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Extracapsular extension

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https://www.readbyqxmd.com/read/27865373/extracapsular-spread-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#1
REVIEW
Maxime Mermod, Genrich Tolstonog, Christian Simon, Yan Monnier
Extracapsular spread (ECS) is one of the most important prognostic factors in head and neck squamous cell carcinoma (HNSCC). However, despite its major clinical relevance, there are still a number of important remaining issues regarding this condition. Indeed, standardized diagnostic and grading criteria of ECS are still lacking. The imaging modality of choice for its diagnosis is a matter of debate. Current research looking at the identification of specific biomarkers is ongoing. Recent findings demonstrate a direct correlation between the level of extension of ECS and a poor prognosis...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27846218/muc1-expression-by-immunohistochemistry-is-associated-with-adverse-pathologic-features-in-prostate-cancer-a-multi-institutional-study
#2
Okyaz Eminaga, Wei Wei, Sarah J Hawley, Heidi Auman, Lisa F Newcomb, Jeff Simko, Antonio Hurtado-Coll, Dean A Troyer, Peter R Carroll, Martin E Gleave, Daniel W Lin, Peter S Nelson, Ian M Thompson, Lawrence D True, Jesse K McKenney, Ziding Feng, Ladan Fazli, James D Brooks
BACKGROUND: The uncertainties inherent in clinical measures of prostate cancer (CaP) aggressiveness endorse the investigation of clinically validated tissue biomarkers. MUC1 expression has been previously reported to independently predict aggressive localized prostate cancer. We used a large cohort to validate whether MUC1 protein levels measured by immunohistochemistry (IHC) predict aggressive cancer, recurrence and survival outcomes after radical prostatectomy independent of clinical and pathological parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27833937/external-validation-of-the-cancer-of-the-prostate-risk-assessment-postsurgical-score-for-prediction-of-disease-recurrence-after-radical-prostatectomy
#3
Taha Numan Yıkılmaz, Erdem Öztürk, Eşref Oğuz Güven, Halil Başar
Objective. The cancer of the prostate risk assessment (CAPRA-S) postsurgical score predicts recurrence, metastasis, and cancer-specific survival after radical prostatectomy (RP). We evaluated the relation between CAPRA-S score and biochemical recurrence (BCR) in prostate cancer after RP in our clinic. Materials and Methods. This study was performed on 203 patients with prostate carcinoma who underwent open RP and regional lymph node dissection in our clinic between 2008 and 2013. We calculated the CAPRA-S scores including prostate-specific antigen (PSA) at diagnosis, pathology Gleason score, surgical margin, seminal vesicle invasion, extracapsular extension, and lymph node involvement...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27800051/assessing-guideline-impact-on-referral-patterns-of-post-prostatectomy-patients-to-radiation-oncologists
#4
Amandeep Taggar, Majed Alghamdi, Derek Tilly, Xanthoula Kostaras, Marc Kerba, Siraj Husain, Geoff Gotto, Michael Sia
INTRODUCTION: Adjuvant radiotherapy (aRT) can improve biochemical progression-free survival in patients with high-risk features (HRF) after radical prostatectomy (RP). Guidelines from Alberta and the Genitourinary Radiation Oncologists of Canada (GUROC) recommend that patients with HRF be referred to radiation oncologists (RO) based on the findings from three randomized, controlled trials (RCT). Our study examines the impact of these recommendations both pre- (2005) and post- (2012) publication of RCT and GUROC guideline establishment...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27774922/clinical-and-histopathological-prognostic-factors-in-locoregional-advanced-laryngeal-cancer
#5
T S Santos, R Estêvão, L Antunes, V Certal, J C Silva, E Monteiro
OBJECTIVE: To evaluate the clinical and histopathological factors affecting the prognosis of patients with squamous cell locoregional advanced laryngeal cancer. METHODS: A retrospective chart review was conducted of 121 patients with locoregional advanced laryngeal cancer, primarily treated with surgery from 2007 to 2011. Disease-free survival and overall survival rates were analysed as oncological outcomes. Prognostic variables, namely gender, pharyngeal invasion, pathological assessment of tumour and nodal stage, adjuvant therapy, margin status, nodal extracapsular extension, tumour differentiation, lymphovascular and perineural invasion, and predominant growth pattern, were also analysed...
October 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27749009/evaluation-of-extracapsular-extension-in-prostate-cancer-using-qualitative-and-quantitative-multiparametric-mri
#6
Wooil Kim, Chan Kyo Kim, Jung Jae Park, Minji Kim, Jae-Hun Kim
PURPOSE: To investigate the value of multiparametric magnetic resonance imaging (mpMRI) for extracapsular extension (ECE) in prostate cancer (PCa). MATERIALS AND METHODS: In all, 292 patients who received radical prostatectomy and underwent preoperative mpMRI at 3T were enrolled retrospectively. For determining the associations with ECE, the likelihood of ECE was assessed qualitatively on T2 -weighted imaging (T2 WI) and combined T2 WI and diffusion-weighted imaging (DWI) or dynamic contrast-enhanced imaging (DCEI)...
October 17, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27743920/development-and-validation-of-a-24-gene-predictor-of-response-to-postoperative-radiotherapy-in-prostate-cancer-a-matched-retrospective-analysis
#7
Shuang G Zhao, S Laura Chang, Daniel E Spratt, Nicholas Erho, Menggang Yu, Hussam Al-Deen Ashab, Mohammed Alshalalfa, Corey Speers, Scott A Tomlins, Elai Davicioni, Adam P Dicker, Peter R Carroll, Matthew R Cooperberg, Stephen J Freedland, R Jeffrey Karnes, Ashley E Ross, Edward M Schaeffer, Robert B Den, Paul L Nguyen, Felix Y Feng
BACKGROUND: Postoperative radiotherapy has an important role in the treatment of prostate cancer, but personalised patient selection could improve outcomes and spare unnecessary toxicity. We aimed to develop and validate a gene expression signature to predict which patients would benefit most from postoperative radiotherapy. METHODS: Patients were eligible for this matched, retrospective study if they were included in one of five published US studies (cohort, case-cohort, and case-control studies) of patients with prostate adenocarcinoma who had radical prostatectomy (with or without postoperative radiotherapy) and had gene expression analysis of the tumour, with long-term follow-up and complete clinicopathological data...
October 12, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27738805/accuracy-of-preoperative-multiparametric-magnetic-resonance-imaging-for-prediction-of-unfavorable-pathology-in-patients-with-localized-prostate-cancer-undergoing-radical-prostatectomy
#8
Hakmin Lee, Chan Kyo Kim, Byung Kwan Park, Hyun Hwan Sung, Deok Hyun Han, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Han Yong Choi, Hyun Moo Lee
INTRODUCTION: We investigated the accuracy of multiparametric MRI (mpMRI) for preoperative staging and its influence on the determination of neurovascular bundle sparing and disease prognosis in patients with localized prostate cancer. METHODS: We reviewed 1045 patients who underwent radical prostatectomy with preoperative mpMRI at a single institution. Clinical local stages determined from mpMRI were correlated with preoperative and postoperative pathological outcomes...
October 13, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27733374/phase-ii-trial-of-post-operative-radiotherapy-with-concurrent-cisplatin-plus-panitumumab-in-patients-with-high-risk-resected-head-and-neck-cancer
#9
R L Ferris, J L Geiger, S Trivedi, N C Schmitt, D E Heron, J T Johnson, S Kim, U Duvvuri, D A Clump, J E Bauman, J P Ohr, W E Gooding, A Argiris
BACKGROUND: Treatment intensification for resected, high-risk, head and neck squamous cell carcinoma (HNSCC) is an area of active investigation with novel adjuvant regimens under study. In this trial, the epidermal growth-factor receptor (EGFR) pathway was targeted using the IgG2 monoclonal antibody panitumumab in combination with cisplatin chemoradiotherapy (CRT) in high-risk, resected HNSCC. PATIENTS AND METHODS: Eligible patients included resected pathologic stage III or IVA squamous cell carcinoma of the oral cavity, larynx, hypopharynx, or human-papillomavirus (HPV)-negative oropharynx, without gross residual tumor, featuring high-risk factors (margins <1 mm, extracapsular extension, perineural or angiolymphatic invasion, or ≥2 positive lymph nodes)...
October 11, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27683103/population-based-external-validation-of-the-updated-2012-partin-tables-in-contemporary-north-american-prostate-cancer-patients
#10
Sami-Ramzi Leyh-Bannurah, Stéphanie Gazdovich, Lars Budäus, Emanuele Zaffuto, Paolo Dell'Oglio, Alberto Briganti, Firas Abdollah, Francesco Montorsi, Jonas Schiffmann, Mani Menon, Shahrokh F Shariat, Margit Fisch, Felix Chun, Markus Graefen, Pierre I Karakiewicz
OBJECTIVE: To externally validate the updated 2012 Partin Tables in contemporary North American patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa) at community institutions. MATERIALS AND METHODS: We examined records of 25,254 patients treated with RP and pelvic lymph node dissection (PLND) between 2010 and 2013, within the surveillance, epidemiology, and end results database. The ROC derived AUC assessed discriminant properties of the updated 2012 Partin Tables of organ confined disease (OC), extracapsular extension (ECE), seminal vesical invasion (SVI), and lymph node invasion (LNI)...
September 29, 2016: Prostate
https://www.readbyqxmd.com/read/27674518/resected-p16-oropharyngeal-cancer-opc-with-nodal-extracapsular-extension-ece-is-adjuvant-chemoradiation-therapy-crt-superior-to-radiation-therapy-rt-alone
#11
J K Russo, A N Snow, A Terrell, S J Vishal, M Laszewski, C Fisher, B Liu, S L Mott, C Hellekson, J Kaelberer, M Furqan, C M Anderson, J Buatti, J M Watkins
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674439/the-prognostic-importance-of-pathologic-extracapsular-extension-in-human-papillomavirus-associated-oropharyngeal-squamous-cell-carcinoma
#12
Y An, H S M Park, J R Kelly, J M Stahl, J N Contessa, Z A Husain
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674385/beyond-positive-margins-and-extracapsular-extension-evaluating-the-impact-of-postoperative-chemoradiation-therapy-in-locally-advanced-head-and-neck-cancer
#13
D M Trifiletti, A Lin, J N Lukens, W M Mendenhall, N Mitra, P W Read, S Swisher-Mcclure
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27667733/clinical-review-of-treatment-outcomes-and-patterns-of-failure-with-adjuvant-radiotherapy-in-node-positive-malignant-melanoma
#14
Lorna G Keenan, Siobhra O'Sullivan, Aisling Glynn, Martin Higgins, Aileen Flavin, Sinead Brennan
INTRODUCTION: Adjuvant radiotherapy is proven to prevent lymph node field relapse after therapeutic lymphadenectomy for melanoma, but does not improve overall survival based on current data. There remains a high rate of distant relapse. This study reports patterns of failure in patients treated with adjuvant radiotherapy, looking at factors associated with distant metastasis and comparing this to recent literature. METHODS: This retrospective study included patients treated with adjuvant nodal irradiation after lymphadenectomy between June 2012 and March 2015...
September 25, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27650933/management-of-prostate-cancer-patients-with-locally-adverse-pathologic-features-after-radical-prostatectomy-feasibility-of-active-surveillance-for-cases-with-gleason-grade-3%C3%A2-%C3%A2-4%C3%A2-%C3%A2-7
#15
Xun Shangguan, Baijun Dong, Yanqing Wang, Fan Xu, Xiaoguang Shao, Jianjun Sha, Yinjie Zhu, Jiahua Pan, Wei Xue
PURPOSE: To evaluate the ability of the new Gleason grade groups (GGGs) to stratify risk in prostate cancer patients with locally adverse pathologic features after radical prostatectomy (RP) thereby allowing more accurate assessment for planning eventual adjuvant therapy. PATIENTS AND METHODS: Data on 172 patients with locally adverse pathologic features (including seminal vesicle invasion, extracapsular extension, or positive surgical margins) who had been treated with wait and see policy after RP were retrospectively analyzed for biochemical recurrence (BCR)-free survival...
September 20, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27623212/reduced-connexin-43-expression-is-associated-with-tumor-malignant-behaviors-and-biochemical-recurrence-free-survival-of-prostate-cancer
#16
Ning Xu, Hui-Jun Chen, Shao-Hao Chen, Xue-Yi Xue, Hong Chen, Qing-Shui Zheng, Yong Wei, Xiao-Dong Li, Jin-Bei Huang, Hai Cai, Xiong-Lin Sun
Connexin 43, a gap junction protein, coordinates cell-to-cell communication and adhesion. Altered Connexin 43 expression associated with cancer development and progression. In this study, we assessed Connexin 43 expression for association with clinicopathological features and biochemical recurrence of prostate cancer after radical prostatectomy. Pathological specimens were collected from 243 patients who underwent radical prostatectomy and from 60 benign prostatic hyperplasia (BPH) patients to construct tissue microarrays and immunohistochemical analysis of Connexin 43 expression...
August 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27612282/postoperative-radiation-therapy-after-nipple-sparing-or-skin-sparing-mastectomy-a-survey-of-european-north-american-and-south-american-practices
#17
Gustavo Nader Marta, Philip M Poortmans, Thomas A Buchholz, Tarek Hijal
Skin sparing mastectomy, a surgical procedure sparing a large portion of the overlying skin of the breast, and nipple-sparing mastectomy, sparing the whole nipple-areolar complex, are increasingly used, although their oncologic efficacy remains unclear. The aim of this study was to assess the radiation oncologists' opinions regarding the indications of radiation therapy (RT) after skin-sparing mastectomy and nipple-sparing mastectomy. Radiation oncology members of four national and international societies were invited to complete a questionnaire comprising of 22 questions to assess their opinions regarding RT indications in the context of skin-sparing and nipple-sparing mastectomy...
September 9, 2016: Breast Journal
https://www.readbyqxmd.com/read/27590518/clues-toward-precision-medicine-in-oral-squamous-cell-carcinoma-utility-of-next-generation-sequencing-for-the-prognostic-stratification-of-high-risk-patients-harboring-neck-lymph-node-extracapsular-extension
#18
Hung-Ming Wang, Chun-Ta Liao, Tzu-Chen Yen, Shu-Jen Chen, Li-Yu Lee, Chia-Hsun Hsieh, Chien-Yu Lin, Shu-Hang Ng
Patients with resected oral squamous cell carcinoma (OSCC) harboring extracapsular extension (ECE) of the involved lymph node, show poor and heterogeneous outcomes. We aim to improve their prognostic stratification by combining genetic information from next-generation sequencing (NGS) using traditional clinicopathological prognosticators. The hotspot mutation regions of 45 cancer-related genes were investigated using NGS with an ultra-deep (>1000×) sequencing approach in formalin-fixed paraffin-embedded samples obtained from 201 patients with resected OSCC harboring ECE...
August 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27576750/the-incremental-role-of-magnetic-resonance-imaging-for-prostate-cancer-staging-before-radical-prostatectomy
#19
Alessandro Morlacco, Vidit Sharma, Boyd R Viers, Laureano J Rangel, Rachel E Carlson, Adam T Froemming, R Jeffrey Karnes
: In the present report we aimed to analyze the incremental value of preoperative magnetic resonance imaging (MRI), in addition to clinical variables and clinically-derived nomograms, in predicting outcomes radical prostatectomy (RP). All Mayo Clinic RP patients who underwent preoperative 1.5-Tesla MRI with endo-rectal coil from 2003 to 2013 were identified. Clinical and histopathological variables were used to calculate Partin estimates and Cancer of the Prostate Risk Assessment (CAPRA) score...
August 28, 2016: European Urology
https://www.readbyqxmd.com/read/27576436/clinical-significance-of-adding-3-tesla-mri-to-the-algorithm-for-decision-making-on-neurovascular-bundle-preservation-in-radical-prostatectomy
#20
Tetsuya Shindo, Hiroshi Kitamura, Ko Kobayashi, Kohei Hashimoto, Sachiyo Nishida, Mitsuharu Tamakawa, Yuriko Kawaai, Naoya Masumori
OBJECTIVES: The aim of this study was to evaluate the additional benefit of 3 Tesla magnetic resonance imaging for neurovascular bundle preservation in radical prostatectomy. METHODS: We retrospectively evaluated patients who underwent 3 T magnetic resonance imaging followed by radical prostatectomy from April 2010 through February 2014 in our university. A total of 50 patients (100 prostate sides) were included in the study. The algorithm previously we described and magnetic resonance imaging findings were considered for the decision on neurovascular bundle preservation...
August 30, 2016: Japanese Journal of Clinical Oncology
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