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https://www.readbyqxmd.com/read/28903529/retrospective-analysis-of-definitive-radiotherapy-for-neck-node-metastasis-from-unknown-primary-tumor-japanese-radiation-oncology-study-group-study
#1
Takuya Yamazaki, Takeshi Kodaira, Yosuke Ota, Tetsuo Akimoto, Hitoshi Wada, Junichi Hiratsuka, Yasumasa Nishimura, Shunichi Ishihara, Takeshi Nonoshita, Kazushige Hayakawa, Shuhei Sekii, Nobue Uchida
Objective: To investigate the optimal treatment method and risk factor of neck node metastasis from unknown primary tumors (NUP) treated by radiotherapy. Methods: Retrospective case study based on a multi-institutional survey was conducted by the Japanese Radiation Oncology Study Group. Patients pathologically diagnosed as having NUP from 1998 to 2007 were identified. Univariate and multivariate analyses of overall survival (OS), progression free survival (PFS), neck progression free survival (NPFS) and mucosal progression free survival (MPFS) were evaluated...
September 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28894823/the-benefit-of-adjuvant-radiation-in-surgically-treated-t1-2-n1-oropharyngeal-squamous-cell-carcinoma
#2
Marcus M Monroe, Luke O Buchmann, Jason P Hunt, Ying J Hitchcock, Shane Lloyd, Mia Hashibe
IMPORTANCE: The benefit of adjuvant radiation in surgically treated T1-2N1 oropharyngeal cancer without adverse pathologic features remains unclear. OBJECTIVES: To compare population-level survival outcomes in surgically-treated T1-2N1 oropharyngeal squamous cell carcinoma (OPSCC) with and without the use of adjuvant radiation. STUDY DESIGN: Retrospective population-based study using the Surveillance, Epidemiology, and End Results (SEER) registry data from 1998-2011...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28876588/postoperative-transient-hypoparathyroidism-incidence-and-risk-factors-a-south-african-perspective
#3
J Downs, K Wilson, F Made, F Malherbe, E Panieri, L Cairncross
BACKGROUND: There is limited published data on the incidence and risk factors for developing postoperative hypoparathyroidism (POHP) in the South African setting. METHOD: All patients who underwent a total thyroidectomy or completion thyroid lobectomy at an academic referral centre from January 2010 to December 2015 were included in this study. Data reviewed included post-operative parathyroid hormone (iPTH) level within 24 hours of surgery, age, gender, type of operation and lymphadenectomy if performed, size and weight of thyroid glands resected, final histological diagnosis, presence of extracapsular extension of carcinomas, number of lymph nodes resected, and the number of parathyroids present in the histology specimen...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28864046/-radiotherapy-for-head-and-neck-squamous-cell-carcinoma-state-of-the-art-and-future-directions
#4
U Schick, F Huguet, Y Pointreau, O Pradier
Therapeutic principles of radiation therapy in head and neck carcinomas will be discussed in this review. Intensity-modulated radiotherapy with concomitant cisplatin should be standard. In case of contraindication to chemotherapy, cetuximab is an option, while hyperfractionation should be considered in patients unfit for concomitant treatment. Concomitant chemotherapy should be administered in the presence of extracapsular extensions and positive margins in the postoperative setting. Current research areas such as desescalation in human papillomavirus-positive tumours, adaptive radiotherapy, radiomics and immunotherapy will also be addressed...
August 29, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28838382/assessing-the-prognostic-impact-of-the-international-association-for-the-study-of-lung-cancer-proposed-definitions-of-complete-uncertain-and-incomplete-resection-in-non-small-cell-lung-cancer-surgery
#5
Matteo Gagliasso, Giuseppe Migliaretti, Francesco Ardissone
OBJECTIVE: The aim of this study was to assess the prognostic impact of the definitions of complete, uncertain, and incomplete resection in non-small cell lung cancer (NSCLC) surgery, as proposed by the International Association for the Study of Lung Cancer (IASLC). PATIENTS AND METHODS: Single institution retrospective study of consecutive patients undergoing surgery for NSCLC between 1998 and 2007. Complete resection was defined by absence of gross and microscopic residual disease; systematic nodal dissection; no extracapsular extension in distal lymph nodes; and negativity of the highest mediastinal node removed...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28834229/prophylactic-central-neck-dissection-in-68-patients-with-lateral-compartment-metastases-from-well-differentiated-thyroid-cancer
#6
Thomas M Kaffenberger, Jessica H Maxwell, Seungwon Kim
Skip metastasis (SM) in Well Differentiated Thyroid Cancer (WDTC) patients are lateral neck lymph node metastasis that have skipped the central neck compartment. In these patients, prophylactic central neck dissection remains controversial. We sought to identify clinicopathological factors associated with SM and determine the accuracy of central neck metastasis imaging in 68 patients at our institution over 16 years. 12 patients (17.6%) had SMs. Compared to the patients with occult central neck metastases, those with SM were more likely to have T1 tumors (p=0...
August 18, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28833217/adjuvant-chemoradiation-does-not-improve-survival-in-elderly-patients-with-high-risk-resected-head-and-neck-cancer
#7
Nicholas J Giacalone, Muhammad M Qureshi, Kimberley S Mak, Diana Kirke, Sagar A Patel, Bhartesh A Shah, Andrew R Salama, Scharukh Jalisi, Minh Tam Truong
OBJECTIVES/HYPOTHESIS: Randomized trials have demonstrated that adjuvant chemoradiotherapy (CRT) confers an overall survival (OS) benefit over adjuvant radiation therapy (RT) alone in patients with resected head and neck squamous cell carcinoma (HNSCC) with adverse pathologic features (positive surgical margins [SM+] and/or extracapsular extension [ECE]). Whether this OS benefit exists in an elderly population remains unknown. STUDY DESIGN: Retrospective database study...
August 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28807747/pretreatment-3t-multiparametric-mri-staging-predicts-for-biochemical-failure-in-high-risk-prostate-cancer-treated-with-combination-high-dose-rate-brachytherapy-and-external-beam-radiotherapy
#8
John V Hegde, D Jeffrey Demanes, Darlene Veruttipong, Jagdeep Raince, Sang-June Park, Steven S Raman, Nicholas G Nickols, Christopher R King, Amar U Kishan, Michael L Steinberg, Mitchell Kamrava
PURPOSE: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). MATERIALS AND METHODS: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28799121/3-t-multiparametric-mri-characteristics-of-prostate-cancer-patients-suspicious-for-biochemical-recurrence-after-primary-focal-cryosurgery-hemiablation
#9
Michael Kongnyuy, Daniel M Halpern, Corinne C Liu, Kaitlin E Kosinski, David J Habibian, Anthony T Corcoran, Aaron E Katz
INTRODUCTION: We aimed to report on multiparametric MRI (mpMRI) characteristics of post-primary focal cryosurgery (PFC) patients suspected of biochemical recurrence (BCR) by the Phoenix criteria. METHODS: We retrospectively reviewed all patients at our institution who had undergone PFC. Prostate-specific antigen nadir was determined using 2 or more post-PFC values. Suspicion of BCR was determined using the Phoenix criteria (nadir + 2 ng/ml). At the discretion of the physician, pre-and post-PFC 3-T mpMRIs were obtained and in a few cases biopsies were performed...
August 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28797467/outcomes-of-oral-cavity-cancer-patients-treated-with-surgery-followed-by-postoperative-intensity-modulated-radiation-therapy
#10
Sean R Quinlan-Davidson, Abdallah S R Mohamed, Jeffrey N Myers, Gary B Gunn, Faye M Johnson, Heath Skinner, Beth M Beadle, Ann M Gillenwater, Jack Phan, Steven J Frank, William N William, Andrew J Wong, Stephen Y Lai, Clifton D Fuller, William H Morrison, David I Rosenthal, Adam S Garden
OBJECTIVES: Although treatment paradigms have not changed significantly, radiotherapy, surgery, and imaging techniques have improved, leading us to investigate oncologic and survival outcomes for oral cavity squamous cell cancer (OCSCC) patients treated with surgery followed by postoperative IMRT. MATERIAL AND METHODS: Records of patients with pathological diagnosis of OCSCC treated between 2000 and 2012 were retrospectively reviewed. Patients' demographic, disease, and treatment criteria were extracted...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28761595/case-spontaneous-regression-of-post-radical-prostatectomy-prostate-specific-antigen-elevation-without-adjuvant-therapy-in-a-patient-with-lymph-node-metastasis
#11
Taehyoung Lee, Yanbo Guo, Saahil Vij, Rahul Bansal, Nathan C Wong, Bobby Shayegan
Prostate cancer remains the most frequently diagnosed cancer among men. The combination of clinical stage, serum prostate-specific antigen (PSA), and Gleason score (biopsy) assists in predictive assessment of pathological stage and prognosis. Furthermore, pathological criteria, including Gleason score, surgical margin status, extracapsular extension, seminal vesicle invasion, and lymph node involvement, provide prognostication in patients undergoing radical prostatectomy (RP). In this paper, we present a case of a patient with high-risk prostate cancer with persistent PSA elevation post-RP who experiences a complete regression of PSA without any adjuvant therapy...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28755705/systemic-treatment-for-squamous-cell-carcinoma-of-the-head-and-neck
#12
REVIEW
Aditya V Shetty, Deborah J Wong
In patients with locally advanced squamous cell cancer of the head and neck, a multimodality treatment approach is recommended. The addition of platinum-based systemic therapy concurrently with radiation has been shown to be superior to radiation alone and is considered standard therapy for locally advanced disease. No study has shown superiority of induction therapy followed by chemoradiotherapy versus chemoradiotherapy alone. In the adjuvant setting only patients with nodal extracapsular extension or positive margins seem to benefit from chemoradiotherapy versus radiotherapy alone...
August 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28740927/adjuvant-radiation-for-salivary-gland-malignancies-is-associated-with-improved-survival-a-national-cancer-database-analysis
#13
Richard L Bakst, William Su, Umut Ozbek, Miriam A Knoll, Brett A Miles, Vishal Gupta, Ryan Rhome
OBJECTIVE: There are no randomized data to support the use of postoperative radiation for salivary gland malignancies. This study uses the National Cancer Database (NCDB) to describe the epidemiology of salivary gland cancer patients and to investigate whether treatment with adjuvant radiation improves overall survival. METHODS AND MATERIALS: A total of 8243 patients diagnosed with a major salivary gland cancer were identified from the NCDB. All patients received primary surgical resection of their malignancy...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28721881/final-report-of-a-prospective-randomized-trial-to-evaluate-the-dose-response-relationship-for-postoperative-radiation-therapy-and-pathologic-risk-groups-in-patients-with-head-and-neck%C3%A2-cancer
#14
RANDOMIZED CONTROLLED TRIAL
David I Rosenthal, Abdallah S R Mohamed, Adam S Garden, William H Morrison, Adel K El-Naggar, Mona Kamal, Randal S Weber, Clifton D Fuller, Lester J Peters
PURPOSE: To present the long-term and final report of a phase 3 trial designed to assess dose-response relationship for postoperative radiation therapy (PORT) and pathologic risk groups in head and neck cancer. METHODS AND MATERIALS: Patients who underwent primary surgery for American Joint Committee on Cancer stage III or IV squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx and who required PORT were eligible. Patients' primary sites and involved necks were independently assigned to higher- or lower-risk categories based on a cumulative point score representing increasing risk of recurrence...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28720374/the-4kscore-predicts-the-grade-and-stage-of-prostate-cancer-in-the-radical-prostatectomy-specimen-results-from-a-multi-institutional-prospective-trial
#15
Sanoj Punnen, Bruno Nahar, Nachiketh S Prakash, Daniel D Sjoberg, Stephen M Zappala, Dipen J Parekh
BACKGROUND: The 4Kscore accurately predicts aggressive prostate cancer (PCa) on prostate biopsy. OBJECTIVE: We assessed how well the 4Kscore predicts pathology at radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: Among 1312 men who prospectively underwent a 4Kscore and biopsy of the prostate at 26 sites throughout the United States from October 2013 to April 2014, we selected men who were diagnosed with cancer and underwent RP...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28719713/lymph-node-positive-cutaneous-nonmelanoma-skin-cancer-a-poor-prognosis-disease-in-need-of-treatment-intensification
#16
Lora S Wang, Elizabeth A Handorf, John A Ridge, Barbara A Burtness, Miriam N Lango, Ranee Mehra, Jeffrey C Liu, Thomas J Galloway
Locoregionally advanced nonmelanoma skin cancer (NMSC) has an aggressive clinical course characterized by high rates of treatment failure and poor survival compared with localized skin cancers. Our goal was to investigate multimodal therapy for lymph-node-positive NMSC. Data from patients with lymph-node-positive NMSC who underwent surgery and adjuvant therapy at a single tertiary center from 2002 to 2012 were retrospectively reviewed. Median follow-up was 1.8 years (range: 0.5 to 8.5). Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28716127/influence-of-tumor-extent-on-central-lymph-node-metastasis-in-solitary-papillary-thyroid-microcarcinomas-a-retrospective-study-of-1092-patients
#17
Xingjie Yin, Chunping Liu, Yawen Guo, Xiaoyu Li, Na Shen, Xiangwang Zhao, Pan Yu, Shan Wang, Zeming Liu
BACKGROUND: The morbidity of papillary thyroid microcarcinomas is increasing worldwide. Surgery is the main treatment for papillary thyroid microcarcinomas, and the choice of surgical method partly depends on the T stage of the tumor. However, according to the American Joint Commission on Cancer staging system (7th edition), the T stage of papillary thyroid microcarcinomas with different tumor extent is unclear. We aimed to study the effect of tumor extent and other factors on central lymph node metastasis to explore the relationship between tumor extent and T stage and to identify the risk factors predicting central lymph node metastasis in papillary thyroid microcarcinomas...
July 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28688690/external-validation-of-the-ajcc-cancer-staging-manual-8th-edition-in-an-independent-cohort-of-oral-cancer-patients
#18
Leandro Luongo Matos, Rogerio Aparecido Dedivitis, Marco Aurélio Vamondes Kulcsar, Evandro Sobroza de Mello, Venâncio Avancini F Alves, Claudio Roberto Cernea
OBJECTIVES: To evaluate the new American Joint Committee on Cancer (AJCC) cancer staging manual (8th edition) in an independent cohort of patients surgically treated for oral squamous cell carcinoma in order to determine whether the upstaging of pT and pN classification was indicative of a worse prognosis. METHODS: A cohort of 298 patients was analyzed retrospectively. RESULTS: Of these patients, 22.8% received an upstaging when the depth of invasion was included into the pT classification...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28650355/axillary-dissection-and-nodal-irradiation-can-be-avoided-for-most-node-positive-z0011-eligible-breast-cancers-a-prospective-validation-study-of-793-patients
#19
Monica Morrow, Kimberly J Van Zee, Sujata Patil, Oriana Petruolo, Anita Mamtani, Andrea V Barrio, Deborah Capko, Mahmoud El-Tamer, Mary L Gemignani, Alexandra S Heerdt, Laurie Kirstein, Melissa Pilewskie, George Plitas, Virgilio S Sacchini, Lisa M Sclafani, Alice Ho, Hiram S Cody
OBJECTIVE: To determine rates of axillary dissection (ALND) and nodal recurrence in patients eligible for ACOSOG Z0011. BACKGROUND: Z0011 demonstrated that patients with cT1-2N0 breast cancers and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-conserving therapy had no difference in locoregional recurrence or survival after SLN biopsy alone or ALND. The generalizability of the results and importance of nodal radiotherapy (RT) is unclear. METHODS: Patients eligible for Z0011 had SLN biopsy alone...
September 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28639060/surgical-options-in-benign-parotid-tumors-a-proposal-for-classification
#20
REVIEW
Miquel Quer, Vincent Vander Poorten, Robert P Takes, Carl E Silver, Carsten C Boedeker, Remco de Bree, Alessandra Rinaldo, Alvaro Sanabria, Ashok R Shaha, Albert Pujol, Peter Zbären, Alfio Ferlito
Different surgical options are currently available for treating benign tumors of the parotid gland, and the discussion on optimal treatment continues despite several meta-analyses. These options include more limited resections (extracapsular dissection, partial lateral parotidectomy) versus more extensive and traditional options (lateral parotid lobectomy, total parotidectomy). Different schools favor one option or another based on their experience, skills and tradition. This review provides a critical analysis of the literature regarding these options...
June 21, 2017: European Archives of Oto-rhino-laryngology
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