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Obese asthma

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https://www.readbyqxmd.com/read/28738263/prenatal-exposure-to-pm2-5-and-birth-weight-a-pooled-analysis-from-three-north-american-longitudinal-pregnancy-cohort-studies
#1
Maria José Rosa, Ashley Pajak, Allan C Just, Perry E Sheffield, Itai Kloog, Joel Schwartz, Brent Coull, Michelle Bosquet Enlow, Andrea A Baccarelli, Kathi Huddleston, John E Niederhuber, Martha María Téllez Rojo, Robert O Wright, Chris Gennings, Rosalind J Wright
A common practice when analyzing multi-site epidemiological data is to include a term for 'site' to account for unmeasured effects at each location. This practice should be carefully considered when site can have complex relationships with important demographic and exposure variables. We leverage data from three longitudinal North American pregnancy cohorts to demonstrate a novel method to assess study heterogeneity and potential combinability of studies for pooled analyses in order to better understand how to consider site in analyses...
July 21, 2017: Environment International
https://www.readbyqxmd.com/read/28737966/effect-of-obesity-on-sinonasal-disease-in-asthma
#2
S Kanagalingam, S S Shehab, D A Kaminsky, R A Wise, J E Lang, A E Dixon
Sinonasal disease can contribute to poor asthma control. There are reports that link obesity with an increased prevalence of sinonasal disease, but no studies evaluating the severity of sinonasal disease in obese asthmatics, and how this impacts asthma control. The purpose of the current study was to determine if obesity is associated with increased severity of sinonasal disease, and/or affects response to nasal corticosteroid treatment in asthma. METHODS: This study included 236 adults participating in a 24-week randomized, double-masked, placebo-controlled study of nasal mometasone for the treatment of poorly controlled asthma...
July 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28737861/effects-of-25-hydroxy-vitamin-d-levels-on-the-severity-and-asthma-control-in-school-age-asthma-patients
#3
Merve Havan, Cem H Razi, Ayse D Bulus, Ali O Köksal, Nesibe Andıran
BACKGROUND: The objective was to determine vitamin D levels in patients between the ages 6 and 18 years, followed for asthma, and the relation between vitamin D levels and asthma control and severity. MATERIALS AND METHODS: Patients with asthma and healthy volunteers between the ages 6 and 18 years were enrolled into the study as patient and control groups, respectively. Patient demographic information and clinical findings were recorded; a respiratory function test was performed...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28734857/comorbidities-in-difficult-to-control-asthma
#4
Pieter-Paul W Hekking, Marijke Amelink, Reinier R Wener, Marcel L Bouvy, Elisabeth H Bel
BACKGROUND: Difficult-to-control asthma is associated with significant medical and financial burden. Comorbidities are known to contribute to uncontrolled asthma. Better insight into the prevalence, nature, and risk factors of comorbidities may optimize treatment strategies in patients with difficult-to-control asthma and decrease disease burden. OBJECTIVES: The objectives of this study were to assess the prevalence, number, and type of comorbidities in difficult-to-control asthma compared with not-difficult-to-control asthma, and to investigate whether specific patient characteristics are associated with particular comorbidities...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734819/the-prevalence-of-chronic-conditions-and-poor-health-among-people-with-and-without-vision-impairment-aged-%C3%A2-65-years-2010-2014
#5
John E Crews, Chiu-Fang Chou, Swathi Sekar, Jinan B Saaddine
PURPOSE: To examine the prevalence of 13 chronic conditions and fair/poor health among people aged ≥65 years in the U.S. with and without vision impairment. DESIGN: Cross-sectional study from the 2010-2014 National Health Interview Survey METHODS: We examined hypertension, heart disease, high cholesterol, stroke, arthritis, asthma, chronic obstructive pulmonary disease, cancer, weak/failing kidneys, diabetes, hepatitis, depression, and hearing impairment. We used logistic regression to show the association between vision impairment and chronic conditions and the association between vision impairment and poor health for those with chronic conditions...
July 19, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28733686/comparison-of-the-proportion-and-healthcare-utilisation-of-adult-patients-with-uncontrolled-severe-asthma-versus-non-severe-asthma-seen-in-a-southeast-asian-hospital-based-respiratory-specialist-clinic
#6
Tunn Ren Tay, Hang Siang Wong, Rosna Ihsan, Hsiao Peng Toh, Xuening Choo, Augustine Kh Tee
INTRODUCTION: Understanding the burden of uncontrolled severe asthma is essential for disease-targeted healthcare planning. There is a scarcity of data regarding the proportion, healthcare utilisation and costs of patients with uncontrolled severe asthma in Asia. This study aimed to plug the knowledge gap in this area. MATERIALS AND METHODS: Consecutive patients with asthma managed in our respiratory specialist clinic were evaluated prospectively. Healthcare utilisation comprising unscheduled asthma-related primary care visits, emergency department (ED) visits and hospital admissions were obtained from the national health records system...
June 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28727539/state-and-local-chronic-disease-surveillance-using-electronic-health-record-systems
#7
Michael Klompas, Noelle M Cocoros, John T Menchaca, Diana Erani, Ellen Hafer, Brian Herrick, Mark Josephson, Michael Lee, Michelle D Payne Weiss, Bob Zambarano, Karen R Eberhardt, Jessica Malenfant, Laura Nasuti, Thomas Land
OBJECTIVES: To assess the feasibility of chronic disease surveillance using distributed analysis of electronic health records and to compare results with Behavioral Risk Factor Surveillance System (BRFSS) state and small-area estimates. METHODS: We queried the electronic health records of 3 independent Massachusetts-based practice groups using a distributed analysis tool called MDPHnet to measure the prevalence of diabetes, asthma, smoking, hypertension, and obesity in adults for the state and 13 cities...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28696535/bmi-predicts-exercise-induced-bronchoconstriction-in-asthmatic-boys
#8
Wilma J van Veen, Jean M M Driessen, Elin T G Kersten, Janneke C van Leeuwen, Marjolein G J Brusse-Keizer, Wim M C van Aalderen, Bernard J Thio
BACKGROUND: Exercise induced bronchoconstriction (EIB) is a frustrating morbidity of asthma in children. Obesity has been associated with asthma and with more severe EIB in asthmatic children. OBJECTIVES: To quantify the effect of BMI on the risk of the occurrence of EIB in children with asthma. METHODS: Data were collected from six studies in which exercise challenge tests were performed according to international guidelines. We included 212 Children aged 7-18 years, with a pediatrician-diagnosed mild-to-moderate asthma...
July 11, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28696379/obesity-and-asthma-a-missing-link
#9
REVIEW
Mª Amelia Gomez-Llorente, Raquel Romero, Natalia Chueca, Ana Martinez-Cañavate, Carolina Gomez-Llorente
Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women...
July 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28692781/depression-as-a-risk-factor-of-organic-diseases-an-international-integrative-review
#10
Teodora Bica, Ruth Castelló, Loren L Toussaint, Pilar Montesó-Curto
PURPOSE AND DESIGN: This integrative review offers a systematic synthesis of the international literature regarding the role of depression as a risk factor in physical illnesses and the mechanisms of this connection. Special attention is paid to those modifiable factors. FINDINGS: Published studies of depression and physical illness and disease(N = 24) from five countries that were indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycNET, Scopus, Dialnet, and CUIDEN were examined...
July 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28684597/dynamic-hyperinflation-and-exercise-limitations-in-obese-asthmatic-women
#11
Palmira Gabriele Ferreira, Patricia Duarte Freitas, Aline Grandi Silva, Desiderio Cano Porras, Rafael Stelmach, Alberto Cukier, Frederico Leon Arrabal Fernandes, Mílton A Martins, Celso R F Carvalho
Obese individuals and patients with asthma can develop dynamic hyperinflation (DH) during exercise; however, no previous study has investigated DH as a factor associated with reduced exercise capacity in obese asthmatic women. The aim of the present study was to examine the occurrence of DH and exercise limitations in obese asthmatics. Obese grade II (obese group (Ob-G); BMI 35-39.9 kg/m2; n=36) and non-obese (non-obese group (NOb-G); BMI 18.5-29.9 kg/m2; n=18) asthmatic patients performed a cardiopulmonary test to quantify peak VO2 and a submaximal exercise test to assess DH...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28680543/a-population-based-cohort-of-adults-with-asthma-mortality-and-participation-in-a-long-term-follow-up
#12
Helena Backman, Linnea Hedman, Caroline Stridsman, Sven-Arne Jansson, Anne Lindberg, Bo Lundbäck, Eva Rönmark
Background and objective: Asthma is a major public health concern. The aim of this study was to characterize a large population-based cohort of adults with asthma, and to study factors associated with all-cause mortality and non-participation in a long-term follow-up. Design: Random and stratified samples from five population-based cohorts were clinically examined during 1986-2001, and all subjects with asthma were included in the study (n = 2055, age 19-72 years, 55% women). Independent associations between different risk factors and (i) mortality and (ii) non-participation in a clinical follow-up in 2012-2014 were estimated...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28673295/the-impact-of-racial-discrimination-on-the-health-of-australian-indigenous-children-aged-5-10%C3%A2-years-analysis-of-national-longitudinal-data
#13
Carrington C J Shepherd, Jianghong Li, Matthew N Cooper, Katrina D Hopkins, Brad M Farrant
BACKGROUND: A growing body of literature highlights that racial discrimination has negative impacts on child health, although most studies have been limited to an examination of direct forms of racism using cross-sectional data. We aim to provide further insights on the impact of early exposure to racism on child health using longitudinal data among Indigenous children in Australia and multiple indicators of racial discrimination. METHODS: We used data on 1239 Indigenous children aged 5-10 years from Waves 1-6 (2008-2013) of Footprints in Time, a longitudinal study of Indigenous children across Australia...
July 3, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28671393/top-20-research-studies-of-2016-for-primary-care-physicians
#14
Mark H Ebell, Roland Grad
This article summarizes the top 20 original research studies and four practice guidelines of 2016, based on regular literature surveillance and as selected by members of the Canadian Medical Association. The studies, known as POEMs (patient-oriented evidence that matters), were rated highly because of their relevance, validity, and potential to change practice. Key hypertension treatment findings include reduced mortality (a benefit not demonstrated in lower-risk persons or persons with diabetes mellitus) but also an increase in harms with a more aggressive blood pressure target in high-risk persons with hypertension and without diabetes...
May 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28670116/treatment-trends-in-patients-with-asthma-copd-overlap-syndrome-in-a-copd-cohort-findings-from-a-real-world-survey
#15
Bo Ding, Mark Small
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized phenotype. Few randomized clinical trials have been conducted in patients with ACOS; therefore, scientific evidence concerning ACOS is scarce and a therapeutic approach remains unclear. The aim of this study was to evaluate current treatment trends for patients with ACOS, identified as those with a dual definition of asthma and COPD, in a real-world COPD cohort. METHODS: Data were analyzed from patients with asthma and COPD in the USA, France, Germany, Italy, Spain, and the UK who participated in the 2012 and 2013 Adelphi Respiratory Disease Specific Programmes (DSPs)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28668238/genetic-variants-and-risk-of-asthma-in-an-american-indian-population
#16
Lyle G Best, Crystal Azure, Alexandre Segarra, Kendra J Enright, Shawn Hamley, Dara Jerome, Marcia A O'Leary, Rae A O'Leary, Ashley Parisien, Kayana Trottier, Joseph M Yracheta, Dara G Torgerson
BACKGROUND: Asthma is recognized as a complex, multifactorial disease with a genetic component that is well recognized. Certain genetic variants are associated with asthma in a number of populations. OBJECTIVE: To determine whether the same variants increase the risk of asthma among American Indian children. METHODS: The electronic medical records of an Indian Health Service facility identified all children between 6 and 17 years of age with case-defining criteria for asthma (n = 108)...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28668107/asthma-in-older-people-hospitalized-with-influenza-in-spain-a-case-control-study
#17
María Morales-Suárez-Varela, Agustín Llopis-González, Carlos Vergara-Hernández, Estrella Fernandez-Fabrellas, Francisco Sanz, María José Perez-Lozano, Vicente Martin, Jenaro Astray, Jesús Castilla, Mikel Egurrola, Luis Force, Diana Toledo, Àngela Domínguez
BACKGROUND: Influenza infection is an exacerbating factor for asthma, and its prevention is critical in older patients with asthma. OBJECTIVE: This study investigated the association between asthma and influenza-related hospitalization, in Spain, of patients ages ≥ 65 years and their clinical evolution. METHODS: A multicenter case-control study was carried out in 20 Spanish hospitals during the 2013-2014 and 2014-2015 influenza seasons. Patients ages ≥ 65 years hospitalized with laboratory-confirmed influenza with and without asthma were matched with controls according to the presence of asthma, sex, age, hospital, and date of hospitalization...
July 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28661182/prenatal-nitrate-exposure-and-childhood-asthma-influence-of-maternal-prenatal-stress-and-fetal-sex
#18
Sonali Bose, Yueh-Hsiu M Chiu, Hsiao-Hsien L Hsu, Qian Di, Maria José Rosa, Alison Lee, Itai Kloog, Ander Wilson, Joel Schwartz, Robert O Wright, Sheldon Cohen, Brent A Coull, Rosalind J Wright
RATIONALE: Impact of ambient pollution upon children's asthma may differ by sex, and exposure dose and timing. Psychosocial stress can also modify pollutant effects. These associations have not been examined for in utero ambient nitrate exposure. OBJECTIVES: We implemented Bayesian distributed lag interaction models (BDLIMs), to identify sensitive prenatal windows for the influence of NO3- on child asthma, accounting for effect modification by sex and stress. METHODS: Analyses included 752 mother-child dyads...
June 29, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28659218/effect-of-dietary-consumption-as-a-modifier-on-the-association-between-fto-gene-variants-and-excess-body-weight-in-children-from-an-admixed-population-in-brazil-the-social-changes-asthma-and-allergy-in-latin-america-scaala-cohort-study
#19
Marília Vilella, Gustavo Nunes de Oliveira Costa, Maurício Lima Barreto, Camila Alexandrina Figueredo, Neuza Maria Alcantara-Neves, Laura Cunha Rodrigues, Sheila Maria Alvim de Matos, Rosemeire Leovigildo Fiaccone, Pablo Oliveira, Aline Rocha, Rita de Cássia Ribeiro-Silva
Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene...
June 29, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28658728/-mediators-of-inflammatory-response-in-asthma-and-its-association-with-obesity
#20
Gustavo Galicia-Negrete, Ramcés Falfán-Valencia
There is an increase in the prevalence of asthma and obesity, constituting a public health problem at national and global levels. The association between the two pathologies has not been clearly determined; however, a certain synergy has been proposed, which leads to more severe bronchospasms, longer recovery time, and more prolonged use of medications in obese asthmatic patients. The discovery of leptin, an adipokine that is directly related to the amount of total body fat and the production of proinflammatory cytokines, has generated greater interest in white adipose tissue...
April 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
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