keyword
https://read.qxmd.com/read/38547441/association-between-cervical-inflammatory-mediators-and-prevalent-cervical-human-papillomavirus-infection
#1
JOURNAL ARTICLE
Temitope Olukomogbon, Bernice Akpobome, Aderonke Omole, Clement A Adebamowo, Sally N Adebamowo
PURPOSE: Inflammatory mediators are important regulators of immune response and can modulate the inflammation caused by viral infections, including human papillomavirus (HPV). In this study, we evaluated the association between cervical immune mediators, including chemokines, cytokines, and growth factors with HPV infections. MATERIALS AND METHODS: We used a nonmagnetic bead-based multiplex assay to determine 27 immune mediators in cervical secretions collected from 275 women in a prospective longitudinal cohort design...
March 2024: JCO global oncology
https://read.qxmd.com/read/38547430/metabolomics-of-multiple-sclerosis-lesions-demonstrates-lipid-changes-linked-to-alterations-in-transcriptomics-based-cellular-profiles
#2
JOURNAL ARTICLE
Dimitrios C Ladakis, Edoardo Pedrini, Maria I Reyes-Mantilla, Muraleetharan Sanjayan, Matthew D Smith, Kathryn C Fitzgerald, Carlos A Pardo, Daniel S Reich, Martina Absinta, Pavan Bhargava
BACKGROUND AND OBJECTIVES: People with multiple sclerosis (MS) have a dysregulated circulating metabolome, but the metabolome of MS brain lesions has not been studied. The aims of this study were to identify differences in the brain tissue metabolome in MS compared with controls and to assess its association with the cellular profile of corresponding tissue. METHODS: MS tissues included samples from the edge and core of chronic active or inactive lesions and periplaque white matter (WM)...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/38547428/eosinophil-expression-of-triggering-receptor-expressed-on-myeloid-cells-1-trem-1-restricts-type-2-lung-inflammation
#3
JOURNAL ARTICLE
Jayden L Bowen, Kathy Keck, Sankar Baruah, Kathy H Nguyen, Andrew L Thurman, Alejandro A Pezzulo, Julia Klesney-Tait
Asthma affects 25 million Americans and recent advances in treatment are effective for only a portion of severe asthma patients. Triggering Receptor Expressed on Myeloid cells 1 (TREM-1), an innate receptor that canonically amplifies inflammatory signaling in neutrophils and monocytes, plays a central role in regulating lung inflammation. It is unknown how TREM-1 contributes to allergic asthma pathology. Utilizing a murine model of asthma, flow cytometry revealed TREM-1+ eosinophils in the lung tissue and airway during allergic airway inflammation...
March 28, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38547424/in-vitro-effect-of-diazoxon-on-cell-signaling-and-second-messengers-in-nile-tilapia-oreochromis-niloticus-leukocytes
#4
JOURNAL ARTICLE
Milton Rafael Camacho-Pérez, Karina Janice Guadalupe Díaz-Resendiz, Rocío Ortiz-Butrón, Carlos Eduardo Covantes-Rosales, Alma Betsaida Benitez-Trinidad, Daniel Alberto Girón-Pérez, Gladys Alejandra Toledo-Ibarra, Lenin Pavón, Manuel Iván Girón-Pérez
The physiological and molecular responses of leukocytes are altered by organophosphate pesticides (OPs). Some reports have shown that diazinon (DZN) causes immunotoxic effects; diazoxon (DZO), the oxon metabolite of DZN, is attributed to influence the immune response by affecting the leukocyte cholinergic system. In this study, the in vitro effects of DZO on molecules involved in cell signaling (cAMP, IP3, DAG, JAK1, and STAT3), which play a crucial role in the activation, differentiation, and survival of leukocytes, were evaluated...
March 28, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38547421/comprehensive-immunogenomic-profiling-of-idh1-2-altered-cholangiocarcinoma
#5
JOURNAL ARTICLE
Shalini Makawita, Sunyoung Lee, Elisabeth Kong, Lawrence N Kwong, Zeyad Abouelfetouh, Anaemy Danner De Armas, Lianchun Xiao, Karthikeyan Murugesan, Natalie Danziger, Dean Pavlick, Anil Korkut, Jeffrey S Ross, Milind Javle
PURPOSE: Isocitrate dehydrogenase ( IDH ) 1 / 2 genomic alterations (GA) occur in 20% of intrahepatic cholangiocarcinoma (iCCA); however, the immunogenomic landscape of IDH1-/2- mutated iCCA is largely unknown. METHODS: Comprehensive genomic profiling (CGP) was performed on 3,067 cases of advanced iCCA. Tumor mutational burden (TMB), PD-L1 expression (Dako 22C3), microsatellite instability (MSI), and genomic loss of heterozygosity (gLOH) as a surrogate marker for homologous recombination deficiency were examined...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38547417/pathologic-features-of-anti-ku-myositis
#6
JOURNAL ARTICLE
Munenori Oyama, Marie-Therese Holzer, Yuko Ohnuki, Yoshihiko Saito, Yukako Nishimori, Shingo Suzuki, Takashi Shiina, Sarah Leonard-Louis, Olivier Benveniste, Udo Schneider, Werner Stenzel, Ichizo Nishino, Shigeaki Suzuki, Akinori Uruha
OBJECTIVE: Characteristics of myositis with anti-Ku antibodies are poorly understood. The purpose of this study was to elucidate the pathologic features of myositis associated with anti-Ku antibodies, compared with immune-mediated necrotizing myopathy (IMNM) with anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies, in muscle biopsy-oriented registration cohorts in Japan and Germany. METHODS: We performed a retrospective pathology review of patients with anti-Ku myositis samples diagnosed in the Japanese and German cohorts...
April 23, 2024: Neurology
https://read.qxmd.com/read/38547331/circulating-factors-in-cancer-cachexia-recent-opportunities-for-translational-research
#7
JOURNAL ARTICLE
Marina de Castro Coêlho, Giovana Parreira de Aquino, Amanda Soares Santos, Marilia Seelaender
PURPOSE OF REVIEW: To discuss the recent discoveries and limitations of the available literature on emerging circulating biomarkers of cancer cachexia. RECENT FINDINGS: Studies on circulating factors in cancer cachexia show promising alternatives for diagnosing the syndrome in a minimally invasive manner in the clinic setting, as well as potential targets for cancer cachexia treatment. Factors secreted by the tumor and the adipose tissue, such as extracellular vesicles and soluble proteins, respectively, have been shown to either directly induce wasting in vitro and in vivo or to be altered in the cachectic phenotype...
March 27, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547316/chronic-viral-infection-impairs-immune-memory-to-a-different-pathogen
#8
JOURNAL ARTICLE
Cheng Yang, Zhicui Liu, Ying Yang, Luis J Cocka, Yongguo Li, Weihong Zeng, Hao Shen
Chronic viral infections cause T cell dysfunction in both animal models and human clinical settings, thereby affecting the ability of the host immune system to clear viral pathogens and develop proper virus-specific immune memory. However, the impact of chronic viral infections on the host's immune memory to other pathogens has not been well described. In this study, we immunized mice with recombinant Listeria monocytogenes expressing OVA (Lm-OVA) to generate immunity to Lm and allow analysis of OVA-specific memory T (Tm) cells...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38547312/aryl-hydrocarbon-receptor-as-a-drug-target-in-advanced-prostate-cancer-therapy-obstacles-and-perspectives
#9
REVIEW
Jiřina Procházková, Zuzana Kahounová, Jan Vondráček, Karel Souček
Aryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that activate AhR signaling has been extended to include a number of endogenous compounds produced by various types of cells via their metabolic activity. AhR signaling is active from the very beginning of embryonal development throughout the life cycle and participates in numerous biological processes such as control of cell proliferation and differentiation, metabolism of aromatic compounds of endogenous and exogenous origin, tissue regeneration and stratification, immune system development and polarization, control of stemness potential, and homeostasis maintenance...
March 28, 2024: Transcription
https://read.qxmd.com/read/38547310/the-wolbachia-wale1-effector-alters-drosophila-endocytosis
#10
JOURNAL ARTICLE
MaryAnn Martin, Sergio López-Madrigal, Irene L G Newton
The most common intracellular bacterial infection is Wolbachia pipientis, a microbe that manipulates host reproduction and is used in control of insect vectors. Phenotypes induced by Wolbachia have been studied for decades and range from sperm-egg incompatibility to male killing. How Wolbachia alters host biology is less well understood. Previously, we characterized the first Wolbachia effector-WalE1, which encodes an alpha-synuclein domain at the N terminus. Purified WalE1 sediments with and bundles actin and when heterologously expressed in flies, increases Wolbachia titer in the developing oocyte...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38547226/outcome-benefits-of-upfront-cytoreductive-nephrectomy-for-patients-with-metastatic-renal-cell-carcinoma-an-analysis-of-the-trinetx-database
#11
JOURNAL ARTICLE
Gu-Shun Lai, Jian-Ri Li, Shian-Shiang Wang, Chuan-Shu Chen, Chun-Kuang Yang, Chia-Yen Lin, Sheng-Chun Hung, Kun-Yuan Chiu, Shun-Fa Yang
BACKGROUND: The role of upfront cytoreductive nephrectomy remains debatable in the present era of tyrosine kinase inhibitors and immune checkpoint inhibitors. Here, we aimed to evaluate the outcomes of metastatic renal cell carcinoma patients treated with upfront CN and modern systemic therapies. METHODS: Using the TriNetX network database, we identified patients, in the period from 2008 to 2022, who were diagnosed with metastatic renal cell carcinoma, receiving first-line systemic therapies with tyrosine kinase inhibitors or immune checkpoint inhibitors...
2024: PloS One
https://read.qxmd.com/read/38547073/stochastic-modeling-of-a-gene-regulatory-network-driving-b-cell-development-in-germinal-centers
#12
JOURNAL ARTICLE
Alexey Koshkin, Ulysse Herbach, María Rodríguez Martínez, Olivier Gandrillon, Fabien Crauste
Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexpected malfunctioning may lead to a range of pathologies, including various malignant formations. One promising way to improve the understanding of malignant transformation is to study the underlying gene regulatory networks (GRNs) associated with cell development and differentiation...
2024: PloS One
https://read.qxmd.com/read/38546951/insights-on-the-genomic-diversity-virulence-and-resistance-profile-of-a-campylobacter-jejuni-strain-isolated-from-a-hospitalized-patient-in-brazil
#13
JOURNAL ARTICLE
Carolina Nogueira Gomes, Miliane Rodrigues Frazão, Amanda Aparecida Seribelli, Dillon Oliver Reese Barker, Emily Victoria Che, Mara Corrêa Lelles Nogueira, Eduardo Napoleon Taboada, Juliana Pfrimer Falcão
Campylobacteriosis is currently recognized as one of the major causes of foodborne bacterial diseases worldwide. In Brazil, there is insufficient data to estimate the impact of Campylobacter in public health. The aim of this present study was to characterize a C. jejuni CJ-HBSJRP strain isolated from a hospitalized patient in Brazil by its ability to invade human Caco-2 epithelial cells, to survive in U937 human macrophages, and to assess its phenotypic antimicrobial resistance profile. In addition, prophages, virulence and antimicrobial resistance genes were search using whole-genome sequencing data...
March 28, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38546813/cysteine-and-glycine-rich-protein-1-predicts-prognosis-and-therapy-response-in-patients-with-acute-myeloid-leukemia
#14
JOURNAL ARTICLE
Qianqian Hao, Yu Liu, Yajun Liu, Luyao Shi, Yufei Chen, Lu Yang, Zhongxing Jiang, Yanfang Liu, Chong Wang, Shujuan Wang, Ling Sun
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. The current risk stratification system is essential but remains insufficient to select the best schedules. Cysteine-rich protein 1 (CSRP1) is a member of the CSRP family and associated with poor clinicopathological features in many tumors. This study aimed to explore the clinical significance and molecular mechanisms of cysteine- and glycine-rich protein 1 (CSRP1) in AML. RT-qPCR was used to detect the relative expression of CSRP1 in our clinical cohort...
March 28, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38546619/neoadjuvant-intent-immunotherapy-in-advanced-resectable-cutaneous-squamous-cell-carcinoma
#15
JOURNAL ARTICLE
Emily Y Kim, Emily S Ruiz, Mia S DeSimone, Sophia Z Shalhout, Glenn J Hanna, David M Miller, Chrysalyne Schmults, Eleni M Rettig, Ruth K Foreman, Rosh Sethi, Manisha Thakuria, Ann W Silk
IMPORTANCE: In clinical trials, preoperative immune checkpoint inhibitors (ICIs) have shown clinical activity in advanced cutaneous squamous cell carcinoma (cSCC). However, these studies excluded patients with relevant comorbidities. OBJECTIVE: To evaluate radiologic and pathologic response rates to neoadjuvant-intent programed cell death protein 1 (PD-1) ICIs in a clinical population. DESIGN, SETTING, AND PARTICIPANTS: This cohort study of patients who were treated with neoadjuvant cemiplimab or pembrolizumab for advanced cSCC from January 2018 to January 2023 was conducted at 2 academic institutions in Boston, Massachusetts...
March 28, 2024: JAMA Otolaryngology—Head & Neck Surgery
https://read.qxmd.com/read/38546608/role-of-the-gut-microbiota-and-innate-immunity-in-polycystic-ovary-syndrome-current-updates-and-future-prospects
#16
REVIEW
Min Zhou, Jing Yu, Xuewei Li, Zheng Ruan, Shaohui Yu
Polycystic ovary syndrome (PCOS) is one of the modern intractable reproductive diseases. The female irregular menstruation, infertility, obesity, and so forth caused by PCOS have become a hot issue affecting family harmony and social development. The aetiology of PCOS is complex. In recent years, many scholars have found that its pathogenesis was related to the imbalance of gut microbiota. Gut microbiota can form two-way communication with the brain through the 'gut-brain axis' and affect the host's metabolism...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38546551/neoadjuvant-dual-checkpoint-inhibitors-vs-anti-pd1-therapy-in-high-risk-resectable-melanoma-a-pooled-analysis
#17
JOURNAL ARTICLE
Ankit Mangla, Chanmi Lee, Matthew M Mirsky, Margaret Wang, Luke D Rothermel, Richard Hoehn, Jeremy S Bordeaux, Bryan T Carrol, Jason Theuner, Shawn Li, Pingfu Fu, John M Kirkwood
IMPORTANCE: Despite the clear potential benefits of neoadjuvant therapy, the optimal neoadjuvant regimen for patients with high-risk resectable melanoma (HRRM) is not known. OBJECTIVE: To compare the safety and efficacy of dual checkpoint inhibitors with anti-programmed cell death protein-1 (anti-PD1) therapy in a neoadjuvant setting among patients with HRRM. DESIGN, SETTING, AND PARTICIPANTS: In this pooled analysis of clinical trials, studies were selected provided they investigated immune checkpoint inhibitor treatment, were published between January 2018 and March 2023, and were phase 1, 2, or 3 clinical trials...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546528/oral-administration-of-egg-ovalbumin-allergen-induces-dysregulation-of-tryptophan-metabolism-in-sensitized-balb-c-mice
#18
JOURNAL ARTICLE
Zhongliang Wang, Jie Zhang, Jin Yuan, Fangfang Min, Jinyan Gao, Wenfeng Liu, Meijia Huang, Yong Wu, Hongbing Chen
Food allergy (FA), triggered by specific dietary allergens, has emerged as a substantial global concern for food safety and public health. While studies have elucidated changes in immune cells and cytokines associated with allergen exposure, a comprehensive analysis of the host's metabolic features and the interaction between metabolites and the gut microbiota has not been conducted. In this study, egg allergen ovalbumin (OVA) was administered by the oral route to sensitized BALB/c mice to faithfully replicate key aspects of human FA, including severe allergic diarrhea, mast cell infiltration, and elevated levels of serum IgE, mMCPT-1, and Th2 cell hallmark cytokines (such as IL-4, IL-5, and IL-13)...
March 28, 2024: Food & Function
https://read.qxmd.com/read/38546434/intestinal-strictures-in-crohn-s-disease-an-update-from-2023
#19
REVIEW
Zishan Liu, Zhuoyan Huang, Yu Wang, Shanshan Xiong, Sinan Lin, Jinshen He, Jinyu Tan, Caiguang Liu, Xiaomin Wu, Jing Nie, Weidong Huang, Yao Zhang, Longyuan Zhou, Ren Mao
Crohn's disease (CD) is a chronic inflammatory disease that leads to intestinal stricture in nearly 35% of cases within 10 years of initial diagnosis. The unknown pathogenesis, lack of universally accepted criteria, and absence of an effective management approach remain unconquered challenges in structuring CD. The pathogenesis of stricturing CD involves intricate interactions between factors such as immune cell dysbiosis, fibroblast activation, and microecology imbalance. New techniques such as single-cell sequencing provide a fresh perspective...
March 28, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38546403/the-necroptosis-related-signature-and-tumor-microenvironment-immune-characteristics-associated-with-clinical-prognosis-and-drug-sensitivity-analysis-in-stomach-adenocarcinoma
#20
JOURNAL ARTICLE
Biao Yang, Yingnan Wang, Tao Liu, Meijing Zhang, Tianhang Luo
PURPOSE: Necroptosis plays an important role in the tumorigenesis, development, metastasis, and drug resistance of malignant tumors. This study explored the new model for assessing stomach adenocarcinoma (STAD) prognosis and immunotherapy by combining long noncoding RNAs associated with necroptosis. METHODS: Patient clinical data and STAD gene expression profiles were curated from The Cancer Genome Atlas (TCGA). Immune-related genes were sourced from a specialized molecular database...
March 27, 2024: Aging
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