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disorders of sexual differentiation

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https://www.readbyqxmd.com/read/28544045/are-there-sensitive-periods-when-child-maltreatment-substantially-elevates-suicide-risk-results-from-a-nationally-representative-sample-of-adolescents
#1
Stephanie H Gomez, Jenny Tse, Yan Wang, Brianna Turner, Alexander J Millner, Matthew K Nock, Erin C Dunn
BACKGROUND: Although child maltreatment is a well documented risk factor for suicidal behavior, little is known about whether the timing of child maltreatment differentially associates with risk of suicidal ideation, suicide plans, or suicide attempts. The goal of this study was to examine whether a first exposure to physical or sexual abuse during specific developmental periods significantly elevated risk for suicidal behavior in adolescents. METHODS: Data came from the National Comorbidity Survey Adolescent Supplement, a population-based sample of US adolescents aged 13-18 years old (n = 9,272)...
May 23, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28484862/disinhibited-exposing-behavior-hypersexuality-and-erectile-dysfunction-as-a-consequence-of-posttraumatic-stress-in-a-42-year-old-male-patient
#2
Mirja Petri-Kelvasa, Olaf Schulte-Herbrüggen
Research into sexual dysfunction and its explanations within a cognitive behavioral framework in patients with posttraumatic stress is sparse. In this report, we present the case of a 42-year-old male with severe posttraumatic stress symptoms who displayed apparent exhibitionistic behavior, hypersexual behavior in the form of excessive masturbation, and erectile dysfunction. Differential diagnostics showed that the presented exhibitionistic behavior could be more accurately classified as non-paraphilic disinhibited exposing behavior...
May 8, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28458903/using-kisspeptin-to-assess-gnrh-function-in-an-unusual-case-of-primary-amenorrhoea
#3
S Vimalesvaran, S Narayanaswamy, L Yang, J K Prague, A Buckley, A D Miras, S Franks, K Meeran, W S Dhillo
SUMMARY: Primary amenorrhoea is defined as the failure to commence menstruation by the age of 15 years, in the presence of normal secondary sexual development. The potential causes of primary amenorrhoea extend from structural to chromosomal abnormalities. Polycystic ovarian syndrome (PCOS) is a common cause of secondary amenorrhoea but an uncommon cause of primary amenorrhoea. An early and prompt diagnosis of PCOS is important, as up to 30% of these women are predisposed to glucose intolerance and obesity, with the subgroup of women presenting with primary amenorrhoea and PCOS displaying a higher incidence of metabolic dysfunction...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28416458/on-the-origins-of-sex-based-differences-in-respiratory-disorders-lessons-and-hypotheses-from-stress-neuroendocrinology-in-developing-rats
#4
REVIEW
Jean-Philippe Rousseau, Luana Tenorio-Lopes, Cécile Baldy, Tara Adele Janes, Stéphanie Fournier, Richard Kinkead
The environment plays a critical role in shaping development and function of the brain. Stress, especially when experienced early in life, can interfere with these processes. In the context of respiratory control, perinatal stress can therefore alter the ability to achieve the "fine-tuning" necessary for proper detection of chemosensory stimuli and production of an adequate motor (respiratory) command. Depending on the timing, intensity, and duration, the detrimental consequences of perinatal exposure to adverse conditions on the respiratory network become manifest at various life stages and can persist into adulthood...
April 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28412334/ovotestis-in-adolescence-2-case-reports
#5
Jyoti D Chouhan, David I Chu, Antoinette Birs, Louise C Pyle, Jason P Van Batavia, Rebecca L Linn, Susan J Back, Pierre Russo, Kassa Darge, Thomas F Kolon, Arun K Srinivasan
We present 2 patients found to have ovotesticular disorder of sexual development (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: 1 with concern for testicular rupture after a straddle injury; 1 with gynecomastia. Further workup, including imaging and laboratory tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype. The second patient with gynecomastia had unilateral ovotestis with hemi-uterus and fallopian tube, contralateral ovarian tissue, and 46,XX/47,XXY Klinefelter mosaic karyotype...
April 13, 2017: Urology
https://www.readbyqxmd.com/read/28401580/military-sexual-trauma-is-associated-with-post-deployment-eating-disorders-among-afghanistan-and-iraq-veterans
#6
Rebecca K Blais, Emily Brignone, Shira Maguen, Marjorie E Carter, Jamison D Fargo, Adi V Gundlapalli
OBJECTIVE: Evaluate the association of military sexual trauma (MST) screen status with eating disorder diagnoses among veterans within 1- and 5-years after initiating Veterans Health Administration (VHA) care, and whether the association varied by sex. METHOD: Retrospective cohort study of US Afghanistan/Iraq veterans who used VHA services between FY 2004 and 2014 (N = 595,525). This study used VHA administrative data to assess the presence of eating disorder diagnoses in medical records within 1- and 5-years of initiating VHA care, and whether a positive screen for MST was associated with eating disorders...
April 12, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28396969/psychological-and-behavioral-moderators-of-the-relationship-between-trauma-severity-and-hiv-transmission-risk-behavior-among-msm-with-a-history-of-childhood-sexual-abuse
#7
Abigail W Batchelder, Peter P Ehlinger, Michael S Boroughs, Jillian C Shipherd, Steven A Safren, Gail H Ironson, Conall O'Cleirigh
Childhood sexual abuse (CSA) is associated with post-traumatic stress disorder (PTSD), which can be associated with condomless sex among men who have sex with men (MSM). However, the impact of moderating factors on the relationship between PTSD symptom severity and condomless sex is poorly understood. We examined whether PTSD symptom severity was associated with condomless sex among MSM with CSA histories, and whether substance dependence, self-esteem, and distress tolerance moderated that relationship (n = 288)...
April 10, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28385526/sex-difference-in-mouse-hypothalamic-transcriptome-profile-in-stress-induced-depression-model
#8
Bhanu Chandra Karisetty, Nitin Khandelwal, Arvind Kumar, Sumana Chakravarty
The influence of sex on prevalence and presentation of human depression necessitates studying its role in depression. Additionally, stress can also affect the incidence and progression of depressive phenotypes. Hypothalamus is a well-reported sexually dimorphic brain region. Hence, we performed a gene-array to uncover the chronic stress-induced transcriptional changes in the hypothalamus of male, intact female (with ovaries) and ovariectomized female mice. Chronic variable mild stress model was used to induce depression-like behavior in mice, assessed by despair behavior in forced swim test...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28376282/history-of-sexual-trauma-moderates-psychotherapy-outcome-for-posttraumatic-stress-disorder
#9
John C Markowitz, Yuval Neria, Karina Lovell, Page E Van Meter, Eva Petkova
BACKGROUND: Moderators of differential psychotherapy outcome for posttraumatic stress disorder (PTSD) are rare, yet have crucial clinical importance. We tested the moderating effects of trauma type for three psychotherapies in 110 unmedicated patients with chronic DSM-IV PTSD. METHODS: Patients were randomized to 14 weeks of prolonged exposure (PE, N = 38), interpersonal psychotherapy (IPT, N = 40), or relaxation therapy (RT, N = 32). The Clinician-Administered PTSD Scale (CAPS) was the primary outcome measure...
April 4, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28372939/c-tactile-mediated-erotic-touch-perception-relates-to-sexual-desire-and-performance-in-a-gender-specific-way
#10
Johanna Bendas, Janniko R Georgiadis, Gerhard Ritschel, Håkan Olausson, Kerstin Weidner, Ilona Croy
BACKGROUND: Unmyelinated low-threshold mechanoreceptors-the so-called C-tactile (CT) afferents-play a crucial role in the perception and conduction of caressing and pleasant touch sensations and significantly contribute to the concept of erotic touch perception. AIM: To investigate the relations between sexual desire and sexual performance and the perception of touch mediated by CT afferents. METHODS: Seventy healthy participants (28 men, 42 women; mean age ± SD = 24...
May 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28366704/sexual-function-and-quality-of-life-in-young-men-with-spina-bifida-could-it-be-neglected-aspects-in-clinical-practice
#11
Eun Kyoung Choi, Yoonhye Ji, Sang Won Han
OBJECTIVE: The purpose of this study was to evaluate the sexual function of young men with spina bifida and the impact of the disorder on the quality of life (QOL). MATERIALS AND METHODS: To assess sexual function and QOL by using self-administered questionnaires (International Index of Erectile Function [IIEF] and 36-Item Short Form Health Survey [SF-36]) for young men with spina bifida. We collected data from 47 young men with spina bifida between June 2013 and October 2013 at the spina bifida clinic of Severance Children's Hospital, Seoul, South Korea RESULTS: Of the 47 men, 13 (27...
March 30, 2017: Urology
https://www.readbyqxmd.com/read/28339706/differential-proliferation-and-metabolic-activity-of-sertoli-cells-in-the-testes-of-broiler-and-layer-breeder-chickens
#12
Mélanie Faure, Edith Guibert, Sabine Crochet, Pascal Chartrin, Jean-Pierre Brillard, Anne Collin, Pascal Froment
Decades of genetic selection have generated 2 different, highly specialized types of chickens in which 1 type, known as the layer-type chicken, expresses high laying performance while the other type, known as the broiler-type chicken, is dedicated to the production of fast-growing birds. Selected lines for the latter type often express disorders in their reproductive performance including early sexual maturation and accelerated, non-reversible seasonal decline of their semen production and mating behavior. The aim of the present study was to characterize some metabolic markers of the Sertoli cell populations...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28325146/hypersexuality-as-a-neuropsychiatric-disorder-the-neurobiology-and-treatment-options
#13
Hatta Sidi, Muna Asiff, Jaya Kumar, Srijit Das, Nurul Hazwani Hatta, Cesar Alfonso
Hypersexuality refers to abnormally increased or extreme involvement in any sexual activity. It is clinically challenging, presents trans-diagnostically and there is extensive medical literature addressing nosology, pathogenesis and neuropsychiatric aspects. Classification includes deviant behaviours, diagnosable entities related to impulsivity, and obsessional phenomena. Some clinicians view an increase in sexual desire as 'normal' while psychodynamic theorists consider it ego-defensive at times alleviating unconscious anxiety rooted in intrapsychic conflicts...
March 21, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28319024/the-prostatic-utricle-an-under-recognized-condition-resulting-in-significant-morbidity-in-boys-with-both-hypospadias-and-normal-external-genitalia
#14
Austin G Hester, Stanley J Kogan
INTRODUCTION: Pediatric presentations of a prostatic utricle have received only scant attention. Though recognized with increased frequency in boys with hypospadias, little is described about their incidence and potential for morbidity in boys with normal external genitalia. METHODS: We initially reviewed a cohort of 64 patients with hypospadias seen over a 3-year period to determine the frequency of investigative lower urinary tract studies and utricle identification...
March 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28301762/sex-differences-in-binge-eating-gonadal-hormone-effects-across-development
#15
Kelly L Klump, Kristen M Culbert, Cheryl L Sisk
Eating disorders are highly sexually differentiated disorders that exhibit a female predominance in risk. Most theories focus on psychosocial explanations to the exclusion of biological/genetic influences. The purpose of this descriptive review is to evaluate evidence from animal and human studies in support of gonadal hormone effects on sex differences in binge eating. Although research is in its nascent stages, findings suggest that increased prenatal testosterone exposure in males appears to protect against binge eating...
May 8, 2017: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/28299405/validation-of-the-international-consultation-on-incontinence-questionnaire-vaginal-symptoms-iciq-vs-in-two-south-asian-languages
#16
Chanil D Ekanayake, Arunasalam Pathmeswaran, Rasika P Herath, H Suharshi S Perera, Malitha Patabendige, Prasantha S Wijesinghe
INTRODUCTION: The multifaceted nature of pelvic floor disorders means that a systematic evaluation is required for optimal treatment outcome. It is also generally acknowledged that a valid tool is necessary to objectively assess symptoms reported by affected women. METHODS: The International Consultation on Incontinence Questionnaire-Vaginal Symptoms (ICIQ-VS) questionnaire was translated to Sinhala and Tamil and a validation study carried out among women attending gynecology clinics at North Colombo Teaching Hospital, Ragama, and the district general hospitals Mannar and Vavuniya...
March 16, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28291299/-neurosyphilis-in-psychiatric-settings-three-case-reports
#17
Erhan Akıncı, Fatih Öncü, Barış Topçular
Syphilis is a generally sexually transmitted and multisystem disease caused by the spirochete Treponema pallidum. All of the organs of the body may be involved during the course of the disease. Neurosyphilis is a clinical form of syphilis with the central nervous system (CNS) involvement. While primarily meningeal and vascular structures are involved in early neurosyphilis, a parenchymal affection of the brain and spinal cord emerges at later stages of neurosyphilis. It presents with symptoms of meningitis, meningovasculitis and parenchymal neurosyphilis (presenting as tabes dorsalis and general paresis)...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28273860/microglial-function-across-the-spectrum-of-age-and-gender
#18
REVIEW
Jillian C Nissen
Microglia constitute the resident immunocompetent cells of the central nervous system. Although much work has focused on their ability to mount an inflammatory response in reaction to pathology, recent studies have delved into their role in maintaining homeostasis in the healthy brain. It is important to note that the function of these cells is more complex than originally conceived, as there is increasing evidence that microglial responses can vary greatly among individuals. Here, this review will describe the changing behavior of microglia from development and birth through to the aged brain...
March 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28207417/adrenarche-unmasks-compound-heterozygous-3%C3%AE-hydroxysteroid-dehydrogenase-deficiency-c-244g-a-p-ala82thr-and-the-novel-931c-t-p-gln311-variant-in-a-non-salt-wasting-severely-undervirilised-46xy
#19
Stephanie Louise Teasdale, Adam Morton
3β-Hydroxysteroid dehydrogenase type II deficiency (3βHSD2) congenital adrenal hyperplasia is a rare cause of ambiguous genitalia, resulting in abnormal virilisation in both 46XY and 46XX. We describe a case of 46XY ambiguous genitalia that was misdiagnosed as androgen insensitivity syndrome. The correct diagnosis was made after adrenarche. Genotyping demonstrated compound heterozygosity in two alleles, the previously described c.244G>A (p.Ala82Thr), and a novel 931C>T(p.Gln311*) variant. We suggest that adrenarche unmasked the condition by driving cortisol production to rates that caused the mutant 3bHSD2 enzyme to become rate limiting for cortisol production...
March 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28202904/genome-wide-dna-de-methylation-is-associated-with-noninfectious-bud-failure-exhibition-in-almond-prunus-dulcis-mill-d-a-webb
#20
Jonathan Fresnedo-Ramírez, Helen M Chan, Dan E Parfitt, Carlos H Crisosto, Thomas M Gradziel
Noninfectious bud-failure (BF) remains a major threat to almond production in California, particularly with the recent rapid expansion of acreage and as more intensive cultural practices and modern cultivars are adopted. BF has been shown to be inherited in both vegetative and sexual progeny, with exhibition related to the age and propagation history of scion clonal sources. These characteristics suggest an epigenetic influence, such as the loss of juvenility mediated by DNA-(de)methylation. Various degrees of BF have been reported among cultivars as well as within sources of clonal propagation of the same cultivar...
February 16, 2017: Scientific Reports
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