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https://www.readbyqxmd.com/read/27865496/peroxisome-proliferator-activated-receptor-delta-facilitates-lipid-secretion-and-catabolism-of-fatty-acids-in-dairy-goat-mammary-epithelial-cells
#1
H B Shi, C H Zhang, W Zhao, J Luo, J J Loor
In rodents, peroxisome proliferator-activated receptor delta (PPARD) is associated primarily with catabolism of fatty acids. However, the role of PPARD in regulating lipid metabolism in ruminant mammary gland remains unknown. In the present study, we assessed the mRNA abundance of PPARD at 3 stages of lactation in goat mammary tissue. Results revealed that PPARD had lower expression at peak lactation than in the nonlactating period. Luciferase assays revealed that GW0742 (GW), a specific PPARD ligand, enhanced the activity of the PPARD response element in goat mammary epithelial cells...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27856609/ppar%C3%AE-is-required-for-exercise-to-attenuate-endoplasmic-reticulum-stress-and-endothelial-dysfunction-in-diabetic-mice
#2
Wai San Cheang, Wing Tak Wong, Lei Zhao, Jian Xu, Li Wang, Chi Wai Lau, Zhen Yu Chen, Ronald Ching Wan Ma, Aimin Xu, Nanping Wang, Xiao Yu Tian, Yu Huang
Physical activity has profound benefits on health especially cardiometablic wellness. Experiments on rodents with trained exercise showed that exercise improves vascular function and reduces vascular inflammation by modulating the balance between nitric oxide (NO) and oxidative stress. However, it is unclear what is the upstream regulator of exercise-induced vascular benefits. We aim to investigate the involvement of peroxisome proliferator-activated receptor δ (PPARδ) in exercise-induced vascular functional improvement...
November 17, 2016: Diabetes
https://www.readbyqxmd.com/read/27818678/transcriptome-wide-analysis-reveals-the-role-of-ppar%C3%AE-controlling-the-lipid-metabolism-in-goat-mammary-epithelial-cells
#3
Hengbo Shi, Wangsheng Zhao, Changhui Zhang, Khuram Shahzad, Jun Luo, Juan J Loor
To explore the large-scale effect of peroxisome proliferator-activated receptor γ (PPARG) in goat mammary epithelial cells (GMEC), an oligonucleotide microarray platform was used for transcriptome profiling in cells overexpressing PPARG and incubated with or without rosiglitazone (ROSI, a PPARγ agonist). A total of 1143 differentially expressed genes (DEG) due to treatment were detected. The Dynamic Impact Approach (DIA) analysis uncovered the most impacted and induced pathways "fatty acid elongation in mitochondria," "glycosaminoglycan biosynthesis-keratan sulfate," and "pentose phosphate pathway...
2016: PPAR Research
https://www.readbyqxmd.com/read/27752041/interactome-transcriptome-analysis-discovers-signatures-complementary-to-gwas-loci-of-type-2-diabetes
#4
Jing-Woei Li, Heung-Man Lee, Ying Wang, Amy Hin-Yan Tong, Kevin Y Yip, Stephen Kwok-Wing Tsui, Si Lok, Risa Ozaki, Andrea O Luk, Alice P S Kong, Wing-Yee So, Ronald C W Ma, Juliana C N Chan, Ting-Fung Chan
Protein interactions play significant roles in complex diseases. We analyzed peripheral blood mononuclear cells (PBMC) transcriptome using a multi-method strategy. We constructed a tissue-specific interactome (T2Di) and identified 420 molecular signatures associated with T2D-related comorbidity and symptoms, mainly implicated in inflammation, adipogenesis, protein phosphorylation and hormonal secretion. Apart from explaining the residual associations within the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) study, the T2Di signatures were enriched in pathogenic cell type-specific regulatory elements related to fetal development, immunity and expression quantitative trait loci (eQTL)...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27697477/lysophosphatidylcholines-activate-ppar%C3%AE-and-protect-human-skeletal-muscle-cells-from-lipotoxicity
#5
Christian Klingler, Xinjie Zhao, Till Adhikary, Jia Li, Guowang Xu, Hans-Ulrich Häring, Erwin Schleicher, Rainer Lehmann, Cora Weigert
Metabolomics studies of human plasma demonstrate a correlation of lower plasma lysophosphatidylcholines (LPC) concentrations with insulin resistance, obesity, and inflammation. This relationship is not unraveled on a molecular level. Here we investigated the effects of the abundant LPC(16:0) and LPC(18:1) on human skeletal muscle cells differentiated to myotubes. Transcriptome analysis of human myotubes treated with 10μM LPC for 24h revealed enrichment of up-regulated peroxisome proliferator-activated receptor (PPAR) target transcripts, including ANGPTL4, PDK4, PLIN2, and CPT1A...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27493725/essential-amino-acid-ratios-and-mtor-affect-lipogenic-gene-networks-and-mirna-expression-in-bovine-mammary-epithelial-cells
#6
Shanshan Li, Afshin Hosseini, Marina Danes, Carolina Jacometo, Jianxin Liu, Juan J Loor
BACKGROUND: The objective of this study was to study how changing the ratio of Lys to Thr, Lys to His, and Lys to Val affects the expression of lipogenic genes and microRNA (miRNA) in bovine mammary epithelial cells. RESULTS: Triplicate cultures with the respective "optimal" amino acid (AA) ratio (OPAA = Lys:Met 2.9:1; Thr:Phe 1.05:1; Lys:Thr 1.8:1; Lys:His 2.38:1; Lys:Val 1.23:1) plus rapamycin (OPAARMC; positive control), OPAA, Lys:Thr 2.1:1 (LT2.1), Lys:Thr 1...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27367537/n-3-fatty-acids-modulate-the-mrna-expression-of-the-nlrp3-inflammasome-and-mtor-in-the-liver-of-rats-fed-with-high-fat-or-high-fat-fructose-diets
#7
Natalia Garay-Lugo, Aarón Domínguez-Lopez, Angel Miliar García, Eliud Aguilar Barrera, Modesto Gómez López, Alejandro Gómez Alcalá, Maria de Los Angeles Martínez Godinez, Eleazar Lara-Padilla
CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. OBJECTIVE: Evaluate the effect of a high-fat or high-fat/fructose diet with and without n-3-PUFAs on hepatic gene expression. MATERIALS AND METHODS: We examined the mRNA expression by RT-PCR of Mtor, Nlrp3, and other 22 genes associated with inflammation in rats livers after a 9-week diet...
October 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27245511/effect-of-dietary-energy-and-polymorphisms-in-brap-and-ghrl-on-obesity-and-metabolic-traits
#8
Takahiro Imaizumi, Masahiko Ando, Masahiro Nakatochi, Yoshinari Yasuda, Hiroyuki Honda, Yachiyo Kuwatsuka, Sawako Kato, Takaaki Kondo, Masamitsu Iwata, Toru Nakashima, Hiroshi Yasui, Hideki Takamatsu, Hiroshi Okajima, Yasuko Yoshida, Shoichi Maruyama
OBJECTIVE: Obesity, a risk factor for all-cause and cardiovascular mortality, is a major health concerns among middle-aged men. The aim of this study was to investigate a possible association of dietary habits and obesity related single nucleotide polymorphisms (SNPs) with obesity and metabolic abnormalities. METHODS: We conducted a retrospective cohort study using annual health examination data of 5112 male workers, obtained between 2007 and 2011. Average dietary energy was estimated using electronically collected meal purchase data from cafeteria...
May 27, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27179873/parturition-in-dairy-cows-temporarily-alters-the-expression-of-genes-in-circulating-neutrophils
#9
M A Crookenden, A Heiser, A Murray, V S R Dukkipati, J K Kay, J J Loor, S Meier, M D Mitchell, K M Moyes, C G Walker, J R Roche
Extensive metabolic and physiologic changes occur during the peripartum, concurrent with a high incidence of infectious disease. Immune dysfunction is a likely contributor to the increased risk of disease at this time. Studies using high-yielding, total mixed ration-fed cows have indicated that neutrophil function is perturbed over the transition period; however, this reported dysfunction has yet to be investigated in moderate-yielding, grazing dairy cows. Therefore, we investigated changes in the expression of genes involved in neutrophil function...
August 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/26964143/ppar%C3%AE-%C3%AE-directs-the-therapeutic-potential-of-mesenchymal-stem-cells-in-arthritis
#10
P Luz-Crawford, N Ipseiz, G Espinosa-Carrasco, A Caicedo, G Tejedor, K Toupet, J Loriau, C Scholtysek, C Stoll, M Khoury, D Noël, C Jorgensen, G Krönke, F Djouad
OBJECTIVES: To define how peroxisome proliferator-activated receptor (PPAR) β/δ expression level in mesenchymal stem cells (MSCs) could predict and direct both their immunosuppressive and therapeutic properties. PPARβ/δ interacts with factors such as nuclear factor-kappa B (NF-κB) and regulates the expression of molecules including vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1. Since these molecules are critical for MSC function, we investigated the role of PPARβ/δ on MSC immunosuppressive properties...
March 8, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26915488/ppard-rs2016520-polymorphism-is-associated-with-metabolic-traits-in-a-large-population-of-chinese-adults
#11
Lizhi Tang, Qingguo Lü, Hongyi Cao, Qiu Yang, Nanwei Tong
AIMS: Polymorphism of rs2016520 in gene PPARD has been associated with lipid metabolism, obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM). We aimed to study the association of rs2016520 with common metabolic traits in a large population of Han Chinese adults. METHODS: The polymorphism was genotyped in 1409 subjects using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS); all participants underwent standard clinical examination and a 75g oral glucose tolerance test (OGTT); associations between the polymorphism and metabolic traits and indices of insulin resistance and insulin sensitivity were analyzed...
July 10, 2016: Gene
https://www.readbyqxmd.com/read/26874076/elafibranor-an-agonist-of-the-peroxisome-proliferator-activated-receptor-%C3%AE-and%C3%A2-%C3%AE-induces-resolution-of-nonalcoholic-steatohepatitis-without-fibrosis-worsening
#12
Vlad Ratziu, Stephen A Harrison, Sven Francque, Pierre Bedossa, Philippe Lehert, Lawrence Serfaty, Manuel Romero-Gomez, Jérôme Boursier, Manal Abdelmalek, Steve Caldwell, Joost Drenth, Quentin M Anstee, Dean Hum, Remy Hanf, Alice Roudot, Sophie Megnien, Bart Staels, Arun Sanyal
BACKGROUND & AIMS: Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-δ. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. We assessed the safety and efficacy of elafibranor in an international, randomized, double-blind placebo-controlled trial of patients with nonalcoholic steatohepatitis (NASH). METHODS: Patients with NASH without cirrhosis were randomly assigned to groups given elafibranor 80 mg (n = 93), elafibranor 120 mg (n = 91), or placebo (n = 92) each day for 52 weeks at sites in Europe and the United States...
May 2016: Gastroenterology
https://www.readbyqxmd.com/read/26840443/genetic-variability-among-power-athletes-the-stronger-vs-the-faster
#13
Sigal Ben-Zaken, Alon Eliakim, Dan Nemet, Yoav Meckel
Athletic events can be divided into "aerobic-type event" or "anaerobic-type event" based on energetic usage. Power, speed, and strength, also used to specify sports subtypes. Weightlifters, sprinters, and jumpers feature high-intensity efforts lasting few seconds. However, their performance requires different proportions of power, speed, and strength. The aim of the current study was to examine genetic differences between subtypes of anaerobic athletes in 3 genetic variants: ACTN3 R577X, which is associated with muscle contractions, AGT Met235Thr which is associated with muscle growth, and PPARD T/C, which is associated with aerobic capacity...
January 29, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/26802562/alterations-in-gene-expression-levels-provide-early-indicators-of-chemical-stress-during-xenopus-laevis-embryo-development-a-case-study-with-perfluorooctane-sulfonate-pfos
#14
Laura San-Segundo, Laura Guimarães, Carlos Fernández Torija, Eulalia M Beltrán, Lúcia Guilhermino, María Victoria Pablos
In the present study, Xenopus laevis embryos were exposed to a range of perfluorooctane sulfonate (PFOS) concentrations (0, 0.5, 6, 12, 24, 48 and 96mg/L) for 96h in laboratorial conditions to establish toxicity along with possible gene expression changes. Mortality and deformities were monitored daily and head-tail length was measured at the end of the assay as an indicator of growth. At 24 and 96h post-exposure (hpe), the mRNA expression levels of the genetic markers involved in general stress responses (hsp70, hsp47, crh-a and ucn1), oxidative stress (cat...
May 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/26725848/genetic-alterations-in-fatty-acid-transport-and-metabolism-genes-are-associated-with-metastatic-progression-and-poor-prognosis-of-human-cancers
#15
Aritro Nath, Christina Chan
Reprogramming of cellular metabolism is a hallmark feature of cancer cells. While a distinct set of processes drive metastasis when compared to tumorigenesis, it is yet unclear if genetic alterations in metabolic pathways are associated with metastatic progression of human cancers. Here, we analyzed the mutation, copy number variation and gene expression patterns of a literature-derived model of metabolic genes associated with glycolysis (Warburg effect), fatty acid metabolism (lipogenesis, oxidation, lipolysis, esterification) and fatty acid uptake in >9000 primary or metastatic tumor samples from the multi-cancer TCGA datasets...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26697060/zebrafish-as-a-model-to-study-the-role-of-peroxisome-proliferating-activated-receptors-in-adipogenesis-and-obesity
#16
REVIEW
Marjo J Den Broeder, Victoria A Kopylova, Leonie M Kamminga, Juliette Legler
The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this review is to describe the role of PPARs in lipid metabolism, adipogenesis, and obesity and evaluate the zebrafish as an emerging vertebrate model to study the function of PPARs. Zebrafish are an appropriate model to study human diseases, including obesity and related metabolic diseases, as pathways important for adipogenesis and lipid metabolism which are conserved between mammals and fish...
2015: PPAR Research
https://www.readbyqxmd.com/read/26602520/serum-from-patients-with-ankylosing-spondylitis-can-increase-ppard-fra-1-mmp7-opg-and-rankl-expression-in-mg63-cells
#17
Zaiying Hu, Dongfang Lin, Jun Qi, Minli Qiu, Qing Lv, Qiuxia Li, Zhiming Lin, Zetao Liao, Yunfeng Pan, Ou Jin, Yuqiong Wu, Jieruo Gu
OBJECTIVES: To explore the effects of serum from patients with ankylosing spondylitis on the canonical Wnt/β-catenin pathway and to assess whether the serum has an osteogenic effect in MG63 cells. METHODS: MG63 cells were cultured with serum from 45 ankylosing spondylitis patients, 30 healthy controls, or 45 rheumatoid arthritis patients. The relative PPARD, fra-1, MMP7, OPG and RANKL mRNA levels were measured using quantitative real-time polymerase chain reaction...
November 2015: Clinics
https://www.readbyqxmd.com/read/26599230/the-functional-snps-in-the-5-regulatory-region-of-the-porcine-ppard-gene-have-significant-association-with-fat-deposition-traits
#18
Yunxia Zhang, Tengsen Gao, Shanyao Hu, Bin Lin, Dechao Yan, Zaiyan Xu, Zijun Zhang, Yuanliang Mao, Huimin Mao, Litong Wang, Guoshui Wang, Yuanzhu Xiong, Bo Zuo
Peroxisome proliferator-activated receptor delta (PPARD) is a key regulator of lipid metabolism, insulin sensitivity, cell proliferation and differentiation. In this study, we identified two Single Nucleotide Polymorphisms (SNPs, g.1015 A>G and g.1018 T>C) constituting four haplotypes (GT, GC, AC and AT) in the 5' regulatory region of porcine PPARD gene. Functional analysis of the four haplotypes showed that the transcriptional activity of the PPARD promoter fragment carrying haplotype AC was significantly lower than that of the other haplotypes in 3T3-L1, C2C12 and PK-15 cells, and haplotype AC had the lowest binding capacities to the nuclear extracts...
2015: PloS One
https://www.readbyqxmd.com/read/26580287/monitoring-of-chicken-rna-integrity-as-a-function-of-prolonged-postmortem-duration
#19
Yuwares Malila, Yanee Srimarut, Juthawut U-Chupaj, Gale Strasburg, Wonnop Visessanguan
Gene expression profiling has offered new insights into postmortem molecular changes associated with meat quality. To acquire reliable transcript quantification, high quality RNA is required. The objective of this study was to analyze integrity of RNA isolated from chicken skeletal muscle (pectoralis major) and its capability of serving as the template in quantitative real-time polymerase chain reaction (qPCR) as a function of postmortem intervals representing the end-points of evisceration, carcass chilling and aging stages in chicken abattoirs...
November 2015: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26578390/identification-of-potential-biomarkers-to-differentially-diagnose-solid-pseudopapillary-tumors-and-pancreatic-malignancies-via-a-gene-regulatory-network
#20
Pengping Li, Yuebing Hu, Jiao Yi, Jie Li, Jie Yang, Jin Wang
BACKGROUND: Solid pseudopapillary neoplasms (SPN) are pancreatic tumors with low malignant potential and good prognosis. However, differential diagnosis between SPN and pancreatic malignancies including pancreatic neuroendocrine tumor (PanNET) and ductal adenocarcinoma (PDAC) is difficult. This study tried to identify candidate biomarkers for the distinction between SPN and the two malignant pancreatic tumors by examining the gene regulatory network of SPN. METHODS: The gene regulatory network for SPN was constructed by a co-expression model...
2015: Journal of Translational Medicine
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