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Extracapsular extension

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https://www.readbyqxmd.com/read/29137426/therapeutic-implications-of-tumor-free-margins-in-head-and-neck-squamous-cell-carcinoma
#1
Clara Backes, Henning Bier, Andreas Knopf
Objectives: The resection status is one of the most important prognostic factors for patients with head and neck squamous cell carcinoma (HNSCC) concerning overall survival (OS) and recurrence free interval (RFI). To assess whether therapy concepts changed depending on different resection margins and extracapsular extension, OS and RFI data were set into clinical context. Methods: All HNSCC patients who underwent head and neck surgery with/without adjuvant therapy (n=534) were selected over a ten-year period (2001-2011)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134670/altered-mitochondrial-genome-content-signals-worse-pathology-and-prognosis-in-prostate-cancer
#2
Anton M F Kalsbeek, Eva K F Chan, Judith Grogan, Desiree C Petersen, Weerachai Jaratlerdsiri, Ruta Gupta, Ruth J Lyons, Anne-Maree Haynes, Lisa G Horvath, James G Kench, Phillip D Stricker, Vanessa M Hayes
BACKGROUND: Mitochondrial genome (mtDNA) content is depleted in many cancers. In prostate cancer, there is intra-glandular as well as inter-patient mtDNA copy number variation. In this study, we determine if mtDNA content can be used as a predictor for prostate cancer staging and outcomes. METHODS: Fresh prostate cancer biopsies from 115 patients were obtained at time of surgery. All cores underwent pathological review, followed by isolation of cancer and normal tissue...
November 14, 2017: Prostate
https://www.readbyqxmd.com/read/29134231/patterns-of-relapse-as-determined-by-68-ga-psma-ligand-pet-ct-after-radical-prostatectomy-importance-for-tailoring-and-individualizing-treatment
#3
Christoph Henkenberens, Thorsten Derlin, Frank M Bengel, Tobias L Ross, Hans-Jürgen Wester, Katja Hueper, Markus A Kuczyk, Hans Christiansen, Christoph A von Klot
PURPOSE: To evaluate the patterns of relapse and impact on the intended treatment when using (68)Ga-prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) imaging for restaging of disease in patients with biochemical relapse after radical prostatectomy (RP) before salvage radiotherapy (sRT). METHODS: In all, 39 patients with biochemical recurrence after RP who had no primary indication for adjuvant RT due to the absence of biologically unfavorable disease (e...
November 13, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29103752/extracapsular-extension-is-associated-with-worse-distant-control-and-progression-free-survival-in-patients-with-lymph-node-positive-human-papillomavirus-related-oropharyngeal-carcinoma
#4
Jeffrey Shevach, Adam Bossert, Richard L Bakst, Jerry Liu, Krzysztof Misiukiewicz, Jessica Beyda, Brett A Miles, Eric Genden, Marshall R Posner, Vishal Gupta
OBJECTIVES: To determine the prognostic utility of pathologic extracapsular extension (ECE) in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC). MATERIALS AND METHODS: Retrospective analysis was performed on patients who underwent surgery for primary HPV-related OPSCC and received adjuvant radiotherapy (RT) between 2006 and 2015. Locoregional control (LRC), distant control (DC), progression-free survival (PFS) and overall survival (OS) were compared between the groups with and without ECE using univariate Kaplan-Meier and multivariate Cox regression survival analyses...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29082376/factors-influencing-non-sentinel-node-metastasis-in-patients-with-macrometastatic-sentinel-lymph-node-involvement-and-validation-of-three-commonly-used-nomograms
#5
Hikmet Erhan Güven, Lütfi Doğan, Mahmut Onur Kültüroğlu, Mehmet Ali Gülçelik, Cihangir Özaslan
OBJECTIVE: Omitting axillary lymph node dissection (ALND) in a subgroup of patients with sentinel lymph node (SLN) metastasis is becoming a widely accepted practice. Avoiding the well-known complications of ALND is the sole aim without compromising the curative intention of surgery. MATERIALS AND METHODS: The data were probed for breast cancer patients that were operated on between February 2014 and June 2016. SLN biopsies were performed in 507 patients and out of 157 patients who underwent ALND for a metastatic SLN, 151 were found eligible for the analyses as having macrometastatic (>2mm) SLN...
October 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/29026057/pathological-outcome-for-chinese-patients-with-low-risk-prostate-cancer-eligible-for-active-surveillance-and-undergoing-radical-prostatectomy-comparison-of-six-different-active-surveillance-protocols
#6
C F Tsang, J Hl Tsu, T Ct Lai, K W Wong, B Sh Ho, A Tl Ng, W K Ma, M K Yiu
INTRODUCTION: Active surveillance is one of the therapeutic options for the management of patients with low-risk prostate cancer. This study compared the performance of six different active surveillance protocols for prostate cancer in the Chinese population. METHODS: Patients who underwent radical prostatectomy for prostate cancer from January 1998 to December 2012 at a university teaching hospital in Hong Kong were reviewed. Six active surveillance protocols were applied to the cohort...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28981735/pathological-and-oncological-features-of-korean-prostate-cancer-patients-eligible-for-active-surveillance-analysis-from-the-k-cap-registry
#7
Kyo Chul Koo, Kwang Suk Lee, Jae Yong Jeong, In Young Choi, Ji Youl Lee, Jun Hyuk Hong, Choung-Soo Kim, Hyun Moo Lee, Sung Kyu Hong, Seok-Soo Byun, Seung Hwan Lee, Koon Ho Rha, Byung Ha Chung
Background: A web-based multicenter Korean Prostate Cancer Database (K-CaP) was established to provide urologists with information on Korean prostate cancer (PCa) patients treated with radical prostatectomy (RP). We utilized the K-CaP registry to identify pathological features and oncological outcomes of Korean PCa patients eligible for active surveillance (AS). Methods: The K-CaP registry consisted of 6415 patients who underwent RP from May 2001 to April 2013 at five institutions...
October 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28971784/over-half-of-contemporary-clinical-gleason-8-on-prostate-biopsy-are-downgraded-at-radical-prostatectomy
#8
Robert Qi, Wen-Chi Foo, Michael N Ferrandino, Leah G Davis, Sitharthan Sekar, Thomas A Longo, Ghalib Jibara, Tracy Han, Ilhan Gokhan, Judd W Moul
INTRODUCTION: Contemporary clinical guidelines utilize the highest Gleason sum (HGS) in any one core on prostate biopsy to determine prostate cancer treatment. Here, we present a large discrepancy between prostate cancer risk stratified as high risk on biopsy and their pathology after radical prostatectomy. MATERIALS AND METHODS: We retrospectively reviewed 1424 men who underwent either open or robotic-assisted prostatectomy between 2004 and 2015. We analyzed 148 men who were diagnosed with HGS 8 on prostate biopsy...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28967564/multidisciplinary-international-survey-of-post-operative-radiation-therapy-practices-after-nipple-sparing-or-skin-sparing-mastectomy
#9
Gustavo Nader Marta, Philip Poortmans, Alfredo C de Barros, José Roberto Filassi, Ruffo Freitas Junior, Riccardo A Audisio, Max Senna Mano, Sarkis Meterissian, Sarah M DeSnyder, Thomas A Buchholz, Tarek Hijal
PURPOSE/OBJECTIVE(S): Skin sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) have entered routine surgical practice for breast cancer, though their oncologic safety has not been established in randomized controlled trials. The aim of this study was to evaluate and compare radiation oncologists' and breast surgeons' opinions concerning the indications of post-operative radiation therapy (PORT) after SSM and NSM. MATERIALS/METHODS: Radiation oncologists and breast surgeons from North America, South America and Europe were invited to contribute in this study...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28952300/the-prognostic-factors-of-biochemical-recurrence-free-survival-following-radical-prostatectomy
#10
Virote Chalieopanyarwong, Worapat Attawettayanon, Watid Kanchanawanichkul, Choosak Pripatnanont
Objective: To evaluate outcomes, biochemical recurrence-free survival (BCRFS) and to identify parameters influencing BCRFS of radical prostatectomy (RP) and bilateral pelvic lymph node dissection in a single-institution. Methods: A retrospective review of prostate cancer (PC) patients received RP was identified from the medical records. Data was collected from 2007 to 2016. 178 patients received RP were enrolled in a study. These patients were evaluated on efficacy of RP by using prostate-specific antigen (PSA) to analyze BCRFS and compared with Gleason score, pathologic staging, margin status and lymph node status with BCRFS...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28941058/a-novel-tool-for-predicting-extracapsular-extension-during-graded-partial-nerve-sparing-in-radical-prostatectomy
#11
Vipul R Patel, Marco Sandri, Angelica A C Grasso, Elisa De Lorenzis, Franco Palmisano, Giancarlo Albo, Rafael F Coelho, Alexander Mottrie, Tadzia Harvey, Darian Kameh, Hariharan Palayapalayam, Peter Wiklund, Silvano Bosari, Stefano Puliatti, Paola Zuccolotto, Giampaolo Bianchi, Bernardo Rocco
OBJECTIVES: To create a statistical tool for the estimation of extracapsular extension (ECE) level of prostate cancer and determine the nerve-sparing (NS) approach that can be safely performed during radical prostatectomy (RP). PATIENTS AND METHODS: A total of 11 794 lobes, from 6 360 patients who underwent robot-assisted RP between 2008 and 2016 were evaluated. Clinicopathological features were included in a statistical algorithm for the prediction of the maximum ECE width...
September 22, 2017: BJU International
https://www.readbyqxmd.com/read/28939351/standardization-of-nodal-radiation-therapy-through-changes-to-a-breast-cancer-clinical-pathway-throughout-a-large-integrated-cancer-center-network
#12
Brian J Gebhardt, Joel Thomas, Zachary D Horne, Colin E Champ, Gretchen M Ahrendt, Emilia Diego, Dwight E Heron, Sushil Beriwal
BACKGROUND: Studies demonstrate safety of omitting axillary nodal dissection for early-stage breast cancer with positive sentinel lymph node (+SLN) biopsy, although trial designs differed in radiation therapy (RT) fields. Regional nodal irradiation was separately shown to improve outcomes in high-risk patients. This led to lack of consensus in RT volumes. Clinical pathways (CPs) standardize care where practice varies unnecessarily. We evaluated the impact of changes to a CP guiding postoperative RT in women with +SLNs on practice patterns throughout a network...
July 20, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28903529/retrospective-analysis-of-definitive-radiotherapy-for-neck-node-metastasis-from-unknown-primary-tumor-japanese-radiation-oncology-study-group-study
#13
Takuya Yamazaki, Takeshi Kodaira, Yosuke Ota, Tetsuo Akimoto, Hitoshi Wada, Junichi Hiratsuka, Yasumasa Nishimura, Shunichi Ishihara, Takeshi Nonoshita, Kazushige Hayakawa, Shuhei Sekii, Nobue Uchida
Objective: To investigate the optimal treatment method and risk factor of neck node metastasis from unknown primary tumors (NUP) treated by radiotherapy. Methods: Retrospective case study based on a multi-institutional survey was conducted by the Japanese Radiation Oncology Study Group. Patients pathologically diagnosed as having NUP from 1998 to 2007 were identified. Univariate and multivariate analyses of overall survival (OS), progression free survival (PFS), neck progression free survival (NPFS) and mucosal progression free survival (MPFS) were evaluated...
September 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28894823/the-benefit-of-adjuvant-radiation-in-surgically-treated-t1-2-n1-oropharyngeal-squamous-cell-carcinoma
#14
Marcus M Monroe, Luke O Buchmann, Jason P Hunt, Ying J Hitchcock, Shane Lloyd, Mia Hashibe
IMPORTANCE: The benefit of adjuvant radiation in surgically treated T1-2N1 oropharyngeal cancer without adverse pathologic features remains unclear. OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation. STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28876588/postoperative-transient-hypoparathyroidism-incidence-and-risk-factors-a-south-african-perspective
#15
J Downs, K Wilson, F Made, F Malherbe, E Panieri, L Cairncross
BACKGROUND: There is limited published data on the incidence and risk factors for developing postoperative hypoparathyroidism (POHP) in the South African setting. METHOD: All patients who underwent a total thyroidectomy or completion thyroid lobectomy at an academic referral centre from January 2010 to December 2015 were included in this study. Data reviewed included post-operative parathyroid hormone (iPTH) level within 24 hours of surgery, age, gender, type of operation and lymphadenectomy if performed, size and weight of thyroid glands resected, final histological diagnosis, presence of extracapsular extension of carcinomas, number of lymph nodes resected, and the number of parathyroids present in the histology specimen...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28864046/-radiotherapy-for-head-and-neck-squamous-cell-carcinoma-state-of-the-art-and-future-directions
#16
REVIEW
U Schick, F Huguet, Y Pointreau, O Pradier
Therapeutic principles of radiation therapy in head and neck carcinomas will be discussed in this review. Intensity-modulated radiotherapy with concomitant cisplatin should be standard. In case of contraindication to chemotherapy, cetuximab is an option, while hyperfractionation should be considered in patients unfit for concomitant treatment. Concomitant chemotherapy should be administered in the presence of extracapsular extensions and positive margins in the postoperative setting. Current research areas such as desescalation in human papillomavirus-positive tumours, adaptive radiotherapy, radiomics and immunotherapy will also be addressed...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28838382/assessing-the-prognostic-impact-of-the-international-association-for-the-study-of-lung-cancer-proposed-definitions-of-complete-uncertain-and-incomplete-resection-in-non-small-cell-lung-cancer-surgery
#17
Matteo Gagliasso, Giuseppe Migliaretti, Francesco Ardissone
OBJECTIVE: The aim of this study was to assess the prognostic impact of the definitions of complete, uncertain, and incomplete resection in non-small cell lung cancer (NSCLC) surgery, as proposed by the International Association for the Study of Lung Cancer (IASLC). PATIENTS AND METHODS: Single institution retrospective study of consecutive patients undergoing surgery for NSCLC between 1998 and 2007. Complete resection was defined by absence of gross and microscopic residual disease; systematic nodal dissection; no extracapsular extension in distal lymph nodes; and negativity of the highest mediastinal node removed...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28834229/prophylactic-central-neck-dissection-in-68-patients-with-lateral-compartment-metastases-from-well-differentiated-thyroid-cancer
#18
Thomas M Kaffenberger, Jessica H Maxwell, Seungwon Kim
Skip metastasis (SM) in Well Differentiated Thyroid Cancer (WDTC) patients are lateral neck lymph node metastasis that have skipped the central neck compartment. In these patients, prophylactic central neck dissection remains controversial. We sought to identify clinicopathological factors associated with SM and determine the accuracy of central neck metastasis imaging in 68 patients at our institution over 16 years. 12 patients (17.6%) had SMs. Compared to the patients with occult central neck metastases, those with SM were more likely to have T1 tumors (p=0...
August 18, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28833217/adjuvant-chemoradiation-does-not-improve-survival-in-elderly-patients-with-high-risk-resected-head-and-neck-cancer
#19
Nicholas J Giacalone, Muhammad M Qureshi, Kimberley S Mak, Diana Kirke, Sagar A Patel, Bhartesh A Shah, Andrew R Salama, Scharukh Jalisi, Minh Tam Truong
OBJECTIVES/HYPOTHESIS: Randomized trials have demonstrated that adjuvant chemoradiotherapy (CRT) confers an overall survival (OS) benefit over adjuvant radiation therapy (RT) alone in patients with resected head and neck squamous cell carcinoma (HNSCC) with adverse pathologic features (positive surgical margins [SM+] and/or extracapsular extension [ECE]). Whether this OS benefit exists in an elderly population remains unknown. STUDY DESIGN: Retrospective database study...
August 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28807747/pretreatment-3t-multiparametric-mri-staging-predicts-for-biochemical-failure-in-high-risk-prostate-cancer-treated-with-combination-high-dose-rate-brachytherapy-and-external-beam-radiotherapy
#20
John V Hegde, D Jeffrey Demanes, Darlene Veruttipong, Jagdeep Raince, Sang-June Park, Steven S Raman, Nicholas G Nickols, Christopher R King, Amar U Kishan, Michael L Steinberg, Mitchell Kamrava
PURPOSE: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). MATERIALS AND METHODS: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI...
August 11, 2017: Brachytherapy
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