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Immune cell VIN vulvar cancer immunology

Emma J Davidson, Christopher M Boswell, Peter Sehr, Michael Pawlita, Anne E Tomlinson, Rhona J McVey, Jennifer Dobson, John St C Roberts, Julian Hickling, Henry C Kitchener, Peter L Stern
This study assessed the immunological and clinical responses of women with human papillomavirus (HPV) 16-associated high-grade vulval intraepithelial neoplasia (VIN) vaccinated with TA-HPV, a recombinant vaccinia virus encoding modified HPV 16 and 18 E6 and E7. Eighteen women with HPV 16-positive high-grade VIN were vaccinated with TA-HPV. The extent of their baseline disease was compared after 24 weeks by lesion measurements and histological analysis. Viral load was assessed pre- and postvaccination by real time PCR...
September 15, 2003: Cancer Research
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