keyword
MENU ▼
Read by QxMD icon Read
search

Global TB

keyword
https://www.readbyqxmd.com/read/27910715/how-do-we-measure-adherence-to-anti-tuberculosis-treatment
#1
Salomé Valencia, Montserrat León, Irene Losada, Victor G Sequera, Manuel Fernandez Quevedo, Alberto L García-Basteiro
Completion of anti-tuberculosis (TB) treatment is of paramount importance for TB patients, as well as for the global efforts of TB control. However, there is neither a gold-standard measure to monitor adherence to TB treatment nor a widely used definition for different levels of adherence. Areas covered: in this review we aim to describe the different methods used to measure patients' adherence to anti-TB treatment, identifying their main strengths and limitations, with a focus on low resource settings. Expert commentary: there is a need for continuing the quest for a low cost, reliable and acceptable measure of adherence to TB treatment...
December 2, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27908271/host-directed-therapeutics-against-mycobacterial-infections
#2
Haruaki Tomioka, Chiaki Sano, Yutaka Tatano
The high incidence of tuberculosis (TB) in the world, especially in developing countries, the resurgence of TB in industrialized countries, and the global increase in the prevalence of Mycobacterium avium complex infections in immunocompromised hosts have prompted the quest for novel antimycobacterial drugs. However, the development of such antimicrobial chemotherapeutics is currently making very slow progress even with using the bioinformatics-based methodology for drug design. It thus appears that devising improved administration protocols for clinical treatment against intractable mycobacterial infections using existing chemotherapeutics is more practical than awaiting the development of new antimycobacterial drugs...
December 2, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27906009/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#3
REVIEW
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
September 26, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27903602/whole-genome-sequencing-of-mycobacterium-tuberculosis-provides-insight-into-the-evolution-and-genetic-composition-of-drug-resistant-tuberculosis-in-belarus
#4
Kurt R Wollenberg, Christopher A Desjardins, Aksana Zalutskaya, Vervara Slodovnikova, Andrew J Oler, Mariam Quiñones, Thomas Abeel, Sinead B Chapman, Michael Tartakovsky, Andrei Gabrielian, Sven Hoffner, Aliaksandr Skrahin, Bruce W Birren, Alexander Rosenthal, Alena Skrahina, Ashlee M Earl
The emergence and spread of drug resistant Mycobacterium tuberculosis (DR-TB) is a critical global health issue. Eastern Europe has some of the highest incidences of DR-TB, particularly multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. To better understand the genetic composition and evolution of MDR- and XDR-TB in the region, we sequenced and analyzed the genomes of 138 M. tuberculosis isolates from 97 patients sampled between 2010 and 2013 in Minsk, Belarus. MDR and XDR-TB isolates were significantly more likely to belong to the Beijing lineage than to the Euro-American lineage, and known resistance-conferring loci accounted for the majority of phenotypic resistance to first- and second-line drugs in MDR and XDR-TB...
November 30, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27890671/target-based-approaches-for-the-discovery-of-new-antimycobacterial-drugs
#5
REVIEW
Chiara Borsari, Stefania Ferrari, A Venturelli, Maria Paola Costi
Tuberculosis (TB) is a major global health problem and control of the disease is hampered by the increasing emergence of multidrug resistance (MDR) strains. Novel drugs are urgently needed to overcome this drug resistance. Among the most relevant targets of the past 3 years, here we consider nine enzymes that have been studied in a target-based approach. These targets are involved mainly in the biosynthesis of the cell wall, α-glucan, coenzyme A and acyl carrier protein precursor, and in energy production, DNA metabolism, and pyrimidine synthesis...
November 23, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27890360/anti-tubercular-peptides-a-quest-of-future-therapeutic-weapon-to-combat-tuberculosis
#6
REVIEW
Ameer Khusro, Chirom Aarti, Paul Agastian
Tuberculosis (TB) is a symbolic menace to mankind, infecting almost one third of the world's populace and causing over a million mortalities annually. Mycobacterium tuberculosis (Mtb) is the key pathogen of TB that invades and replicates inside the host's macrophage. With the emerging dilemma of multi-drug resistant tuberculosis (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB), the exigency for developing new TB drugs is an obligation now for worldwide researchers. Among the propitious antimycobacterial agents examined in last few decades, anti-tubercular peptides have been substantiated to be persuasive with multiple advantages such as low immunogenicity, selective affinity to bacterial negatively charged cell envelopes and most importantly divergent mechanisms of action...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27888000/enhanced-laboratory-capacity-development-a-boost-for-effective-tb-control-in-resource-limited-settings
#7
Abraham Sunday Alabi, Afsatou Ndama Traoré, Marguerite Massinga Loembe, Ulysse Ateba-Ngoa, Matthias Frank, Ayola Akim Adegnika, Bertrand Lell, Jocelyn Mahoumbou, Carsten Köhler, Peter Gottfried Kremsner, Martin Peter Grobusch
Both routine and research tuberculosis laboratory capacity urgently need to be expanded in large parts of sub-Saharan Africa. In 2009, the "Centre de Recherches Médicales de Lambaréné" (CERMEL), took a strategic decision to expand its activities by building tuberculosis (TB) laboratory capacity to address research questions and to improve routine diagnostic and treatment capacity. Over those past seven years, we have developed a standard a standard laboratory contributing significantly to TB diagnosis, treatment and control in Gabon; and providing training for TB research staff in Central Africa...
November 22, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27884842/predictors-of-in-hospital-mortality-among-patients-with-pulmonary-tuberculosis-a-protocol-of-systematic-review-and-meta-analysis-of-observational-studies
#8
Carlos Podalirio Borges de Almeida, Rachel Couban, Sun Makosso Kallyth, Vagner Kunz Cabral, Samantha Craigie, Jason Walter Busse, Denise Rossato Silva
INTRODUCTION: Tuberculosis (TB) continues to be a major public health issue worldwide, with 1.4 million deaths occurring annually. There is uncertainty regarding which factors are associated with in-hospital mortality among patients with pulmonary TB. This knowledge gap complicates efforts to identify and improve the management of those individuals with TB at greatest risk of death. The aim of this systematic review and meta-analysis is to establish predictors of in-hospital mortality among patients with pulmonary TB to enhance the evidence base for public policy...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27883374/association-between-body-mass-index-and-sputum-culture-conversion-among-south-korean-patients-with-multi-drug-resistant-tuberculosis-in-a-tuberculosis-referral-hospital
#9
Hyun Oh Park, Sung Hwan Kim, Seong Ho Moon, Joung Hun Byun, Jong Woo Kim, Chung Eun Lee, Jong Duk Kim, In Seok Jang, Jun Ho Yang
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is an important global health problem. Furthermore, the time to identify a positive sputum culture is an important risk factor for the spread of tuberculosis, and several factors can predict a prolonged time to culture conversion. Moreover, the relationship between poor nutritional status and infectious disease is clearly established. Therefore, the present study aimed to investigate the association between body mass index (BMI) and sputum culture conversion within 3 months among patients with MDR-TB...
November 21, 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27880044/tuberculosis-airway-obstruction-and-mortality-in-a-finnish-population
#10
Tiina Mattila, Markku Heliövaara, Harri Rissanen, Paul Knekt, Pauli Puukka, Tuula Vasankari
There is little long-term follow-up data concerning the association between past pulmonary tuberculosis (TB), airway obstruction and mortality. We aimed to analyse a national health examination survey data from 6701 adult Finns undergoing spirometry between 1978 and 1980 (follow-up through 2013). We identified TB either through a disease history or by a TB-indicative scar on a chest x-ray. We specified obstruction using the lower limit of normal (LLN) and classified severity using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-4...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27872018/preventive-therapy-for-latent-tuberculosis-infection-the-promise-and-the-challenges
#11
REVIEW
G J Fox, C C Dobler, B J Marais, J T Denholm
Around one third of the world's population may harbour latent tuberculosis infection (LTBI), an asymptomatic immunological state that confers a heightened risk of subsequently developing tuberculosis (TB). Effectively treating LTBI will be essential if the End TB Strategy is to be realised This review evaluates the evidence the effectiveness preventive antibiotic therapy to treat LTBI due to both drug susceptible and drug resistant bacteria. We summarise current national and international preventive therapy guidelines, as well as ongoing randomised trials evaluating regimen to prevent drug resistant TB...
November 18, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27872016/tuberculosis-eradication-versus-control
#12
Marco Schito, Debra Hanna, Alimuddin Zumla
According to the World Health Organization (WHO), 10.4 million people succumbed to tuberculosis (TB) in 2015 and is now the number one cause of death world-wide from a preventable infectious disease. Bold vision is needed from global leaders and plans have been proposed to end the TB epidemic. However enthusiasm must be matched by tangible and achievable goals based on the science and available funding. In order to reach the target and goals set by the WHO's End-TB Strategy, the challenges for TB eradication need to be addressed...
November 18, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27868278/differences-in-vigibase%C3%A2-reporting-of-aminoglycoside-and-capreomycin-suspected-ototoxicity-during-tuberculosis-treatment
#13
Evans L Sagwa, Patrick C Souverein, Inês Ribeiro, Hubert G M Leufkens, Aukje K Mantel-Teeuwisse
PURPOSE: To evaluate the association between the use of streptomycin, amikacin, kanamycin and capreomycin in tuberculosis (TB) treatment and the pharmacovigilance reporting of ototoxicity (deafness or hearing loss, tinnitus and vertigo). Second, to analyze patient demographic and geographic factors that influence the reporting of ototoxicity in TB treatment. METHODS: A case/non-case disproportionality analysis of the VigiBase® individual case safety reports (ICSRs) of patients treated for TB using multidrug regimens that contain either of streptomycin, amikacin, kanamycin or capreomycin...
November 20, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27866957/gender-and-the-circadian-pattern-of-body-temperature-in-normoxia-and-hypoxia
#14
REVIEW
Jacopo P Mortola
Circadian patterns are at the core of many physiological processes, and their disruption can have short- and long-term consequences. This essay focuses on one of the best known patterns, the daily oscillation of body temperature (Tb), and the possibility of its difference between genders. From human and animal studies globally considered, the tentative conclusion is reached that differences in Tb circadian pattern between genders are very small and probably limited to the timing of the Rhythm, not to its amplitude...
November 17, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27865387/microrna-expression-signatures-in-lungs-of-mice-infected-with-mycobacterium-tuberculosis
#15
Thiago Malardo, Luiz Gustavo Gardinassi, Bernardo Pereira Moreira, Éverton Padilha, Júlio César Cetrulo Lorenzi, Luana Silva Soares, Ana Flávia Gembre, Isabela Cardoso Fontoura, Luciana Previato de Almeida, Isabel Kinney Ferreira de Miranda Santos, Célio Lopes Silva, Arlete Aparecida Martins Coelho-Castelo
Tuberculosis (TB) is a major public health concern worldwide; however the factors that account for resistance or susceptibility to disease are not completely understood. Although some studies suggest that the differential expression of miRNAs in peripheral blood of TB patients could be useful as biomarkers of active disease, their involvement during the inflammatory process in lungs of infected individuals is unknown. Here, we evaluated the global expression of miRNAs in the lungs of mice experimentally infected with Mycobacterium tuberculosis on 30 and 60 days post-infection...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27865379/antibodies-and-tuberculosis
#16
REVIEW
Ashley J Jacobs, Juthathip Mongkolsapaya, Gavin R Screaton, Helen McShane, Robert J Wilkinson
Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine is the only licensed vaccine against TB, but its protective effect does not extend to controlling the development of infectious pulmonary disease in adults. The development of a more effective vaccine against TB is therefore a pressing need for global health. Although it is established that cell-mediated immunity is necessary for the control of latent infection, the presupposition that such immunity is sufficient for vaccine-induced protection has recently been challenged...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27855693/modelling-the-effect-of-short-course-multidrug-resistant-tuberculosis-treatment-in-karakalpakstan-uzbekistan
#17
James M Trauer, Jay Achar, Nargiza Parpieva, Atadjan Khamraev, Justin T Denholm, Dennis Falzon, Ernesto Jaramillo, Anita Mesic, Philipp du Cros, Emma S McBryde
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a major threat to global TB control. MDR-TB treatment regimens typically have a high pill burden, last 20 months or more and often lead to unsatisfactory outcomes. A 9-11 month regimen with seven antibiotics has shown high success rates among selected MDR-TB patients in different settings and is conditionally recommended by the World Health Organization. METHODS: We construct a transmission-dynamic model of TB to estimate the likely impact of a shorter MDR-TB regimen when applied in a low HIV prevalence region of Uzbekistan (Karakalpakstan) with high rates of drug resistance, good access to diagnostics and a well-established community-based MDR-TB treatment programme providing treatment to around 400 patients...
November 18, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27853505/current-strategies-to-treat-tuberculosis
#18
REVIEW
Anthony T Podany, Susan Swindells
Tuberculosis (TB) has been a leading cause of death for more than a century. While effective therapies exist, treatment is long and cumbersome. TB control is complicated by the overlapping problems created by global inadequacy of public health infrastructures, the interaction of the TB and human immunodeficiency virus (HIV) epidemics, and the emergence of drug-resistant TB. After a long period of neglect, there is now significant progress in the development of novel treatment regimens for TB. Focusing on treatment for active disease, we review pathways to TB regimen development and the new and repurposed anti-TB agents in clinical development...
2016: F1000Research
https://www.readbyqxmd.com/read/27852420/prisoners-co-infected-with-tuberculosis-and-hiv-a-systematic-review
#19
REVIEW
Chantal L Edge, Emma J King, Kate Dolan, Martin McKee
INTRODUCTION: Almost from the beginning of the HIV epidemic in 1981, an association with tuberculosis (TB) was recognized. This association between HIV and TB co-infection has been particularly evident amongst prisoners. However, despite this, few studies of TB in prisons have stratified results by HIV status. Given the high prevalence of HIV-positive persons and TB-infected persons in prisons and the documented risk of TB in those infected with HIV, it is of interest to determine how co-infection varies amongst prison populations worldwide...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27847016/low-prevalence-of-hepatitis-b-and-c-among-tuberculosis-patients-in-duhok-province-kurdistan-are-hbsag-and-anti-hcv-prerequisite-screening-parameters-in-tuberculosis-control-program
#20
Muayad A Merza, Safer M Haji, Abid Mohialdeen Hasan Alsharafani, Shivan U Muhammed
OBJECTIVE/BACKGROUND: Viral hepatitis, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), infections and tuberculosis (TB) are a global public health concern. Co-infection with HBV or HCV among TB patients may potentiate the risk of hepatotoxicity induced by anti-TB drugs. Hence, the aim of this study was to identify the prevalence of HBV and HCV among TB patients included in the Duhok National Tuberculosis Program (NTP). METHODS: The Duhok NTP Center is a specialized institution in Duhok City, Iraq, concerned with management and follow-up of TB patients...
September 2016: International Journal of Mycobacteriology
keyword
keyword
9071
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"