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Valeria Schindler, Christoph Gubler, Alexander Turk, Anton S Becker, Daniel Pohl
No abstract text is available yet for this article.
December 15, 2017: Gut
Augustin Ernoult, Benoît Fabre, Cassandre Balosso-Bardin, Ilya Franciosi, Patricio de la Cuadra
After defining the mechanical framework of the bag control of bagpipe, this paper presents a study of the bag pressure control in a musical context through the comparison of six players and two bagpipes: one Galician (gaita) and one Majorcan (xeremies), the latter mainly differentiated organologically by a much larger bag size. General observations first lead to the identification and interpretation of the range of control parameters observed. A more detailed analysis of the control parameters during the production of steady notes highlights the coordination between insufflations and the arm displacement necessary to produce a stable and continuous sound...
September 2017: Journal of the Acoustical Society of America
Kae Okoshi, Taro Minami, Masahiro Kikuchi, Yasuko Tomizawa
Playing musical instruments can bring joy to people, but can also cause a wide variety of health issues that range from mild disorders to potentially fatal conditions. Although sports medicine is an established medical subspecialty, relatively few studies have investigated the health issues associated with musical instruments. Here we present an overview of these health issues. These include infections due to microorganisms, allergic reactions, as well as mechanical injuries from sustained high pressures within the oral, mediastinal, thoracic, and abdominal cavities...
September 2017: Tohoku Journal of Experimental Medicine
Patricia Mendoza-García, Fredrik Hugosson, Mahsa Fallah, Michael L Higgins, Yasuno Iwasaki, Kathrin Pfeifer, Georg Wolfstetter, Gaurav Varshney, Dmitry Popichenko, J Peter Gergen, Korneel Hens, Bart Deplancke, Ruth H Palmer
The Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) plays a critical role in the specification of founder cells (FCs) in the Drosophila visceral mesoderm (VM) during embryogenesis. Reporter gene and CRISPR/Cas9 deletion analysis reveals enhancer regions in and upstream of the Alk locus that influence tissue-specific expression in the amnioserosa (AS), the VM and the epidermis. By performing high throughput yeast one-hybrid screens (Y1H) with a library of Drosophila transcription factors (TFs) we identify Odd-paired (Opa), the Drosophila homologue of the vertebrate Zic family of TFs, as a novel regulator of embryonic Alk expression...
April 2017: PLoS Genetics
Patricia Blanco-Piñeiro, M Pino Díaz-Pereira, Aurora Martínez Vidal
OBJECTIVE: Bad posture increases the risk that a musician may suffer from musculoskeletal disorders. This study compared posture quality required by different instruments or families of instruments. METHODS: Using an ad-hoc postural observation instrument embracing 11 postural variables, four experts evaluated the postures of 100 students attending a Spanish higher conservatory of music. RESULTS: The agreement of the experts' evaluations was statistically confirmed by a Cohen's κ value between 0...
June 2018: International Journal of Occupational Safety and Ergonomics: JOSE
Denis Seyres, Yad Ghavi-Helm, Guillaume Junion, Ouarda Taghli-Lamallem, Céline Guichard, Laurence Röder, Charles Girardot, Eileen E M Furlong, Laurent Perrin
Developmental patterning and tissue formation are regulated through complex gene regulatory networks (GRNs) driven through the action of transcription factors (TFs) converging on enhancer elements. Here, as a point of entry to dissect the poorly defined GRN underlying cardiomyocyte differentiation, we apply an integrated approach to identify active enhancers and TFs involved in Drosophila heart development. The Drosophila heart consists of 104 cardiomyocytes, representing less than 0.5% of all cells in the embryo...
December 1, 2016: Development
Michael Coote
Doug Johnson was a clinician-scientist who made great contributions to the understanding of outflow from the eye. This lecture is in honour of Doug and explores the author's understanding of outflow in the surgical context. HOW TO CITE THIS ARTICLE: Coote M. Blebs, Barriers, and Bagpipes: Why is It so Hard? J Curr Glaucoma Pract 2016; 10(3):79-84.
September 2016: Journal of Current Glaucoma Practice
Jenny King, Malcolm Richardson, Anne-Marie Quinn, Jayne Holme, Nazia Chaudhuri
No abstract text is available yet for this article.
April 2017: Thorax
Da-Un Jeong, Je-Yong Choi, Dae-Won Kim
Nkx3.2, the vertebrate homologue of Drosophila bagpipe, has been implicated as playing a role in chondrogenic differentiation. In brief, Nkx3.2 is initially expressed in chondrocyte precursor cells and later during cartilage maturation, its expression is diminished in hypertrophic chondrocytes. In addition to Nkx3.2 expression analyses, previous studies using ex vivo chick embryo cultures and in vitro cell cultures have suggested that Nkx3.2 can suppress chondrocyte hypertrophy. However, it has never been demonstrated that Nkx3...
January 2017: Journal of Cellular Physiology
Gissela De la Cadena, Anna Papadopoulou, Jean-Michel Maes, Jesús Gómez-Zurita
The interactions between herbivores and their host plants play a key role in ecological processes. Understanding the width and nature of these interactions is fundamental to ecology and conservation. Recent research on DNA-based inference of trophic associations suggests that the host range of phytophagous insects in the tropics may be wider than previously thought based on traditional observation. However, the reliability of molecular inference of ecological associations, still strongly dependent on PCR and thus exposed to the risk of contamination with environmental DNA, is under debate...
April 2017: Insect Science
C J Brainerd, Robyn E Holliday, Koyuki Nakamura, Valerie F Reyna
Recent research on the overdistribution principle implies that episodic memory is infected by conjunction illusions. These are instances in which an item that was presented in a single context (e.g., List 1) is falsely remembered as having been presented in multiple contexts (e.g., List 1 and List 2). Robust conjunction illusions were detected in source-monitoring designs in which conjunctive probes ("Was bagpipe presented on List 1 and List 2?") were added to the traditional nonconjunctive probes ("Was bagpipe presented on List 1?")...
November 2014: Journal of Experimental Psychology. Learning, Memory, and Cognition
Anna Papadopoulou, Douglas Chesters, Indiana Coronado, Gissela De la Cadena, Anabela Cardoso, Jazmina C Reyes, Jean-Michel Maes, Ricardo M Rueda, Jesús Gómez-Zurita
Rapid degradation of tropical forests urges to improve our efficiency in large-scale biodiversity assessment. DNA barcoding can assist greatly in this task, but commonly used phenetic approaches for DNA-based identifications rely on the existence of comprehensive reference databases, which are infeasible for hyperdiverse tropical ecosystems. Alternatively, phylogenetic methods are more robust to sparse taxon sampling but time-consuming, while multiple alignment of species-diagnostic, typically length-variable, markers can be problematic across divergent taxa...
January 2015: Molecular Ecology Resources
Sandrine Faure, Maxime Georges, Jennifer McKey, Sébastien Sagnol, Pascal de Santa Barbara
Regulation of the Bone Morphogenetic Protein (BMP) signaling pathway is essential for the normal development of vertebrate gastrointestinal (GI) tract, but also for the differentiation of the digestive mesenchymal layer into smooth muscles and submucosal layer. Different studies demonstrated that Bapx1 (for bagpipe homeobox homolog 1) negatively regulates the BMP pathway, but its precise expression pattern during the development and the differentiation of the GI tract mesenchyme actually remains to be examined...
December 2013: Gene Expression Patterns: GEP
Hsiao Yun Chan, Sivakamasundari V, Xing Xing, Petra Kraus, Sook Peng Yap, Patricia Ng, Siew Lan Lim, Thomas Lufkin
Efficient and stoichiometric expression of genes concatenated by bi- or multi-cistronic vectors has become an invaluable tool not only in basic biology to track and visualize proteins in vivo, but also for vaccine development and in the clinics for gene therapy. To adequately compare, in vivo, the effectiveness of two of the currently popular co-expression strategies - the internal ribosome entry site (IRES) derived from the picornavirus and the 2A peptide from the foot-and-mouth disease virus (FDMV) (F2A), we analyzed two locus-specific knock-in mouse lines co-expressing SRY-box containing gene 9 (Sox9) and enhanced green fluorescent protein (EGFP) linked by the IRES (Sox9(IRES-EGFP)) or the F2A (Sox9(F2A-EGFP)) sequence...
2011: PloS One
Patrick J Drew, Andy Y Shih, David Kleinfeld
Neural activity in the brain is followed by localized changes in blood flow and volume. We address the relative change in volume for arteriole vs. venous blood within primary vibrissa cortex of awake, head-fixed mice. Two-photon laser-scanning microscopy was used to measure spontaneous and sensory evoked changes in flow and volume at the level of single vessels. We find that arterioles exhibit slow (<1 Hz) spontaneous increases in their diameter, as well as pronounced dilation in response to both punctate and prolonged stimulation of the contralateral vibrissae...
May 17, 2011: Proceedings of the National Academy of Sciences of the United States of America
Karl R Wotton, Frida K Weierud, José L Juárez-Morales, Lúcia E Alvares, Susanne Dietrich, Katharine E Lewis
Nk homeobox genes are important regulators of many different developmental processes including muscle, heart, central nervous system and sensory organ development. They are thought to have arisen as part of the ANTP megacluster, which also gave rise to Hox and ParaHox genes, and at least some NK genes remain tightly linked in all animals examined so far. The protostome-deuterostome ancestor probably contained a cluster of nine Nk genes: (Msx)-(Nk4/tinman)-(Nk3/bagpipe)-(Lbx/ladybird)-(Tlx/c15)-(Nk7)-(Nk6/hgtx)-(Nk1/slouch)-(Nk5/Hmx)...
October 2009: Development Genes and Evolution
Karl R Wotton, Frida K Weierud, José L Juárez-Morales, Lúcia E Alvares, Susanne Dietrich, Katharine E Lewis
Nk homeobox genes are important regulators of many different developmental processes including muscle, heart, central nervous system and sensory organ development. They are thought to have arisen as part of the ANTP megacluster, which also gave rise to Hox and ParaHox genes, and at least some NK genes remain tightly linked in all animals examined so far. The protostome-deuterostome ancestor probably contained a cluster of nine Nk genes: (Msx)-(Nk4/tinman)-(Nk3/bagpipe)-(Lbx/ladybird)-(Tlx/c15)-(Nk7)-(Nk6/hgtx)-(Nk1/slouch)-(Nk5/Hmx)...
January 14, 2010: Development Genes and Evolution
Satoshi Yamashita, Masataka Andoh, Hiroe Ueno-Kudoh, Tempei Sato, Shigeru Miyaki, Hiroshi Asahara
The transcription factor, Sry-related High Mobility Group (HMG) box containing gene 9 (Sox9), plays a critical role in cartilage development by initiating chondrogenesis and preventing the subsequent maturation process called chondrocyte hypertrophy. This suppression mechanism by Sox9 on late-stage chondrogenesis partially results from the inhibition of Runt-related transcription factor 2 (Runx2), the main activator of hypertrophic chondrocyte differentiation. However, the precise mechanism by which Sox9 regulates late chondrogenesis is poorly understood...
August 1, 2009: Experimental Cell Research
Yan Zhang, Rebecca A Fillmore, Warren E Zimmer
Nkx3.1 is a member of the NK2 class of homeodomain proteins and is expressed in development, being an early marker of the sclerotome and prostate gland. It has been shown to be a critical factor for prostate differentiation and function. Previous studies suggested that Nkx3.1 interacts with Serum Response Factor (SRF) to transactivate the Smooth Muscle gamma-Actin (SMGA) promoter. In studies presented here, we examined the molecular mechanisms underlying the functional synergy of these factors upon SMGA transcription...
March 2008: Experimental Biology and Medicine
Janus S Jakobsen, Martina Braun, Jeanette Astorga, E Hilary Gustafson, Thomas Sandmann, Michal Karzynski, Peter Carlsson, Eileen E M Furlong
Smooth muscle plays a prominent role in many fundamental processes and diseases, yet our understanding of the transcriptional network regulating its development is very limited. The FoxF transcription factors are essential for visceral smooth muscle development in diverse species, although their direct regulatory role remains elusive. We present a transcriptional map of Biniou (a FoxF transcription factor) and Bagpipe (an Nkx factor) activity, as a first step to deciphering the developmental program regulating Drosophila visceral muscle development...
October 1, 2007: Genes & Development
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