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https://www.readbyqxmd.com/read/29236387/effect-of-3-substituted-1-4-benzodiazepin-2-ones-on-bradykinin-induced-smooth-muscle-contraction
#1
P A Virych, O V Shelyuk, T A Kabanova, E I Khalimova, V S Martynyuk, V I Pavlovsky, S A Andronati
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contraction in rats was investigated. Compounds MX-1775 and MX-1828 demonstrated the similar inhibition effect on bradykinin-induced contraction of smooth muscle like competitive inhibitor des-arg9-bradykinin-acetate to bradykinin B2-receptors. MX-1626 demonstrated unidirectional changes of maximal normalized rate and force of smooth muscle that proportionally depended on bradykinin concentration in the range 10-10-10-6 M...
January 2017: Ukrainian Biochemical Journal
https://www.readbyqxmd.com/read/29236300/creepiness-creeps-in-uncanny-valley-feelings-are-acquired-in-childhood
#2
Kimberly A Brink, Kurt Gray, Henry M Wellman
The uncanny valley posits that very human-like robots are unsettling, a phenomenon amply demonstrated in adults but unexplored in children. Two hundred forty 3- to 18-year-olds viewed one of two robots (machine-like or very human-like) and rated their feelings toward (e.g., "Does the robot make you feel weird or happy?") and perceptions of the robot's capacities (e.g., "Does the robot think for itself?"). Like adults, children older than 9 judged the human-like robot as creepier than the machine-like robot-but younger children did not...
December 13, 2017: Child Development
https://www.readbyqxmd.com/read/29236277/clouds-of-different-colors-a-prospective-look-at-head-and-neck-surgical-resident-call-experience
#3
Jonathan Melzer
Graduate medical education programs typically set up call under the assumption that residents will have similar experiences. The terms black cloud and white cloud have frequently been used to describe residents with more difficult (black) or less difficult (white) call experiences. This study followed residents in the department of head and neck surgery during call to determine whether certain residents have a significantly different call experience than the norm. It is a prospective observational study conducted over 16 months in a tertiary care center with a resident training program in otolaryngology...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236217/the-association-between-medical-diagnosis-and-caregiver-burden-a-cross-sectional-study-of-recipients-of-informal-support-and-caregivers-from-the-general-population-study-good-aging-in-sk%C3%A3-ne-sweden
#4
Sölve Elmståhl, Beth Dahlrup, Henrik Ekström, Eva Nordell
BACKGROUND: Different kinds of chronic diseases might imply different dimensions of caregiver burden, not previously described among the caregivers to recipients from the general elder population. AIM: The main objective was to examine differences in burden between the 343 caregivers to persons with different diagnoses. METHODS: A group of elderly recipients of informal care (n = 343) from the general population study 'Good Aging in Skåne' (GÅS) Sweden, were divided into five diagnostic groups: dementia (n = 90), heart and lung diseases (n = 48), stroke (n = 62), fractures (n = 66), depression (n = 40) and the group "other", consisting of different diagnoses (n = 37) according to ICD-10...
December 13, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29236210/perceptions-of-physical-activity-participation-among-adolescents-with-autism-spectrum-disorders-a-conceptual-model-of-conditional-participation
#5
Susann Arnell, Kajsa Jerlinder, Lars-Olov Lundqvist
Adolescents with an autism spectrum disorder (ASD) are less physically active compared to typically developing peers. The reasons for not being physically active are complex and depend on several factors, which have not been comprehensively described from the adolescent's perspective. Therefore, the aim was to describe how adolescents with an ASD perceive, experience and reflect on their participation in physical activity. Interviews with 24 adolescents diagnosed with high-functioning ASD, aged 12-16 years, were analysed with qualitative content analysis with an inductive approach...
December 13, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29236163/evaluation-of-pain-perception-associated-with-use-of-the-magnetic-end-ureteric-double-j-stent-for-short-term-ureteric-stenting
#6
S Sevcenco, K Eredics, L Lusuardi, Hans Christoph Klingler
PURPOSE: To investigate the morbidity, complication rate, and pain perception during removal of a novel ureteric stent with a magnetic end using a-traumatic retrieval catheter. METHODS: Between November 2013 and July 2015, 151 consecutive patients who underwent semirigid ureterorenoscopy (URS) for stone removal were prospectively enrolled. Stent removal was performed under local anesthesia using a special magnetic-end stent remover 1 week following URS. At follow-up, we obtained patients' medical history, urine culture result, renal ultrasonogram, and visual analog scale (VAS) score regarding stent irritation (VAS 1) and pain during removal (VAS 2)...
December 13, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29236127/-basic-knowledge-on-the-efficacy-of-hearing-aids-depending-on-the-type-of-hearing-impairment-for-ear-nose-throat-specialists
#7
REVIEW
T Steffens, S C Marcrum
For Ear, Nose & Throat specialists, the physiological and psychoacoustical deficits related to hearing impairment and the compensatory capabilities of hearing aids are topics of prime importance. In conductive hearing loss, the foremost deficit is decreased audibility, for which hearing aids can compensate almost entirely through the use of level independent gain. In the instance of sensorineural hearing loss, however, the irreversible loss of outer and inner hair cells causes a distorted sound perception, which is particularly troublesome when trying to understand speech in noisy environments...
December 13, 2017: HNO
https://www.readbyqxmd.com/read/29236094/hospital-perceptions-of-medicare-s-sepsis-quality-reporting-initiative
#8
Ian J Barbash, Kimberly J Rak, Courtney C Kuza, Jeremy M Kahn
BACKGROUND: In October 2015, the Centers for Medicare and Medicaid Services (CMS) implemented the Sepsis CMS Core Measure (SEP-1) program, requiring hospitals to report data on the quality of care for their patients with sepsis. OBJECTIVE: We sought to understand hospital perceptions of and responses to the SEP-1 program. DESIGN: A thematic content analysis of semistructured interviews with hospital quality officials. SETTING: A stratified random sample of short-stay, nonfederal, general acute care hospitals in the United States...
December 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29236014/identification-of-potential-sewer-mining-locations-a-monte-carlo-based-approach
#9
I K Tsoukalas, C K Makropoulos, S N Michas
Rapid urbanization affecting demand patterns, coupled with potential water shortages due to supply side impacts of climatic changes, has led to the emergence of new technologies for water and wastewater reuse. Sewer mining (SM) is a novel decentralized option that could potentially provide non-potable water for urban uses, including for example the irrigation of urban green spaces, providing a mid-scale solution to effective wastewater reuse. SM is based on extracting wastewater from local sewers and treatment at the point of demand and entails in some cases the return of treatment residuals back to the sewer system...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235967/effect-of-alternating-postures-on-cognitive-performance-for-healthy-people-performing-sedentary-work
#10
Bernhard Schwartz, Jay M Kapellusch, Andreas Schrempf, Kathrin Probst, Michael Haller, Arnold Baca
Prolonged sitting is a risk factor for several diseases and the prevalence of worksite-based interventions such as sit-to-stand workstations is increasing. Although their impact on sedentary behaviour has been regularly investigated, the effect of working in alternating body postures on cognitive performance is unclear. To address this uncertainty, forty-five students participated in a two-arm, randomized controlled cross-over trial under laboratory conditions. Subjects executed validated cognitive tests (working speed, reaction time, concentration performance) either in sitting or alternating working postures on two separate days (ClinicalTrials...
December 13, 2017: Ergonomics
https://www.readbyqxmd.com/read/29235943/-trapped-in-an-empty-waiting-room-the-existential-human-core-of-loneliness-in-old-age-a-meta-synthesis
#11
Gabriele Kitzmüller, Anne Clancy, Mojtaba Vaismoradi, Charlotte Wegener, Terese Bondas
Loneliness in old age has a negative influence on quality of life, health, and survival. To understand the phenomenon of loneliness in old age, the voices of lonely older adults should be heard. Therefore, the purpose of this meta-synthesis was to synthesize scientific studies of older adults' experiences of loneliness. Eleven qualitative articles that met the inclusion criteria were analyzed and synthesized according to Noblit and Hare's meta-ethnographic approach. The analysis revealed the overriding meaning of the existential human core of loneliness in old age expressed through the metaphor "trapped in an empty waiting room...
January 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29235935/interplay-of-gravicentric-egocentric-and-visual-cues-about-the-vertical-in-the-control-of-arm-movement-direction
#12
Otmar Bock, Nils Bury
Our perception of the vertical corresponds to the weighted sum of gravicentric, egocentric, and visual cues. Here we evaluate the interplay of those cues not for the perceived but rather for the motor vertical. Participants were asked to flip an omnidirectional switch down while their egocentric vertical was dissociated from their visual-gravicentric vertical. Responses were directed mid-between the two verticals; specifically, the data suggest that the relative weight of congruent visual-gravicentric cues averages 0...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/29235594/salivary-endocannabinoids-and-n-acylethanolamines-upon-mastication-of-a-semisolid-food-implications-in-fat-taste-appetite-and-food-liking
#13
Ilario Mennella, Rossella Di Monaco, Adriana Balazy, Rosalia Ferracane, Nicoletta A Miele, Silvana Cavella, Paola Vitaglione
This study aimed to evaluate whether salivary endocannabinoid (EC) and N-acylethanolamine (NAE) concentrations upon mastication of a semisolid food were involved in the sensory perception of fat taste, food liking and appetite in humans. A fat-enriched (FEP) and a low-fat control (CP) pudding were developed and used in a randomized cross-over study with 19 healthy volunteers. The study protocol combined a Modified Sham-Feeding (MSF) with a multiple-spoon Temporal Dominance of Sensations method. Subjects masticated and expectorated 10 spoons of the pudding and selected the dominant sensations among a list of attributes...
December 13, 2017: Food & Function
https://www.readbyqxmd.com/read/29235437/impact-of-a-in-situ-laboratory-on-physician-expectancy
#14
Romain Brulé, Marianne Sarazin, Nicole Tayeb, Martine Roubille, Anton Szymanowicz
Biological examinations are essential for clinicians' medical care. The aim of this study is to assess clinicians' expectations in healthcare facilities and their perception of medical biology in different types of organization. We performed a prospective transversal study by electronic questionnaire conducted among 242 practitioners in four healthcare facilities. The aspects explored were as follows: quality, reliability, rendering time of examination results and biology platform support. Analyses were conducted after rectification of the sample by weight...
December 13, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29235370/factors-determining-perceptions-of-fairness-in-access-to-hospital-outpatient-departments-in-taiwan
#15
Ta-Ping Lu, Pei-Luen Patrick Rau, Zhi Guo, Cui-Ling Chen
Objectives To investigate the effects of four factors on perceptions of fairness in access to outpatient services: proportions of walk-in versus scheduled registration, consultation queues, regulations for late patients and particular categories of patients getting better access. Methods A total of 124 young adults were asked to consider nine different scenarios and report their views of the fairness of each one. Results As regards the balance of types of patients, 60% walk-in registration was seen as fair to both walk-in and scheduled patients...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29235229/self-imposed-pressure-or-organizational-norms-further-examination-of-the-construct-of-workplace-telepressure
#16
Matthew J Grawitch, Paul M Werth, Sarah N Palmer, Kaitlyn R Erb, Kristi N Lavigne
Information and communication technologies (ICTs) are rapidly becoming indispensable organizational tools. Though the benefits of such technologies have been trumpeted, recent research has examined the unique pressures that may be introduced through the lens of a construct called workplace telepressure, defined as an urge for and preoccupation with quickly responding to ICTs (e.g., email). The current study further explores the workplace telepressure construct as a unique contributor to measures of workplace well-being over and above perceived workplace demands and individual differences, introducing new constructs into the study of workplace telepressure...
December 13, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29235175/acetate-provokes-mitochondrial-stress-and-cell-death-in-ustilago-maydis
#17
Matthias Kretschmer, Scott Lambie, Daniel Croll, James W Kronstad
The fungal pathogen Ustilago maydis causes disease on maize by mating to establish an infectious filamentous cell type that invades the host and induces tumours. We previously found that β-oxidation mutants were defective in virulence and did not grow on acetate. Here we demonstrate that acetate inhibits filamentation during mating and in response to oleic acid. We therefore examined the influence of different carbon sources by comparing the transcriptomes of cells grown on acetate, oleic acid or glucose, with expression changes for the fungus during tumour formation in planta...
December 13, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29235132/mitochondrial-donation-patient-engagement-and-narratives-of-hope
#18
Cathy Herbrand, Rebecca Dimond
This article develops the sociology of hope and patient engagement by exploring how patients' perceptions and actions are shaped by narratives of hope surrounding the clinical introduction of novel reproductive techniques. In 2015, after extensive public debates, the UK became the first country to legalise a mitochondrial donation technique aimed at preventing the transmission of inherited disorders. The article draws on the accounts of twenty-two women of reproductive age who are at risk of having a child with mitochondrial disease and would be the potential target of the technique...
December 12, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29234956/work-participation-among-employees-with-common-mental-disorders-a-meta-synthesis
#19
REVIEW
Cecilie Nørby Thisted, Claus Vinther Nielsen, Merete Bjerrum
Purpose The aim was to aggregate knowledge about the opportunities, challenges and need for support employees with common mental disorders experience in relation to work participation in order to develop recommendations for practice. Methods A meta-synthesis was conducted using a meta-aggregative approach to accurately and reliably present findings that could be used to meet our aim. Qualitative inductive content analysis was used to analyze and synthesize the findings. Results In all, 252 findings were extracted from 16 papers, and six categories were generated and aggregated into two synthesized findings...
December 12, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29234861/neural-coding-of-sound-envelope-structure-in-songbirds
#20
Santiago Boari, Ana Amador
Songbirds are a well-established animal model to study the neural basis of learning, perception and production of complex vocalizations. In this system, telencephalic neurons in HVC present a state-dependent, highly selective response to auditory presentations of the bird's own song (BOS). This property provides an opportunity to study the neural code behind a complex motor behavior. In this work, we explore whether changes in the temporal structure of the sound envelope can drive changes in the neural responses of highly selective HVC units...
December 12, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
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