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https://www.readbyqxmd.com/read/28431829/utility-of-the-new-movement-disorder-society-clinical-diagnostic-criteria-for-parkinson-s-disease-applied-retrospectively-in-a-large-cohort-study-of-recent-onset-cases
#1
Naveed Malek, Michael A Lawton, Katherine A Grosset, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Tom Foltynie, John Hardy, Huw R Morris, Nigel M Williams, Nicholas Wood, Donald G Grosset
OBJECTIVE: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients. METHODS: Recently diagnosed (<3.5 years) PD cases fulfilling United Kingdom (UK) brain bank criteria in Tracking Parkinson's, a UK multicenter prospective natural history study were assessed by retrospective application of the MDS criteria. RESULTS: In 2000 cases, 1835 (91.7%) met MDS criteria for PD, either clinically established (n = 1261, 63...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28431779/propranolol
#2
Abdulrahman A Al-Majed, Ahmed H H Bakheit, Hatem A Abdel Aziz, Fahad M Alajmi, Haitham AlRabiah
Propranolol is a noncardioselective β-blocker. It is reported to have membrane-stabilizing properties, but it does not own intrinsic sympathomimetic activity. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. It is also used to control symptoms of sympathetic overactivity in the management of hyperthyroidism, anxiety disorders, and tremor. Other indications cover the prophylaxis of migraine and of upper gastrointestinal bleeding in patients with portal hypertension...
2017: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/28431624/opsoclonus-myoclonus-ataxia-associated-with-west-nile-virus-infection-a-dramatic-presentation-with-benign-prognosis
#3
Roy Zaltzman, Colin Klein, Carlos R Gordon
Opsoclonus myoclonus and ataxia is a combination of severe neurological signs associated with several pathologic agents and conditions. Only few cases of opsoclonus have been related to West Nile virus infection. We report on a 61-year-old woman and on a 55-year-old man who had history of recent fever, who were hospitalized because of acute severe truncal ataxia, opsoclonus and tremor with minimal myoclonic jerks. A through work-up revealed the presence of both IgM and IgG antibodies against West Nile virus both in the serum and Cerebrospinal Fluid and excluded other causes known to be associated with this combination of neurological signs...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28428905/deep-brain-stimulation-target-selection-in-an-advanced-parkinson-s-disease-patient-with-significant-tremor-and-comorbid-depression
#4
Amar S Patel
CLINICAL VIGNETTE: A 67-year-old female with advanced Parkinson's disease (PD), medically refractory tremor, and a history of significant depression presented for evaluation of deep brain stimulation (DBS) candidacy. CLINICAL DILEMMA: Traditionally, the subthalamic nucleus (STN) has been preferred over the globus pallidus interna (GPi) as a DBS target for PD patients with levodopa-responsive fluctuations in rigidity and akinesia, for whom tremor is also a significant source of impairment...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28427709/upper-limb-impairment-is-associated-with-use-of-assistive-devices-and-unemployment-in-multiple-sclerosis
#5
Ruth Ann Marrie, Gary R Cutter, Tuula Tyry, Stacey S Cofield, Robert Fox, Amber Salter
BACKGROUND: Individuals with multiple sclerosis (MS) frequently suffer from impaired sensory function, reduced strength and tremor in the upper limbs, which may interfere with upper limb function. However, upper limb impairment in MS is under-recognized and understudied. We aimed to evaluate the prevalence of upper limb impairment in a large sample of persons with MS; the association between upper limb function and employment status in MS; and the frequency of use of assistive devices aimed at addressing upper limb impairments...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28426143/coronal-transcranial-sonography-and-m-mode-tremor-frequency-determination-in-parkinson-s-disease-and-essential-tremor
#6
Daniel Richter, Dirk Woitalla, Siegfried Muhlack, Ralf Gold, Lars Tönges, Christos Krogias
BACKGROUND AND PURPOSE: The axial mesencephalic transcranial sonography plane is an established and sensitive diagnostic tool for the differentiation of Parkinson's disease and essential tremor. However, the substantia nigra can also be depicted in a second coronal examination plane, whose diagnostic value has not yet been evaluated. Furthermore, the M-mode tremor frequency determination represents another sonographic tool, which might yield additional diagnostic value. METHODS: We included patients with diagnosed Parkinson's disease (n = 31), essential tremor (n = 16), and healthy age-matched controls (n = 16)...
April 20, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28425095/psychomotor-tremor-and-proprioceptive-control-problems-in-current-and-former-stimulant-drug-users-an-accelerometer-study-of-heavy-users-of-amphetamine-mdma-and-other-recreational-stimulants
#7
Luke A Downey, Brenda Tysse, Talitha C Ford, Angela C Samuels, Rory P Wilson, Andrew C Parrott
The recreational use of various stimulant drugs has been implicated in the development of movement disorders through dysregulation of the dopaminergic and serotoninergic neurotransmitter systems. The present study investigated psychomotor differences in current and former recreational stimulant drug users compared with nonusing controls. Sixty participants comprised 3 groups: 20 current stimulant drug users (CSUs; 11 men, aged 31.4 ± 9.1 years), 20 former stimulant drug users (FSUs; 5 men, aged 39.1 ± 8.5 years), and 20 nonuser controls (NUCs; 5 men, aged 35...
April 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28424962/phase-i-dose-escalation-study-of-milciclib-in-combination-with-gemcitabine-in-patients-with-refractory-solid-tumors
#8
Sandrine Aspeslagh, Kunwar Shailubhai, Rastilav Bahleda, Anas Gazzah, Andréa Varga, Antoine Hollebecque, Christophe Massard, Anna Spreafico, Michele Reni, Jean-Charles Soria
BACKGROUND: This phase I trial evaluated the safety and tolerability of milciclib, an inhibitor of multiple cyclin-dependent kinases and tropomycin receptor kinase A, in combination with gemcitabine in patients with refractory solid tumors. DESIGN: Sixteen patients were enrolled and treated with milciclib at three dose levels (45 mg/m(2)/day, n = 3; 60 mg/m(2)/day, n = 3; and 80 mg/m(2)/day, n = 10) with a fixed dose of gemcitabine (1000 mg/m(2)/day). Milciclib was administered orally once daily for 7 days on/7 days off in a 4-week cycle, and gemcitabine was administered intravenously on days 1, 8 and 15 in a 4-week cycle...
April 19, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28422926/targeting-high-calcineurin-inhibitor-levels-after-acute-rejection-with-less-tremor-a-new-strategy
#9
Tarek Alhamad, Karthikeyan Venkatachalam, Reem Daloul, Daniel Brennan, Andrew Malone
No abstract text is available yet for this article.
April 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28420978/resting-state-fmri-reveals-increased-subthalamic-nucleus-and-sensorimotor-cortex-connectivity-in-patients-with-parkinson-s-disease-under-medication
#10
Bo Shen, Yang Gao, Wenbin Zhang, Liyu Lu, Jun Zhu, Yang Pan, Wenya Lan, Chaoyong Xiao, Li Zhang
Functional connectivity (FC) between the subthalamic nucleus (STN) and the sensorimotor cortex is increased in off-medication patients with Parkinson's disease (PD). However, the status of FC between STN and sensorimotor cortex in on-medication PD patients remains unclear. In this study, resting state functional magnetic resonance imaging was employed on 31 patients with PD under medication and 31 healthy controls. Two-sample t-test was used to study the change in FC pattern of the STN, the FC strength of the bilateral STN was correlated with overall motor symptoms, while unilateral STN was correlated with offside motor symptoms...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420958/electrical-stimulation-of-afferent-pathways-for-the-suppression-of-pathological-tremor
#11
Jakob L Dideriksen, Christopher M Laine, Strahinja Dosen, Silvia Muceli, Eduardo Rocon, José L Pons, Julian Benito-Leon, Dario Farina
Pathological tremors are involuntary oscillatory movements which cannot be fully attenuated using conventional treatments. For this reason, several studies have investigated the use of neuromuscular electrical stimulation for tremor suppression. In a recent study, however, we found that electrical stimulation below the motor threshold also suppressed tremor, indicating involvement of afferent pathways. In this study, we further explored this possibility by systematically investigating how tremor suppression by afferent stimulation depends on the stimulation settings...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28418778/parkinsonism-signs-and-symptoms-in-agricultural-pesticide-handlers-in-washington-state
#12
Susan Searles Nielsen, Shu-Ching Hu, Harvey Checkoway, Maria Negrete, Pablo Palmández, Theresa Bordianu, Brad A Racette, Christopher D Simpson
OBJECTIVES: Examine associations between pesticide exposure and signs or symptoms of parkinsonism. METHODS: Prior to the 2014 pesticide spray season we examined 38 active pesticide handlers age 35-65 (median 43.5) who participated in the State of Washington's cholinesterase monitoring program in the Yakima Valley, where cholinesterase-inhibiting insecticides are applied in fruit orchards. A movement disorders specialist assessed the workers using the Unified Parkinson's Disease Rating Scale (UPDRS) motor subscore 3 (UPDRS3)...
April 18, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28415166/holmes-tremor-with-shoulder-pain-treated-by-deep-brain-stimulation-of-unilateral-ventral-intermediate-thalamic-nucleus-and-globus-pallidus-internus
#13
Sabri Aydın, Huseyin Canaz, Ezgi Tuna Erdogan, Nazlı Durmaz, Barıs Topcular
A 21-year-old male was admitted with severe right arm and hand tremors after a thalamic hemorrhage caused by a traffic accident. He was also suffering from agonizing pain in his right shoulder that manifested after the tremor. Neurologic examination revealed a disabling, severe, and irregular kinetic and postural tremor in the right arm during target-directed movements. There was also an irregular ipsilateral rest tremor and dystonic movements in the distal part of the right arm. The amplitude was moderate at rest and extremely high during kinetic and intentional movements...
April 18, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28414676/pheochromocytoma-of-the-organ-zuckerkandl
#14
C Lee, E Chang, J Gimenez, R McCarron
INTRODUCTION: Pheochromocytomas (PCCs);, or intra-adrenal paragangliomas (PGLs);, are neuroendocrine tumors arising within the adrenal medulla. Extra-adrenal paragangliomas may arise in the sympathetic or parasympathetic paraganglia and more rarely in other organs. One of the most common extra-adrenal sites is in the organ of Zuckerkandl, a collection of chromaffin cells near the origin of the inferior mesenteric artery or near the aortic bifurcation. The following is a case of a patient with resistant hypertension secondary to an extra-adrenal paraganglioma in the organ of Zuckerkandl...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413642/ginsenoside-rd-as-a-potential-neuroprotective-agent-prevents-trimethyltin-injury
#15
Jingang Hou, Jianjie Xue, Mira Lee, Changkeun Sung
Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including the neocortex, cerebellum, and hippocampus. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. TMT induced neurotoxicity in a seven-day primary hippocampal neuron culture in a dose-dependent manner (2.5-10 µM). However, pre-treatment with 20 µg/ml ginsenoside Rd for 24 h reversed the toxic action...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28412948/a-computerized-tablet-system-for-evaluating-treatment-of-essential-tremor-by-magnetic-resonance-guided-focused-ultrasound
#16
Fred Tam, Yuexi Huang, Michael L Schwartz, Tom A Schweizer, Kullervo Hynynen, Simon J Graham
BACKGROUND: Transcranial magnetic resonance guided focused ultrasound is an emerging technology under evaluation for treatment of essential tremor, a prevalent movement disorder. A qualitative evaluation is performed by a clinician periodically during the procedure to maximize treatment effects and minimize adverse effects. The present work demonstrates a magnetic resonance-compatible method to enable more precise, quantitative measurement of tremor severity. METHODS: Tremor severity was measured in 12 patients pre-, post-, and intra-operatively, using a magnetic resonance-compatible tablet and a computerized adaptation of drawing tasks from the widely-used Fahn-Tolosa-Marin Tremor Rating Scale...
April 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28412232/accuracy-of-video-observation-and-a-three-dimensional-head-tracking-system-for-detecting-and-quantifying-robot-simulated-head-movements-in-cone-beam-computed-tomography
#17
Rubens Spin-Neto, Louise H Matzen, Lars Schropp, Thomas S Sørensen, Erik Gotfredsen, Ann Wenzel
OBJECTIVES: To assess the accuracy of detecting robot-simulated head movements using video observation (VO) and 3-dimensional head tracking (HT) in a cone beam computed tomography examination setup. STUDY DESIGN: A mannequin head was mounted on a robot that was programmed to simulate patient head movements. Six types of movement (tremor, nodding, lateral rotation, lifting, swallowing, and anteroposterior translation), 3 distances (0.25, 1, and 5 mm), and 2 speeds (1 and 5 mm/s) were tested in triplicate (108 examinations)...
February 28, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28409827/topiramate-for-essential-tremor
#18
REVIEW
Elisa Bruno, Alessandra Nicoletti, Graziella Quattrocchi, Roberta Allegra, Graziella Filippini, Carlo Colosimo, Mario Zappia
BACKGROUND: Essential tremor (ET) is one of the most common movement disorders. The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy. However, these treatments can be ineffective in 25% to 55% of people and are frequently associated with serious adverse events (AEs). For these reasons, it is worthwhile evaluating other treatments for ET. Topiramate has been suggested as a potentially useful agent for the treatment of ET but there is uncertainty about its efficacy and safety...
April 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28409750/clinical-characteristics-of-parkinson-s-disease-developed-from-essential-tremor
#19
Dong-Woo Ryu, Si-Hoon Lee, Yoon-Sang Oh, Jae-Young An, Jeong-Wook Park, In-Uk Song, Kwang-Soo Lee, Joong-Seok Kim
BACKGROUND: Recent genetic and epidemiological studies have shown that there is a link between essential tremor and Parkinson's disease (PD). However, there is a lack of data about the clinical features of PD developed from essential tremor. OBJECTIVE: To explore and describe the clinical characteristics of Parkinson's disease developed from essential tremor (ET-PD). METHODS: Twenty-five ET-PD patients and 124 IPD controls were enrolled according to each criterion...
April 13, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28405133/risperidone-induced-adverse-drug-reactions-and-role-of-drd2-141-c-ins-del-and-5htr2c-759-c-t-genetic-polymorphisms-in-patients-with-schizophrenia
#20
Charanraj Goud Alladi, Anbarasan Mohan, Deepak Gopal Shewade, Ravi Philip Rajkumar, Surendiran Adithan, Karthick Subramanian
OBJECTIVE: To determine the adverse drug reaction (ADR) profile of risperidone and their association with dopamine (DRD2 - 141 C Ins/Del/rs1799732) and serotonin receptor (5HTR2C -759 C>T/rs3813929) gene polymorphisms in patients with schizophrenia. MATERIALS AND METHODS: The study was conducted among 289 patients who were diagnosed with schizophrenia and were on treatment with risperidone (4-8 mg/day)-based therapy for a minimum of 4 weeks. Genotyping was carried by real-time quantitative polymerase chain reaction...
January 2017: Journal of Pharmacology & Pharmacotherapeutics
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