottic-pharyngeal stenosis using intubationless Optiflow high-flow nasal cannula (HFNC). METHODS: A 55-year-old male presented with dyspnea and dysphagia secondary to severe supraglottic-pharyngeal stenosis in the setting of previous chemoradiation for a T0N2aM0 squamous cell carcinoma...
September 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28763490/conformational-risk-factors-of-brachycephalic-obstructive-airway-syndrome-boas-in-pugs-french-bulldogs-and-bulldogs
#4
Nai-Chieh Liu, Eileen L Troconis, Lajos Kalmar, David J Price, Hattie E Wright, Vicki J Adams, David R Sargan, Jane F Ladlow
Extremely brachycephalic, or short-muzzled, dog breeds such as pugs, French bulldogs, and bulldogs are prone to the conformation-related respiratory disorder-brachycephalic obstructive airway syndrome (BOAS). Affected dogs present with a wide range of clinical signs from snoring and exercise intolerance, to life-threatening events such as syncope. In this study, conformational risk factors for BOAS that could potentially aid in breeding away from BOAS were sought. Six hundred and four pugs, French bulldogs, and bulldogs were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28718208/quantification-of-nasal-airflow-resistance-in-english-bulldogs-using-computed-tomography-and-computational-fluid-dynamics
#5
Eric T Hostnik, Brian A Scansen, Rachel Zielinski, Samir N Ghadiali
Stenotic nares, edematous intranasal turbinates, mucosal swelling, and an elongated, thickened soft palate are common sources of airflow resistance for dogs with brachycephalic airway syndrome. Surgery has focused on enlarging the nasal apertures and reducing tissue of the soft palate. However, objective measures of surgical efficacy are lacking. Twenty-one English bulldogs without previous surgery were recruited for this prospective, pilot study. Computed tomography was performed using conscious sedation and without endotracheal intubation using a 128 multidetector computed tomography scanner...
September 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28371091/novel-magnetic-resonance-imaging-for-assessment-of-bronchial-stenosis-in-lung-transplant-recipients
#6
K Mahmood, L Ebner, M He, S H Robertson, Z Wang, H P McAdams, M M Wahidi, S L Shofer, Y T Huang, B Driehuys
Bronchial stenosis in lung transplant recipients is a common disorder that adversely affects clinical outcomes. It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations. We hypothesize that MRI using both ultrashort echo time (UTE) scans and hyperpolarized (HP) (129) Xe gas can offer structural and functional assessment of bronchial stenosis seen after lung transplantation. Six patients with lung transplantation-related bronchial stenosis underwent HP (129) Xe MRI and UTE MRI in the same session...
July 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28331451/vanishing-bronchus-after-lung-transplantation-the-role-of-sequential-airway-dilatations
#7
Abdul Hamid Alraiyes, Hanine Inaty, Michael S Machuzak
BACKGROUND: Airway complications after lung transplant play an important role in patient survival. Early recognition and treatment of these complications are necessary to help ensure that patients who receive lung transplants have good outcomes. CASE REPORT: A 61-year-old female with a history of pulmonary venous occlusive disease presented to our hospital for a double-lung transplant. Her postoperative course was complicated by severe primary graft dysfunction...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28291399/resection-and-primary-closure-of-edematous-glossoepiglottic-mucosa-in-a-dog-causing-laryngeal-obstruction
#8
Kevin J Schabbing, Jeffrey A Seaman
An approximately 22 mo old male neutered English bulldog was evaluated for acute onset of dyspnea with suspected brachycephalic obstructive airway syndrome (BOAS). Laryngoscopic exam revealed diffuse, severe edema and static displacement of redundant glossoepiglottic (GE) mucosa causing complete obstruction of the larynx and epiglottic entrapment. Static displacement of the GE mucosa was observed and determined to be the overriding component of dyspnea in this patient with BOAS. Resection and primary closure with two separate, simple continuous sutures of the GE mucosa were performed...
May 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27859294/tgf-%C3%AE-antagonist-attenuates-fibrosis-but-not-luminal-narrowing-in-experimental-tracheal-stenosis
#9
COMPARATIVE STUDY
Juan L Antón-Pacheco, Alicia Usategui, Iván Martínez, Carmen M García-Herrero, Antonio P Gamez, Montserrat Grau, Ana M Martínez, José L Rodríguez-Peralto, José L Pablos
OBJECTIVE: Acquired tracheal stenosis (ATS) is an unusual disease often secondary to prolonged mechanical trauma. Acquired tracheal stenosis pathogenesis involves inflammation and subsequent fibrosis with narrowing of the tracheal lumen. Transforming growth factor-β1 (TGF-β) represents a pivotal factor in most fibrotic processes, and therefore a potential target in this context. The aim of this study is to analyze the role of TGF-β as a target for anti-fibrotic interventions in tracheal stenosis...
March 2017: Laryngoscope
https://www.readbyqxmd.com/read/27290957/air-q-laryngeal-airway-for-rescue-and-tracheal-intubation
#10
Ayman Ads, Frederic Auerbach, Kelly Ryan, Abdel R El-Ganzouri
We report the successful use of the Air-Q laryngeal airway (Air-Q LA) as a ventilatory device and a conduit for tracheal intubation to rescue the airway in a patient with difficult airway and tracheal stenosis. This is the first case report of the device to secure the airway after two episodes of hypoxemia in the operating room and intensive care unit. Consent for submission of this case report was obtained from our institution's human studies institutional review board given that the patient died a few months after his discharge from the hospital before his personal consent could be obtained and before preparation of this report...
August 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27159898/whole-body-barometric-plethysmography-characterizes-upper-airway-obstruction-in-3-brachycephalic-breeds-of-dogs
#11
N-C Liu, V J Adams, L Kalmar, J F Ladlow, D R Sargan
BACKGROUND: A novel test using whole-body barometric plethysmography (WBBP) was developed recently to diagnose brachycephalic obstructive airway syndrome (BOAS) in unsedated French bulldogs. HYPOTHESIS/OBJECTIVES: The hypotheses of this study were: (1) respiratory characteristics are different between healthy nonbrachycephalic dogs and brachycephalic dogs; and among pugs, French bulldogs, and bulldogs; and (2) obesity and stenotic nares are risk factors for BOAS...
May 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27117724/the-efficacy-of-submucosal-corticosteroid-injection-and-dilatation-in-subglottic-stenosis-of-different-aetiology
#12
M Wierzbicka, M Tokarski, M Puszczewicz, W Szyfter
OBJECTIVE: To determine the long-term efficacy of submucosal corticosteroid injection plus dilatation for subglottic stenosis as a single modality treatment in granulomatosis with polyangiitis and relapsing polychondritis, as compared with idiopathic subglottic stenosis and traumatic subglottic stenosis. METHOD: Patients who underwent dilatation for autoimmune causes were identified. Corticosteroid injection into the submucosa of a stenotic segment was followed by serial dilatation...
July 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27103559/newborn-nasal-obstruction-due-to-congenital-nasal-pyriform-aperture-stenosis
#13
Thiago L I Serrano, Leopoldo Pfeilsticker, Vanessa Silva, Igor Hazboun, Jorge Paschoal, Rebecca Maunsell, Eulalia Sakano
INTRODUCTION: Nasal obstruction is an important condition that can lead to severe respiratory distress in newborns. There are several differential diagnoses, and one of them is congenital nasal pyriform aperture stenosis (CNPAS). CNPAS is a rare case of respiratory distress caused by excessive growth of the nasal process of the maxilla and leads to narrowing of the anterior third of the nasal cavity. Diagnosis, associated anomalies, and treatment strategies are reviewed by the following presentation of two cases...
January 2016: Allergy & Rhinology
https://www.readbyqxmd.com/read/27090537/extensive-upper-respiratory-tract-sarcoidosis
#14
Mafalda Trindade Soares, Carolina Sousa, Luísa Garanito, Filipe Freire
Sarcoidosis is a chronic granulomatous disease of unknown aetiology. It can affect any part of the organism, although the lung is the most frequently affected organ. Upper airway involvement is rare, particularly if isolated. Sarcoidosis is a diagnosis of exclusion, established by histological evidence of non-caseating granulomas and the absence of other granulomatous diseases. The authors report a case of a man with sarcoidosis manifesting as a chronic inflammatory stenotic condition of the upper respiratory tract and trachea...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27080697/treatment-of-multiple-level-tracheobronchial-stenosis-secondary-to-endobronchial-tuberculosis-using-bronchoscopic-balloon-dilatation-with-topical-mitomycin-c
#15
Mohamed Faisal, Hafaruzi Harun, Tidi M Hassan, Andrea Y L Ban, Sanjay H Chotirmall, Jamalul Azizi Abdul Rahaman
BACKGROUND: Tracheobronchial stenosis is a known complication of endobronchial tuberculosis. Despite antituberculous and steroid therapy, the development of bronchial stenosis is usually irreversible and requires airway patency to be restored by either bronchoscopic or surgical interventions. We report the use of balloon dilatation and topical mitomycin-C to successful restore airway patency. CASE PRESENTATION: We present a 24-year old lady with previous pulmonary tuberculosis and laryngeal tuberculosis in 2007 and 2013 respectively who presented with worsening dyspnoea and stridor...
April 14, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27012936/brachycephalic-syndrome
#16
REVIEW
Gilles Dupré, Dorothee Heidenreich
Animals presenting with brachycephalic syndrome suffer from multilevel obstruction of the airways as well as secondary structural collapse. Stenotic nares, aberrant turbinates, nasopharyngeal collapse, soft palate elongation and hyperplasia, laryngeal collapse, and left bronchus collapse are being described as the most common associated anomalies. Rhinoplasty and palatoplasty as well as newer surgical techniques and postoperative care strategies have resulted in significant improvement of the prognosis even in middle-aged dogs...
July 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/26981272/idiopathic-laryngotracheal-stenosis
#17
Christina L Costantino, Douglas J Mathisen
Idiopathic laryngotracheal stenosis (ILTS) is a rare inflammatory disease of unknown etiology. Infectious, traumatic and immunologic processes must first be excluded. The majority of patients affected are female who present with progressive symptoms of upper airway obstruction, which can extend over a number of years. ILTS is characterized by short segment, circumferential stenotic lesions, located particularly at the level of the cricoid. Bronchoscopic evaluation is essential for establishing the diagnosis and operative planning...
March 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26897434/how-does-multilevel-upper-airway-surgery-influence-the-lives-of-dogs-with-severe-brachycephaly-results-of-a-structured-pre-and-postoperative-owner-questionnaire
#18
Sabine Pohl, Frauke S Roedler, Gerhard U Oechtering
Brachycephalic airway syndrome in dogs is typified by a variety of anatomical abnormalities causing a diverse spectrum of clinical signs of varying intensity. This variability makes the assessment of the surgical outcome after upper airway surgery difficult. Using a structured questionnaire, the present study investigated the dog owner-perceived severity and frequency of a broad spectrum of welfare-relevant impairments 2 weeks before and 6 months after brachycephalic dogs underwent a recently developed multi-level upper airway surgery...
April 2016: Veterinary Journal
https://www.readbyqxmd.com/read/26542300/stent-implantation-into-the-tracheo-bronchial-system-in-rabbits-histopathologic-sequelae-in-bare-metal-vs-drug-eluting-stents
#19
Matthias Sigler, Julia Klötzer, Thomas Quentin, Thomas Paul, Oliver Möller
BACKGROUND: Stent implantation into the tracheo-bronchial system may be life-saving in selected pediatric patients with otherwise intractable stenosis of the upper airways. Following implantation, significant tissue proliferation may occur, requiring re-interventions. We sought to evaluate the effect of immunosuppressive coating of the stents on the extent of tissue proliferation in an animal model. METHODS: Bare metal and sirolimus-coated stents (Bx Sonic and Cypher Select, Johnson & Johnson, Cordis) were implanted into non-stenotic lower airways of New Zealand white rabbits (weight 3...
December 2015: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/26412460/endoscopic-management-of-congenital-anterior-glottic-stenosis
#20
Mi Jin Yoo, Soham Roy, Lee P Smith
INTRODUCTION: Congenital anterior glottic stenosis (web) is a rare condition usually presenting with airway obstruction, stridor or dysphonia. Symptomatic infants may require tracheotomy to bridge the neonatal period. Early open surgical reconstruction may have significant risks and failure may still result in tracheotomy. We introduce an endoscopic surgical approach with balloon dilation for primary management of congenital anterior glottic stenosis. METHODS: We present three cases of congenital anterior glottic stenosis in children 7, 14, and 90 days old presenting with stridor, dyspnea, and dysphonia...
December 2015: International Journal of Pediatric Otorhinolaryngology
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