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https://www.readbyqxmd.com/read/29223242/decades-old-windshield-glass-perforating-injury-with-limbal-iris-incarceration-zonular-fiber-defect-and-equatorial-lens-capsule-injury-with-capsule-fibrosis-and-dense-cataract-november-consultation-1
#1
https://www.readbyqxmd.com/read/29223081/dispersion-of-traffic-derived-air-pollutants-into-urban-parks
#2
Yang Xing, Peter Brimblecombe
Scarce land resources in dense cities means that small urban parks are important as a leisure and amenity resource for the urban population. However, streets with heavily traffic often surround these fragmented parks and increase the potential user exposure to air pollutants from vehicles. The dispersion profiles of PM2.5 and black carbon from roadside into urban parks at pedestrian level, in Hong Kong, were measured using mobile high time resolution instruments. In the downwind direction, pollutant concentrations decreased rapidly from roadside and by some tens of metres reached relatively constant values...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29222736/usefulness-and-limitations-of-dual-layer-spectral-detector-computed-tomography-for-diagnosing-biliary-stones-not-detected-by-conventional-computed-tomography-a-report-of-three-cases
#3
Hirokazu Saito, Kana Noda, Koji Ogasawara, Shutaro Atsuji, Hiroko Takaoka, Hiroo Kajihara, Jiro Nasu, Shoji Morishita, Ikuo Matsushita, Kazuhiro Katahira
Computed tomography (CT) is useful for diagnosing biliary stones. However, the presence of stones not detected by conventional CT, such as iso-dense stones with CT numbers similar to those of bile or small stones, is problematic. Although conventional CT provides only 120-kVp images corresponding to CT numbers at approximately 70 keV, dual-layer spectral detector CT uses one X-ray source and dual-layer detectors to collect low- and high-energy data simultaneously; retrospective spectral analysis, including virtual monochromatic images with photon energy levels of 40-200 keV, material decomposition images, and spectral curves, can be immediately performed on demand...
December 8, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29222468/dissecting-the-genetic-basis-of-local-adaptation-in-soybean
#4
Nonoy B Bandillo, Justin E Anderson, Michael B Kantar, Robert M Stupar, James E Specht, George L Graef, Aaron J Lorenz
Soybean (Glycine max) is the most widely grown oilseed in the world and is an important source of protein for both humans and livestock. Soybean is widely adapted to both temperate and tropical regions, but a changing climate demands a better understanding of adaptation to specific environmental conditions. Here, we explore genetic variation in a collection of 3,012 georeferenced, locally adapted landraces from a broad geographical range to help elucidate the genetic basis of local adaptation. We used geographic origin, environmental data and dense genome-wide SNP data to perform an environmental association analysis and discover loci displaying steep gradients in allele frequency across geographical distance and between landrace and modern cultivars...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222422/reconfigurable-yagi-uda-antenna-based-on-a-silicon-reflector-with-a-solid-state-plasma
#5
Da-Jin Kim, Jang-Soon Park, Cheol Ho Kim, Jae Hur, Choong-Ki Kim, Young-Kyun Cho, Jun-Bong Ko, Bonghyuk Park, Dongho Kim, Yang-Kyu Choi
This paper describes the fabrication and characterization of a reconfigurable Yagi-Uda antenna based on a silicon reflector with a solid-state plasma. The silicon reflector, composed of serially connected p-i-n diodes, forms a highly dense solid-state plasma by injecting electrons and holes into the intrinsic region. When this plasma silicon reflector is turned on, the front-realized gain of the antenna increases by more than 2 dBi beyond 5.3 GHz. To achieve the large gain increment, the structure of the antenna is carefully designed with the aid of semiconductor device simulation and antenna simulation...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222086/genome-wide-dna-methylation-profiling-using-the-methylation-dependent-restriction-enzyme-lpnpi
#6
Ruben Boers, Joachim Boers, Bas de Hoon, Christel Kockx, Zeliha Ozgur, Anco Molijn, Wilfred van IJcken, Joop Laven, Joost Gribnau
DNA methylation is a well-known epigenetic modification that plays a crucial role in gene regulation, but genome-wide analysis of DNA methylation remains technically challenging and costly. DNA methylation-dependent restriction enzymes can be used to restrict CpG methylation analysis to methylated regions of the genome only, which significantly reduces the required sequencing depth and simplifies subsequent bioinformatics analysis. Unfortunately, this approach has been hampered by complete digestion of DNA in CpG methylation-dense regions, resulting in fragments that are too small for accurate mapping...
December 8, 2017: Genome Research
https://www.readbyqxmd.com/read/29221906/presynaptic-active-zones-of-mammalian-neuromuscular-junctions-nanoarchitecture-and-selective-impairments-in-aging
#7
REVIEW
Yomna Badawi, Hiroshi Nishimune
Neurotransmitter release occurs at active zones, which are specialized regions of the presynaptic membrane. A dense collection of proteins at the active zone provides a platform for molecular interactions that promote recruitment, docking, and priming of synaptic vesicles. At mammalian neuromuscular junctions (NMJs), muscle-derived laminin β2 interacts with presynaptic voltage-gated calcium channels to organize active zones. The molecular architecture of presynaptic active zones has been revealed using super-resolution microscopy techniques that combine nanoscale resolution and multiple molecular identification...
December 5, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29221390/%C3%AF-scf-a-direct-energy-targeting-method-to-mean-field-excited-states
#8
Hong-Zhou Ye, Matthew Welborn, Nathan D Ricke, Troy Van Voorhis
The mean-field solutions of electronic excited states are much less accessible than ground state (e.g., Hartree-Fock) solutions. Energy-based optimization methods for excited states, like Δ-SCF (self-consistent field), tend to fall into the lowest solution consistent with a given symmetry-a problem known as "variational collapse." In this work, we combine the ideas of direct energy-targeting and variance-based optimization in order to describe excited states at the mean-field level. The resulting method, σ-SCF, has several advantages...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29220827/exploring-divers-of-forest-degradation-and-fragmentation-in-sudan-the-case-of-erawashda-forest-and-its-surrounding-community
#9
Hussein M Sulieman
Sudan is a hot spot for forest degradation. Efforts to maintain what remains of its forests should be of the highest priority. However, precise information on its forests' current state is very limited. Therefore, in order to effectively intervene in support of existing resources, it is important to have a better understanding of processes taking place in the country and impacting those resources. The objectives of this study are to quantify the consequences of land use and land cover (LULC) changes on forest degradation and fragmentation and to analyze the anthropogenic factors causing it, taking Erawashda Forest, eastern Sudan, as an example...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220718/spatial-and-temporal-dynamics-of-pathogenic-leptospira-in-surface-waters-from-the-urban-slum-environment
#10
Arnau Casanovas-Massana, Federico Costa, Irina N Riediger, Marcelo Cunha, Daiana de Oliveira, Diogenes C Mota, Erica Sousa, Vladimir A Querino, Nivisson Nery, Mitermayer G Reis, Elsio A Wunder, Peter J Diggle, Albert I Ko
Leptospirosis has emerged as an important urban health problem as slum settlements have expanded worldwide. Yet the dynamics of the environmentally transmitted Leptospira pathogen has not been well characterized in these settings. We used a stratified dense sampling scheme to study the dynamics of Leptospira abundance in surface waters from a Brazilian urban slum community. We collected surface water samples during the dry, intermediate and rainy seasons within a seven-month period and quantified pathogenic Leptospira by quantitative PCR (qPCR)...
November 30, 2017: Water Research
https://www.readbyqxmd.com/read/29220674/actb-loss-of-function-mutations-result-in-a-pleiotropic-developmental-disorder
#11
Sara Cuvertino, Helen M Stuart, Kate E Chandler, Neil A Roberts, Ruth Armstrong, Laura Bernardini, Sanjeev Bhaskar, Bert Callewaert, Jill Clayton-Smith, Cristina Hernando Davalillo, Charu Deshpande, Koenraad Devriendt, Maria C Digilio, Abhijit Dixit, Matthew Edwards, Jan M Friedman, Antonio Gonzalez-Meneses, Shelagh Joss, Bronwyn Kerr, Anne Katrin Lampe, Sylvie Langlois, Rachel Lennon, Philippe Loget, David Y T Ma, Ruth McGowan, Maryse Des Medt, James O'Sullivan, Sylvie Odent, Michael J Parker, Céline Pebrel-Richard, Florence Petit, Zornitza Stark, Sylvia Stockler-Ipsiroglu, Sigrid Tinschert, Pradeep Vasudevan, Olaya Villa, Susan M White, Farah R Zahir, Adrian S Woolf, Siddharth Banka
ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have not been proven conclusively. We describe heterozygous ACTB deletions and nonsense and frameshift mutations in 33 individuals with developmental delay, apparent intellectual disability, increased frequency of internal organ malformations (including those of the heart and the renal tract), growth retardation, and a recognizable facial gestalt (interrupted wavy eyebrows, dense eyelashes, wide nose, wide mouth, and a prominent chin) that is distinct from characteristics of individuals with BRWS...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29220360/substitutions-of-prp-n-terminal-histidine-residues-modulate-scrapie-disease-pathogenesis-and-incubation-time-in-transgenic-mice
#12
Sabina Eigenbrod, Petra Frick, Uwe Bertsch, Gerda Mitteregger-Kretzschmar, Janina Mielke, Marko Maringer, Niklas Piening, Alexander Hepp, Nathalie Daude, Otto Windl, Johannes Levin, Armin Giese, Vignesh Sakthivelu, Jörg Tatzelt, Hans Kretzschmar, David Westaway
Prion diseases have been linked to impaired copper homeostasis and copper induced-oxidative damage to the brain. Divalent metal ions, such as Cu2+ and Zn2+, bind to cellular prion protein (PrPC) at octapeptide repeat (OR) and non-OR sites within the N-terminal half of the protein but information on the impact of such binding on conversion to the misfolded isoform often derives from studies using either OR and non-OR peptides or bacterially-expressed recombinant PrP. Here we created new transgenic mouse lines expressing PrP with disrupted copper binding sites within all four histidine-containing OR's (sites 1-4, H60G, H68G, H76G, H84G, "TetraH>G" allele) or at site 5 (composed of residues His-95 and His-110; "H95G" allele) and monitored the formation of misfolded PrP in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29219967/primordial-clays-on-mars-formed-beneath-a-steam-or-supercritical-atmosphere
#13
Kevin M Cannon, Stephen W Parman, John F Mustard
On Mars, clay minerals are widespread in terrains that date back to the Noachian period (4.1 billion to 3.7 billion years ago). It is thought that the Martian basaltic crust reacted with liquid water during this time to form hydrated clay minerals. Here we propose, however, that a substantial proportion of these clays was formed when Mars' primary crust reacted with a dense steam or supercritical atmosphere of water and carbon dioxide that was outgassed during magma ocean cooling. We present experimental evidence that shows rapid clay formation under conditions that would have been present at the base of such an atmosphere and also deeper in the porous crust...
December 6, 2017: Nature
https://www.readbyqxmd.com/read/29219754/shunt-scissors-technical-note
#14
Ralph G Dacey, Oliver E Flouty, M Sean Grady, Matthew A Howard, Marc R Mayberg
OBJECTIVE When performing ventriculoperitoneal shunt surgery it is necessary to create a subgaleal pocket that is of sufficient size to accommodate a shunt valve. In most cases the valve is placed over the posterior skull where the galea begins to transition to suboccipital neck fascia. Dense fibrous attachments in this region of the skull make it technically awkward to develop the subgaleal valve pocket using standard scissors and a blunt dissection technique. In this report the authors describe a new device that enables surgeons to create the shunt valve pocket by using a simple semi-sharp dissection technique...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29219582/fast-nondestructive-parallel-readout-of-neutral-atom-registers-in-optical-potentials
#15
M Martinez-Dorantes, W Alt, J Gallego, S Ghosh, L Ratschbacher, Y Völzke, D Meschede
We demonstrate the parallel and nondestructive readout of the hyperfine state for optically trapped ^{87}Rb atoms. The scheme is based on state-selective fluorescence imaging and achieves detection fidelities >98% within 10 ms, while keeping 99% of the atoms trapped. For the readout of dense arrays of neutral atoms in optical lattices, where the fluorescence images of neighboring atoms overlap, we apply a novel image analysis technique using Bayesian inference to determine the internal state of multiple atoms...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219562/force-and-mass-dynamics-in-non-newtonian-suspensions
#16
Melody X Lim, Jonathan Barés, Hu Zheng, Robert P Behringer
Above a certain solid fraction, dense granular suspensions in water exhibit non-Newtonian behavior, including impact-activated solidification. Although it has been suggested that solidification depends on boundary interactions, quantitative experiments on the boundary forces have not been reported. Using high-speed video, tracer particles, and photoelastic boundaries, we determine the impactor kinematics and the magnitude and timings of impactor-driven events in the body and at the boundaries of cornstarch suspensions...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219541/spatiotemporal-self-organization-of-fluctuating-bacterial-colonies
#17
Tobias Grafke, Michael E Cates, Eric Vanden-Eijnden
We model an enclosed system of bacteria, whose motility-induced phase separation is coupled to slow population dynamics. Without noise, the system shows both static phase separation and a limit cycle, in which a rising global population causes a dense bacterial colony to form, which then declines by local cell death, before dispersing to reinitiate the cycle. Adding fluctuations, we find that static colonies are now metastable, moving between spatial locations via rare and strongly nonequilibrium pathways, whereas the limit cycle becomes almost periodic such that after each redispersion event the next colony forms in a random location...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219489/glassiness-and-heterogeneous-dynamics-in-dense-solutions-of-ring-polymers
#18
Davide Michieletto, Negar Nahali, Angelo Rosa
Understanding how topological constraints affect the dynamics of polymers in solution is at the basis of any polymer theory and it is particularly needed for melts of rings. These polymers fold as crumpled and space-filling objects and, yet, they display a large number of topological constraints. To understand their role, here we systematically probe the response of solutions of rings at various densities to "random pinning" perturbations. We show that these perturbations trigger non-Gaussian and heterogeneous dynamics, eventually leading to nonergodic and glassy behavior...
November 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219457/finite-temperature-green-s-function-approach-for-excited-state-and-thermodynamic-properties-of-cool-to-warm-dense-matter
#19
J J Kas, J J Rehr
We present a finite-temperature extension of the retarded cumulant Green's function for calculations of exited-state, correlation, and thermodynamic properties of electronic systems. The method incorporates a cumulant to leading order in the screened Coulomb interaction W, and improves on the GW approximation of many-body perturbation theory. Results for the homogeneous electron gas are presented for a wide range of densities and temperatures, from cool to warm dense matter regimes, which reveal several hitherto unexpected properties...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219433/vortices-enhance-diffusion-in-dense-granular-flows
#20
Prashidha Kharel, Pierre Rognon
This Letter introduces unexpected diffusion properties in dense granular flows and shows that they result from the development of partially jammed clusters of grains, or granular vortices. Transverse diffusion coefficients D and average vortex sizes ℓ are systematically measured in simulated plane shear flows at differing inertial numbers I revealing (i) a strong deviation from the expected scaling D∝d^{2}γ[over ˙] involving the grain size d and shear rate γ[over ˙] and (ii) an increase in average vortex size ℓ at low I, following ℓ∝dI^{-1/2} but limited by the system size...
October 27, 2017: Physical Review Letters
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