DENSE

INTRODUCTION: In response to the critical need for enhancing breast cancer screening for women with dense breasts, this study explored the understanding of challenges and requirements for implementing supplementary breast cancer screening for such women among clinical radiographers and radiologists in Europe. METHOD: Fourteen (14) semi-structured online interviews were conducted with European clinical radiologists (n = 5) and radiographers (n = 9) specializing in breast cancer screening from 8 different countries: Denmark, Finland, Greece, Italy, Malta, the Netherlands, Switzerland, United Kingdom...

In recent years, deep learning (DL) has shown great potential in the field of dermatological image analysis. However, existing datasets in this domain have significant limitations, including a small number of image samples, limited disease conditions, insufficient annotations, and non-standardized image acquisitions. To address these shortcomings, we propose a novel framework called DermSynth3D. DermSynth3D blends skin disease patterns onto 3D textured meshes of human subjects using a differentiable renderer and generates 2D images from various camera viewpoints under chosen lighting conditions in diverse background scenes...

Artificial antigen-presenting cells (aAPCs) are currently used to manufacture T cells for adoptive therapy in cancer treatment, but a readily tunable and modular system could enable both rapid T cell expansion and control over T cell phenotype. Here, we show that microgels with tailored surface biochemical properties can serve as aAPCs to mediate T cell activation and expansion. Surface functionalization of microgels was achieved via layer-by-layer coating using oppositely charged polymers, forming a thin but dense polymer layer on the surface...

If two phases exist at the same time, such as a gas and a liquid, they have the same temperature. This fundamental law of equilibrium physics is known to apply even to many non-equilibrium systems. However, recently, there has been much attention in the finding that inertial self-propelled particles like Janus colloids in a plasma or microflyers could self-organize into a hot gas-like phase that coexists with a colder liquid-like phase. Here, we show that a kinetic temperature difference across coexisting phases can occur even in equilibrium systems when adding generic (overdamped) self-propelled particles...

The potential establishment of a nuclear power plant (NPP) in the West Kalimantan is under consideration to address low electrification rates. This research assesses the demographic characteristics and population growth in the vicinity of the proposed NPP site in West Kalimantan. The investigation focuses on demographic aspects, population density, and anticipated growth during the operational phase of the reactor. The study area encompasses districts within a 25 km radius of the site. Employing a descriptive quantitative approach, this research integrates verified population data and utilizes spatial and temporal analysis...

Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic (5-HTergic) systems. Herein, we discovered that lysine acetyltransferase (KAT) 3B increases stx1a neuronal transcription and TTK21, a KAT3 activator, induces stx1a transcription and 5-HT release in vitro. Furthermore, glucose-derived CSP-TTK21 could restore decreased stx1a expression, 5-HTergic systems in the brain, and low LI in stx1a (+/-) mice by crossing the blood-brain barrier, whereas the KAT3 inhibitor suppresses stx1a expression, 5-HTergic systems, and LI behaviors in wild-type mice...

Insect herbivores and their parasitoids play a crucial role in terrestrial trophic interactions in tropical forests. These interactions occur across the entire vertical gradient of the forest. This study compares how caterpillar communities, and their parasitism rates, vary across vertical strata and between caterpillar defensive strategies in a semi deciduous tropical forest in Nditam, Cameroon. Within a 0.1 ha plot, all trees with a diameter at breast height (DBH) ≥ 5 cm were felled and systematically searched for caterpillars...

Citrus fruits are among the most economically important crops in the world. In the global market, the Citrus peel is often considered a byproduct but substitutes an important phenotypic characteristic of the fruit and a valuable source of essential oils, flavonoids, carotenoids, and phenolic acids with variable concentrations. The Mediterranean basin is a particularly dense area of autochthonous genotypes of Citrus that are known for being a source of healthy foods, which can be repertoires of valuable genes for molecular breeding with the focus on plant resistance and quality improvement...

The compressibility of soft colloids influences their phase behavior and flow properties, especially in concentrated suspensions. Particle compressibility, which is proportional to the reciprocal of the bulk modulus K, is a key parameter for soft polymer-based particles that can be compressed in crowded environments. Here, microgels with different degrees of crosslinking, i.e. softness, are investigated below and above their volume phase transition temperature VPTT. By combining molecular dynamics simulations with small-angle neutron scattering with contrast variation, a change in the particle bulk moduli of two orders of magnitude is observed...

High-frequency gravitational waves (HFGWs) carry a wealth of information on the early Universe with a tiny comoving horizon and astronomical objects of small scale but with dense energy. We demonstrate that the nearby planets, such as Earth and Jupiter, can be utilized as a laboratory for detecting the HFGWs. These GWs are then expected to convert to signal photons in the planetary magnetosphere, across the frequency band of astronomical observation. As a proof of concept, we present the first limits from the existing low-Earth-orbit satellite for specific frequency bands and project the sensitivities for the future more-dedicated detections...

We report experimental measurements of the second-order coherence function g^{(2)}(τ) of the light emitted by a laser-driven dense ensemble of ^{87}Rb atoms. We observe a clear departure from the Siegert relation valid for Gaussian chaotic light. Measuring intensity and first-order coherence, we conclude that the violation is not due to the emergence of a coherent field. This indicates that the light obeys non-Gaussian statistics, stemming from non-Gaussian correlations in the atomic medium. More specifically, the steady state of this driven-dissipative many-body system sustains high-order correlations in the absence of first-order coherence...

The clinical severity of multiple sclerosis (MS), an autoimmune disorder of the central nervous system, is thought to be determined by environmental and genetic factors that have not yet been identified. In a recent genome-wide association study (GWAS), a single nucleotide polymorphism (SNP), rs10191329, has been associated with MS severity in two large independent cohorts of patients. Different approaches were followed by the authors to prioritize the genes that are transcriptionally regulated by such an SNP...

Pancreatic ductal adenocarcinoma (PDAC) is a solid-tumor malignancy. To enhance the treatment landscape of PDAC, a 3D model optimized for rigorous drug screening is essential. Within the PDAC tumor microenvironment, a dense stroma comprising a large extracellular matrix and cancer-associated fibroblasts (CAFs) is well-known for its vital role in modulating tumor growth, cellular heterogeneity, bidirectional paracrine signaling, and chemoresistance. In this study, we employed a fibroblast-populated collagen lattice (FPCL) modeling approach that has the ability to replicate fibroblast contractility in the collagenous matrix to build dense stroma...

The Chinese goral ( Naemorhedus griseus ) is identified as a vulnerable species on the Red List of China's Biodiversity and listed as a national second-class key protected wild animal in China. It is a representative flagship ungulate in Beijing. Its distribution range is fragmented and small populations are separated by dense infrastructures and tourism sites. Understanding its population status provides a foundation to plan effective conservation strategies. In this study, a population viability analysis was conducted with VORTEX (10...

Avian influenza viruses (AIVs), which circulate endemically in wild aquatic birds, pose a significant threat to poultry and raise concerns for their zoonotic potential. From August 2021 to April 2022, a multi-site cross-sectional study involving active AIV epidemiological monitoring was conducted in wetlands of the Emilia-Romagna region, northern Italy, adjacent to densely populated poultry areas. A total of 129 cloacal swab samples (CSs) and 407 avian faecal droppings samples (FDs) were collected, with 7 CSs (5...

The Al-Mn alloy heat exchanger fin production process includes a brazing treatment at s high temperature of 600 °C, in which coarse grains are preferred for their high resistance to deformation at elevated temperatures by decreasing the grain boundary sliding. In this study, Al-1.57Mn-1.57Zn-0.58Si-0.17Fe alloy foils cold rolled by 81.7% (1.1 mm in thickness) and 96.5% (0.21 mm in thickness) were annealed at 100-550 °C for 1 h to investigate their recrystallization behavior, grain sizes, and precipitates by increasing the annealing temperature, using micro-hardness measurement, electron back-scattered diffraction (EBSD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques...

To prepare a soft magnetic powder core, the magnetic powder surface has to be insulated by phosphating treatment. Organic chemicals such as ethanol and acetone are generally used as solvents for phosphoric acid, which may cause serious environmental problems. This work proposed deionized water as the environmentally friendly phosphating solvent for FeSiCr powder. The soft magnetic composites (SMCs) were prepared using phosphoric acid for inorganic coating and modified silicon polymer for organic coating. The effect of different phosphating solvents, including deionized water, ethanol, and acetone, on the structure and magnetic properties of SMCs were investigated...

Copper metal catalyst seeds have recently triggered much research interest for the development of low-cost and high-performance metallic catalysts with industrial applications. Herein, we present metallic Cu catalyst seeds deposited by an atomic layer deposition method on polymer substrates. The atomic layer deposited Cu (ALD-Cu) can ideally substitute noble metals Ag, Au, and Pd to catalyze Cu electroless deposition. The optimized deposition temperature and growth cycles of an ALD-Cu catalyzed seed layer have been obtained to achieve a flexible printed circuit (FPC) with a high performance electroless plating deposited Cu (ELD-Cu) film...

In this study, the induction plasma spheroidization (IPS) technique was adopted to improve the microstructure and properties of the traditional agglomerated ZrO2 -7wt%Y2 O3 (YSZ) powders used in thermal barrier coating (TBC) applications. Compared with agglomerated YSZ powders, IPS-treated powder has a more desirable microstructure, and the overall performance of the spray powders for TBC preparation is significantly improved. Specifically, IPS-treated powder has a dense, solid, defect-free, and chemically uniform microstructure, and its apparent density, flowability, and powder strength are significantly improved, which is believed to substantially enhance the coating performance when prepared with this IPS-treated powder...

The main objective of this study was to use flash boiling atomization as a new method to inject suspensions with high solid content into the high-power plasma flow. The water-based suspension was prepared with submicron titanium oxide particles with an average size of 500 nm. The investigated solid concentrations were 20, 40, 55 and 70 wt%. Two plasma torches operated at 33, 70 and 110 kW were used to investigate the effect of increasing power on the deposited microstructure and deposition efficiency. At low torch power, the deposition efficiency decreased with increasing solid concentration, and deposits with a high number of unmelted particles were obtained with 70 wt% suspensions...