Cédric Couturier, Quentin Ronzon, Giulia Lattanzi, Iain Lingard, Sebastien Coyne, Veronique Cazals, Nelly Dubarry, Stephane Yvon, Corinne Leroi-Geissler, Obdulia Rabal Gracia, Joanne Teague, Sylvie Sordello, David Corbett, Caroline Bauch, Chantal Monlong, Lloyd Payne, Thomas Taillier, Hazel Fuchs, Mark Broenstrup, Peter H Harrison, Lucile Moynié, Abirami Lakshminarayanan, Tiberiu-Marius Gianga, Rohanah Hussain, James H Naismith, Michael Mourez, Eric Bacqué, Fredrik Björkling, Jean-Francois Sabuco, Henrik Franzyk
Tridecaptins comprise a class of linear cationic lipopeptides with an N-terminal fatty acyl moiety. These 13-mer antimicrobial peptides consist of a combination of d- and l-amino acids, conferring increased proteolytic stability. Intriguingly, they are biosynthesized by non-ribosomal peptide synthetases in the same bacterial species that also produce the cyclic polymyxins displaying similar fatty acid tails. Previously, the des-acyl analog of TriA1 (termed H-TriA1 ) was found to possess very weak antibacterial activity, albeit it potentiated the effect of several antibiotics...
December 23, 2023: European Journal of Medicinal Chemistry