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Extracapsular extension

Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong, Young Deuk Choi
BACKGROUND: Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous related studies had utilized outdated staging criteria or small sample cohorts. In this study, we analyzed predictors of APFs after RP in low-risk PC using classification under the current criteria. MATERIALS AND METHODS: We retrospectively reviewed medical records of 546 low-risk PC patients who had undergone RP...
May 9, 2018: BMC Cancer
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
Marisa R Buchakjian, Timothy Ginader, Kendall K Tasche, Nitin A Pagedar, Brian J Smith, Steven M Sperry
Objective To conduct a multivariate analysis of a large cohort of oral cavity squamous cell carcinoma (OCSCC) cases for independent predictors of local recurrence (LR) and overall survival (OS), with emphasis on the relationship between (1) prognosis and (2) main specimen permanent margins and intraoperative tumor bed frozen margins. Study Design Retrospective cohort study. Setting Tertiary academic head and neck cancer program. Subjects and Methods This study included 426 patients treated with OCSCC resection between 2005 and 2014 at University of Iowa Hospitals and Clinics...
May 1, 2018: Otolaryngology—Head and Neck Surgery
Gustavo Mendez, Bryan R Foster, Xin Li, Jackilen Shannon, Mark Garzotto, Christopher L Amling, Fergus V Coakley
OBJECTIVE: To evaluate the length of contact between dominant tumor foci and the prostatic capsule as a sign of extracapsular extension at endorectal multiparametric MR imaging. MATERIALS AND METHODS: We retrospectively identified 101 patients over a three-year interval who underwent endorectal multiparametric prostate MR imaging prior to radical prostatectomy for prostate cancer. Two readers identified the presence of dominant tumor focus (largest lesion with PI-RADS version 2 score of 4 or 5), and measured the length of tumor capsular contact and likelihood of extracapsular extension by standard criteria (1-5 Likert scale)...
April 25, 2018: Clinical Imaging
Fabrizio Dal Moro, Tommaso Prayer-Galetti, Lorenzo Angelini, Fabio Vianello, Marina Gardiman, Massimo Rugge, Filiberto Zattoni
BACKGROUND: Prostate cancer (PC) represents the second most frequent cancer in the male population worldwide. It is mandatory to have a very accurate staging to choice the best possible treatment. AIMS: To test the possibility of improving the performance of Partin's tables in predicting the pathological staging of PC by introducing bioptic parameters through an innovative statistic tool (Fagan's two-step nomogram). METHODS: We prospectivelly collected data of all 1048 consecutive patients undergoing saturation 24-core transrectal prostate biopsy...
May 2, 2018: Aging Clinical and Experimental Research
Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner, Jens Neumann
BACKGROUND: Extra-capsular growth (ECG) describes the extension of neoplastic cells beyond the lymph node capsule. Aim of this study was to investigate the prognostic value of ECG and its association with a stem cell like phenotype indicated by expression of the transcription factor SOX9 in gastric cancer. METHODS: By histological evaluation, 199 patients with nodal positive gastric cancer or adeoncarcinoma of the esophageal-gastric junction (AEG) were divided into two groups according to the presence (ECG) or absence (ICG) of extracapsular growth in at least one nodal metastasis...
April 27, 2018: BMC Cancer
Alberto Martini, Akriti Gupta, Sara C Lewis, Shivaram Cumarasamy, Kenneth G Haines, Alberto Briganti, Francesco Montorsi, Ash K Tewari
OBJECTIVES: To develop a nomogram for predicting side-specific extracapsular extension (ECE) for planning nerve sparing radical prostatectomy (NSRP). MATERIALS AND METHODS: We retrospectively analyzed data from 561 patients who underwent robot-assisted radical prostatectomy between February 2014 and October 2015. To develop a side-specific predictive model, we considered the prostatic lobes separately. Four variables were included: PSA, highest ipsilateral biopsy Gleason grade, highest ipsilateral percentage core involvement and ECE on multiparametric MRI (mpMRI)...
April 19, 2018: BJU International
Jacob Y Shin, Ja Kyoung Yoon, Aaron K Shin, Aidnag Z Diaz
BACKGROUND: The purpose of this study was to determine the impact of adjuvant radiotherapy (RT) in locoregionally advanced oral cavity cancer. METHODS: Data were extracted from the National Cancer Data Base, of which overall survival (OS) is the only outcome variable available. The chi-square test and Cox regression models were used. RESULTS: A total of 6654 patients were identified. The utilization of adjuvant RT has increased over time. A propensity matched cohort included 3946 patients, exactly one-half of whom received adjuvant RT...
April 17, 2018: Head & Neck
Julia Bergheim, Alexander Semaan, Heidrun Gevensleben, Susanne Groening, Andreas Knoblich, Jörn Dietrich, Julia Weber, Jörg C Kalff, Friedrich Bootz, Glen Kristiansen, Dimo Dietrich
BACKGROUND: Septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) methylation in circulating cell-free DNA (ccfDNA) are powerful biomarkers for colorectal cancer (CRC) screening, as well as head and neck squamous cell carcinoma staging and monitoring. In the present study, we investigated SEPT9 and SHOX2 ccfDNA methylation as auxiliary pre and post-therapeutic staging parameters in CRC patients. METHODS: ccfDNA methylation was quantified in 184 prospectively enrolled patients prior to and 3-10 days after surgery, and biomarker levels were associated with clinico-pathological parameters...
April 3, 2018: British Journal of Cancer
Etienne Lavallée, Michelle Bergeron, François-Alexandre Buteau, Annie-Claude Blouin, Nicolas Duchesnay, Thierry Dujardin, Rabi Tiguert, Louis Lacombe, Vincent Fradet, Molière Makao-Nguile, Yves Fradet, Jean-Mathieu Beauregard, Frédéric Pouliot
BACKGROUND: The accuracy of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to stage prostate cancer (PCa) is limited. However, Gleason 8-10 PCa and more aggressive metastatic PCa have been shown to exhibit a higher glycolytic activity. OBJECTIVE: To evaluate the potential of intraprostatic FDG uptake to prognose Gleason 8-10 PCa patients prior to prostatectomy, based on tumour intrinsic biology. DESIGN, SETTING, AND PARTICIPANTS: FDG-PET/CT and a bone scan were performed as a staging procedure prior to prostatectomy in 148 consecutive patients diagnosed with PCa with a Gleason sum of ≥8 at biopsy...
March 30, 2018: European Urology Focus
Edinson Najera, Carl H Snyderman, Juan C Fernandez-Miranda
In this video, we describe the technical nuances of an endoscopic endonasal approach (EEA) for a complex macroadenoma with suprasellar and retrochiasmatic extension. The patient is a 51-year-old male with several years' history of progressive visual loss. Neuro-ophthalmology assessment revealed a profound visual loss with homonymous hemianopsia and left optic nerve atrophy. His pituitary hormonal profile was normal. The options for surgical approach included transcranial, endoscopic endonasal, or a combination of both...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Qing-Shui Zheng, Shao-Hao Chen, Yu-Peng Wu, Hui-Jun Chen, Hong Chen, Yong Wei, Xiao-Dong Li, Jin-Bei Huang, Xue-Yi Xue, Ning Xu
Purpose Paxillin regulates cell-cell adhesion, and altered Paxillin expression has been associated with human carcinogenesis. This study analyzed the association between Paxillin expression in prostate cancer (PCa) tissues with clinicopathological features, lymph node metastasis and biochemical PCa recurrence. Methods A total of 386 tissue specimens from PCa patients who received radical prostatectomy and 60 tissue specimens from benign prostatic hyperplasia (BPH) cases were collected to construct tissue microarrays, which were subsequently immunostained for Paxillin expression...
2018: Journal of Cancer
Cristina Dominguez, Mauricio Plata, Juan Guillermo Cataño, Mauricio Palau, Diego Aguirre, Jorge Narvaez, Stephanie Trujillo, Felipe Gómez, Carlos Gustavo Trujillo, Juan Ignacio Caicedo, Camilo Medina
OBJECTIVES: To evaluate the diagnostic performance of preoperative multiparametric magnetic resonance imaging (mp-MRI) as a predictor of extracapsular extension (ECE) and unfavorable Gleason score (GS) in patients with intermediate and high-risk prostate cancer (PCa). MATERIALS AND METHODS: Patients with clinically localized PCa who underwent radical prostatectomy (RP) and had preoperative mp-MRI between May-2011 and December-2013. Mp-MRI was evaluated according to the European Society of Urogenital Radiology MRI prostate guidelines by two different readers...
March 23, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Shirin Muhsen, Tracy-Ann Moo, Sujata Patil, Michelle Stempel, Simon Powell, Monica Morrow, Mahmoud El-Tamer
BACKGROUND/OBJECTIVE: Guidelines concur that postmastectomy radiation therapy (PMRT) in T1-2 tumors with one to three positive (+) lymph nodes (LNs) decreases locoregional recurrence (LRR) but advise limiting PMRT to patients at highest risk to balance against potential harms. In this study, we identify the risks of LRR after mastectomy in patients with T1-2N1 disease, treated with modern chemotherapy, and identify predictors of LRR when omitting PMRT. METHODS: Patients with T1-2N1 breast cancer undergoing mastectomy between 1995 and 2006 were categorized by receipt of PMRT...
March 21, 2018: Annals of Surgical Oncology
U S Vishal Rao, Shrinidhi Koya, Sowjanya Gandla, Sataksi Chatterjee, Ashutosh A Patil, Ravi C Nayar, Kumar Kallur
The incidence of small differentiated thyroid carcinomas is increasing worldwide in the recent years, especially tumours of size less than 2 cm in diameter. In this study, we have analysed the patterns of behaviour of small-sized thyroid carcinomas (<2 cm, T1 tumours) in comparison with large-sized thyroid carcinomas. This is a retrospectively analysed data of patients with thyroid carcinoma. The following parameters were analysed: distribution with regard to age, sex and the presence of metastasis based on radioiodine scan...
March 2018: Indian Journal of Surgical Oncology
Salvina Barra, Liliana Belgioia, Michela Marcenaro, Serena Callegari, Alice Pastorino, Luca Trapani, Francesca Cavagnetto, Stefania Garelli, Renzo Corvò
Background: After radical prostatectomy (RP) radiotherapy (RT) plays a role, both as adjuvant or salvage treatment. If negative features are present such as extracapsular extension, seminal vesicle invasion, lymph invasion, and positive surgical margins, RT after RP reduces the risk of recurrence, although it is associated with an increased risk of acute and late toxicities. An intensified RT delivered in a shortened time could improve clinical outcome and be safely combined with hormonal therapy (HT)...
2018: Cancer Management and Research
Mariana Andozia Morini, Roberto Lodeiro Muller, Paulo César Barbosa de Castro Junior, Rafael José de Souza, Eliney Ferreira Faria
INTRODUCTION: Prostate cancer (PC) most of the time presents with an indolent course. Thus, delays in treatment due to any causes might not affect long-term survival and may not affect cancer cure rates. PURPOSE: In this study, we evaluated the effect of delay-time between PC diagnosis and radical prostatectomy regarding oncological outcomes: Gleason score upgrade on surgical specimen, pathologic extracapsular extension (ECE) on surgical specimen, and postoperative biochemical recurrence (BCR) on follow-up...
March 16, 2018: World Journal of Urology
Kai Qian, Lu Di, Kai Guo, Xiaoke Zheng, Qinghai Ji, Zhuoying Wang
PURPOSE: Salivary duct carcinoma (SDC) is an aggressive malignancy that is not yet fully understood. We designed the present retrospective study to investigate the factors affecting the prognosis of SDC and the effects of adjuvant therapies on the clinical outcomes of patients. MATERIALS AND METHODS: Patients with SDC treated surgically from 2006 to 2016 were enrolled in the present retrospective cohort study. The demographic data, clinical pathologic characteristics, and follow-up results were recorded...
February 19, 2018: Journal of Oral and Maxillofacial Surgery
Dhouha Bacha, Zeineb Mzoughi, Oussama Belkacem, Salsabil Rejaibi, Ahlem Lahmar, Lassad Gharbi, Saadia Bouraoui
BACKGROUND: Extracapsular extension of nodal metastasis has recently emerged as an important prognostic factor in different malignancies. In colorectal cancer (CRC), only a limited number of studies have been published and its prognostic value has not yet been completely established. AIMS: To assess the incidence of extracapsular invasion (ECI) in lymph node (LN) metastasis in colorectal adenocarcinoma and to investigate the correlation between this parameter and other clinico-pathological factors...
June 2017: La Tunisie Médicale
Ramez Philips, Daniel Martin, Antoine Eskander, Jeffrey Schord, Nicole Brown, Songzhu Zhao, Guy Brock, Bhavna Kumar, Ricardo Carrau, Enver Ozer, Amit Agrawal, Stephen Y Kang, James W Rocco, David Schuller, Syed Ali, Dukagjin Blakaj, Aashish Bhatt, John Grecula, Theodoros Teknos, Virginia Diavolitsis, Matthew Old
OBJECTIVES: to examine the impact of radiotherapy center volume on overall survival in patients with oral cavity and oropharyngeal squamous cell carcinoma getting adjuvant radiation therapy after receiving surgery at a high-volume center. MATERIALS AND METHODS: a retrospective study was conducted on patients with oral cavity squamous cell carcinoma or oropharyngeal squamous cell carcinoma treated surgically at a tertiary institution from 2000 to 2012 who received adjuvant radiotherapy...
March 2018: Oral Oncology
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