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Extranodal extension

Jay P Reddy, Curtis A Pettaway, Lawrence B Levy, Lance C Pagliaro, Pheroze Tamboli, Priya Rao, Isuru Jayaratna, Karen E Hoffman
OBJECTIVE: To identify factors associated with regional recurrence (RR) following lymphadenectomy for penile cancer in order to determine which patients might benefit from adjuvant therapy. MATERIALS/METHODS: Men who underwent lymphadenectomy for penile squamous cell carcinoma from 1977-2014 were identified from an institutional database. Kaplan-Meier curves estimated recurrence-free survival (RFS) calculated from the date of lymphadenectomy. Cox regression models evaluated the association between RFS and patient and tumor characteristics...
October 18, 2016: BJU International
Anil Gungor, Lindsey Pennington, Senthil Sankararaman, Samer Zaid-Kaylani, Majed Aldin Jeroudi
Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subtypes. ENKTL, nasal type occurs in the nose and can extend to the upper aero-digestive tract as reported in this longitudinal case study. This is a longitudinal report of progress of a 14-year-old boy with ENKTL originating in the nasal cavity with subsequent extension and recurrence in the contralateral nose, nasopharynx, larynx and trachea presenting with varying degrees of respiratory problems and eventually, respiratory distress...
August 12, 2016: American Journal of Otolaryngology
Michael C Stauder, Abigail S Caudle, Pamela K Allen, Simona F Shaitelman, Benjamin D Smith, Karen E Hoffman, Thomas A Buchholz, Mariana Chavez-Macgregor, Kelly K Hunt, Funda Meric-Bernstam, Wendy A Woodward
PURPOSE: We sought to determine the rate of postmastectomy radiation therapy (PMRT) among women treated with axillary lymph node dissection (ALND) after positive sentinel lymph node (SLN) biopsy results and to establish the effect of negative ALND results and PMRT on locoregional recurrence (LRR) and overall survival (OS). METHODS AND MATERIALS: All patients were treated with mastectomy and ALND after positive SLN biopsy results. All patients had clinical N0 or NX disease at the time of mastectomy and received no neoadjuvant therapy...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Hu Hei, Yongping Song, Jianwu Qin
BACKGROUND AND OBJECTIVES: Central compartment neck dissection (CCND) is recommended for patients with papillary thyroid carcinoma (PTC). However, whether to perform contralateral CCND remains unclear. An individualized estimation of the contralateral central neck metastasis (CNM) risk would assist in the tailoring of treatment for PTC patients. METHODS: Consecutive patients who underwent bilateral CCND for unilateral PTC between 2012 and 2014 in a tertiary center were identified...
September 16, 2016: Journal of Surgical Oncology
Nathalie Chereau, Xavier Giudicelli, Francois Pattou, Jean-Chistophe Lifante, Frederic Triponez, Eric Mirallié, Pierre Goudet, Laurent Brunaud, Christophe Trésallet, Frédérique Tissier, Laurence Leenhardt, Sophie Tezenas du Montcel, Fabrice Menegaux
CONTEXT: Diffuse Sclerosing Variant (DSV) is a rare and aggressive subtype of papillary thyroid carcinoma (PTC). OBJECTIVE: To investigate the clinicopathological features and prognosis of DSV patients and compare these findings to all other PTC and high risk PTC. DESIGN AND SETTING: The data of patients who underwent surgery for DSV and PTC between 2003 and 2014 in 7 surgical departments specialized in endocrine surgery were reviewed. PATIENTS: 56 DSV patients were included (mean age 32...
September 14, 2016: Journal of Clinical Endocrinology and Metabolism
Sunghwan Suh, Kyoungjune Pak, Ju Won Seok, In Joo Kim
PURPOSE: Thyroid cancer is the most common endocrine cancer and its incidence has continuously increased in the last three decades all over the world. We aimed to evaluate the prognostic value of extranodal extension (ENE) of thyroid cancer. MATERIALS AND METHODS: We performed a systematic search of MEDLINE (from inception to June 2014) and EMBASE (from inception to June 2014) for English-language publication. The inclusion criteria were studies of thyroid cancer that reported the prognostic value of ENE in thyroid cancer...
November 2016: Yonsei Medical Journal
Nicola Nicolai, Mario Catanzaro, Michele Zazzara
PURPOSE OF REVIEW: Prognosis of penile squamous cell cancer (PeSCC) depends on the involvement of the groin(s) as first step. We introduce the current available evidences that should rule the use of surgery in the management of PeSCC. RECENT FINDINGS: Prophylactic inguinal node dissection in patients with no palpable nodes associates with immediate and long-term side-effects in up to 70% of patients. Recent findings support selective intervention based on early identification of dynamic sentinel node biopsy (DSNB) with false negative rate of 4-12%...
November 2016: Current Opinion in Urology
Claire Wen-Chi Yang, Chun-Wei Wang, Ruey-Long Hong, Chiao-Ling Tsai, Ming Yao, Jih-Luh Tang, Chung-Wu Lin, Ann-Lii Cheng, Sung-Hsin Kuo
Treatment strategies for nasal extranodal NK/T-cell lymphoma (ENKTL), including sequential chemotherapy followed by radiotherapy (SCRT), concurrent chemoradiotherapy (CCRT), or radiotherapy alone (RT), remain varied. The purpose of this study was to assess the treatment outcome, the toxicity, and the potential prognostic factors for patients with early-stage nasal ENKTL treated using definitive RT (minimum of 50 Gy) with or without chemotherapy. From 1998 to 2014, 37 patients were included in the study. Eight patients were treated with RT alone, 1 with CCRT, and 28 with SCRT...
August 16, 2016: Journal of Radiation Research
Cherry Kim, Jung Hwan Baek, EunJu Ha, Jeong Hyun Lee, Young Jun Choi, Dong Eun Song, Jae Kyun Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong
BACKGROUND: Although there are many well-known prognostic predictors of medullary thyroid carcinoma (MTC), the ultrasonography (US) findings of MTC have not been sufficiently validated in this regard. PURPOSE: To investigate the US findings of MTC and their relationship with the biological behavior of MTC. MATERIAL AND METHODS: The US findings and clinical and pathology records of 123 MTC nodules from 108 patients were retrospectively analyzed at two tertiary referral hospitals...
July 26, 2016: Acta Radiologica
Nicola Veronese, Matteo Fassan, Laura D Wood, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Alessia Nottegar, Giuseppe Sergi, Enzo Manzato, Sara Carraro, Marco Maruzzo, Ivana Cataldo, Fabio Bagante, Mattia Barbareschi, Liang Cheng, Maria Bencivenga, Giovanni de Manzoni, Claudio Luchini
INTRODUCTION: The extranodal extension (ENE) of nodal metastases (the extension of neoplastic cells through the nodal capsule into the perinodal soft tissue) is a histological feature that has been considered a prognostic factor in several cancers, but the role in gastric cancer was not yet investigated. We aimed to investigate the prognostic role of ENE in patients affected by gastric cancer through a systematic review and meta-analysis. MATERIAL AND METHODS: Two independent authors searched major databases until 09/30/2015 to identify studies providing data on gastric cancer patients' prognostic parameters and comparing patients with ENE (ENE+) vs intra-nodal extension (ENE-)...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Gianluigi Reda, Ramona Cassin, Sonia Fabris, Gabriella Ciceri, Bruno Fattizzo, Mariarita Sciumè, Nicola Orofino, Umberto Gianelli, Antonino Neri, Agostino Cortelezzi
Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia in a high-grade lymphoma usually presenting nodal and bone marrow involvement. Richter syndrome can be localized at extranodal sites including the gastrointestinal tract, lungs, and skin. Cutaneous RS is an extremely rare disease apparently showing a less aggressive course than common presentations. While nodal RS has been extensively investigated in literature, pathogenesis and prognosis of cutaneous RS are still partially unknown, even if a role of Epstein-Barr virus infection and p53 disruption has been suggested...
July 12, 2016: Hematological Oncology
Claudio Luchini, Laura D Wood, Liang Cheng, Alessia Nottegar, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Giuseppe Sergi, Enzo Manzato, Matteo Fassan, Fabio Bagante, Elfriede Bollschweiler, Simone Giacopuzzi, Takuma Kaneko, Giovanni de Manzoni, Mattia Barbareschi, Aldo Scarpa, Nicola Veronese
The extranodal extension (ENE) of nodal metastasis is the extension of neoplastic cells through the nodal capsule into the perinodal adipose tissue. This histological feature has recently been indicated as an important prognostic factor in different types of malignancies; in this manuscript, we aim at defining its role in the prognosis of oesophageal cancer with the tool of meta-analysis. Two independent authors searched SCOPUS and PubMed until 31 August 2015 without language restrictions. The studies with available data about prognostic parameters in subjects with oesophageal cancer, comparing patients with the presence of ENE (ENE+) versus only intranodal extension (ENE-), were considered as eligible...
July 7, 2016: Journal of Clinical Pathology
Doonyapat Sa-Nguanraksa, Monthira Suntiparpluacha, Anchalee Kulprom, Tanawan Kummalue, Tuenjai Chuangsuwanich, Panissadee Avirutnan, Pornchai O-Charoenrat
Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Delphine Mtf Vervloet, Michel De Pauw, Laurent Demulier, Jan Vercammen, Wim Terryn, Eva Steel, Linos Vandekerckhove
Cardiac masses are rare, the differential diagnosis includes infections with vegetations or abscesses, neoplasms, thrombi, and structural abnormalities. A pathology specimen is essential in therapeutic strategy planning for a cardiac mass, also if the primary imaging findings look dramatic at the start. Even in an inoperable setting, a life-saving therapy might be available. We report a case of a 49-year-old man, known with HIV-1, who was several times admitted with pericarditis. Now he was hospitalized with progressive lower limb edema, atrial fibrillation and detection of a giant cardiac mass in left and right atrium with infiltration of surrounding tissues...
June 14, 2016: Acta Clinica Belgica
Nathalie Guedj, Léon Maggiori, Nicolas Poté, Emma Norkowski, Jérôme Cros, Pierre Bedossa, Yves Panis
This observational prospective study aimed to assess the distribution of intramural and mesorectal tumor spread in mid/low rectal cancer after neoadjuvant radiochemotherapy. Distribution of mesorectal metastatic lymph nodes (MLNs) and mesorectal extranodal cancer tissue (EX), according to the tumor location, were analyzed. Distal intramural tumor spread was also performed. A total of 1676 LNs, 135 MLNs, and 69 EX were detected on 124 consecutive surgical specimens. Forty-two patients (34%) had MLNs. Six patients (4...
June 2016: Human Pathology
Hyunsung Kim, Abdul Rehman, Yumin Chung, Kijong Yi, Young Chan Wi, Yeseul Kim, Kiseok Jang, Se Min Jang, Seung Sam Paik
Background. This study investigated the clinicopathologic significance of extranodal tumor extension in colorectal adenocarcinoma with lymph node metastasis. Method. Included were 419 patients who underwent curative resection for primary colorectal adenocarcinoma. Results. Extranodal tumor extension was observed more frequently in tumors with ulceroinfiltrative gross type (p = 0.026), higher histologic grade (p = 0.012), high grade tumor budding (p = 0.003), vascular invasion (p < 0.001), perineural invasion (p = 0...
2016: Gastroenterology Research and Practice
Juan Putra, Deborah L Ornstein
Küttner tumor/chronic sclerosing sialadenitis is a fibroinflammatory process that characteristically involves the submandibular gland of patients with IgG4-related disease. Histologic examination is often important to make the diagnosis because of its nonspecific clinical and radiologic findings. Microscopically, Küttner tumor should be distinguished from other entities such as extranodal marginal zone lymphoma, Sjögren's syndrome, and lymphoepithelial sialadenitis. The lesion is histologically well-demarcated with lobular architecture, extensive fibrosis, marked lymphoplasmacytic inflammation, formation of lymphoid follicles, acinar atrophy, and obliterative phlebitis, without the presence of lymphoepithelial lesions...
May 18, 2016: Head and Neck Pathology
Y M Lee, T Y Sung, W B Kim, K W Chung, J H Yoon, S J Hong
BACKGROUND: This study evaluated the impact of lymph node-related factors on the risk of and site of recurrence in patients who had papillary thyroid carcinoma with lymph node metastasis in the lateral compartment (classified as pN1b). METHODS: Patients underwent total thyroidectomy with unilateral modified radical neck dissection for classical papillary thyroid carcinoma. Risk factors for recurrence were evaluated according to the pattern of recurrence. RESULTS: A total of 324 patients were included in the study...
July 2016: British Journal of Surgery
Yiting Li, Wei Cui, Janet M Woodroof, Da Zhang
Primary B-cell lymphoma exhibiting a spindle dominant pattern is extremely rare and represents a potential diagnostic pitfall. Here we report two cases of extranodal B cell lymphoma with spindle cell dominant morphology (sp-BCL) of uterus and maxillary sinus. Case 1 was a 54-year-old female with a large mass in the lower uterine segment, inseparable from the wall of the rectum and the urinary bladder. This is the first report of primary sp-BCL arising in the lower uterine segment. Case 2 was a 54-year-old male with a permeative mass involving the maxillary sinus wall with extension into the premaxillary soft tissues...
2016: Annals of Clinical and Laboratory Science
Eugenie Du, Bruce M Wenig, Henry K Su, Meghan E Rowe, Grace C Haser, Sylvia L Asa, Zubair Baloch, William C Faquin, Giovanni Fellegara, Thomas Giordano, Ronald Ghossein, Virginia A LiVolsi, Ricardo Lloyd, Ozgur Mete, Umut Ozbek, Juan Rosai, Saul Suster, Lester D Thompson, Andrew T Turk, Mark L Urken
BACKGROUND: Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its microscopic diagnosis, and its identification is subject to inter-observer variability. The objective of this study was to determine the level of agreement among expert pathologists in the identification of ENE in PTC cases. METHODS: Eleven expert pathologists from the United States, Italy, and Canada were asked to review 61 scanned slides of representative permanent sections of PTC specimens from Mount Sinai Beth Israel Medical Center in New York...
June 2016: Thyroid: Official Journal of the American Thyroid Association
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