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https://www.readbyqxmd.com/read/29040183/the-prognostic-impact-of-the-pathological-response-to-neoadjuvant-dose-dense-therapy-for-ovarian-carcinoma
#1
Takahiro Ebata, Mayu Yunokawa, Hiroshi Yoshida, Seiko Bun, Tatsunori Shimoi, Akihiko Shimomura, Makoto Kodaira, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Tomoyasu Kato, Kenji Tamura
OBJECTIVE: The aim of this study was to assess the use of the pathological response to neoadjuvant chemotherapy (NAC) for predicting disease prognosis in patients with advanced ovarian cancer who received neoadjuvant dose-dense weekly paclitaxel and carboplatin (dd-TC) therapy. METHODS: We retrospectively investigated patients with advanced epithelial ovarian, tubal, or peritoneal carcinoma treated at our hospital from July 2004 to October 2014. Patients received dd-TC therapy as NAC followed by interval debulking surgery (IDS)...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29040115/keratitis-after-post-kala-azar-dermal-leishmaniasis
#2
Aditya Pradhan, Samar Basak, Tuhin Chowdhury, Ayan Mohanta, Ananya Chatterjee
PURPOSE: To report 2 cases of keratitis occurring after post-kala-azar dermal leishmaniasis (PKDL) in immunocompetent patients. METHODS: Case report and literature review. RESULTS: Two male patients presented with a dense stromal infiltrate in the temporal and superior aspects of the cornea, respectively. Microbiological workup in both patients did not show any offending organism. Both patients were undergoing treatment for PKDL in the form of oral miltefosine...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29040039/breast-cancer-risk-associations-with-digital-mammographic-density-by-pixel-brightness-threshold-and-mammographic-system
#3
Tuong L Nguyen, Yoon-Ho Choi, Ye K Aung, Christopher F Evans, Nhut H Trinh, Shuai Li, Gillian S Dite, Myeong-Seong Kim, Patrick C Brennan, Mark A Jenkins, Joohon Sung, Yun-Mi Song, John L Hopper
Purpose To compare three mammographic density measures defined by different pixel intensity thresholds as predictors of breast cancer risk for two different digital mammographic systems. Materials and Methods The Korean Breast Cancer Study included 398 women with invasive breast cancer and 737 control participants matched for age at mammography (±1 year), examination date, mammographic system, and menopausal status. Mammographic density was measured by using the automated Laboratory for Individualized Breast Radiodensity Assessment (LIBRA) software and the semiautomated Cumulus software at the conventional threshold (Cumulus) and at increasingly higher thresholds (Altocumulus and Cirrocumulus, respectively)...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29036930/automatic-hotspot-and-sun-glint-detection-in-uav-multispectral-images
#4
Damian Ortega-Terol, David Hernandez-Lopez, Rocio Ballesteros, Diego Gonzalez-Aguilera
Last advances in sensors, photogrammetry and computer vision have led to high-automation levels of 3D reconstruction processes for generating dense models and multispectral orthoimages from Unmanned Aerial Vehicle (UAV) images. However, these cartographic products are sometimes blurred and degraded due to sun reflection effects which reduce the image contrast and colour fidelity in photogrammetry and the quality of radiometric values in remote sensing applications. This paper proposes an automatic approach for detecting sun reflections problems (hotspot and sun glint) in multispectral images acquired with an Unmanned Aerial Vehicle (UAV), based on a photogrammetric strategy included in a flight planning and control software developed by the authors...
October 15, 2017: Sensors
https://www.readbyqxmd.com/read/29036611/progranulin-mediated-deficiency-of-cathepsin-d-results-in-ftd-and-ncl-like-phenotypes-in-neurons-derived-from-ftd-patients
#5
Clarissa Valdez, Yvette C Wong, Michael Schwake, Guojun Bu, Zbigniew K Wszolek, Dimitri Krainc
Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders characterized by cognitive and behavioral impairments. Heterozygous mutations in progranulin (PGRN) cause familial FTD and result in decreased PGRN expression, while homozygous mutations result in complete loss of PGRN expression and lead to the neurodegenerative lysosomal storage disorder neuronal ceroid lipofuscinosis (NCL). However, how dose-dependent PGRN mutations contribute to these two different diseases is not well understood...
September 25, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036604/accomplishing-reform-successful-case-studies-drawn-from-the-health-systems-of-60-countries
#6
Jeffrey Braithwaite, Russell Mannion, Yukihiro Matsuyama, Paul Shekelle, Stuart Whittaker, Samir Al-Adawi, Kristiana Ludlow, Wendy James, Hsuen P Ting, Jessica Herkes, Louise A Ellis, Kate Churruca, Wendy Nicklin, Clifford Hughes
Healthcare reform typically involves orchestrating a policy change, mediated through some form of operational, systems, financial, process or practice intervention. The aim is to improve the ways in which care is delivered to patients. In our book 'Health Systems Improvement Across the Globe: Success Stories from 60 Countries', we gathered case-study accomplishments from 60 countries. A unique feature of the collection is the diversity of included countries, from the wealthiest and most politically stable such as Japan, Qatar and Canada, to some of the poorest, most densely populated or politically challenged, including Afghanistan, Guinea and Nigeria...
September 20, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29036272/lep-map3-robust-linkage-mapping-even-for-low-coverage-whole-genome-sequencing-data
#7
Pasi Rastas
Motivation: Accurate and dense linkage maps are useful in family-based linkage and association studies, quantitative trait locus mapping, analysis of genome synteny and other genomic data analyses. Moreover, linkage mapping is one of the best ways to detect errors in de novo genome assemblies, as well as to orient and place assembly contigs within chromosomes. A small mapping cross of tens of individuals will detect many errors where distant parts of the genome are erroneously joined together...
August 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036085/local-receptive-field-constrained-stacked-sparse-autoencoder-for-classification-of-hyperspectral-images
#8
Xiaoqing Wan, Chunhui Zhao
As a competitive machine learning algorithm, the stacked sparse autoencoder (SSA) has achieved outstanding popularity in exploiting high-level features for classification of hyperspectral images (HSIs). In general, in the SSA architecture, the nodes between adjacent layers are fully connected and need to be iteratively fine-tuned during the pretraining stage; however, the nodes of previous layers further away may be less likely to have a dense correlation to the given node of subsequent layers. Therefore, to reduce the classification error and increase the learning rate, this paper proposes the general framework of locally connected SSA; that is, the biologically inspired local receptive field (LRF) constrained SSA architecture is employed to simultaneously characterize the local correlations of spectral features and extract high-level feature representations of hyperspectral data...
June 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035603/competition-level-not-associated-with-diet-quality-in-marching-artists
#9
Colleen R McConnell, Alyssa McPherson, Kathleen Woolf
Marching artists are a unique group of athletes whose performance can be influenced by nutrition. Because physical demands are thought to be moderate to high, adequate energy and a variety of nutrient-dense foods are needed. The purpose of this study was to examine diet quality, physical activity, and eating behavior of marching artists across elite and non-elite competition levels. This cross-sectional analysis used the validated National Cancer Institute Diet History Questionnaire II, International Physical Activity Questionnaire, and Eating Behavior Patterns Questionnaire...
October 16, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29034934/complex-coacervates-based-on-recombinant-mussel-adhesive-proteins-their-characterization-and-applications
#10
REVIEW
Hyo Jeong Kim, Byeongseon Yang, Tae Yoon Park, Seonghye Lim, Hyung Joon Cha
Complex coacervates are a dense liquid phase of oppositely charged polyions formed by the associative separation of a mixture of polyions. Coacervates have been widely employed in many fields including the pharmaceutical, cosmetic, and food industries due to their intriguing interfacial and bulk material properties. More recently, attempts to develop an effective underwater adhesive have been made using complex coacervates that are based on recombinant mussel adhesive proteins (MAPs) due to the water immiscibility of complex coacervates and the adhesiveness of MAPs...
October 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/29034678/additive-models-reveal-sources-of-metals-and-organic-pollutants-in-norwegian-marine-sediments
#11
Gert Everaert, Anders Ruus, Dag Øystein Hjermann, Katrine Borgå, Norman Green, Stepan Boitsov, Henning Jensen, Amanda E Poste
We characterized spatial patterns of surface sediment concentrations of seven polychlorinated biphenyls (PCBs), seven polycyclic aromatic hydrocarbons (PAHs), three chlorinated pesticides and five metals in Norwegian waters and Skagerrak. In total, we analysed 5,036 concentrations of 22 chemical substances that were measured between 1986 and 2014 at 333 sampling sites by means of generalized additive models (GAMs). We found that GAMs with organic carbon content of the sediment and latitude and longitude as covariates explained ca...
October 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29034477/hybrid-bodies-and-the-materiality-of-everyday-life-how-people-living-with-pacemakers-and-defibrillators-reinvent-everyday-routines-and-intimate-relations
#12
Nelly Oudshoorn
Technologies inside bodies pose new challenges in a technological culture. For people with pacemakers and defibrillators, activities such as passing security controls at airports, using electromagnetic machines, electrical domestic appliances and electronic devices, and even intimate contacts with their loved ones can turn into events where the proper functioning of their device may be at risk. Anticipation of potentially harmful events and situations thus becomes an important part of the choreography of everyday life...
October 15, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29034232/maternally-contributed-folate-receptor-1-is-expressed-in-ovarian-follicles-and-contributes-to-preimplantation-development
#13
Trine Strandgaard, Solveig Foder, Anders Heuck, Erik Ernst, Morten S Nielsen, Karin Lykke-Hartmann
Folates have been shown to play a crucial role for proper development of the embryo as folate deficiency has been associated with reduced developmental capacity such as increased risk of fetal neural tube defects and spontanous abortion. Transcripts encoding the reduced folate carrier RFC1 (SLC19A1 protein) and the high-affinity folate receptor FOLR1 are expressed in oocytes and preimplantation embryos, respectively. In this study, we observed maternally contributed FOLR1 protein during mouse and human ovarian follicle development, and 2-cell mouse embryos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29033917/newly-isolated-bacteriophages-from-the-podoviridae-siphoviridae-and-myoviridae-families-have-variable-effects-on-putative-novel-dickeya-spp
#14
Špela Alič, Tina Naglič, Magda Tušek-Žnidarič, Maja Ravnikar, Nejc Rački, Matjaž Peterka, Tanja Dreo
Soft rot pathogenic bacteria from the genus Dickeya cause severe economic losses in orchid nurseries worldwide, and there is no effective control currently available. In the last decade, the genus Dickeya has undergone multiple changes as multiple new taxa have been described, and just recently a new putative Dickeya species was reported. This study reports the isolation of three bacteriophages active against putative novel Dickeya spp. isolates from commercially produced infected orchids that show variable host-range profiles...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033820/pachyderma-in-primary-cutaneous-nk-and-t-cell-lymphoma-and-leukemia-cutis
#15
Eve Lebas, Cesar Chian, Nazli Nikkels-Tassoudji, Jorge E Arrese, Arjen F Nikkels
BACKGROUND: Pachyderma is defined as severely thickened skin with deep folds and is occasionally observed with primary cutaneous NK and T-cell lymphoma (pCNKTCL), primary cutaneous B-cell lymphoma (pCBCL), and leukemia cutis (LC). AIM: To describe the clinical, histological, and therapeutic particularities of a series of pCNKTCL, pCBCL, and LC patients with pachyderma. RESULTS: In a series of pCNKTCL (n = 70), pCBCL (n = 12), and LC (n = 2) patients followed up during 9 years, 6 cases of pachyderma were observed...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033796/laminar-and-cellular-distribution-of-monoamine-receptors-in-rat-medial-prefrontal-cortex
#16
REVIEW
Noemí Santana, Francesc Artigas
The prefrontal cortex (PFC) is deeply involved in higher brain functions, many of which are altered in psychiatric conditions. The PFC exerts a top-down control of most cortical and subcortical areas through descending pathways and is densely innervated by axons emerging from the brainstem monoamine cell groups, namely, the dorsal and median raphe nuclei (DR and MnR, respectively), the ventral tegmental area and the locus coeruleus (LC). In turn, the activity of these cell groups is tightly controlled by afferent pathways arising from layer V PFC pyramidal neurons...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29033653/melicope-stonei-section-pelea-rutaceae-a-new-species-from-kaua-i-hawaiian-islands-with-notes-on-its-distribution-ecology-conservation-status-and-phylogenetic-placement
#17
Kenneth R Wood, Marc S Appelhans, Warren L Wagner
Melicope stonei K.R. Wood, Appelhans & W.L. Wagner (section Pelea, Rutaceae), a new endemic tree species from Kaua'i, Hawaiian Islands, is described and illustrated with notes on its distribution, ecology, conservation status, and phylogenetic placement. The new species differs from its Hawaiian congeners by its unique combination of distinct carpels and ramiflorous inflorescences arising on stems below the leaves; plants monoecious; leaf blades (5-)8-30 × (4-)6-11 cm, with abaxial surface densely tomentose, especially along midribs; and very long petioles of up to 9 cm...
2017: PhytoKeys
https://www.readbyqxmd.com/read/29033018/irradiated-recycled-plastic-as-a-concrete-additive-for-improved-chemo-mechanical-properties-and-lower-carbon-footprint
#18
Carolyn E Schaefer, Kunal Kupwade-Patil, Michael Ortega, Carmen Soriano, Oral Büyüköztürk, Anne E White, Michael P Short
Concrete production contributes heavily to greenhouse gas emissions, thus a need exists for the development of durable and sustainable concrete with a lower carbon footprint. This can be achieved when cement is partially replaced with another material, such as waste plastic, though normally with a tradeoff in compressive strength. This study discusses progress toward a high/medium strength concrete with a dense, cementitious matrix that contains an irradiated plastic additive, recovering the compressive strength while displacing concrete with waste materials to reduce greenhouse gas generation...
October 9, 2017: Waste Management
https://www.readbyqxmd.com/read/29032630/risk-factors-of-poor-complementary-feeding-practices-in-pakistani-children-aged-6-23%C3%A2-months-a-multilevel-analysis-of-the-demographic-and-health-survey-2012-2013
#19
Muzi Na, Víctor M Aguayo, Mary Arimond, Christine P Stewart
Appropriate feeding practices are crucial for survival, growth, and development in childhood. This paper analyzes Pakistan's Demographic and Health Survey 2012-2013 to fill the knowledge gap in risk factors of poor complementary feeding practices in Pakistani children. Multilevel models were applied to fit the multistage cluster sample of 2,827 children aged 6-23 months from 489 communities. Introduction of solid, semi-solid, or soft foods (intro) was achieved in 67% infants aged 6-8 months. Among children aged 6-23 months, the proportion of children meeting minimum meal frequency, dietary diversity (MDD), and acceptable diet criteria were 63%, 22% and 15%, respectively...
October 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29032253/laparoscopic-dissection-of-extensive-secondary-disseminated-peritoneal-leiomyomatosis-dpl
#20
Karicha Mairaing, Kuan-Gen Huang
STUDY OBJECTIVE: To demonstrate a minimal invasive surgical (MIS) technique for curative excision of extensive secondary disseminated peritoneal leiomyomatosis (DPL). SETTING: In MIS, the myoma has to be divided into small fragments for piecemeal retrieval through a small incision [1], a widely used technique is morcellation (confined or unconfined) [2]. Disseminated peritoneal leiomyomatosis (DPL) is a rare sequel following laparoscopic morcellation. Since this entity is rarely reported, this video demonstrates laparoscopic technique for safe removal of DPL post laparoscopic myomectomy and morcellation...
October 12, 2017: Journal of Minimally Invasive Gynecology
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