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JOURNAL ARTICLE
Alana Z Slavin, Ian C Fischer, Robert H Pietrzak
Adverse childhood experiences (ACEs) are robustly associated with adverse mental health outcomes across the lifespan. Military veterans may be particularly vulnerable to adverse mental health effects of ACEs given their potentially higher prevalence of childhood traumas and compounding effects of military service-related traumas. To date, however, scarce research has examined the differential impact of individual ACEs on mental health outcomes in population-based samples of veterans. To address this gap, we analyzed data from the National Health and Resilience in Veterans Study (NHRVS), which surveyed a nationally representative sample of 4069 U...
February 26, 2024: Journal of Psychiatric Research
#22
JOURNAL ARTICLE
Danielle Fearon, Christopher M Perlman, Scott Leatherdale, John P Hirdes, Joel Dubin
BACKGROUND: Trauma is commonly overlooked or undiagnosed in clinical care settings. Undetected trauma has been associated with elevated substance use highlighting the need to prioritize identifying individuals with undetected trauma through common characteristics. OBJECTIVE: The purpose of this study is to identify classifications of traumatic life experiences and substance use among persons admitted to inpatient psychiatry in Ontario and to identify covariates associated with classification membership...
February 2, 2024: Journal of Psychiatric Research
#23
JOURNAL ARTICLE
Jordan C Alvarez, Dominic M Denning, Jorge Castro Lebron, Veronica Ho, Sabrina Chen, Tiffany A Brown
Prior research has been conflicted on whether gay community involvement serves as a risk or protective factor for body image and eating disorders (EDs) in sexual minority men (SMM), perhaps given that prior research has examined community involvement unidimensionally. The present study examined whether non-appearance-based ("social activism") and appearance-based ("going out/nightlife") community involvement differentially predicted ED prevention outcomes in SMM. SMM ( N = 73) enrolled in a randomized controlled trial of an ED prevention program completed measures of community involvement, drive for muscularity, body dissatisfaction, and bulimic symptoms at pre-intervention, post-intervention, and 1-month follow-up...
February 20, 2024: Eating Disorders
#24
JOURNAL ARTICLE
Hina Singh, Jeffrey Koury, Ricky Maung, Amanda J Roberts, Marcus Kaul
Human immunodeficiency virus-1 (HIV-1) infects the central nervous system (CNS) and causes HIV-associated neurocognitive disorders (HAND) in about half of the population living with the virus despite combination anti-retroviral therapy (cART). HIV-1 activates the innate immune system, including the production of type 1 interferons (IFNs) α and β. Transgenic mice expressing HIV-1 envelope glycoprotein gp120 (HIVgp120tg) in the CNS develop memory impairment and share key neuropathological features and differential CNS gene expression with HIV patients, including the induction of IFN-stimulated genes (ISG)...
February 13, 2024: Brain, Behavior, and Immunity
#25
JOURNAL ARTICLE
Ryan T McCallum, Rachel-Karson Thériault, Joshua D Manduca, Isaac S B Russell, Angel M Culmer, Janan Shoja Doost, Tami A Martino, Melissa L Perreault
BACKGROUND: Major depressive disorder (MDD) is a recurring affective disorder that is two times more prevalent in females than males. Evidence supports immune system dysfunction as a major contributing factor to MDD, notably in a sexually dimorphic manner. Nuclear factor erythroid 2-related factor 2 (Nrf2), a regulator of antioxidant signalling during inflammation, is dysregulated in many chronic inflammatory disorders; however, its role in depression and the associated sex differences have yet to be explored...
February 13, 2024: Biology of Sex Differences
#26
JOURNAL ARTICLE
Nora M Laskowski, Gerrit Brandt, Georgios Paslakis
OBJECTIVE: From the very beginning of the COVID-19 pandemic, gender was shown to play a significant role in how people were affected by it, while aspects related to sexual and gender minorities (SGM) have been rather understudied. The aim of this review was to synthesize systematic reviews and meta-analyses that explicitly addressed the impact of gender within the context of the pandemic, with a focus on SGM. METHODS: We based the narrative synthesis of results on a literature search of PubMed...
February 2024: Psychotherapie, Psychosomatik, Medizinische Psychologie
#27
JOURNAL ARTICLE
Ziyi Xie, Zhizhuang Duan
BACKGROUND: In 2021, a Chinese court, based on the newly enacted Civil Code, first revoked a marriage license due to the spouse's failure to disclose their HIV infection before the marriage. This landmark case ignited a fresh debate on whether people living with HIV (PLHIV) have a legal duty to inform their spouses and sexual partners. Advances in medicine have partially isolated HIV transmission from sexual contact, extending the legal basis for the obligation to disclose beyond disease prevention...
February 4, 2024: Harm Reduction Journal
#28
JOURNAL ARTICLE
Pedro Marra, Tomoteru Seki, Yoshitaka Nishizawa, Gloria Chang, Kyosuke Yamanishi, Tsuyoshi Nishiguchi, Kazuki Shibata, Patricia Braun, Gen Shinozaki
BACKGROUND: Military sexual trauma (MST) is a prevalent issue within the U.S. military. Victims are more likely to develop comorbid diseases such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). Nonetheless, not everyone who suffers from MST develops PTSD and/or MDD. DNA methylation, which can regulate gene expression, might give us insight into the molecular mechanisms behind this discrepancy. Therefore, we sought to identify genomic loci and enriched biological pathways that differ between patients with and without MST, PTSD, and MDD...
February 1, 2024: Journal of Affective Disorders
#29
JOURNAL ARTICLE
Aasiya Lakhi, Sylvia Fanucchi
Forkhead box P2 (FOXP2) regulates expression of various genes and is associated with language, speech and neural development as well as cancer. Since there may be a putative link between sex and language and because transcription factors rarely function in isolation, this study aims to investigate whether FOXP2 directly associates with oestrogen receptor α (ER1), a nuclear receptor responsible for sexual differentiation that is also associated with cancer. Isothermal titration calorimetry and fluorescence anisotropy were used to investigate the interaction between the DNA-binding forkhead domain (FHD) of FOXP2, the N-terminal region (NT) of FOXP2, and the ligand-binding domain (LBD) of ER1...
January 29, 2024: Biochimie
#30
REVIEW
Li Ren, Tiehua Zhang, Jie Zhang
As a nuclear transcription factor, the androgen receptor (AR) plays a crucial role not only in normal male sexual differentiation and growth of the prostate, but also in benign prostatic hyperplasia, prostatitis, and prostate cancer. Multiple population-based epidemiological studies demonstrated that prostate cancer risk was inversely associated with increased dietary intakes of green tea, soy products, tomato, and so forth. Therefore, this review aimed to summarize the structure and function of AR, and further illustrate the structural basis for antagonistic mechanisms of the currently clinically available antiandrogens...
January 27, 2024: Medicinal Research Reviews
#31
REVIEW
Chiara Di Tucci, Ludovico Muzii
Chronic pelvic pain (CPP) is generally defined as non-cyclic pain perceived in the pelvic area that has persisted from three to six months or longer and is unrelated to pregnancy. The etiology of CPP is complex, multifactorial, with heterogeneous presentation, and includes several diseases such as endometriosis, adenomyosis, and interstitial cystitis/bladder pain syndrome. It may also be associated with sexual dysfunction, musculoskeletal disorders, and comorbid psychiatric symptoms. Vulvar pain disorders (VPDs) are typically categorized separately from chronic pelvic pain; among all VPDs, vulvodynia is a chronic vulvar pain of unknown etiology, lasting at least 3 months and that might be associated with other potentially linked factors...
December 19, 2023: Biomedicines
#32
JOURNAL ARTICLE
Fengting Yu, Chengjie Ma, Xia Jin, Hongxin Zhao, Jiang Xiao, Li Li, Shujing Song, Xiaohui Xie, Siyuan Yang, Yunxia Tang, Linghang Wang, Fujie Zhang
BACKGROUND: In HIV-1 infection, more than 95% of CD4+ T cells die of caspase-1 mediated pyroptosis. What governs the increased susceptibility of CD4+ T cells to pyroptosis is poorly understood. METHODS: Blood samples were obtained from 31 untreated HIV-infected patients (UNT), 29 antiretroviral therapy treated HIV-infected patients (ART), and 21 healthy control donors (HD). Plasma levels of IL-18 and IL-1β, caspase-1 expression, mitochondrial mass (MM) and mitochondrial fusion/fisson genes of CD4+ T subsets were measured...
January 24, 2024: BMC Infectious Diseases
#33
Sajid Ali, Tariq Latif, Muhammad Ali Sheikh, Muhammad Bilal Shafiq
INTRODUCTION: Wilms tumor is the most common renal malignancy in children. The occurrence of Wilms tumor with various congenital genitourinary anomalies has been reported, particularly in horseshoe kidneys, hypospadias, disorder of sexual development, and double collecting system. However, Wilms tumor with crossed renal ectopia is a rare finding. CASE DESCRIPTION: We are reporting a case report of Wilms tumor in a 3-year-old girl who presented with a huge left flank mass with cross-fused renal ectopia...
2024: Journal of cancer & allied specialties
#34
JOURNAL ARTICLE
Gonzalo R Quintana, Fernando P Ponce, Javier I Escudero-Pastén, Juan F Santibáñez-Palma, Léna Nagy, Mónika Koós, Shane W Kraus, Zsolt Demetrovics, Marc N Potenza, Rafael Ballester-Arnal, Dominik Batthyány, Sophie Bergeron, Joël Billieux, Peer Briken, Julius Burkauskas, Georgina Cárdenas-López, Joana Carvalho, Jesús Castro-Calvo, Lijun Chen, Giacomo Ciocca, Ornella Corazza, Rita I Csako, David P Fernandez, Elaine F Fernandez, Hironobu Fujiwara, Johannes Fuss, Roman Gabrhelík, Ateret Gewirtz-Meydan, Biljana Gjoneska, Mateusz Gola, Joshua B Grubbs, Hashim T Hashim, Md Saiful Islam, Mustafa Ismail, Martha C Jiménez-Martínez, Tanja Jurin, Ondrej Kalina, Verena Klein, András Költő, Chih-Ting Lee, Sang-Kyu Lee, Karol Lewczuk, Chung-Ying Lin, Christine Lochner, Silvia López-Alvarado, Kateřina Lukavská, Percy Mayta-Tristán, Dan J Miller, Oľga Orosová, Gábor Orosz, Gabriel C Quintero Garzola, Jano Ramos-Diaz, Kévin Rigaud, Ann Rousseau, Marco De Tubino Scanavino, Marion K Schulmeyer, Pratap Sharan, Mami Shibata, Sheikh Shoib, Vera Sigre-Leirós, Luke Sniewski, Ognen Spasovski, Vesta Steibliene, Dan J Stein, Berk C Ünsal, Marie-Pier Vaillancourt-Morel, Marie Claire Van Hout, Beáta Bőthe
BACKGROUND: Depression and anxiety are among the most prevalent mental health issues experienced worldwide. However, whereas cross-cultural studies utilize psychometrically valid and reliable scales, fewer can meaningfully compare these conditions across different groups. To address this gap, the current study aimed to psychometrically assess the Brief Symptomatology Index (BSI) in 42 countries. METHODS: Using data from the International Sex Survey (N = 82,243; Mage = 32...
January 18, 2024: Journal of Affective Disorders
#35
JOURNAL ARTICLE
Chelsea D Kilimnik, Grisel García-Ramírez, Nashalys K Salamanca, G Mitchell Mazzone, K Nicole Mullican, Kelly Cue Davis, Lindsay M Orchowski, Ruschelle M Leone, Debra Kaysen, Amanda K Gilmore
BACKGROUND: Sexual assault (SA) is experienced by a substantial proportion of emerging adult college students and is associated with elevated rates of posttraumatic stress disorder (PTSD) and alcohol use. This study examines the mediating role of posttraumatic stress symptoms (PTSS) in the associations among SA severity, drinking to cope with anxiety, and average weekly drinks while considering the moderating roles of gender identity and sexual orientation. METHODS: A total of 2160 college students who were diverse in gender (cisgender women, 64...
November 2023: Alcohol Clin Exp Res (Hoboken)
#36
JOURNAL ARTICLE
Abigail W Batchelder, M Claire Greene, Jillian R Scheer, Jacklyn Foley, Hyo Jin Jenny Shin, Kyrié M Koehn, John F Kelly
PURPOSE: Sexual minority (SM; e.g., gay, lesbian, bisexual) individuals are disproportionately impacted by alcohol and other drug (AOD) use disorders and psychosocial factors that can exacerbate AOD use disorders and hinder recovery. This study examines SM sub-group differences (monosexual [gay/lesbian] versus bisexual) regarding adaptation to recovery measured by indices of psychosocial functioning. Identifying differential needs of gay/lesbian versus bisexual individuals could improve services to better meet the needs of SM individuals in recovery...
June 2024: Addictive Behaviors Reports
#37
JOURNAL ARTICLE
Duncan Nowling, Kathleen I Crum, Jane Joseph
BACKGROUND AND PURPOSE: Understanding sex differences in typical development of the face processing network is important for elucidating disruptions during atypical development in sex-linked developmental disorders like autism spectrum disorder. Based on prior sex difference studies in other cognitive domains, this study examined whether females show increased integration of core and extended face regions with age for face viewing, while males would show increased segregation. METHODS: This study used a cross-sectional design with typically developing children and adults (n = 133) and a functional MRI face localizer task...
January 2, 2024: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
#38
JOURNAL ARTICLE
Hyun-Ju Kim, Jieun Kim, Ki-Hwan Yook, Tai Kiu Choi, Sang-Hyuk Lee
OBJECTIVE: Early trauma significantly affects the severity of panic disorder (PD) symptoms and suicidal ideation. However, few studies have explored the specific effects of different early trauma subtypes on PD. This study analyzed how childhood trauma subtypes, including general, physical, emotional, and sexual, influence panic and phobia levels and suicidal ideation in adults with PD and healthy controls (HCs). METHODS: In total, 455 adults with PD and 149 HCs participated in this study...
December 2023: Psychiatry Investigation
#39
REVIEW
Understanding Hypoactive Sexual Desire Disorder (HSDD) in Women: Etiology, Diagnosis, and Treatment.
Vaishnavi Ronghe, Krutika Pannase, Kavita P Gomase, Manjusha G Mahakalkar
Hypoactive Sexual Desire Disorder (HSDD) is a complex and multifaceted condition that significantly impacts the sexual well-being and overall quality of life of women. This comprehensive review aims to provide a holistic understanding of HSDD by exploring its etiology, diagnostic criteria, treatment approaches, and broader societal implications. The review delves into the intricate interplay of biological factors, including hormonal changes and neurotransmitter imbalances, that contribute to HSDD. Psychological factors, such as relationship issues, body image, and stress, are examined with sociocultural factors like societal norms, cultural influences, and media portrayals of sexuality...
November 2023: Curēus
#40
JOURNAL ARTICLE
Tom Mazur, Jennifer O'Donnell, Peter A Lee
46, XX individuals born with severely masculinized genitals due to congenital adrenal hyperplasia (CAH) who have been assigned males at birth and reared male can successfully establish a male gender identity/role, find employment, marry, function sexually with a female partner, and develop positive mental health status. While there were a few individuals who reportedly did not fare well or who changed gender to female, the majority of those identifying as males appear to have an overall good quality of life...
December 27, 2023: Journal of Clinical Research in Pediatric Endocrinology
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