keyword
https://read.qxmd.com/read/38058059/%C3%AE-sitosterol-enhances-lung-epithelial-cell-permeability-by-suppressing-the-nf-%C3%AE%C2%BAb-signaling-pathway
#1
JOURNAL ARTICLE
Xingdong Chen, Juan Chen, Yi Ren, Mengmeng Wang, Zhizhou Yang, Wei Zhang, Quan Li, Chao Liu, Zhaorui Sun, Shinan Nie
BACKGROUND: The dysregulation between pro-inflammatory and anti-inflammatory responses during sepsis is a crucial factor in driving sepsis progression. Acute lung injury (ALI) resulting from excessive production and accumulation of inflammatory mediators in the lungs contributes to impaired lung barrier function. The activation of the NF-κB signaling pathway during inflammation leads to the transcriptional activation of multiple inflammatory genes. Given the plausible impact of NF-κB signaling suppression in mitigating lung injury, substantive evidence demonstrates beta-sitosterol (BS)'s proficient ability to block NF-κB activation...
December 2023: Discovery Medicine
https://read.qxmd.com/read/38043864/the-erythromycin-polyketide-compound-tmc-154-stimulates-ros-generation-to-exert-antibacterial-effects-against-streptococcus-pyogenes
#2
JOURNAL ARTICLE
Yuan-Feng Yan, Ying Liu, Hangeri Liang, Le Cai, Xiao-Yan Yang, Tian-Peng Yin
The erythromycin polyketide compound TMC-154 is a secondary metabolite that is isolated from the rhizospheric fungus Clonostachys rogersoniana associated with Panax notoginseng, which possesses antibacterial activity. However, its antibacterial mechanism has not been investigated thus far. In this study, proteomics coupled with bioinformatics approaches was used to explore the antibacterial mechanism of TMC-154. KEGG pathway enrichment analysis indicated that eight signaling pathways were associated with TMC-154, including oxidative phosphorylation, cationic antimicrobial peptide (CAMP) resistance, benzoate degradation, heme acquisition systems, glycine/serine and threonine metabolism, beta-lactam resistance, ascorbate and aldarate metabolism, and phosphotransferase system (PTS)...
December 1, 2023: Journal of Proteomics
https://read.qxmd.com/read/37867269/topical-anti-ulcerogenic-effect-of-the-beta-adrenergic-blockers-on-diabetic-foot-ulcers-recent-advances-and-future-prospectives
#3
JOURNAL ARTICLE
Prateek Singh, Shweta Sharma, Pramod Kumar Sharma, Aftab Alam
BACKGROUND: Patients with diabetes suffer from major complications like Diabetic Retinopathy, Diabetic Coronary Artery Disease, and Diabetic Foot ulcers (DFUs). Diabetes complications are a group of ailments whose recovery time is especially delayed, irrespective of the underlying reason. The longer duration of wound healing enhances the probability of problems like sepsis and amputation. The delayed healing makes it more critical for research focus. By understanding the molecular pathogenesis of diabetic wounds, it is quite easy to target the molecules involved in the healing of wounds...
October 20, 2023: Current Diabetes Reviews
https://read.qxmd.com/read/37864530/ethanol-exposed-lung-fibroblasts-cause-airway-epithelial-barrier-dysfunction
#4
JOURNAL ARTICLE
Viranuj Sueblinvong, Xian Fan, Craishun Hart, Samuel Molina, Michael Koval, David M Guidot
BACKGROUND: Chronic alcohol ingestion predisposes to lung injury and disrepair during sepsis. Our previous studies outlined roles for transforming growth factor-beta 1 (TGFβ1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in epithelial barrier homeostasis and how alcohol perturbs their expression and signaling. Here we hypothesize that ethanol-exposed lung fibroblasts (LF) are a source of dysregulated TGFβ1 and GM-CSF and thereby alter airway epithelial barrier function...
October 2023: Alcohol Clin Exp Res (Hoboken)
https://read.qxmd.com/read/37013347/%C3%AF-%C3%AF-interferon-%C3%AE-alleviates-sepsis-by-sirt1-mediated-blockage-of-endothelial-glycocalyx-shedding
#5
Suhong Duan, Seung-Gook Kim, Hyung-Jin Lim, Hwa-Ryung Song, Myung-Kwan Han
Sepsis is a life-threatening multi-organ dysfunction with high mortality caused by the body's improper response to microbial infection. No new effective therapy that can adequately treat patients with sepsis has emerged. We previously demonstrated that interferon-beta (IFN-β) protects against sepsis via sirtuin 1- (SIRT1)-mediated immunosuppression. Another study also reported its significant protective effect against acute respiratory distress syndrome, a complication of severe sepsis, in human patients...
April 4, 2023: BMB Reports
https://read.qxmd.com/read/36909244/the-potential-roles-of-galectin-3-in-aki-and-ckd
#6
REVIEW
Fengyun Wang, Lixin Zhou, Amity Eliaz, Chang Hu, Xinhua Qiang, Li Ke, Glenn Chertow, Isaac Eliaz, Zhiyong Peng
Acute kidney injury (AKI) is a common condition with high morbidity and mortality, and is associated with the development and progression of chronic kidney disease (CKD). The beta-galactoside binding protein galectin-3 (Gal3), with its proinflammatory and profibrotic properties, has been implicated in the development of both AKI and CKD. Serum Gal3 levels are elevated in patients with AKI and CKD, and elevated Gal3 is associated with progression of CKD. In addition, Gal3 is associated with the incidence of AKI among critically ill patients, and blocking Gal3 in murine models of sepsis and ischemia-reperfusion injury results in significantly lower AKI incidence and mortality...
2023: Frontiers in Physiology
https://read.qxmd.com/read/36398226/protective-effect-of-endothelial-progenitor-cell-derived-exosomal-microrna-382-3p-on-sepsis-induced-organ-damage-and-immune-suppression-in-mice
#7
JOURNAL ARTICLE
Yang Liu, Tingting Luo, Hong Li, Xueke Zhao, Mingyu Zhou, Mingliang Cheng
OBJECTIVE: To explore the role of endothelial progenitor cell (EPC)-derived exosomal microRNA-382-3p (miR-382-3p) in septic injury in mice. METHODS: A murine model of sepsis was introduced by cecal ligation and puncture (CLP). The model mice were treated with EPC-derived exosomes (Exos). The lung, kidney and liver tissues of mice were collected and stained with hematoxylin and eosin. The lymphocytes in murine spleen tissues, and the proportion and phenotype of the T helper cells (Ths) were examined by flow cytometry...
2022: American Journal of Translational Research
https://read.qxmd.com/read/35571566/metformin-improves-the-prognosis-of-adult-mice-with-sepsis-associated-encephalopathy-better-than-that-of-aged-mice
#8
JOURNAL ARTICLE
Gaofei Song, Huoyan Liang, Heng Song, Xianfei Ding, Dong Wang, Xiaojuan Zhang, Tongwen Sun
Sepsis-associated encephalopathy (SAE) is often associated with increased ICU occupancy and hospital mortality and poor long-term outcomes, with currently no specific treatment. Pathophysiological mechanisms of SAE are complex and may involve activation of microglia, multiple intracranial inflammatory factors, and inflammatory pathways. We hypothesized that metformin may have an effect on microglia, which affects the prognosis of SAE. In this study, metformin treatment of mice with SAE induced by lipopolysaccharide (LPS) reduced the expression of microglia protein and related inflammatory factors...
2022: Journal of Immunology Research
https://read.qxmd.com/read/35145069/blocking-the-human-common-beta-subunit-of-the-gm-csf-il-5-and-il-3-receptors-markedly-reduces-hyperinflammation-in-ards-models
#9
JOURNAL ARTICLE
Hao Wang, Damon J Tumes, Timothy R Hercus, K H Yip, Christian Aloe, Ross Vlahos, Angel F Lopez, Nick Wilson, Catherine M Owczarek, Steven Bozinovski
Acute respiratory distress syndrome (ARDS) is triggered by various aetiological factors such as trauma, sepsis and respiratory viruses including SARS-CoV-2 and influenza A virus. Immune profiling of severe COVID-19 patients has identified a complex pattern of cytokines including granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin (IL)-5, which are significant mediators of viral-induced hyperinflammation. This strong response has prompted the development of therapies that block GM-CSF and other cytokines individually to limit inflammation related pathology...
February 10, 2022: Cell Death & Disease
https://read.qxmd.com/read/34999571/the-application-of-landiolol-in-the-cardiovascular-and-intensive-care
#10
JOURNAL ARTICLE
Péter Radics, Boldizsár Kiss, Enikő Kovács, Dávid Pilecky, Zoltán Ruzsa, Éva Straub, Csaba Fejér, László Gellér, Béla Merkely, Endre Zima
Összefoglaló. A landiolol intravénásan alkalmazandó, kifejezetten cardioselectiv, gyors hatású és rövid felezési idejű béta-1-receptor-blokkoló, mely elsősorban negatív chronotrop és inotrop hatással bír, vérnyomáscsökkentő hatása elhanyagolható. Főleg hemodinamikailag instabil állapotú, supraventricularis ritmuszavarban szenvedő betegek kamrafrekvenciájának csökkentésére használható. Nagy esetszámú, randomizált vizsgálatok igazolták hatékonyságát szívműtétek után jelentkező pitvarfibrilláció megelőzésében, valamint súlyos akut szívelégtelenségben és szívműtétek posztoperatív szakában jelentkező pitvari tachyarrhythmiák kezelésében...
January 9, 2022: Orvosi Hetilap
https://read.qxmd.com/read/34276631/dna-blocks-the-lethal-effect-of-human-beta-defensin-2-against-neisseria-meningitidis
#11
JOURNAL ARTICLE
Gabriela M Wassing, Kenny Lidberg, Sara Sigurlásdóttir, Jonas Frey, Kristen Schroeder, Nathalie Ilehag, Ann-Christin Lindås, Kristina Jonas, Ann-Beth Jonsson
Neisseria meningitidis is a gram-negative bacterium that often asymptomatically colonizes the human nasopharyngeal tract. These bacteria cross the epithelial barrier can cause life-threatening sepsis and/or meningitis. Antimicrobial peptides are one of the first lines of defense against invading bacterial pathogens. Human beta-defensin 2 (hBD2) is an antimicrobial peptide with broad antibacterial activity, although its mechanism of action is poorly understood. Here, we investigated the effect of hBD2 on N. meningitidis ...
2021: Frontiers in Microbiology
https://read.qxmd.com/read/34141509/steroid-induced-sinus-bradycardia
#12
Kanika Khandelwal, Rajasekhar R Madathala, Nikhita Chennaiahgari, Mohammed Yousuffuddin
Steroids are one of the most commonly used drugs and known to be associated with several side effects. There have been case reports about the associated sinus bradycardia with pulse dose corticosteroids administration both IV and oral. We present a case of asymptomatic sinus bradycardia associated with oral prednisone 40 mg. A 69-year-old male was admitted to the ICU for sepsis and subsequently was found to have gastrointestinal (GI) bleed. He developed an acute gout attack during hospitalization and was treated with prednisone 40 mg...
May 16, 2021: Curēus
https://read.qxmd.com/read/32808473/is-lactate-lower-in-septic-patients-who-are-prescribed-beta-blockers-retrospective-cohort-study-of-an-intensive-care-population
#13
JOURNAL ARTICLE
Diem Pham, Harrison Ward, Brian Yong, Jayanand Mahendra Raj, Mariam Awad, Martyn Harvey, Steven Doherty, Grant Cave
OBJECTIVE: Elevated serum lactate has long been considered an important marker of sepsis severity. Increasing evidence supports catecholamine-stimulated aerobic glycolysis being a major contributor to the hyperlactataemia seen in sepsis. Beta-blockade may blunt such catecholamine mediated rise in lactate analogous to the way it can mask tachycardia. This could impact the way we evaluate sepsis severity and adequacy of initial treatment. The objective of this study is to investigate whether septic patients who were on beta-blocker treatment at presentation have lower serum lactate level...
February 2021: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/32534175/three-novel-prevention-diagnostic-and-treatment-options-for-covid-19-urgently-necessitating-controlled-randomized-trials
#14
JOURNAL ARTICLE
Richard I Horowitz, Phyllis R Freeman
PURPOSE: Asymptomatic or minimally symptomatic infection with COVID-19 can result in silent transmission to large numbers of individuals, resulting in expansion of the pandemic with a global increase in morbidity and mortality. New ways of screening the general population for COVID-19 are urgently needed along with novel effective prevention and treatment strategies. HYPOTHESIS: A hypothetical three-part prevention, diagnostic, and treatment approach based on an up-to-date scientific literature review for COVID-19 is proposed...
October 2020: Medical Hypotheses
https://read.qxmd.com/read/32442451/perivascular-adipose-tissue-phenotype-and-sepsis-vascular-dysfunction-differential-contribution-of-no-ros-and-beta-3-adrenergic-receptor
#15
JOURNAL ARTICLE
Clarissa Germano Barp, Patricia Oliveira Benedet, Jamil Assreuy
AIMS: Vascular dysfunction plays a key role in sepsis but the role of perivascular adipose tissue (PVAT) in this condition is relatively unknown. MAIN METHODS: Sepsis was induced by cecal ligation and puncture (CLP). The responses of the aorta and superior mesenteric artery to norepinephrine in the presence or absence of PVAT were evaluated. Fluorescent probes measured the production of nitric oxide (NO) and reactive oxygen species (ROS). NO synthases (NOS) and β3-adrenoceptor expression were detected by immunofluorescence and S-nitrosylation by the biotin switch assay...
August 1, 2020: Life Sciences
https://read.qxmd.com/read/32025431/effect-of-beta-blockers-on-tachycardia-in-patients-with-pulmonary-embolism
#16
JOURNAL ARTICLE
Hafiz M Aslam, Hafiz S Naeem, Swati Prabhakar, Talha Awwal, Muhammad Khalid, Anand Kaji
Hypothesis Beta-blockers (BBs) lower the heart rate, which may mask the diagnosis of pulmonary embolism (PE) since one of the main clinical diagnoses of PE is tachycardia. The endpoint of our retrospective study is to determine if the pre-existing use of (BB) significantly affects the utility of these scoring criteria in diagnosing PE. Introduction Diagnosing PE is a challenge because of the non-specificity of its symptoms and signs. The initial step is to assess the patient's likelihood of having a PE. This involves using a scoring system to stratify patients into different levels of risk of having PE (for example, as 'low,' 'moderate,' or 'high' risk)...
December 30, 2019: Curēus
https://read.qxmd.com/read/31771622/msc-secreted-tgf-%C3%AE-regulates-lipopolysaccharide-stimulated-macrophage-m2-like-polarization-via-the-akt-foxo1-pathway
#17
JOURNAL ARTICLE
Feng Liu, Haibo Qiu, Ming Xue, Shi Zhang, Xiwen Zhang, Jingyuan Xu, Jianxiao Chen, Yi Yang, Jianfeng Xie
BACKGROUND: An uncontrolled inflammatory response is a critical pathophysiological feature of sepsis. Mesenchymal stem cells (MSCs) induce macrophage phenotype polarization and reduce inflammation in sepsis. MSC-secreted transforming growth factor beta (TGF-β) participated in the immune modulatory function of MSCs. However, the underlying mechanism of MSC-secreted TGF-β was not fully elucidated in regulation macrophage M2-like polarization. METHODS: The paracrine effects of MSCs on macrophage polarization were studied using a co-culture protocol with LPS-stimulated RAW264...
November 26, 2019: Stem Cell Research & Therapy
https://read.qxmd.com/read/29969314/formoterol-treatment-prevents-the-effects-of-endotoxin-on-muscle-tnf-nf-kb-akt-mtor-and-proteolytic-pathways-in-a-rat-model-role-of-igf-i-and-mirna-29b
#18
JOURNAL ARTICLE
Ana Isabel Martín, Ana Belén Gómez-SanMiguel, Teresa Priego, Asunción López-Calderón
Inflammatory diseases are associated with muscle wasting as a result of an increase in proteolysis. The purpose of this study was to elucidate whether administration of a β2 adrenergic agonist, formoterol, was able to prevent the acute effects of sepsis induced by liposaccharide (LPS) injection on rat gastrocnemius muscle and to evaluate the possible roles of corticosterone, IGF-I, miR-23a, and miR-29b. For this purpose, male Wistar rats were injected with LPS and/or formoterol. Formoterol treatment decreased LPS-induced increase in serum corticosterone, TNFα upregulation, and NF-κB(p65) and Forkhead box protein O1 activation in the gastrocnemius...
October 1, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/28658023/preadmission-use-of-calcium-channel-blocking-agents-is-associated-with-improved-outcomes-in-patients-with-sepsis-a-population-based-propensity-score-matched-cohort-study
#19
COMPARATIVE STUDY
Chien-Chang Lee, Meng-Tse Gabriel Lee, Wan-Chien Lee, Chih-Cheng Lai, Christin Chih-Ting Chao, Wan-Ting Hsu Hsu, Shy-Shin Chang, Matthew Lee
OBJECTIVES: Use of calcium channel blockers has been found to improve sepsis outcomes in animal studies and one clinical study. This study determines whether the use of calcium channel blockers is associated with a decreased risk of mortality in patients with sepsis. DESIGN: Population-based matched cohort study. SETTING: National Health Insurance Research Database of Taiwan. PATIENTS: Hospitalized severe sepsis patients identified from National Health Insurance Research Database by International Classification of Diseases, Ninth Revision, Clinical Modification codes...
September 2017: Critical Care Medicine
https://read.qxmd.com/read/28501779/coenzyme-q10-improves-the-survival-mesenteric-perfusion-organs-and-vessel-functions-in-septic-rats
#20
JOURNAL ARTICLE
Erdem Kamil Ozer, Mustafa Tugrul Goktas, Ibrahim Kilinc, Sultan Pehlivan, Hulagu Bariskaner, Ceyhan Ugurluoglu, Alper Bektas Iskit
BACKGROUND: Coenzyme Q10 (CoQ10) is a naturally occurring, lipid-soluble antioxidant and an essential electron carrier in the mitochondrial respiratory chain. In sepsis, CoQ10 deficiency induced by mitochondrial failure can lead to hypoxia, hypoperfusion, oxidative organ damage and finally death. We aimed to investigate the effects of CoQ10 on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis...
July 2017: Biomedicine & Pharmacotherapy
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