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APOE Gene

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https://www.readbyqxmd.com/read/28229235/modulation-of-apoe-and-sorl1-genes-on-hippocampal-functional-connectivity-in-healthy-young-adults
#1
Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Yu
Apolipoprotein E (APOE) and sortilin-related receptor (SORL1) genes act on the same metabolic pathway and have been associated with Alzheimer's disease (AD) characterized by hippocampal impairment. Although the effects of APOE on hippocampal resting-state functional connectivity (rsFC) have been reported, the main effects of SORL1 and SORL1 × APOE interactions on hippocampal rsFC in healthy subjects remain largely unknown. Here, we systematically investigated the main effects of SORL1 rs2070045, and APOE, and their interaction effects on hippocampal rsFC in healthy young adults...
February 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28224023/evaluation-of-liver-cirrhosis-and-hepatocellular-carcinoma-using-protein-protein-interaction-networks
#2
Mohammad Javad Ehsani Ardakani, Akram Safaei, Afsaneh Arefi Oskouie, Hesam Haghparast, Mehrdad Haghazali, Hamid Mohaghegh Shalmani, Hassan Peyvandi, Nosratollah Naderi, Mohammad Reza Zali
AIM: In the current study, we analysised only the articles that investigate serum proteome profile of cirrhosis patients or HCC patients versus healthy controls. BACKGROUND: Increased understanding of cancer biology has enabled identification of molecular events that lead to the discovery of numerous potential biomarkers in diseases. Protein-protein interaction networks is one of aspect that could elevate the understanding level of molecular events and protein connections that lead to the identification of genes and proteins associated with diseases...
December 2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28218786/gene-expressions-levels-of-14-3-3a-nkccla-apo-14-and-na-k-atpase%C3%AE-in-gill-tissue-of-mugil-cephalus-acclimated-to-low-salinity
#3
L Li, M Jiang, X Q Shen
Fishes adapt to salinity changes primarily through osmotic pressure regulation, a process often associated with several genes, including 14-3-3a, NKCCla, APO-14, and Na(+)-K(+)-ATPaseβ. The present study investigated the differential expression of genes 14-3-3a, NKCCla, APO-14, and Na(+)-K(+)-ATPaseβ in the gill tissue of Mugil cephalus acclimated to low salinity. Susceptibility relationships between the four gene expressions levels and salinity were detected and analyzed using polymerase chain reaction-restriction fragment length polymorphism...
February 16, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28218653/proteomic-analysis-of-mitochondria-enriched-fraction-isolated-from-the-frontal-cortex-and-hippocampus-of-apolipoprotein-e-knockout-mice-treated-with-alda-1-an-activator-of-mitochondrial-aldehyde-dehydrogenase-aldh2
#4
Aneta Stachowicz, Rafał Olszanecki, Maciej Suski, Katarzyna Głombik, Agnieszka Basta-Kaim, Dariusz Adamek, Ryszard Korbut
The role of different genotypes of apolipoprotein E (apoE) in the etiology of Alzheimer's disease is widely recognized. It has been shown that altered functioning of apoE may promote 4-hydroxynonenal modification of mitochondrial proteins, which may result in mitochondrial dysfunction, aggravation of oxidative stress, and neurodegeneration. Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme considered to perform protective function in mitochondria by the detoxification of the end products of lipid peroxidation, such as 4-hydroxynonenal and other reactive aldehydes...
February 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28212448/hepatic-transcriptome-analysis-and-identification-of-differentially-expressed-genes-response-to-dietary-oxidized-fish-oil-in-loach-misgurnus-anguillicaudatus
#5
Yin Zhang, Yang Li, Xiao Liang, Xiaojuan Cao, Longfei Huang, Jie Yan, Yanxing Wei, Jian Gao
RNA sequencing and short-read assembly were utilized to produce a transcriptome of livers from loaches (Misgurnus anguillicaudatus) fed with three different diets respectively containing fresh fish oil (FO group), medium oxidized fish oil (MO group) and high oxidized fish oil (HO group). A total of 60,663 unigenes were obtained in this study, with mean length 848.74 bp. 50,814, 49,584 and 49,814 unigenes were respectively obtained from FO, MO and HO groups. There were 2,343 differentially expressed genes between FO and MO, with 855 down- and 1,488 up-regulated genes in the MO group...
2017: PloS One
https://www.readbyqxmd.com/read/28211809/the-methylenetetrahydrofolate-reductase-c677t-polymorphism-and-risk-for-late-onset-alzheimer-s-disease-further-evidence-in-an-italian-multicenter-study
#6
Andrea Stoccoro, Pierpaola Tannorella, Maria Grazia Salluzzo, Raffaele Ferri, Corrado Romano, Benedetta Nacmias, Gabriele Siciliano, Lucia Migliore, Fabio Coppedè
BACKGROUND: A functional polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, namely C677T (rs1801133), results in increased Hcy levels and has been associated with risk of late-onset Alzheimer's disease (LOAD). Many investigators reported association between rs1801133 and LOAD risk in Asian populations and in carriers of the apolipoprotein E (APOE) ɛ4 allele, but recent meta-analyses suggest a contribution also in other populations, including Caucasians and/or northern Africans...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28208058/monitoring-of-macrophage-accumulation-in-statin-treated-atherosclerotic-mouse-model-using-sodium-iodide-symporter-imaging-system
#7
Ran Ji Yoo, Min Hwan Kim, Sang-Keun Woo, Kwang Il Kim, Tae Sup Lee, Yang-Kyu Choi, Joo Hyun Kang, Sang Moo Lim, Yong Jin Lee
INTRODUCTION: Macrophages play a key role in atherosclerotic plaque formation in atherosclerosis, but its detailed understanding has poorly investigated until now. Thus, we sought to demonstrate a noninvasive technique for macrophage tracking to atherosclerotic lesions in apolipoprotein E(-/-)(ApoE(-/-)) mice with an imaging system based on sodium iodide symporter (NIS) gene coupled with (99m)Tc-single-photon emission computed tomography (SPECT). METHODS AND RESULTS: Macrophage cells (RAW264...
January 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28206976/lipid-and-alzheimer-s-disease-genes-associated-with-healthy-aging-and-longevity-in-healthy-oldest-old
#8
Lauren C Tindale, Stephen Leach, John J Spinelli, Angela R Brooks-Wilson
Several studies have found that long-lived individuals do not appear to carry lower numbers of common disease-associated variants than ordinary people; it has been hypothesized that they may instead carry protective variants. An intriguing type of protective variant is buffering variants that protect against variants that have deleterious effects. We genotyped 18 variants in 15 genes related to longevity or healthy aging that had been previously reported as having a gene-gene interaction or buffering effect...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28199971/association-and-interaction-effects-of-alzheimer-s-disease-associated-genes-and-lifestyle-on-cognitive-aging-in-older-adults-in-a-taiwanese-population
#9
Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao
Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. In this study, we assessed whether single nucleotide polymorphisms (SNPs) within these 27 AD-associatedgenes are linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28193673/structure-of-the-escherichia-coli-proq-rna-chaperone-protein
#10
Grecia Gonzalez, Steven Hardwick, Sarah L Maslen, J Mark Skehel, Erik Holmqvist, Jörg Vogel, Alex Bateman, Ben Luisi, R William Broadhurst
The protein ProQ has recently been identified as a global RNA chaperone in Salmonella, and a similar role is anticipated for its numerous homologues in divergent bacterial species. We report the solution structure of Escherichia coli ProQ, revealing an N-terminal FinO-like domain, a C-terminal domain that unexpectedly has a Tudor-domain fold commonly found in eukaryotes, and an elongated bridging intra-domain linker that is flexible but nonetheless incompressible. Structure based sequence analysis suggests that the Tudor domain was acquired through horizontal gene transfer and gene fusion to the ancestral FinO-like domain...
February 13, 2017: RNA
https://www.readbyqxmd.com/read/28188215/cystathionine-gamma-lyase-protects-vascular-endothelium-a-role-for-inhibition-of-histone-deacetylase-6
#11
Thorsten Martin Leucker, Yohei Nomura, Jae Hyung Kim, Anil Bhatta, Victor Wang, Andrea Wecker, Sandeep S Jandu, Lakshmi Santhanam, Dan E Berkowitz, Lewis Romer, Deepesh Pandey
Endothelial cystathionine -lyase (CSE) contributes to cardiovascular homeostasis, mainly through production of hydrogen sulfide. However, the molecular mechanisms that control CSE gene expression in endothelium during cardiovascular diseases are unclear. The aim of the current study is to determine the role of specific histone deacetylases (HDAC) in the regulation of endothelial CSE. Reduced CSE mRNA expression and protein abundance were observed in human aortic endothelial cells (HAEC) exposed to OxLDL and in aortas from atherogenic ApoE-/- mice fed a high-fat diet as compared with controls...
February 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28187530/structural-and-dynamic-characterization-of-a-freestanding-acyl-carrier-protein-involved-in-the-biosynthesis-of-cyclic-lipopeptide-antibiotics
#12
Subrata Paul, Hiroaki Ishida, Leonard T Nguyen, Zhihong Liu, Hans J Vogel
Friulimicin is a cyclic lipodecapeptide antibiotic that is produced by Actinoplanes friuliensis. Like the related lipopeptide drug daptomycin, the peptide skeleton of friulimicin is synthesized by a large multienzyme Nonribosomal Peptide Synthetase (NRPS) system. The LipD protein plays a major role in the acylation reaction of friulimicin. The attachment of the fatty acid group promotes its antibiotic activity. Phylogenetic analysis reveals that LipD is most closely related to other freestanding Acyl Carrier Proteins (ACPs), for which the genes are located near to NRPS gene clusters...
February 10, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28185955/endothelial-nox4-based-nadph-oxidase-regulates-atherosclerosis-via-soluble-epoxide-hydrolase
#13
Pingping Hu, Xiaojuan Wu, Alok R Khandelwal, Weimin Yu, Zaicheng Xu, Lili Chen, Jian Yang, Robert M Weisbrod, Kin Sing Stephen Lee, Francesca Seta, Bruce D Hammock, Richard A Cohen, Chunyu Zeng, Xiaoyong Tong
: Nox4-based NADPH oxidase is a major reactive oxygen species-generating enzyme in the vasculature, but its role in atherosclerosis remains controversial. OBJECTIVE: Our goal was to investigate the mechanisms of endothelial Nox4 in regulating atherosclerosis. APPROACH AND RESULTS: Atherosclerosis-prone conditions (disturbed blood flow, type I diabetes, and Western diet) downregulated endothelial Nox4 mRNA in arteries. To address whether the downregulated endothelial Nox4 was directly involved in the development of atherosclerosis, we generated mice carrying a human Nox4 P437H dominant negative mutation (Nox4DN), driven by the endothelial specific promoter Tie-2, on atherosclerosis-prone genetic background (ApoE deficient mice) to mimic the effect of decreased endothelial Nox4...
February 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28185214/prevention-of-cardiovascular-complications-in-patients-with-lp-a-hyperlipoproteinemia-and-progressive-cardiovascular-disease-by-long-term-lipoprotein-apheresis-according-to-german-national-guidelines
#14
Reinhard Klingel, Andreas Heibges, Cordula Fassbender
Lipoprotein(a) (Lp(a)) is an independent cardiovascular risk factor playing a causal role for atherosclerotic cardiovascular disease (CVD). Lipoprotein apheresis (LA) is a safe well-tolerated outpatient treatment to lower LDL-C and Lp(a) by 60-70%, and is the ultimate escalating therapeutic option in patients with hyperlipoproteinemias (HLP) involving LDL particles. Major therapeutic effect of LA is preventing cardiovascular events. Lp(a)-HLP associated with progressive CVD has been approved as indication for regular LA in Germany since 2008...
February 9, 2017: Clinical Research in Cardiology Supplements
https://www.readbyqxmd.com/read/28183529/hippocampal-thinning-linked-to-longer-tomm40-poly-t-variant-lengths-in-the-absence-of-the-apoe-%C3%AE%C2%B54-variant
#15
Alison C Burggren, Zanjbeel Mahmood, Theresa M Harrison, Prabha Siddarth, Karen Miller, Gary Small, David A Merrill, Susan Bookheimer
INTRODUCTION: The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with apolipoprotein E (APOE), has received attention more recently as a promising gene in Alzheimer's disease (AD) risk. TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL) is the most likely brain region for identifying early manifestations of AD-related morphology changes. METHODS: In this study, we examined the effects of TOMM40 using high-resolution magnetic resonance imaging in 65 healthy, older subjects with and without the APOE ε4 AD-risk variant...
February 6, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28183528/transethnic-genome-wide-scan-identifies-novel-alzheimer-s-disease-loci
#16
Gyungah R Jun, Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W Beecham, David A Bennett, Joseph D Buxbaum, Goldie S Byrd, Minerva M Carrasquillo, Paul K Crane, Carlos Cruchaga, Philip De Jager, Nilufer Ertekin-Taner, Denis Evans, M Danielle Fallin, Tatiana M Foroud, Robert P Friedland, Alison M Goate, Neill R Graff-Radford, Hugh Hendrie, Kathleen S Hall, Kara L Hamilton-Nelson, Rivka Inzelberg, M Ilyas Kamboh, John S K Kauwe, Walter A Kukull, Brian W Kunkle, Ryozo Kuwano, Eric B Larson, Mark W Logue, Jennifer J Manly, Eden R Martin, Thomas J Montine, Shubhabrata Mukherjee, Adam Naj, Eric M Reiman, Christiane Reitz, Richard Sherva, Peter H St George-Hyslop, Timothy Thornton, Steven G Younkin, Badri N Vardarajan, Li-San Wang, Jens R Wendlund, Ashley R Winslow, Jonathan Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard Schellenberg, Kathryn L Lunetta, Lindsay A Farrer
BACKGROUND: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset...
February 6, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28179583/pravastatin-activates-activator-protein-2-alpha-to-argument-the-angiotensin-ii-induced-abdominal-aortic-aneurysms
#17
Hui Ma, Wen-Jing Liang, Mei-Rong Shan, Xue-Qing Wang, Sheng-Nan Zhou, Yuan Chen, Tao Guo, Peng Li, Hai-Ya Yu, Chao Liu, Ya-Ling Yin, Yu-Lin Wang, Bo Dong, Xin-Yan Pang, Shuang-Xi Wang
We have previously reported that activation of AMP-activated kinase alpha 2 (AMPKα2) by nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms (AAA) in Apoe-/- mice. Statins, used to treat hyperlipidemia widely, activate AMPK in vascular cells. We sought to examine the effects of pravastatin on AAA formation and uncover the molecular mechanism. The AAA model was induced by AngII and evaluated by incidence, elastin degradation, and maximal abdominal aortic diameter in Apoe-/- mice...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28174304/the-pyruvate-and-%C3%AE-ketoglutarate-dehydrogenase-complexes-of-pseudomonas-aeruginosa-catalyze-pyocyanin-and-phenazine-1-carboxylic-acid-reduction-via-the-subunit-dihydrolipoamide-dehydrogenase
#18
Nathaniel R Glasser, Benjamin X Wang, Julie A Hoy, Dianne K Newman
Phenazines are a class of redox-active molecules produced by diverse bacteria and archaea. Many of the biological functions of phenazines, such as mediating signaling, iron acquisition, and redox homeostasis, derive from their redox activity. While prior studies have focused on extracellular phenazine oxidation by oxygen and iron, here we report a search for reductants and catalysts of intracellular phenazine reduction in Pseudomonas aeruginosa Enzymatic assays in cell-free lysate, together with crude fractionation and chemical inhibition, indicate that P...
February 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28167353/genetic-risk-analysis-of-coronary-artery-disease-in-pakistani-subjects-using-a-genetic-risk-score-of-21-variants
#19
Saleem Ullah Shahid, Shabana, Jackie A Cooper, Katherine E Beaney, Kawah Li, Abdul Rehman, Steve E Humphries
BACKGROUND AND AIMS: Conventional coronary artery disease (CAD) risk factors like age, gender, blood lipids, hypertension and smoking have been the basis of CAD risk prediction algorithms, but provide only modest discrimination. Genetic risk score (GRS) may provide improved discrimination over and above conventional risk factors. Here we analyzed the genetic risk of CAD in subjects from Pakistan, using a GRS of 21 variants in 18 genes and examined whether the GRS is associated with blood lipid levels...
January 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28167099/27-hydroxycholesterol-regulates-cholesterol-synthesis-and-transport-in-c6-glioma-cells
#20
Yu An, Dan-Di Zhang, Huan-Ling Yu, Wei-Wei Ma, Yan-Hui Lu, Quan-Ri Liu, Rong Xiao
The oxysterol 27-Hydroxycholesterol (27-OHC) is a major cholesterol metabolite that can cross the blood brain barrier (BBB) from peripheral circulation to the brain. Currently, the role of 27-OHC on cholesterol homeostasis in astrocytes and the underlying mechanisms are not defined. Since all brain cholesterol is essentially synthesized in brain itself and astrocytes as net producers of cholesterol are essential for normal brain function, here we investigated the effects of 27-OHC on cholesterol synthesis and transport in C6 glioma cells...
February 3, 2017: Neurotoxicology
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