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Extranodal extension

Marn Joon Park, Jungsu S Oh, Jong-Lyel Roh, Jae Seung Kim, Jeong Hyun Lee, Soon Yuhl Nam, Sang Yoon Kim
PURPOSE: Salivary gland carcinoma (SGC) is rare tumor with various histological type and metastatic potential. Pretreatment detection of metastases can contribute to planning the appropriate treatment of SGC. Therefore, the present study evaluated the utility of F-FDG PET/CT versus contrast-enhanced CT for detection of metastases and prediction of outcomes in SGC patients. METHODS: Sixty-seven consecutive SGC patients who were prospectively evaluated by F-FDG PET/CT and contrast-enhanced CT and subsequently underwent surgery with or without postoperative radiotherapy/chemoradiotherapy were included...
January 9, 2017: Clinical Nuclear Medicine
Sonja P Dawsey, Jason A Gregory, Alexander W Brown, Frances J Jones
Multiple lymphomatous polyposis (MLP) as an extranodal manifestation of mantle cell lymphoma (MCL) in the gastrointestinal tract is rare and not often reported in the literature. We describe the case of a 63-year-old female with asymptomatic MLP found during staging bidirectional endoscopy of MCL. The patient presented only with dyspnea, but was found on physical exam to have diffuse lymphadenopathy, and subsequent positron emission tomography (PET) CT showed extensive lymph node adenopathy consistent with lymphoma...
September 2016: Case Reports in Oncology
Young Chang Lim, Lihua Liu, Jae Won Chang, Bon Seok Koo
BACKGROUND: This study analyzed the incidence, pattern, and predictive factors for lateral lymph node (LN) recurrence in patients with papillary thyroid cancer (PTC) without clinical evidence of lateral LN metastasis. METHODS: A retrospective analysis was performed on 246 patients with PTC who underwent total thyroidectomy and central neck dissection from 2004 to 2010. None of the patients had clinical evidence of lateral LN metastasis at the time of diagnosis. Predictive factors for lateral LN recurrence were evaluated using the chi-square test...
November 2016: Oral Oncology
Philip Kin-Wai Wong, Daniel J Lee, Saul Harari, Bruce J Barron
Langerhan's histiocytosis is a not uncommon disease, but a related disorder, Rosai-Dorfman (RDD) with extensive or exclusive extranodal distribution, is relatively rare. Ga and PET/CT imaging have typically been used for diagnosis and tracking response to treatment. The authors present a very unusual case wherein lesions of RDD actively accumulated Tc-sestamibi, which was injected as part of a scan to localize a parathyroid adenoma.
December 2016: Clinical Nuclear Medicine
Zai-Shang Li, Chuang-Zhong Deng, Kai Yao, Yong Tang, Nan Liu, Peng Chen, Bin Wang, Xiang Li, Xiao-Feng Chen, Hong Liao, Qi-Wu Mi, Yong-Hong Lei, Qi Zhao, Pei-Zhen Zhao, Xue-Ying Li, Jie-Ping Chen, Qiang-Hua Zhou, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Yun-Lin Ye, Hua Tu, Zi-Jun Zou, Xing Bi, Feng Yang, Ying-Ming Xiao, Jing Li, Xiang-Tian Lin, Wei-Cong Liang, Hui Han, Fang-Jian Zhou
BACKGROUND: Current guidelines recommend pelvic lymphadenectomy (PLND) for patients with pelvic lymph node metastasis and special state. However, these data and recommendations do not distinguish the role of PLND in different patient groups and confirm the final benefits. The aim of this study was to confirm the efficacy of pelvic lymphadenectomy (PLND) for the different groups of patients. METHODS: Data obtained from 7 centers were retrospectively analyzed. Of the patients, 190 pN2-3 penile carcinoma patients confirmed by bilateral inguinal lymph node excision were included in this study...
October 22, 2016: Journal of Cancer Research and Clinical Oncology
Jay P Reddy, Curtis A Pettaway, Lawrence B Levy, Lance C Pagliaro, Pheroze Tamboli, Priya Rao, Isuru Jayaratna, Karen E Hoffman
OBJECTIVE: To identify factors associated with regional recurrence (RR) following lymphadenectomy for penile cancer in order to determine which patients might benefit from adjuvant therapy. MATERIALS/METHODS: Men who underwent lymphadenectomy for penile squamous cell carcinoma from 1977-2014 were identified from an institutional database. Kaplan-Meier curves estimated recurrence-free survival (RFS) calculated from the date of lymphadenectomy. Cox regression models evaluated the association between RFS and patient and tumor characteristics...
October 18, 2016: BJU International
Anil Gungor, Lindsey Pennington, Senthil Sankararaman, Samer Zaid-Kaylani, Majed Aldin Jeroudi
Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subtypes. ENKTL, nasal type occurs in the nose and can extend to the upper aero-digestive tract as reported in this longitudinal case study. This is a longitudinal report of progress of a 14-year-old boy with ENKTL originating in the nasal cavity with subsequent extension and recurrence in the contralateral nose, nasopharynx, larynx and trachea presenting with varying degrees of respiratory problems and eventually, respiratory distress...
November 2016: American Journal of Otolaryngology
Michael C Stauder, Abigail S Caudle, Pamela K Allen, Simona F Shaitelman, Benjamin D Smith, Karen E Hoffman, Thomas A Buchholz, Mariana Chavez-Macgregor, Kelly K Hunt, Funda Meric-Bernstam, Wendy A Woodward
PURPOSE: We sought to determine the rate of postmastectomy radiation therapy (PMRT) among women treated with axillary lymph node dissection (ALND) after positive sentinel lymph node (SLN) biopsy results and to establish the effect of negative ALND results and PMRT on locoregional recurrence (LRR) and overall survival (OS). METHODS AND MATERIALS: All patients were treated with mastectomy and ALND after positive SLN biopsy results. All patients had clinical N0 or NX disease at the time of mastectomy and received no neoadjuvant therapy...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Hu Hei, Yongping Song, Jianwu Qin
BACKGROUND AND OBJECTIVES: Central compartment neck dissection (CCND) is recommended for patients with papillary thyroid carcinoma (PTC). However, whether to perform contralateral CCND remains unclear. An individualized estimation of the contralateral central neck metastasis (CNM) risk would assist in the tailoring of treatment for PTC patients. METHODS: Consecutive patients who underwent bilateral CCND for unilateral PTC between 2012 and 2014 in a tertiary center were identified...
November 2016: Journal of Surgical Oncology
Nathalie Chereau, Xavier Giudicelli, Francois Pattou, Jean-Christophe Lifante, Frederic Triponez, Eric Mirallié, Pierre Goudet, Laurent Brunaud, Christophe Trésallet, Frédérique Tissier, Laurence Leenhardt, Sophie Tezenas du Montcel, Fabrice Menegaux
CONTEXT: Diffuse sclerosing variant (DSV) is a rare and aggressive subtype of papillary thyroid carcinoma (PTC). OBJECTIVE: The objective of the study was to investigate the clinicopathological features and prognosis of DSV patients and compare these findings with all other PTCs and high-risk PTCs. DESIGN AND SETTING: The data of patients who underwent surgery for DSV and PTC between 2003 and 2014 in seven surgical departments specialized in endocrine surgery were reviewed...
December 2016: Journal of Clinical Endocrinology and Metabolism
Sunghwan Suh, Kyoungjune Pak, Ju Won Seok, In Joo Kim
PURPOSE: Thyroid cancer is the most common endocrine cancer and its incidence has continuously increased in the last three decades all over the world. We aimed to evaluate the prognostic value of extranodal extension (ENE) of thyroid cancer. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to June 2014) and EMBASE (from inception to June 2014) for English-language publication. The inclusion criteria were studies of thyroid cancer that reported the prognostic value of ENE in thyroid cancer...
November 2016: Yonsei Medical Journal
Nicola Nicolai, Mario Catanzaro, Michele Zazzara
PURPOSE OF REVIEW: Prognosis of penile squamous cell cancer (PeSCC) depends on the involvement of the groin(s) as first step. We introduce the current available evidences that should rule the use of surgery in the management of PeSCC. RECENT FINDINGS: Prophylactic inguinal node dissection in patients with no palpable nodes associates with immediate and long-term side-effects in up to 70% of patients. Recent findings support selective intervention based on early identification of dynamic sentinel node biopsy (DSNB) with false negative rate of 4-12%...
November 2016: Current Opinion in Urology
Claire Wen-Chi Yang, Chun-Wei Wang, Ruey-Long Hong, Chiao-Ling Tsai, Ming Yao, Jih-Luh Tang, Chung-Wu Lin, Ann-Lii Cheng, Sung-Hsin Kuo
Treatment strategies for nasal extranodal NK/T-cell lymphoma (ENKTL), including sequential chemotherapy followed by radiotherapy (SCRT), concurrent chemoradiotherapy (CCRT), or radiotherapy alone (RT), remain varied. The purpose of this study was to assess the treatment outcome, the toxicity, and the potential prognostic factors for patients with early-stage nasal ENKTL treated using definitive RT (minimum of 50 Gy) with or without chemotherapy. From 1998 to 2014, 37 patients were included in the study. Eight patients were treated with RT alone, 1 with CCRT, and 28 with SCRT...
August 16, 2016: Journal of Radiation Research
Cherry Kim, Jung Hwan Baek, EunJu Ha, Jeong Hyun Lee, Young Jun Choi, Dong Eun Song, Jae Kyun Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong
BACKGROUND: Although there are many well-known prognostic predictors of medullary thyroid carcinoma (MTC), the ultrasonography (US) findings of MTC have not been sufficiently validated in this regard. PURPOSE: To investigate the US findings of MTC and their relationship with the biological behavior of MTC. MATERIAL AND METHODS: The US findings and clinical and pathology records of 123 MTC nodules from 108 patients were retrospectively analyzed at two tertiary referral hospitals...
July 26, 2016: Acta Radiologica
Nicola Veronese, Matteo Fassan, Laura D Wood, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Alessia Nottegar, Giuseppe Sergi, Enzo Manzato, Sara Carraro, Marco Maruzzo, Ivana Cataldo, Fabio Bagante, Mattia Barbareschi, Liang Cheng, Maria Bencivenga, Giovanni de Manzoni, Claudio Luchini
INTRODUCTION: The extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. MATERIAL AND METHODS: Two independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients' prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE-)...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Gianluigi Reda, Ramona Cassin, Sonia Fabris, Gabriella Ciceri, Bruno Fattizzo, Mariarita Sciumè, Nicola Orofino, Umberto Gianelli, Antonino Neri, Agostino Cortelezzi
Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia in a high-grade lymphoma usually presenting nodal and bone marrow involvement. Richter syndrome can be localized at extranodal sites including the gastrointestinal tract, lungs, and skin. Cutaneous RS is an extremely rare disease apparently showing a less aggressive course than common presentations. While nodal RS has been extensively investigated in literature, pathogenesis and prognosis of cutaneous RS are still partially unknown, even if a role of Epstein-Barr virus infection and p53 disruption has been suggested...
July 12, 2016: Hematological Oncology
Claudio Luchini, Laura D Wood, Liang Cheng, Alessia Nottegar, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Giuseppe Sergi, Enzo Manzato, Matteo Fassan, Fabio Bagante, Elfriede Bollschweiler, Simone Giacopuzzi, Takuma Kaneko, Giovanni de Manzoni, Mattia Barbareschi, Aldo Scarpa, Nicola Veronese
The extranodal extension (ENE) of nodal metastasis is the extension of neoplastic cells through the nodal capsule into the perinodal adipose tissue. This histological feature has recently been indicated as an important prognostic factor in different types of malignancies; in this manuscript, we aim at defining its role in the prognosis of oesophageal cancer with the tool of meta-analysis. Two independent authors searched SCOPUS and PubMed until 31 August 2015 without language restrictions. The studies with available data about prognostic parameters in subjects with oesophageal cancer, comparing patients with the presence of ENE (ENE+) versus only intranodal extension (ENE-), were considered as eligible...
July 7, 2016: Journal of Clinical Pathology
Doonyapat Sa-Nguanraksa, Monthira Suntiparpluacha, Anchalee Kulprom, Tanawan Kummalue, Tuenjai Chuangsuwanich, Panissadee Avirutnan, Pornchai O-Charoenrat
Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Delphine Mtf Vervloet, Michel De Pauw, Laurent Demulier, Jan Vercammen, Wim Terryn, Eva Steel, Linos Vandekerckhove
Cardiac masses are rare, the differential diagnosis includes infections with vegetations or abscesses, neoplasms, thrombi, and structural abnormalities. A pathology specimen is essential in therapeutic strategy planning for a cardiac mass, also if the primary imaging findings look dramatic at the start. Even in an inoperable setting, a life-saving therapy might be available. We report a case of a 49-year-old man, known with HIV-1, who was several times admitted with pericarditis. Now he was hospitalized with progressive lower limb edema, atrial fibrillation and detection of a giant cardiac mass in left and right atrium with infiltration of surrounding tissues...
June 14, 2016: Acta Clinica Belgica
Nathalie Guedj, Léon Maggiori, Nicolas Poté, Emma Norkowski, Jérôme Cros, Pierre Bedossa, Yves Panis
This observational prospective study aimed to assess the distribution of intramural and mesorectal tumor spread in mid/low rectal cancer after neoadjuvant radiochemotherapy. Distribution of mesorectal metastatic lymph nodes (MLNs) and mesorectal extranodal cancer tissue (EX), according to the tumor location, were analyzed. Distal intramural tumor spread was also performed. A total of 1676 LNs, 135 MLNs, and 69 EX were detected on 124 consecutive surgical specimens. Forty-two patients (34%) had MLNs. Six patients (4...
June 2016: Human Pathology
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