keyword
MENU ▼
Read by QxMD icon Read
search

Ppard

keyword
https://www.readbyqxmd.com/read/28287878/association-of-peroxisome-proliferator-activated-receptor-delta-and-additional-gene-smoking-interaction-on-cardiovascular-disease
#1
Wenqi Yang, Shudan Mao, Baoze Qu, Fengxiang Zhang, Zhaolong Xu
AIMS: To investigate the impact of peroxisome proliferator-activator receptor delta (PPARD) gene polymorphism and additional gene-smoking interaction on cardiovascular disease (CVD) risk based on this Chinese population. METHODS: A total of 1048 subjects (617 males, 431 females) with a mean age of 52.9 ± 14.1 years old were selected, including 520 CVD patients and 528 normal control subjects. The logistic regression model was used to examine the association between three SNPs and CVD risk, odds ratio (OR), and 95% confident interval (95%CI) were calculated...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28237587/hepatic-mrna-expression-for-genes-related-to-somatotropic-axis-glucose-and-lipid-metabolisms-and-inflammatory-response-of-periparturient-dairy-cows-treated-with-recombinant-bovine-somatotropin
#2
P R B Silva, W J Weber, B A Crooker, R J Collier, W W Thatcher, R C Chebel
Objectives of this experiment were to evaluate the effects of recombinant bovine somatotropin (rbST) treatment of periparturient dairy cows on hepatic mRNA expression for genes related to the somatotropic axis, insulin, glucose, and lipid metabolism, inflammation, and oxidative stress. Holstein cows were enrolled in the experiment at 253 ± 3 d of gestation and assigned to 1 of 3 treatments: untreated control (n = 53), 87.5 mg of rbST (n = 56; rbST87.5), and 125 mg of rbST (n = 57; rbST125). Cows in the rbST87...
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28218777/comparative-study-of-13-candidate-genes-applying-multi-reference-normalization-to-detect-the-expression-of-different-fineness-in-skin-tissues-of-wool-sheep
#3
COMPARATIVE STUDY
Y Z Tian, T Usman, K C Tian, J Di, X X Huang, X M Xu, H Tulafu, W W Wu, X F Fu, Y Bai, M Tuerxun, A Maimaiti
Fiber diameter is a useful indicator of wool traits and it is the main determinant of wool quality and value. A comparative study was conducted to analyze the abundance and expression of 13 candidate genes using expression profile microarray analysis and to identify novel molecular markers associated with wool traits to provide a molecular basis for improving wool quality in sheep. Genes associated with fineness of skin tissue were identified using a real-time reverse transcriptase-polymerase chain reaction method with 18SrRNA, β-Actin, and GAPDH used for multi-reference normalization...
February 16, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28168966/extracorporeal-membrane-oxygenation-for%C3%A2-acute-respiratory-distress-syndrome-after-pneumonectomy
#4
Jeremie Reeb, Anne Olland, Julien Pottecher, Xavier Delabranche, Mickael Schaeffer, Stephane Renaud, Nicola Santelmo, Romain Kessler, Gilbert Massard, Pierre-Emmanuel Falcoz
BACKGROUND: Postpneumonectomy acute respiratory distress syndrome (ppARDS) is a life-threatening condition with a disastrous prognosis. This study assessed the efficacy of venovenous extracorporeal membrane oxygenation (VV-ECMO) in adult patients with unresponsive severe ppARDS. METHODS: We retrospectively reviewed data of all patients treated with VV-ECMO for ppARDS from January 2009 to December 2015. We calculated the Sequential Organ Failure Assessment score before ECMO insertion and monitored the subsequent mechanical ventilation settings...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28128413/protective-role-of-294-t-c-rs2016520-polymorphism-of-ppard-in-mexican-patients-with-colorectal-cancer
#5
M A Rosales-Reynoso, L I Wence-Chavez, A R Arredondo-Valdez, S Dumois-Petersen, P Barros-Núñez, M P Gallegos-Arreola, S E Flores-Martínez, J Sánchez-Corona
PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metabolic syndrome, and type 2 diabetes mellitus. The aim of this study was to determine whether the single nucleotide polymorphism +294T/C (rs2016520) in PPARD is associated with colorectal cancer (CRC) in the Mexican population...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28118822/genome-wide-association-study-for-conformation-traits-in-three-danish-pig-breeds
#6
Thu H Le, Ole F Christensen, Bjarne Nielsen, Goutam Sahana
BACKGROUND: Selection for sound conformation has been widely used as a primary approach to reduce lameness and leg weakness in pigs. Identification of genomic regions that affect conformation traits would help to improve selection accuracy for these lowly to moderately heritable traits. Our objective was to identify genetic factors that underlie leg and back conformation traits in three Danish pig breeds by performing a genome-wide association study followed by meta-analyses. METHODS: Data on four conformation traits (front leg, back, hind leg and overall conformation) for three Danish pig breeds (23,898 Landrace, 24,130 Yorkshire and 16,524 Duroc pigs) were used for association analyses...
January 24, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28118678/effect-of-sex-on-the-acute-skeletal-muscle-response-to-sprint-interval-exercise
#7
Lauren E Skelly, Jenna B Gillen, Martin J MacInnis, Brian J Martin, Adeel Safdar, Mahmood Akhtar, Maureen J MacDonald, Mark A Tarnopolsky, Martin J Gibala
What is the central question of this study? Are there sex-based differences in the acute skeletal muscle response to sprint interval training (SIT)? What is the main finding and its importance? In response to a SIT protocol that involved three 20 s bouts of 'all-out' cycling, the expression of multiple genes associated with mitochondrial biogenesis, metabolic control and structural remodelling was largely similar between men and women matched for fitness. Our findings cannot explain previous reports of sex-based differences in the adaptive response to SIT and suggest that the mechanistic basis for these differences remains to be elucidated...
January 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28115213/two-novel-candidate-genes-identified-in-adults-from-the-newfoundland-population-with-addictive-tendencies-towards-food
#8
Pardis Pedram, Guangju Zhai, Wayne Gulliver, Hongwei Zhang, Guang Sun
Food addiction (FA) is a distinguished clinical feature affecting about 5% adults of the general population in Canada. FA contributes to obesity, however, the underlying genes in FA are largely unknown. The aim of the current study was to search for FA candidate genes using an exome sequencing followed by a verification study using the most significantly associated identified genes. From a total of 752 adults, 24 subjects were selected including 8 obese with high and 8 obese with low/zero FA clinical symptom score (FAO, NFO), and 8 healthy controls with normal BMI and low/zero FA symptom score (Ctrl)...
January 20, 2017: Appetite
https://www.readbyqxmd.com/read/28105924/molecular-determinants-of-the-adrenal-gland-functioning-related-to-stress-sensitive-hypertension-in-isiah-rats
#9
Larisa A Fedoseeva, Leonid O Klimov, Nikita I Ershov, Yury V Alexandrovich, Vadim M Efimov, Arcady L Markel, Olga E Redina
BACKGROUND: The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems. RESULTS: The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats...
December 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28097239/metastasis-regulation-by-ppard-expression-in-cancer-cells
#10
Xiangsheng Zuo, Weiguo Xu, Min Xu, Rui Tian, Micheline J Moussalli, Fei Mao, Xiaofeng Zheng, Jing Wang, Jeffrey S Morris, Mihai Gagea, Cathy Eng, Scott Kopetz, Dipen M Maru, Asif Rashid, Russell Broaddus, Daoyan Wei, Mien-Chie Hung, Anil K Sood, Imad Shureiqi
Peroxisome proliferator-activated receptor-δ (PPARD) is upregulated in many major human cancers, but the role that its expression in cancer cells has in metastasis remains poorly understood. Here, we show that specific PPARD downregulation or genetic deletion of PPARD in cancer cells significantly repressed metastasis in various cancer models in vivo. Mechanistically, PPARD promoted angiogenesis via interleukin 8 in vivo and in vitro. Analysis of transcriptome profiling of HCT116 colon cancer cells with or without genetic deletion of PPARD and gene expression patterns in The Cancer Genome Atlas colorectal adenocarcinoma database identified novel pro-metastatic genes (GJA1, VIM, SPARC, STC1, SNCG) as PPARD targets...
January 12, 2017: JCI Insight
https://www.readbyqxmd.com/read/28050012/ppar-delta-promotes-survival-of-chronic-lymphocytic-leukemia-cells-in-energetically-unfavorable-conditions
#11
Y-J Li, L Sun, Y Shi, G Wang, X Wang, S E Dunn, C Iorio, R A Screaton, D E Spaner
Targeting the mechanisms that allow chronic lymphocytic leukemia (CLL) cells to survive in harsh cancer microenvironments should improve patient outcomes. The nuclear receptor peroxisome proliferator activated receptor delta (PPARδ) sustains other cancers, and in silico analysis showed higher PPARD expression in CLL cells than normal lymphocytes and other hematologic cancers. A direct association was found between PPARδ protein levels in CLL cells and clinical score. Transgenic expression of PPARδ increased the growth and survival of CD5(+) Daudi cells and primary CLL cells in stressful conditions including exhausted tissue culture media, low extracellular glucose, hypoxia and exposure to cytotoxic drugs...
January 31, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27938626/prepartum-maternal-diets-supplemented-with-oilseeds-alter-the-fatty-acid-profile-in-bovine-neonatal-plasma-possibly-through-reduced-placental-expression-of-fatty-acid-transporter-protein-4-and-fatty-acid-translocase
#12
Reza Salehi, Divakar J Ambrose
In the present study, we determined the effects of maternal dietary fat and the type of fat on plasma fatty acids and the expression of placental fatty acid transporter genes. In Experiment 1, Holstein cows in the last 35 days of gestation received diets containing sunflower seed (n=8; high in linoleic acid (LA)), canola seed (n=7; high in oleic acid (OLA)) or no oilseed (n=7; control). Fatty acids were quantified in dam and neonate plasma at calving. In Experiment 2, placental cotyledons were collected (LA: n=4; OLA: n=4; control: n=5) to quantify gene expression...
December 12, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27865496/peroxisome-proliferator-activated-receptor-delta-facilitates-lipid-secretion-and-catabolism-of-fatty-acids-in-dairy-goat-mammary-epithelial-cells
#13
H B Shi, C H Zhang, W Zhao, J Luo, J J Loor
In rodents, peroxisome proliferator-activated receptor delta (PPARD) is associated primarily with catabolism of fatty acids. However, the role of PPARD in regulating lipid metabolism in ruminant mammary gland remains unknown. In the present study, we assessed the mRNA abundance of PPARD at 3 stages of lactation in goat mammary tissue. Results revealed that PPARD had lower expression at peak lactation than in the nonlactating period. Luciferase assays revealed that GW0742 (GW), a specific PPARD ligand, enhanced the activity of the PPARD response element in goat mammary epithelial cells...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27856609/ppar%C3%AE-is-required-for-exercise-to-attenuate-endoplasmic-reticulum-stress-and-endothelial-dysfunction-in-diabetic-mice
#14
Wai San Cheang, Wing Tak Wong, Lei Zhao, Jian Xu, Li Wang, Chi Wai Lau, Zhen Yu Chen, Ronald Ching Wan Ma, Aimin Xu, Nanping Wang, Xiao Yu Tian, Yu Huang
Physical activity has profound benefits on health, especially on cardiometabolic wellness. Experiments in rodents with trained exercise have shown that exercise improves vascular function and reduces vascular inflammation by modulating the balance between nitric oxide (NO) and oxidative stress. However, the upstream regulator of exercise-induced vascular benefits is unclear. We aimed to investigate the involvement of peroxisome proliferator-activated receptor δ (PPARδ) in exercise-induced vascular functional improvement...
February 2017: Diabetes
https://www.readbyqxmd.com/read/27818678/transcriptome-wide-analysis-reveals-the-role-of-ppar%C3%AE-controlling-the-lipid-metabolism-in-goat-mammary-epithelial-cells
#15
Hengbo Shi, Wangsheng Zhao, Changhui Zhang, Khuram Shahzad, Jun Luo, Juan J Loor
To explore the large-scale effect of peroxisome proliferator-activated receptor γ (PPARG) in goat mammary epithelial cells (GMEC), an oligonucleotide microarray platform was used for transcriptome profiling in cells overexpressing PPARG and incubated with or without rosiglitazone (ROSI, a PPARγ agonist). A total of 1143 differentially expressed genes (DEG) due to treatment were detected. The Dynamic Impact Approach (DIA) analysis uncovered the most impacted and induced pathways "fatty acid elongation in mitochondria," "glycosaminoglycan biosynthesis-keratan sulfate," and "pentose phosphate pathway...
2016: PPAR Research
https://www.readbyqxmd.com/read/27752041/interactome-transcriptome-analysis-discovers-signatures-complementary-to-gwas-loci-of-type-2-diabetes
#16
Jing-Woei Li, Heung-Man Lee, Ying Wang, Amy Hin-Yan Tong, Kevin Y Yip, Stephen Kwok-Wing Tsui, Si Lok, Risa Ozaki, Andrea O Luk, Alice P S Kong, Wing-Yee So, Ronald C W Ma, Juliana C N Chan, Ting-Fung Chan
Protein interactions play significant roles in complex diseases. We analyzed peripheral blood mononuclear cells (PBMC) transcriptome using a multi-method strategy. We constructed a tissue-specific interactome (T2Di) and identified 420 molecular signatures associated with T2D-related comorbidity and symptoms, mainly implicated in inflammation, adipogenesis, protein phosphorylation and hormonal secretion. Apart from explaining the residual associations within the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) study, the T2Di signatures were enriched in pathogenic cell type-specific regulatory elements related to fetal development, immunity and expression quantitative trait loci (eQTL)...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27697477/lysophosphatidylcholines-activate-ppar%C3%AE-and-protect-human-skeletal-muscle-cells-from-lipotoxicity
#17
Christian Klingler, Xinjie Zhao, Till Adhikary, Jia Li, Guowang Xu, Hans-Ulrich Häring, Erwin Schleicher, Rainer Lehmann, Cora Weigert
Metabolomics studies of human plasma demonstrate a correlation of lower plasma lysophosphatidylcholines (LPC) concentrations with insulin resistance, obesity, and inflammation. This relationship is not unraveled on a molecular level. Here we investigated the effects of the abundant LPC(16:0) and LPC(18:1) on human skeletal muscle cells differentiated to myotubes. Transcriptome analysis of human myotubes treated with 10μM LPC for 24h revealed enrichment of up-regulated peroxisome proliferator-activated receptor (PPAR) target transcripts, including ANGPTL4, PDK4, PLIN2, and CPT1A...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27493725/essential-amino-acid-ratios-and-mtor-affect-lipogenic-gene-networks-and-mirna-expression-in-bovine-mammary-epithelial-cells
#18
Shanshan Li, Afshin Hosseini, Marina Danes, Carolina Jacometo, Jianxin Liu, Juan J Loor
BACKGROUND: The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA (miRNA) in bovine mammary epithelial cells. RESULTS: Triplicate cultures with the respective "optimal" amino acid (AA) ratio (OPAA = Lys:Met 2.9:1; Thr:Phe 1.05:1; Lys:Thr 1.8:1; Lys:His 2.38:1; Lys:Val 1.23:1) plus rapamycin (OPAARMC; positive control), OPAA, Lys:Thr 2.1:1 (LT2.1), Lys:Thr 1...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27367537/n-3-fatty-acids-modulate-the-mrna-expression-of-the-nlrp3-inflammasome-and-mtor-in-the-liver-of-rats-fed-with-high-fat-or-high-fat-fructose-diets
#19
Natalia Garay-Lugo, Aarón Domínguez-Lopez, Angel Miliar García, Eliud Aguilar Barrera, Modesto Gómez López, Alejandro Gómez Alcalá, Maria de Los Angeles Martínez Godinez, Eleazar Lara-Padilla
CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. OBJECTIVE: Evaluate the effect of a high-fat or high-fat/fructose diet with and without n-3-PUFAs on hepatic gene expression. MATERIALS AND METHODS: We examined the mRNA expression by RT-PCR of Mtor, Nlrp3, and other 22 genes associated with inflammation in rats livers after a 9-week diet...
October 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27245511/effect-of-dietary-energy-and-polymorphisms-in-brap-and-ghrl-on-obesity-and-metabolic-traits
#20
Takahiro Imaizumi, Masahiko Ando, Masahiro Nakatochi, Yoshinari Yasuda, Hiroyuki Honda, Yachiyo Kuwatsuka, Sawako Kato, Takaaki Kondo, Masamitsu Iwata, Toru Nakashima, Hiroshi Yasui, Hideki Takamatsu, Hiroshi Okajima, Yasuko Yoshida, Shoichi Maruyama
OBJECTIVE: Obesity, a risk factor for all-cause and cardiovascular mortality, is a major health concerns among middle-aged men. The aim of this study was to investigate a possible association of dietary habits and obesity related single nucleotide polymorphisms (SNPs) with obesity and metabolic abnormalities. METHODS: We conducted a retrospective cohort study using annual health examination data of 5112 male workers, obtained between 2007 and 2011. Average dietary energy was estimated using electronically collected meal purchase data from cafeteria...
May 27, 2016: Obesity Research & Clinical Practice
keyword
keyword
90708
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"