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https://www.readbyqxmd.com/read/29223037/a-microfabricated-platform-for-the-study-of-chondrogenesis-under-different-compressive-loads
#1
Reza Kowsari-Esfahan, Azadeh Jahanbakhsh, Mohammad Said Saidi, Shahin Bonakdar
Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture...
December 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29221904/tensile-behaviour-of-individual-fibre-bundles-in-the-human-lumbar-anulus-fibrosus
#2
Diana T Pham, Joe G Shapter, John J Costi
Disc degeneration is a common medical affliction whose origins are not fully understood. An improved understanding of its underlying mechanisms could lead to the development of more effective treatments. The aim of this paper was to investigate the effect of (1) degeneration, (2) circumferential region and (3) strain rate on the microscale mechanical properties (toe region modulus, linear modulus, extensibility, phase angle) of individual fibre bundles in the anulus fibrosus lamellae of the human intervertebral disc...
November 28, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29214787/myocardial-layer-specific-strain-analysis-in-children-with-mitochondrial-disease
#3
Lucy Youngmin Eun, Young Mock Lee
PURPOSE: Children with mitochondrial disease (MD) have clinical phenotypes that are more severe than those found in adults. In this study, we assessed cardiac function in children with MD using conventional and advanced echocardiographic measurements, explored any unique patterns present, and investigated the development of early cardiomyopathy (CMP). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 33 children with MD. All patients underwent transthoracic echocardiography with conventional and advanced myocardial analysis...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29210085/subclinical-systolic-and-diastolic-dysfunctions-in-patients-with-metabolic-syndrome-and-angiographically-normal-coronary-arteries-an-echocardiographic-study
#4
Niloufar Samiei, Maryam Bayat, Ata Firouzi, Faezeh Dehghani, Mozhgan Parsaee, Shahin Rahimi, Somayyeh Ahmadi, Maryam Pourmojib, Zahra Ghaemmaghami, Yousef Rezaei, Mohammad Mehdi Peighambari
BACKGROUND: The metabolic syndrome (MetS), as a combination of cardiovascular risk factors, is associated with subclinical cardiovascular diseases. We sought to evaluate the subclinical myocardial dysfunctions using echocardiography in patients with normal coronary arteries. MATERIALS AND METHODS: In this cross-sectional study, we assessed 50 consecutive patients with angiographically-proven normal coronary arteries and a left ventricular (LV) ejection fraction (EF) ≥55%...
December 6, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29209744/preserved-myocardial-deformation-after-successful-coarctation-repair-a-cmr-feature-tracking-study
#5
Elles J Dijkema, Martijn G Slieker, Johannes M P J Breur, Tim Leiner, Heynric B Grotenhuis
Arterial vasculopathy and residual aortic obstruction can lead to left ventricular (LV) dysfunction in patients with coarctation of the aorta (CoA) related to adverse ventriculo-arterial coupling. This study aimed to investigate potential differences in LV myocardial deformation indices between repaired CoA patients and healthy controls. Twenty-two CoA patients (age 30 ± 10.6 years) after surgical repair (n = 12) or balloon angioplasty (BA) (n = 10) without residual stenosis, between 3 months and 16 years of age with > 10 years follow-up were compared to 22 healthy age- and gender-matched controls (age 30 ± 3...
December 5, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29208418/left-atrial-volumes-and-strain-in-healthy-children-measured-by-three-dimensional-echocardiography-normal-values-and-maturational-changes
#6
Sunil J Ghelani, David W Brown, Joseph D Kuebler, Douglas Perrin, Divya Shakti, David N Williams, Gerald R Marx, Steven D Colan, Tal Geva, David M Harrild
BACKGROUND: Assessment of left atrial (LA) size and function is important in a number of pediatric cardiac conditions including those affecting the diastolic performance of the left ventricle. Measurements of LA volume and strain by two-dimensional echocardiography rely upon inaccurate geometric assumptions and are hampered by out-of-plane motion. The objective of this study was to characterize LA volumes and strain by three-dimensional echocardiography in healthy children. METHODS: LA volumes and strain were retrospectively measured by three-dimensional echocardiography in healthy children with no known structural or functional heart disease using a commercial speckle-tracking package applied to the LA to compute maximum volume (Vmax), minimum volume (Vmin), ejection volume (LAEV), ejection fraction (LAEF), and the following components of global strain: 3D principal (3DS), longitudinal (GLS), and circumferential (GCS)...
December 2, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29205626/feasibility-and-reproducibility-of-feature-tracking-based-strain-and-strain-rate-measures-of-the-left-ventricle-in-different-diseases-and-genders
#7
Alicia M Maceira, Luis Tuset-Sanchis, Miguel López-Garrido, Marta San Andres, M Pilar López-Lereu, Jose V Monmeneu, M Pilar García-González, Laura Higueras
BACKGROUND: The measurement of myocardial deformation by strain analysis is an evolving tool to quantify regional and global myocardial function. PURPOSE: To assess the feasibility and reproducibility of myocardial strain/strain rate measurements with magnetic resonance feature tracking (MR-FT) in healthy subjects and in patient groups. STUDY TYPE: Prospective study. POPULATION: Sixty patients (20 hypertensives with left ventricular (LV) hypertrophy (H); 20 nonischemic dilated cardiomyopathy (D); 20 ischemic heart disease (I); as well as 20 controls (C) were included, 10 men and 10 women in each group...
December 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29205484/subclinical-left-ventricular-systolic-and-diastolic-dysfunction-in-type-1-diabetic-children-and-adolescents-with-good-metabolic-control
#8
Tamer Yoldaş, Utku Arman Örün, Elif Sagsak, Zehra Aycan, Özkan Kaya, Senem Özgür, Selmin Karademir
OBJECTIVE: Cardiac dysfunction is a well-known consequence of diabetes mellitus. This study was designed to assess whether type 1 diabetic children and adolescents with good metabolic control have early echocardiographic signs of subclinical left ventricular dysfunction and whether diabetes duration has any influence, using conventional and nonconventional echocardiographic tools. METHODS: A total of 100 patients with type 1 diabetes mellitus and 80 gender- and age-matched healthy controls were included...
December 3, 2017: Echocardiography
https://www.readbyqxmd.com/read/29199058/one-year-follow-up-study-detects-myocardial-changes-with-cardiovascular-magnetic-resonance-tagging-in-active-rheumatoid-arthritis
#9
Lauri Lehmonen, Aino-Maija Vuorinen, Riitta Koivuniemi, Marjatta Leirisalo-Repo, Miia Holmström, Sari Kivistö, Touko Kaasalainen
RATIONALE AND OBJECTIVES: To evaluate the effects of 1 year of medical treatment on myocardial function in active rheumatoid arthritis (RA). MATERIALS AND METHODS: Thirty-nine female patients with RA without any known cardiovascular disease underwent a cardiovascular magnetic resonance (CMR) examination before and after 1 year of antirheumatic treatment. The population comprised untreated active early RA (ERA) and chronic RA patients, who were grouped accordingly...
November 30, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29189933/cardiac-structure-and-function-in-elite-native-hawaiian-and-pacific-islander-rugby-football-league-athletes-an-exploratory-study
#10
Christopher Johnson, Lynsey Forsythe, John Somauroo, Michael Papadakis, Keith George, David Oxborough
The aim of this exploratory study was to define the Athletes Heart (AH) phenotype in Native Hawaiian & Pacific Islander (NH&PI) Rugby Football League (RFL) athletes. Specifically, (1) to describe conventional echocardiographic indices of left ventricle (LV) and right ventricle (RV) structure and function in NH&PI RFL players and matched RFL Caucasian controls (CC) and (2) to demonstrate LV and RV mechanics in these populations. Ethnicity is a contributory factor to the phenotypical expression of the AH. There are no data describing the cardiac phenotype in NH&PI athletes...
November 30, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29188318/myocardial-strain-using-cardiac-mr-feature-tracking-and-speckle-tracking-echocardiography-in-duchenne-muscular-dystrophy-patients
#11
Bryan Siegel, Laura Olivieri, Heather Gordish-Dressman, Christopher F Spurney
Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder with an incidence of 1 in 3500 male births, and cardiomyopathy is becoming the leading cause of death. While Cardiac MRI (CMR) and late gadolinium enhancement (LGE) are important tools in recognizing myocardial involvement, myocardial strain imaging may demonstrate early changes and allow patients to avoid gadolinium contrast. We performed CMR feature tracking (FT) and echo-based speckle tracking (STE) strain measures on DMD patients and age/sex matched controls who had received a CMR with contrast and transthoracic echocardiogram...
November 29, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29187724/in-depth-insight-into-the-mechanisms-of-cardiac-dysfunction-in-patients-with-childhood-cancer-after-anthracycline-treatment-using-layer-specific-strain-analysis
#12
Kana Yazaki, Ken Takahashi, Sachie Shigemitsu, Mariko Yamada, Takeshi Iso, Maki Kobayashi, Katsumi Akimoto, Hiroyuki Tamaichi, Junya Fujimura, Masahiro Saito, Masaki Nii, Toshiaki Shimizu
BACKGROUND: Anthracycline cardiotoxicity affects clinical outcomes, and its early detection using methods that rely on conventional echocardiography, such as left ventricular ejection fraction (LVEF) is difficult. This study aimed to evaluate the characteristics and the differences in cardiac dysfunction among childhood cancer survivors in 3 age groups using layer-specific strain analysis in a wide age range.Methods and Results:The 56 patients (median age: 15 [range: 6.8-40.2] years) who had been treated with anthracycline for childhood cancer were divided into 3 age groups (C1: 6-12 years, C2: 13-19 years, C3: 20-40 years) after anthracycline treatment, and 72 controls of similar ages were divided into 3 corresponding groups (N1, N2, and N3)...
November 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29181827/reference-ranges-for-three-dimensional-feature-tracking-cardiac-magnetic-resonance-comparison-with-two-dimensional-methodology-and-relevance-of-age-and-gender
#13
Boyang Liu, Ahmed M Dardeer, William E Moody, Manvir K Hayer, Shanat Baig, Anna M Price, Francisco Leyva, Nicola C Edwards, Richard P Steeds
Myocardial deformation is a sensitive marker of sub-clinical myocardial dysfunction that carries independent prognostic significance across a broad range of cardiovascular diseases. It is now possible to perform 3D feature tracking of SSFP cines on cardiac magnetic resonance imaging (FT-CMR). This study provides reference ranges for 3D FT-CMR and assesses its reproducibility compared to 2D FT-CMR. One hundred healthy individuals with 10 men and women in each of 5 age deciles from 20 to 70 years, underwent 2D and 3D FT-CMR of left ventricular myocardial strain and strain rate using SSFP cines...
November 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29178894/changes-in-overall-ventricular-myocardial-architecture-in-the-setting-of-a-porcine-animal-model-of-right-ventricular-dilation
#14
Peter Agger, Christine Ilkjær, Christoffer Laustsen, Morten Smerup, Jesper R Frandsen, Steffen Ringgaard, Michael Pedersen, John B Partridge, Robert H Anderson, Vibeke Hjortdal
BACKGROUND: Chronic pulmonary regurgitation often leads to myocardial dysfunction and heart failure. It is not fully known why secondary hypertrophy cannot fully protect against the increase in wall stress brought about by the increased end-diastolic volume in ventricular dilation. It has been assumed that mural architecture is not deranged in this situation, but we hypothesised that there might be a change in the pattern of orientation of the aggregations of cardiomyocytes, which would contribute to contractile impairment...
November 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29174705/associations-between-ecg-changes-and-echocardiographic-findings-in-patients-with-acute-non-st-elevation-myocardial-infarction
#15
Suvi Sirkku Tuohinen, Jani Rankinen, Tanja Skyttä, Heini Huhtala, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen, Kjell Nikus
BACKGROUND: ST segment depression (STD) and T wave inversion (TWI) are typical electrocardiographic (ECG) findings in non-ST elevation myocardial infarction (NSTEMI). In ST elevation myocardial infarction, ST changes represent transmural ischemia. The pathophysiological mechanisms of the ECG changes in NSTEMI are unclear. PURPOSE: We studied the associations between ECG and the echocardiographic findings in NSTEMI patients. METHODS: Twenty patients with acute NSTEMI were recruited during their hospital stay...
November 21, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29168209/subclinical-left-ventricular-systolic-dysfunction-detected-by-two-dimensional-speckle-tracking-echocardiography-in-patients-with-pheochromocytoma-and-paraganglioma-and-preserved-ejection-fraction
#16
Li Ding, Wen Ling Zhu, Zheng Pei Zeng, Han Zhong Li, Jin Ji, Li Gang Fang, Jing Ping Sun
BACKGROUND: Excessive catecholamine leads to pressure overload and left ventricular (LV) remodeling. The goal of this study was to explore subclinical LV systolic dysfunction and the mechanism of preserved left ventricular ejection fraction (LVEF) in patients with pheochromocytoma and paraganglioma using two-dimensional speckle tracking echocardiography. METHODS: A total of 48 patients with pheochromocytoma and paraganglioma and preserved LVEF and 38 age- and gender-matched volunteers were studied...
November 22, 2017: Echocardiography
https://www.readbyqxmd.com/read/29167183/evolution-of-subclinical-myocardial-dysfunction-detected-by-two-dimensional-and-three-dimensional-speckle-tracking-in-asymptomatic-type-1-diabetic-patients-a-long%C3%A2-term-follow-up-study
#17
Anne Ringle, Anne Dornhorst, Michaela B Rehman, Cristina Ruisanchez, Petros Nihoyannopoulos
BACKGROUND: We sought to assess the long-term evolution of left ventricular (LV) function using two-dimensional (2D) and three-dimensional (3D) speckle tracking echocardiography (STE) for the detection of preclinical diabetic cardiomyopathy, in asymptomatic type 1 diabetic patients, over a 6-year follow-up. DESIGN AND METHODS: Sixty-six asymptomatic type 1 diabetic patients with no cardiovascular risk factors were compared to 26 matched healthy controls. Conventional, 2D and 3D-STE were performed at baseline...
December 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/29166645/angiotensin-ii-infusion-does-not-cause-abdominal-aortic-aneurysms-in-apolipoprotein-e-deficient-rats
#18
Evan H Phillips, Mandy S Chang, Sydney Gorman, Hamna J Qureshi, Karin F K Ejendal, Tamara L Kinzer-Ursem, A Nicole Blaize, Craig J Goergen
The apolipoprotein E-deficient (apoE-/-) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. This spontaneous model recapitulates aspects of human atherosclerosis, and allows for the development of dissecting abdominal aortic aneurysms (AAAs) when combined with angiotensin II. We characterized apoE-/- rats and hypothesized that, similar to mice, they would develop dissecting AAAs. We created rats with a 16-bp deletion of the apoE gene using transcription activator-like effector nucleases...
November 23, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/29162223/effects-of-pectus-excavatum-repair-on-right-and-left-ventricular-strain
#19
Chieh-Ju Chao, Dawn Jaroszewski, Michael Gotway, MennatAllah Ewais, Susan Wilansky, Steven Lester, Samuel Unzek, Christopher P Appleton, Hari P Chaliki, Brantley D Gaitan, Farouk Mookadam, Tasneem Z Naqvi
BACKGROUND: The cardiopulmonary benefits of pectus excavatum repair have been debated. Echocardiographic speckle-tracking strain and strain rate have been used to evaluate and detect subclinical myocardial dysfunction in patients receiving cardiotoxic chemotherapy, and patients with valvular heart disease. This technology was applied to evaluate the effects of pectus excavatum surgery on left ventricular (LV) and right ventricular (RV) function. METHODS: Speckle tracing strain evaluation was performed on intraoperative transesophageal echocardiographic images acquired immediately before and after Nuss repair in adult patients (aged 18 years or more) from 2011 to 2014...
November 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29151290/-early-detection-of-the-cardiotoxicity-induced-by-chemotherapy-drug-through-two-dimensional-speckle-tracking-echocardiography-combined-with-high-sensitive-cardiac-troponin-t
#20
W Wang, Y Kang, X H Shu, X D Shen, B He
Objective: To investigate the clinical value of two-dimensional speckle tracking echocardiography(2D-STE) combined with high-sensitive cardiac troponin T (hs-cTnT) in early detection of the cardiotoxicity induced by chemotherapy drug. Methods: Seventy-five non-Hodgkin's lymphoma patients who received the CHOP regimen were recruited in this study. Conventional echocardiography and 2D-STE were performed on these patients before chemotherapy, the second day after the third course of chemotherapy (during chemotherapy) and the second day after the last course of chemotherapy (after chemotherapy)...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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