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Extranodal extension

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https://www.readbyqxmd.com/read/28547978/correlation-between-obesity-and-prognostic-predictive-parameters-with-emphasis-on-the-importance-of-lymph-node-metastases-in-patients-with-invasive-breast-carcinoma
#1
Orsolya Hankó-Bauer, Rares Georgescu, Marius F Coros, Monica Boros, Iulia Barsan, Simona Stolnicu
We aimed to evaluate whether obese women experience more advanced invasive breast carcinoma (IBC) with a higher number of involved lymph nodes, higher range of axillary lymph node ratio (LNR) and presence and size of extracapsular extension as it may have an impact on prognosis and management. 245 patients diagnosed with IBC were divided into normal weight (NW), overweight (OW) and obese (OB) groups. Patients were divided into high range of LNR (LNR over or equal to 0.2) and low LNR (LNR less than 0.2). The extracapsular extension dimensions were measured on the original slides of each case and grouped into ≤ 1 mm and > 1 mm...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/28539662/extranodal-extension-of-lymph-node-metastasis-influences-recurrence-in-prostate-cancer-a-systematic-review-and-meta-analysis
#2
Claudio Luchini, Achim Fleischmann, Joost L Boormans, Matteo Fassan, Alessia Nottegar, Paola Lucato, Brendon Stubbs, Marco Solmi, Antonio Porcaro, Nicola Veronese, Matteo Brunelli, Aldo Scarpa, Liang Cheng
The extranodal extension (ENE) of nodal metastasis involves the extension of neoplastic cells through the lymph node capsule into the perinodal adipose tissue. This morphological feature has recently been indicated as an important prognostic factor in various cancer types, but its role in prostate cancer is still unclear. We aimed to clarify it, performing the first meta-analysis on this issue, comparing prognostic parameters in surgically treated, node-positive prostate cancer patients with (ENE+) vs. without (ENE-) ENE...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506687/human-immunodeficiency-virus-hiv-and-epstein-barr-virus-ebv-related-lymphomas-pathology-view-point
#3
REVIEW
Ebru Linke-Serinsöz, Falko Fend, Leticia Quintanilla-Martinez
The contribution of Epstein Barr virus (EBV) and Kaposi sarcoma herpes virus (KSHV) to the development of specific types of malignant lymphomas occurring in the human immunodeficiency virus (HIV) setting has been extensively studied since the beginning of the HIV epidemic 35 years ago. The introduction of highly active antiretroviral therapies (HAART) in 1996 has changed dramatically the incidence of HIV-related malignancies. Nevertheless, malignant lymphomas continue to be the major group of malignances observed in HIV infected individuals, and the most common cause of cancer related-deaths...
April 7, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28501122/association-of-patient-age-with-high-risk-pathologic-features-in-papillary-thyroid-cancer
#4
Adam C Niemann, Alexander T Reid, Joshua Smith, James Hammond, Stephanie A DeBolle, Iris Wei, Christopher Soong-Ho Lee, David T Hughes
BACKGROUND: Certain patient demographics and histopathologic features are risk factors for papillary thyroid cancer (PTC) recurrence after initial treatment. Our objective was to determine whether very young age is associated with aggressive pathologic features in patients with PTC. MATERIALS AND METHODS: A retrospective analysis was performed for PTC patients who underwent surgical treatment at the University of Michigan between 2006 and 2012. Patients with known distant metastases were excluded...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28454248/primary-bone-mantle-cell-lymphomas-with-multiple-vertebral-compression-fractures-a-case-report
#5
Peng Yang, Jun Lin, Hao Liu, Hao Shen, Hui-Lin Yang
Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma. Patients with MCL generally present with extensive lymphadenopathy and extranodal involvement. To the best of our knowledge, no cases of primary bone MCL with multiple vertebral compression fractures have been reported in the literature thus far. The current study reports the case of a 75-year-old Chinese male patient presenting with lower back pain for 1 year. B symptoms were not observed in the patient's medical history. X-ray revealed osteoporosis, and mixed osteolytic and osteosclerotic lesions in the T10 and L1 vertebrae with decreased height...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28438345/richter-syndrome-with-extensive-isolated-pleural-extranodal-involvement-the-importance-of-pet-ct-imaging
#6
Luis Gorospe Sarasúa, Ana Jaureguízar-Oriol, Carlos Almonacid-Sánchez, María Eugenia Rioja-Martín
No abstract text is available yet for this article.
April 21, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28430988/prognostic-significance-of-surgical-extranodal-extension-in-head-and-neck-squamous-cell-carcinoma-patients
#7
Fumihiko Matsumoto, Taisuke Mori, Satoko Matsumura, Yoshifumi Matsumoto, Masahiko Fukasawa, Masanori Teshima, Kenya Kobayashi, Seiichi Yoshimoto
Background: Lymph node metastasis with extranodal extension represents one of the most important adverse prognostic factors for survival in patients with head and neck squamous cell carcinoma. We propose that extranodal extension occurs to differing extents. The aim of this study was to determine the prognostic significance of extranodal extension in patients with head and neck squamous cell carcinoma. Methods: Two hundred and ninety-eight patients with head and neck squamous cell carcinoma who underwent surgical resection and neck dissection were included...
April 18, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28413664/extranodal-natural-killer-t-cell-lymphoma-presenting-as-cavernous-sinus-syndrome
#8
Hong-Cheng Mai, Dan-Xia Chen, Dan Lu, Yu-Sheng Zhang
Extranodal natural killer (NK)/T-cell lymphomas are rare, highly aggressive tumors of the central nervous system (CNS) that commonly affect the nasal cavity or paranasal sinuses. NK/T-cell lymphomas are associated with a poor prognosis, as they exhibit a wide range of unique clinical presentations and neuroimaging findings that are currently difficult to detect. Pathological examination is considered to be more reliable for defining the pathological entity of NK/T-cell lymphoma. Early testing for fluorodeoxyglucose (FDG)-positron emission tomography combined with computed tomography may improve the evaluation of lymphomas, which have been known to display avid (18)FDG uptake...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28394767/concurrent-chemoradiotherapy-in-the-adjuvant-treatment-of-high-risk-primary-salivary-gland-malignancies
#9
Brian J Gebhardt, James P Ohr, Robert L Ferris, Umamaheswar Duvvuri, Seungwon Kim, Jonas T Johnson, Dwight E Heron, David A Clump
OBJECTIVES: Adjuvant radiation therapy (RT) is indicated for patients with salivary gland malignancies with risk factors for recurrence following resection. We analyzed patients treated with adjuvant RT with or without concurrent chemotherapy to determine the impact of prognostic and treatment factors. MATERIALS AND METHODS: Retrospective analysis was performed of 128 patients treated with surgical resection followed by intensity-modulated radiotherapy. In total, 31 (24...
April 7, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28374646/staged-surgery-for-advanced-thyroid-cancers-safety-and-oncologic-outcomes-of-neural-monitored-surgery
#10
Behzad Salari, Rebecca J Hammon, Dipti Kamani, Gregory W Randolph
Objective Thyroidectomy with extensive multicompartment bilateral neck dissections for advanced-stage thyroid cancer may lead to increased risk of complications, including bilateral recurrent laryngeal nerve (RLN) paralysis and hypoparathyroidism. A planned staged approach derived from a detailed preoperative radiographic map is associated with a low complication profile. This study evaluates oncologic results and safety of neural monitored, staged thyroid cancer surgery for management of advanced thyroid cancer...
May 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28348632/primary-ocular-adnexal-extranodal-marginal-zone-mucosa-associated-lymphoid-tissue-malt-lymphoma-presenting-as-orbital-apex-syndrome
#11
Carlen A Yuen, John H Pula, Milap Mehta
A 75-year-old female with a past medical history significant for prior stroke and atrial fibrillation presented with acute onset of orbital apex syndrome with chemosis and periorbital ecchymosis. Following initial treatment to relieve intraocular pressure, she began spontaneously haemorrhaging retro-orbitally. Preliminary investigation with neuroimaging demonstrated a left orbital mass with extension into the orbital apex. A provisional diagnosis of cavernous haemangioma was made. She was treated with transorbital resection of the orbital mass...
April 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28325057/-multiple-organ-resection-for-extensive-lymphoma-in-the-abdominal-cavity
#12
L Hlaváčová, R Vrba, M Gregořík, Č Neoral
Extranodal lymphomas are quite rare, and they usually present as non-Hodgkin lymphomas. The most common localization is the gastrointestinal tract, mainly the stomach - primary gastric lymphoma; histologically, diffuse large B-cell lymphoma (DLBCL) is the most frequent type. The diagnosis is established based on endoscopic examination with biopsy of the tumor. It is an aggressive tumor, highly chemosensitive, which is why primary systemic chemotherapy is indicated in early, as well as late, stages of the disease...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28323338/the-prognostic-value-of-extranodal-extension-in-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma
#13
Yi An, Henry S Park, Jacqueline R Kelly, John M Stahl, Wendell G Yarbrough, Barbara A Burtness, Joseph N Contessa, Roy H Decker, Matthew Koshy, Zain A Husain
BACKGROUND: Extranodal (or extracapsular) extension (ENE) is an adverse prognostic factor in patients with head and neck cancers who undergo primary surgery. However, the significance of ENE in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is not well established, and single-institution studies have not established that ENE predicts inferior outcome. The authors investigated the prognostic value of ENE in HPV-positive patients who underwent primary surgery and whether adjuvant chemoradiation improved overall survival (OS) compared with radiation alone in ENE-positive patients...
March 21, 2017: Cancer
https://www.readbyqxmd.com/read/28267534/cross-sectional-imaging-to-evaluate-the-extent-of-regional-nodal-disease-in-breast-cancer-patients-undergoing-neoadjuvant-systemic-therapy
#14
Tara L Anderson, Katrina N Glazebrook, Brittany L Murphy, Lyndsay D Viers, Tina J Hieken
PURPOSE: Cross-sectional imaging often is performed in breast cancer patients undergoing neoadjuvant systemic therapy (NST) and may identify level III axillary and extra-axillary nodal disease. Our aim was to investigate associations of radiologic nodal staging with pathological N (pN) stage at operation and to explore how this might aid surgical and radiotherapy treatment planning. MATERIALS AND METHODS: With IRB approval, we reviewed pre-treatment breast MRI, PET/CT, and CT imaging and clinicopathologic data on 348 breast cancer patients with imaging available for review undergoing NST followed by operation at our institution 1/2008-9/2013...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28261866/morphologic-and-immunophenotypic-features-of-hairy-cell-leukemia-involving-lymph-nodes-and-extranodal-tissues
#15
Jacqueline M Cortazar, Daniel J DeAngelo, Geraldine S Pinkus, Elizabeth A Morgan
Hairy cell leukemia (HCL) is a rare B-cell neoplasm that mainly affects bone marrow (BM), peripheral blood (PB), and spleen. Involvement of lymph nodes and extranodal structures is considered infrequent. Herein we describe our institutional experience of nodal (n=10) and extranodal (n=3) HCL over a thirty-year period. Ten patients had prior evidence of HCL within the BM or PB at a median 35.8 months before nodal/extranodal diagnosis (range, <1 to 175 months), and HCL was diagnosed concurrently within the bone marrow of 1 additional patient...
March 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28249644/lymph-node-characteristics-for-predicting-locoregional-recurrence-of-papillary-thyroid-cancer-in-adolescents-and-young-adults
#16
Yungang Sun, Xiang Liu, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang
PURPOSE: To determine lymph node (LN) characteristics predictive of locoregional recurrence (LRR) in adolescent and young adult (AYA) ages 15-39years presenting with papillary thyroid cancer (PTC) and cervical pathologically proven LN metastases (pN1). METHODS AND MATERIALS: Retrospective chart review was performed for all patients with PTC and nodal metastases who had undergone total thyroidectomy, LN dissection, and postoperative radioactive iodine therapy in a university hospital between 2006 and 2014...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28215641/coexistence-of-age-related-ebv-associated-follicular-hyperplasia-and-large-b-cell-ebv-lymphoma-of-the-elderly-two-distinct-features-of-the-same-t-cell-dysfunction-related-to-senescence
#17
Jean-Baptiste Gibier, Brigitte Bouchindhomme, Romain Dubois, Benedicte Hivert, Nathalie Grardel, Marie-Christine Copin
Age-related EBV-associated lymphoproliferative disorders form a new clinicopathological group. Until recently, this group was associated with diffuse large B-cell lymphoma (DLBCL), characterised by an aggressive clinical presentation and a poor prognosis. Recent findings in Western Caucasian patients, however, suggest that this entity covers a wide spectrum of diseases, ranging from reactive follicular hyperplasia (HR) to DLBCL. We report the case of an 85-year-old Caucasian man showing lymphadenopathy and numerous hypodense lesions of the liver...
March 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28210574/rosai-dorfman-disease-affecting-the-maxilla
#18
Thaís Gimenez Miniello, Juliane Piragine Araujo, Norberto Nobuo Sugaya, Fernando Melhem Elias, Oslei Paes de Almeida, Fabio Abreu Alves
Rosai-Dorfman disease (RDD), formerly called sinus histiocytosis with massive lymphadenopathy, is a non-neoplastic proliferative histiocytic disorder with behavior ranging from highly aggressive to spontaneous remission. Although the lymph nodes are more commonly involved, any organ can be affected. This study aimed to describe the features and the follow-up of a case of extranodal RDD. Our patient was a 39-year-old woman who was referred with an 11-month history of pain in the right maxilla. On clinical examination, some upper right teeth presented full mobility with normal appearance of the surrounding gingiva...
October 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/28195263/kikuchi-fujimoto-disease-a-clinicopathologic-update
#19
F Pepe, S Disma, C Teodoro, P Pepe, G Magro
Kikuchi-Fujmoto disease (KFD), also known as "histiocytic necrotizing lymphadenitis", is a rare lymphadenitis of unknown origin, but with an excellent prognosis. It is more common in Asia, but isolated cases are also reported in America, Africa and Europe. The disease can have an acute or subacute course, usually develops in 1 to 3 weeks, with spontaneous resolution in 1-4 months. The main clinical sign is cervical lymphadenopathy, especially in the posterior cervical triangle with bulky and painful lymph nodes, usually affecting only one side; rare cases of generalized lymphadenopathy can be seen...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28194321/extranodal-natural-killer-t-cell-lymphoma-presenting-as-orbital-cellulitis
#20
Hanis Zuhaimy, Hayati Abdul Aziz, Suresh Vasudevan, Siah Hui Hui
Objective: To report an aggressive case of extranodal natural killer/T-cell lymphoma (NKTCL) of the ethmoid sinus presenting as orbital cellulitis Method: Case report Results: A 56-year-old male presented with right eye redness, reduced vision, and periorbital swelling for 5 weeks duration associated with a two-month history of blocked nose. The visual acuity of the right eye was 6/18. The eye was proptosed with periorbital oedema and conjunctival chemosis. The pupil was mid-dilated but there was no relative afferent pupillary defect...
2017: GMS Ophthalmology Cases
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