Milton Rafael Camacho-Pérez, Karina Janice Guadalupe Díaz-Resendiz, Rocío Ortiz-Butrón, Carlos Eduardo Covantes-Rosales, Alma Betsaida Benitez-Trinidad, Daniel Alberto Girón-Pérez, Gladys Alejandra Toledo-Ibarra, Lenin Pavón, Manuel Iván Girón-Pérez
The physiological and molecular responses of leukocytes are altered by organophosphate pesticides (OPs). Some reports have shown that diazinon (DZN) causes immunotoxic effects; diazoxon (DZO), the oxon metabolite of DZN, is attributed to influence the immune response by affecting the leukocyte cholinergic system. In this study, the in vitro effects of DZO on molecules involved in cell signaling (cAMP, IP3, DAG, JAK1, and STAT3), which play a crucial role in the activation, differentiation, and survival of leukocytes, were evaluated...
March 28, 2024: Journal of Leukocyte Biology