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Extracapsular extension

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https://www.readbyqxmd.com/read/28537668/the-role-of-clinicopathologic-and-molecular-prognostic-factors-in-the-post-mastectomy-radiotherapy-pmrt-a-retrospective-analysis-of-912-patients
#1
S Ursino, F Fiorica, V Mazzotti, D Delishaj, A Cristaudo, S Spagnesi, C Laliscia, F Pasqualetti, A Fontana, M Ghilli, R Morganti, A Falcone, M Roncella, F Paiar
OBJECTIVE: To assess the association of clinicopathologic and molecular features with loco-regional recurrence (LRR) in post-mastectomy breast cancer patients with or without adjuvant radiotherapy (PMRT). PATIENTS AND METHODS: We retrospectively reviewed data of patients undergone to mastectomy followed or not by PMRT between January 2004 and June 2013. The patients were divided according to clinicopathologic and molecular sub-classification features. LRR and Cancer Specific Survival (CSS) were calculated using the Kaplan-Meier method; the prognostic factors were compared using long-rank tests and Cox regression model...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28524830/using-ultrasonography-to-evaluate-the-relationship-between-capsular-invasion-or-extracapsular-extension-and-lymph-node-metastasis-in-papillary-thyroid-carcinomas
#2
Wei-Ping Jiao, Lei Zhang
BACKGROUND: Previous studies have demonstrated that ultrasonography is the recommended imaging modality for preoperative staging of papillary thyroid carcinomas (PTCs). However, only a few studies have kept watch on preoperative evaluation of capsular invasion (CI) or extracapsular extension (ECE) and cervical lymph node metastasis using preoperative ultrasonography. This study aimed to investigate the relationship between the CI or ECE and the cervical lymph node metastasis in PTCs using preoperative ultrasonography and postoperative pathology in Chinese patients...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28503230/utility-of-preoperative-3-tesla-pelvic-phased-array-multiparametric-magnetic-resonance-imaging-in-prediction-of-extracapsular-extension-and-seminal-vesicle-invasion-of-prostate-cancer-and-its-impact-on-surgical-margin-status-experience-at-a-canadian-academic
#3
Taehyoung Lee, Jen Hoogenes, Ian Wright, Edward D Matsumoto, Bobby Shayegan
INTRODUCTION: To evaluate the utility of 3 Tesla (3T) pelvic phased-array (PPA) multiparametric magnetic resonance imaging (mpMRI) to predict extracapsular extension (ECE) and seminal vesicle invasion (SVI) and its subsequent effect on radical prostatectomy (RP) surgical margin status. METHODS: A retrospective evaluation was conducted of RP patients who underwent preoperative 3T PPA mpMRI (without endorectal coil) based on clinical probability of adverse pathological features...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28483014/value-of-contrast-enhanced-ultrasound-and-conventional-ultrasound-in-the-diagnosis-of-papillary-thyroid-carcinoma-with-cervical-lymph-node-metastases
#4
Yan Zhang, Yukun Luo, Mingbo Zhang, Ming Yang, Ying Zhang, Junlai Li, Jie Tang
Objective To compare the ultrasound features of papillary thyroid carcinoma with or without cervical lymph node metastasis (LNM). Methods Patients suspected of thyroid cancer underwent the conventional ultrasound and contrast-enhanced ultrasound (CEUS) examinations. Patients' age,sex,and ultrasound characteristics of lesions were recorded. With the surgical pathology as the golden standard,the ultrasound features were compared between the cervical LNM group and non-LNM group. Results Of 144 patients,51 had cervical LNM and 93 did not...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28475848/beyond-positive-margins-and-extracapsular-extension-evaluating-the-utilization-and-clinical-impact-of-postoperative-chemoradiotherapy-in-resected-locally-advanced-head-and-neck-cancer
#5
Daniel M Trifiletti, Andrew Smith, Nandita Mitra, Surbhi Grover, John N Lukens, Roger B Cohen, Paul Read, William M Mendenhall, Alexander Lin, Samuel Swisher-McClure
Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT...
May 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28473218/predicting-extracapsular-involvement-in-prostate-cancer-through-the-tumor-contact-length-and-the-apparent-diffusion-coefficient
#6
M F Granja, C M Pedraza, D C Flórez, J A Romero, M A Palau, D A Aguirre
OBJECTIVE: To evaluate the diagnostic performance of the length of the tumor contact with the capsule (LTC) and the apparent diffusion coefficient (ADC) map in the prediction of microscopic extracapsular extension in patients with prostate cancer who are candidates for radical prostatectomy. MATERIAL AND METHODS: We used receiver operating curves to retrospectively study the diagnostic performance of the ADC map and the LTC as predictors of microscopic extracapsular extension in 92 patients with prostate cancer and moderate to high risk who were examined between May 2011 and December 2013...
May 1, 2017: Radiología
https://www.readbyqxmd.com/read/28469180/utility-of-quantitative-contrast-enhanced-ultrasound-for-the-prediction-of-extracapsular-extension-in-papillary-thyroid-carcinoma
#7
Yi Liu, Hua Liu, Chang-Lin Qian, Mei-Sui Lin, Feng-Hua Li
The aim of this study was to find an accurate method for the detection of extracapsular extension (ECE) in papillary thyroid carcinoma (PTC). A total of 102 patients with 109 PTC nodules were retrospectively enrolled. Contrast-enhanced ultrasound (CEUS) characteristics were evaluated. The diagnostic efficacy of quantitative CEUS and tumor size was analyzed. The qualitative CEUS features did not differ significantly between the ECE and non-ECE groups (P > 0.05). All of the quantitative CEUS parameters with the exception of peak intensity and tumor size were found to differ significantly between the ECE and non-ECE groups (P < 0...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28460801/obesity-is-associated-with-biochemical-recurrence-after-radical-prostatectomy-a-multi-institutional-extended-validation-study
#8
Agnes B Maj-Hes, Romain Mathieu, Mehmet Özsoy, Francesco Soria, Marco Moschini, Mohammad Abufaraj, Alberto Briganti, Morgan Roupret, Pierre I Karakiewicz, Tobias Klatte, Shahrokh F Shariat
BACKGROUND: There are no clear data regarding the association between body mass index (BMI) and outcomes after radical prostatectomy (RP). This study aimed to investigate the association between BMI and biochemical recurrence (BCR) after RP in a large international contemporary cohort of patients with prostate cancer. METHODS: We retrospectively analyzed data from 6,519 patients who underwent RP at 5 institutions. BMI was analyzed as both a continuous and categorical variable (<25kg/m(2), 25-29...
April 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28459044/prostate-mri-prior-to-radical-prostatectomy-effects-on-nerve-sparing-and-pathological-margin-status
#9
Sasha C Druskin, Jen-Jane Liu, Allen Young, Zhaoyong Feng, Seyed S Dianat, Wesley W Ludwig, Bruce J Trock, Katarzyna J Macura, Christian P Pavlovich
OBJECTIVES: The aim of this study was to assess the positive surgical margin (PSM) and nerve sparing (NS) rates in patients who underwent prostate MRI (pMRI) prior to radical prostatectomy (RP) and compare them with matched, nonimaged control RP patients. METHODS: We identified 204 men who underwent preoperative pelvic MRI (pelMRI), of whom 176 (86.3%) underwent pMRIs, within 60 days of RP, and compared them (1:1) with a nonim-aged control group matched by surgeon, age, race, body mass index (BMI), prostate-specific antigen (PSA), pathological Gleason score, prostate specimen weight, and RP year...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28437038/impact-of-preoperative-risk-on-metastatic-progression-and-cancer-specific-death-in-patients-with-adverse-pathology-at-radical-prostatectomy
#10
Katharina Boehm, Sami-Ramzi Leyh-Bannurah, Clemens Rosenbaum, Laurenz S Brandi, Lars Budäus, Markus Graefen, Hartwig Huland, Axel Haferkamp, Derya Tilki
OBJECTIVE: To evaluate the impact of preoperative risk category on metastatic disease (MetD) and prostate cancer mortality (CSM) in prostate cancer (PCa) patients with adverse pathology at radical prostatectomy (RP). PATIENTS AND METHODS: The records of 6943 patients who underwent radical prostatectomy (RP) in a European tertiary-center were analysed. Biochemical recurrence (BCR), MetD and CSM were assessed for patients with adverse pathology at RP and stratified according to preoperative low- vs...
April 24, 2017: BJU International
https://www.readbyqxmd.com/read/28428019/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-executive-summary-of-an-astro-evidence-based-clinical-practice-guideline
#11
David J Sher, David J Adelstein, Gopal K Bajaj, David M Brizel, Ezra E W Cohen, Aditya Halthore, Louis B Harrison, Charles Lu, Benjamin J Moeller, Harry Quon, James W Rocco, Erich M Sturgis, Roy B Tishler, Andy Trotti, John Waldron, Avraham Eisbruch
PURPOSE: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT). METHODS AND MATERIALS: The American Society for Radiation Oncology convened the OPSCC Guideline Panel to perform a systematic literature review investigating the following key questions: (1) When is it appropriate to add systemic therapy to definitive RT in the treatment of OPSCC? (2) When is it appropriate to deliver postoperative RT with and without systemic therapy following primary surgery for OPSCC? (3) When is it appropriate to use induction chemotherapy in the treatment of OPSCC? (4) What are the appropriate dose, fractionation, and volume regimens with and without systemic therapy in the treatment of OPSCC? RESULTS: Patients with stage IV and stage T3 N0-1 OPSCC treated with definitive RT should receive concurrent high-dose intermittent cisplatin...
April 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28424130/invasive-pleomorphic-lobular-histology-is-an-adverse-prognostic-factor-on-survival-in-patients-with-breast-cancer
#12
Suleyman Sahin, Fatih Karatas, Gokmen U Erdem, Bekir Hacioglu, Kadri Altundag
Invasive pleomorphic lobular carcinoma (IPLC) is defined to be an uncommon and different subtype of classical invasive lobular carcinoma (ILC). This special variant is characterized by significant cytological atypia and pleomorphism which differs from the cytological uniformity of ILC. IPLC has been shown to have some poor prognostic factors such as axillary node metastasis and higher histological grade which may lead to poor clinical courses including a short relapse time, increased risk of recurrence and a decreased survival...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28422039/-urinary-tract-lymphoepithelial-carcinoma-report-of-two-cases-and-bibliographic-review
#13
Sebastian Valverde Martínez, Waleska Salcedo Mercado, Isabel Rodríguez Cruz, Sara Belén Prieto Nogal, Mario Martín Hernández, Luis Miguel Gómez Tejeda
OBJECTIVE: We report two cases of patients diagnosed with lymphoepithelioma-like carcinomas of the urinary tract. We review the literature of this rare entity. The objective is to clarify the clinical and therapeutic characteristics. METHODS: We present a retrospective review of medical records of two patients diagnosed with lymphoepithelioma-like carcinomas, one in the renal pelvis and the other in the bladder. We review the epidemiology, diagnosis and therapeutic alternatives...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28418916/clinicopathologic-study-of-invasive-micropapillary-carcinoma-of-the-breast
#14
Shen-Li Tang, Ji-Qiao Yang, Zheng-Gui Du, Qiu-Wen Tan, Yu-Ting Zhou, Di Zhang, Qing Lv
Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast carcinoma. It is presumed to be more aggressive than invasive ductal carcinoma (IDC), though it is uncertain whether the prognoses of IMPC and IDC differ. In this retrospective study, we compared the clinicopathologic characteristics and survival between 170 female patients with IMPC (pure or mixed with IDC) and 728 with pure IDC. The IMPC patients had higher clinical stages and histologic grades, higher incidences of lymphovascular invasion and axillary lymph node extracapsular extension, and a higher degree of lymph node involvement than IDC patients...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411392/clinical-prognostic-markers-in-stage-iiic-melanoma
#15
Max F Madu, Jaap H H Schopman, Danique M S Berger, Willem M C Klop, Katarzyna Jóźwiak, Michel W J M Wouters, Jos A van der Hage, Alexander C J van Akkooi
BACKGROUND: Although the EORTC 18071-trial has shown a clear survival benefit for adjuvant ipilimumab, accurately selecting patients for this toxic adjuvant therapy is important. We aimed to identify prognostic factors for death and disease recurrence in AJCC stage IIIC melanoma patients. PATIENTS AND METHODS: Retrospective analysis of patients who underwent lymph node dissection (LND) for stage IIIC melanoma in our institution between 2000 and 2016. Baseline characteristics, melanoma-specific survival (MSS), and disease-free survival (DFS) were assessed, and prognostic factors for recurrence and survival were analyzed using uni- and multivariable analysis...
April 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28404758/regional-radiation-therapy-impacts-outcome-for-node-positive-cutaneous-melanoma
#16
Tobin Strom, Javier F Torres-Roca, Akash Parekh, Arash O Naghavi, Jimmy J Caudell, Daniel E Oliver, Jane L Messina, Nikhil I Khushalani, Jonathan S Zager, Amod Sarnaik, James J Mulé, Andy M Trotti, Steven A Eschrich, Vernon K Sondak, Louis B Harrison
Background: Regional radiation therapy (RT) has been shown to reduce the risk of regional recurrence with node-positive cutaneous melanoma. However, risk factors for regional recurrence, especially in the era of sentinel lymph node biopsy (SLNB), are less clear. Our goals were to identify risk factors associated with regional recurrence and to determine whether a radiosensitivity index (RSI) gene expression signature (GES) could identify patients who experience a survival benefit with regional RT. Methods: A single-institution, Institutional Review Board-approved study was performed including 410 patients treated with either SLNB with or without completion lymph node dissection (LND; n=270) or therapeutic LND (n=91)...
April 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28403595/factors-affecting-surgical-margin-positivity-in-robotic-assisted-radical-prostatectomy
#17
Mustafa Yuksel, Kaan Karamık, Hakan Anıl, Ekrem Islamoglu, Mutlu Ates, Murat Savas
OBJECTIVES: After radical prostatectomy, surgical margin positivity is an important indicator of biochemical recurrence and progression. In our study we want to compare the surgical margin positivity rates for retropubic radical prostatectomy (RRP) and robotic assisted radical prostatectomy (RALP) and investigate the factors affecting surgical margin positivity in RALP. MATERIALS AND METHODS: Data from 78 RRP and 62 RALP patients operated from 2011 May to 2016 March were retrospectively screened...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28397563/pathologic-markers-in-surgically-treated-hpv-associated-oropharyngeal-cancer-retrospective-study-systematic-review-and-meta-analysis
#18
Patrick Tassone, Meghan Crawley, Cory Bovenzi, Tingting Zhan, William Keane, David Cognetti, Adam Luginbuhl, Joseph Curry
OBJECTIVE: Human papillomavirus-associated (HPV) oropharyngeal cancer is a unique clinical entity whose incidence is increasing. It is controversial whether traditional pathologic markers of aggressive head and neck cancer also apply in surgically treated HPV-associated disease. STUDY DESIGN: Retrospective study, systematic review, and meta-analysis Data Sources: PubMed and Cochrane review. REVIEW METHODS: PubMed and Cochrane review were searched for published articles on surgically treated HPV-associated oropharyngeal cancer...
May 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28370570/unknown-primary-head-and-neck-squamous-cell-carcinoma-in-the-era-of-fluorodeoxyglucose-positron-emission-tomography-ct-and-intensity-modulated-radiotherapy
#19
Mischa de Ridder, Martin Klop, Olga Hamming-Vrieze, JanPaul de Boer, Bas Jasperse, Laura Smit, Wouter Vogel, Michiel van den Brekel, Abrahim Al-Mamgani
BACKGROUND: The diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome. METHODS: We conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28366574/patterns-of-care-in-adjuvant-therapy-for-resected-oral-cavity-squamous-cell-cancer-in-elderly-patients
#20
Erqi L Pollom, Alexander L Chin, Nancy Y Lee, C Jillian Tsai
PURPOSE: To characterize the patterns of care and potential barriers to access to care for elderly patients with oral cavity cancer in the adjuvant setting. METHODS AND MATERIALS: We performed a retrospective cohort study using the National Cancer Data Base and identified patients with resected oral cavity squamous cell carcinoma diagnosed between 2004 and 2012, who survived for ≥3 months after surgery. We used logistic regression models to assess the association between age (<70, 70-79, and ≥80 years) and the receipt of adjuvant therapy within 3 months of surgery...
February 2, 2017: International Journal of Radiation Oncology, Biology, Physics
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