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https://www.readbyqxmd.com/read/29782359/brca1-mutations-associated-with-increased-risk-of-brain-metastases-in-breast-cancer-a-1-2-matched-pair-analysis
#1
Peter J Zavitsanos, David E Wazer, Jaroslaw T Hepel, Yihong Wang, Kamaljeet Singh, Kara L Leonard
BACKGROUND: Brain metastases (BM) occur in ∼5% of breast cancer patients. BRCA1-associated cancers are often basal-like and basal-like cancers are known to have a predilection for central nervous system metastases. We performed a matched-pair analysis of breast cancer patients with and without BRCA mutations and compared the frequency of BM in both groups. MATERIALS AND METHODS: From a database of 1935 patients treated for localized breast cancer at our institution from 2009 to 2014 we identified 20 patients with BRCA1 or BRCA2 mutations and manually matched 40 patients without BRCA mutations accounting for age, stage, estrogen receptor expression, and human epidermal growth factor receptor 2 (HER2) expression...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29777533/combination-of-apatinib-and-continuous-nutritional-support-for-a-gastric-cancer-patient-with-brain-metastasis-prolongs-survival
#2
Y Yang, X Pei, M Yang
WHAT IS KNOWN AND OBJECTIVES: Gastric cancer is the most common gastrointestinal malignant tumour in China, which rarely metastasizes into the central nervous system. However, brain metastasis leads to increased risk of death. CASE SUMMARY: Here, we report a case of brain metastasis from gastric cancer, which was treated with apatinib and continual nutritional support, with a survival time of 2 years. WHAT IS NEW AND CONCLUSION: The combination of apatinib and continual nutritional support may be an option for the treatment of brain metastasis from gastric cancer...
May 18, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29772358/tumor-to-lesion-metastasis-a-case-report-of-carcinoma-metastasis-to-multiple-sclerosis-lesion
#3
Jian-Qiang Lu, Suresh Menon, Crystal Fong, Boleslaw Lach, Christopher Power
BACKGROUND: The term of "tumor-to-lesion metastasis" is an extension of "tumor-to-tumor metastasis", which is a rare but well-documented phenomenon. Tumor metastasis to the meninges and/or central nervous system (CNS) is rare in patents with multiple sclerosis (MS), although MS lesions bear many similarities to the primary tumor microenvironment and the metastatic niche. We present the first case of malignant tumor metastasis to MS lesions with immunophenotyping of inflammatory cells in the metastatic foci...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770253/simultaneous-cerebrospinal-fluid-and-hematologic-metastases-in-a-high-grade-ependymoma
#4
Daniel Diaz-Aguilar, Sergei Terterov, Alexander M Tucker, Shaina Sedighim, Rudi Scharnweber, Stephanie Wang, Catherine Merna, Shayan Rahman
Background: Ependymomas are relatively uncommon tumors that constitute about 7% of all primary intracranial neoplasms. Among these, high-grade ependymomas are locally aggressive and recur most commonly at the primary site following resection. Ependymomas are also known to be the one glial neoplasm that tends to frequently metastasize inside and outside the central nervous system (CNS) that complicates workup and management. Metastasis due to surgical manipulation is common and neurosurgeons should be well-versed in the most effective methods to remove these tumors in order to avoid such metastases...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29764516/somatic-mutation-landscape-of-a-meningioma-and-its-pulmonary-metastasis
#5
Yaran Du, Ting Lu, Song Huang, Fangfang Ren, Gang Cui, Jian Chen
BACKGROUND: Extracranial metastasis (ENM) of meningiomas is extremely rare, and typically occurs several years after a primary tumor is diagnosed. However, the genetic changes underlying ENM events have not yet been investigated. CASE PRESENTATION: A 58-year-old male patient was sent to the emergency room of our hospital because of a sudden fall. Magnetic resonance imaging detected a mass at the right frontal sagittal sinus. He underwent tumor resection and recovered well, but post-operative computed tomography revealed three lumps on the right side of his chest...
May 4, 2018: Cancer communications
https://www.readbyqxmd.com/read/29753293/risk-assessment-of-in-hospital-mortality-of-patients-with-epilepsy-a-large-cohort-study
#6
Yang Si, Xiaoqiang Xiao, Shunju Xiang, Jing Liu, Qianning Mo, Hongbin Sun
PURPOSE: This study aimed to explore the mortality risks of hospitalized patients with epilepsy (PWE). METHODS: Our data source was extracted from discharge abstracts in a hospital medical database. Various clinical variables, including demographical characteristics, natural features of epilepsy, and comprehensive set of comorbidities, were screened to investigate the risk. Comorbidities were defined using a validated ICD-10-based classification. The distributions of comorbid conditions and demographics were presented...
May 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29746255/a-novel-functional-polymorphism-of-gfap-decrease-glioblastoma-susceptibility-through-inhibiting-the-binding-of-mir-139
#7
Jie Wang, Ming-Lei Wang, Chang-Hui Wang, Shu-Yan Sun, Han-Bing Zhang, Yang-Yang Jiang, Qi-Wu Xu, Ying Wang, Shi-Xin Gu
Glioblastoma (GBM) is the most commonly diagnosed solid tumor outside the central nervous system. However, genetic factors underlying GBM remain largely unclear. Previous studies indicated that Glial fibrillary acidic protein ( GFAP ) might play an important role in the aggressiveness of GBM and also contributed to its poor overall survival. The present study aims to test (1) the associations between GFAP single nucleotide polymorphisms (SNPs) and GBM cells chemoresistance and metastasis, and (2) the molecular mechanism accounting for their effects...
May 10, 2018: Aging
https://www.readbyqxmd.com/read/29745056/neuroproteins-in-cancer-assumed-bystanders-become-culprits
#8
Xiang Li, Matt D Dun, Sam Faulkner, Hubert Hondermarck
Recent breakthrough discoveries have highlighted the stimulatory role of nerves in cancer initiation and progression, through the release of neurotransmitters and growth factors by nerve terminals in the tumor microenvironment. Intriguingly, neuroproteins such as neuronal membrane proteins, synaptic proteins, neurotransmitters and neurotrophic growth factors as well as their corresponding receptors, to name only a few, are frequently found in proteomic analyses of cancer tissues external to the brain and central nervous system...
May 9, 2018: Proteomics
https://www.readbyqxmd.com/read/29738653/-prognostic-factors-in-patients-with-breast-cancer-and-brain-metastasis-as-the-first-site-of-recurrence
#9
Alejandro Mohar-Betancourt, Alberto Alvarado-Miranda, Juan Alejandro Torres-Domínguez, Paula Cabrera, Fernando Lara-Medina, Yaudim Sadid Villarreal-Gómez, Nancy Reynoso-Noverón
OBJECTIVE: To evaluate the prognostic factors (clinicalpathological characteristics and treatments) in patients with breast cancer and metastasis to central nervous system (CNS) as the first site of the disease. MATERIAL AND METHODS: Kaplan-Meier method and life tables were used to estimate overall survival time over a retrospective cohort of 125 breast cancer patients treated at the Instituto Nacional de Cancerología (INCan) during 2007-2015, who presented metastasis to the CNS as the first site of extension of the disease...
March 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29736685/emerging-trends-in-the-management-of-brain-metastases-from-non-small-cell-lung-cancer
#10
REVIEW
Thomas M Churilla, Stephanie E Weiss
PURPOSE OF REVIEW: To summarize current approaches in the management of brain metastases from non-small cell lung cancer (NSCLC). RECENT FINDINGS: Local treatment has evolved from whole-brain radiotherapy (WBRT) to increasing use of stereotactic radiosurgery (SRS) alone for patients with limited (1-4) brain metastases. Trials have established post-operative SRS as an alternative to adjuvant WBRT following resection of brain metastases. Second-generation TKIs for ALK rearranged NSCLC have demonstrated improved CNS penetration and activity...
May 7, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29736308/spocd1-promotes-the-proliferation-and-metastasis-of-glioma-cells-by-up-regulating-ptx3
#11
Quan Liu, Xiao-Yu Wang, Yuan-Yuan Qin, Xian-Lei Yan, Hong-Mou Chen, Qi-Dan Huang, Jia-Kang Chen, Jie-Min Zheng
Gliomas are the most prevalent type of primary brain tumors in adults, accounting for more than 40% of neoplasms in the central nervous system. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) has been recently identified and found to discriminate progressive from non-progressive bladder cancers. In this study, we detected high-level of SPOCD1 expression in glioma and its high expression significantly associated with advanced tumor grade and poor prognosis. In vitro assays showed that knockdown of SPOCD1 significantly inhibited cell proliferation and colony formation capacities in U373 and U87 cells...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29717928/impact-of-the-autonomic-nervous-system-on-the-skeleton
#12
Florent Elefteriou
It is from the discovery of leptin and the central nervous system as a regulator of bone remodeling that the presence of autonomic nerves within the skeleton transitioned from a mere histological observation to the mechanism whereby neurons of the central nervous system communicate with cells of the bone microenvironment and regulate bone homeostasis. This shift in paradigm sparked new preclinical and clinical investigations aimed at defining the contribution of sympathetic, parasympathetic, and sensory nerves to the process of bone development, bone mass accrual, bone remodeling, and cancer metastasis...
July 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29703764/emerging-gene-fusion-drivers-in-primary-and-metastatic-central-nervous-system-malignancies-a-review-of-available-evidence-for-systemic-targeted-therapies
#13
REVIEW
Priscilla K Brastianos, Franziska Maria Ippen, Umbreen Hafeez, Hui K Gan
Primary and metastatic tumors of the central nervous system present a difficult clinical challenge, and they are a common cause of disease progression and death. For most patients, treatment consists primarily of surgery and/or radiotherapy. In recent years, systemic therapies have become available or are under investigation for patients whose tumors are driven by specific genetic alterations, and some of these targeted treatments have been associated with dramatic improvements in extracranial and intracranial disease control and survival...
April 27, 2018: Oncologist
https://www.readbyqxmd.com/read/29700002/zika-virus-selectively-kills-aggressive-human-embryonal-cns-tumor-cells-in-vitro-and-in-vivo
#14
Carolini Kaid, Ernesto Goulart, Luiz Carlos Caires-Júnior, Bruno Henrique Silva Araujo, Alessandra Soares-Schanoski, Heloisa Maria Siqueira Bueno, Kayque Alves Telles Silva, Renato M Astray, Amanda F Assoni, Antonio F Ribeiro Júnior, Daniella Cristina Ventini, Ana L P Puglia, Roselane P Gomes, Mayana Zatz, Oswaldo K Okamoto
Zika virus (ZIKV) is largely known for causing brain abnormalities due to its ability to infect neural progenitor stem cells (NPC) during early development. Here we show that ZIKV is also capable of infecting and destroying stem-like cancer cells from aggressive human embryonal tumors of the central nervous system (CNS). When evaluating the oncolytic properties of Brazilian Zika virus strain (ZIKVBR) against human breast, prostate, colorectal, and embryonal CNS tumor cell lines, we verified a selective infection of CNS tumor cells followed by massive tumor cell death...
April 26, 2018: Cancer Research
https://www.readbyqxmd.com/read/29687085/orbital-melanocytoma-when-a-tumor-becomes-a-relieving-surprise
#15
Haytham E Nasr, Mohamed A Nouh, Rania A Ahmed, Abdelrahman M Elhusseiny
Purpose: Melanocytomas are rare pigmented tumors that arise form melanocytes and have been reported in the central nervous system. Orbital melanocytomas "also known as blue nevus" are rarely reported. The occurrence of choroidal melanoma and orbital melanocytomas has never been described. Observations: This is a case of orbital melanocytoma in a 34 year old female who presented with left proptosis and ecchymosis. She has the right eye enucleated to treat a large choroidal melanoma, 6 years earlier...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29686118/pearls-oy-sters-the-critical-role-of-histopathology-in-diagnosing-cancer-associated-necrotizing-cns-vasculitis
#16
Joshua Sheehan, Jessica Tate, Ryan Mott, Carol Geer, Rachel Wolfe, Roy E Strowd, Amy Guzik
OBJECTIVE: To highlight the importance of a broad differential and histopathologic confirmation in patients with newly diagnosed cancer with brain lesions atypical for CNS metastasis. METHODS: We report 2 cases of biopsy-proven CNS vasculitis in patients undergoing treatment for a newly diagnosed nonmetastatic cancer. Comprehensive medical record review was performed to identify the clinical presentation, representative neuroimaging, histopathologic features, and response to treatment...
April 24, 2018: Neurology
https://www.readbyqxmd.com/read/29685116/characterization-treatment-and-prognosis-of-retinoblastoma-with-central-nervous-system-metastasis
#17
Huimin Hu, Weiling Zhang, Yizhuo Wang, Dongsheng Huang, Jitong Shi, Bin Li, Yi Zhang, Yan Zhou
BACKGROUND: Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of the largest tertiary eye centers in China. METHODS: Clinical data of 31 consecutive retinoblastoma patients with CNS metastases, who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital between September 2005 and December 2015, were retrospective analyzed...
April 23, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29682040/widespread-intra-abdominal-carcinomatosis-from-a-rhabdoid-meningioma-after-placement-of-a-ventriculoperitoneal-shunt-a-case-report-and-review-of-the-literature
#18
Jun Jie Ng, Kok Ann Teo, Asim Shabbir, Tseng Tsai Yeo
Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). However, there has been no previous reports in literature involving meningiomas. A case of primary rhabdoid meningioma with widespread intra-abdominal carcinomatosis after placement of a VPS in a 36-year-old man is described. The patient underwent preoperative angioembolization of the tumor, craniotomy, and surgical excision, followed by postoperative gamma knife radiosurgery...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29678476/cabazitaxel-plus-lapatinib-as-therapy-for-her2-metastatic-breast-cancer-with-intracranial-metastases-results-of-a-dose-finding-study
#19
Denise A Yardley, Lowell L Hart, Patrick J Ward, Gail L Wright, Mythili Shastry, Lindsey Finney, Laura M DeBusk, John D Hainsworth
BACKGROUND: Lapatinib is an oral small molecule tyrosine kinase epidermal growth factor receptor-1/HER2 inhibitor that crosses the blood-brain barrier and is active against central nervous system (CNS) metastases. Cabazitaxel is a taxoid that is effective against taxane-resistant metastatic breast cancer (MBC) and has distinguished itself by its ability to cross the blood-brain barrier. The present phase II study (ClinicalTrials.gov identifier, NCT01934894) evaluated the combination of these agents to treat HER2+ MBC patients with CNS metastases...
March 8, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29666949/precision-medicine-against-alk-positive-non-small-cell-lung-cancer-beyond-crizotinib
#20
REVIEW
Biagio Ricciuti, Andrea De Giglio, Carmen Mecca, Cataldo Arcuri, Sabrina Marini, Giulio Metro, Sara Baglivo, Angelo Sidoni, Guido Bellezza, Lucio Crinò, Rita Chiari
Anaplastic lymphoma kinase (ALK) rearrangements represent the molecular driver of a subset of non-small cell lung cancers (NSCLCs). Despite the initial response, virtually all ALK-positive patients develop an acquired resistance to the ALK inhibitor crizotinib, usually within 12 months. Several next-generation ALK inhibitors have been developed in order to overcome crizotinib limitation, providing an unprecedented survival for this subset of patients. The aim of this review to summarize the current knowledge on ALK tyrosine kinase inhibitors (TKIs) in the treatment of advanced ALK-positive NSCLC, focusing on the role of novel ALK inhibitors in this setting...
April 17, 2018: Medical Oncology
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