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long term effects of proton pump inhibitors

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https://www.readbyqxmd.com/read/29770171/risk-of-gastric-cancer-development-after-eradication-of-helicobacter-pylori
#1
REVIEW
Ka-Shing Cheung, Wai K Leung
Helicobacter pylori ( H. pylori ) infection is the most important risk factor for gastric cancer (GC) development through the Correa's gastric carcinogenesis cascade. However, H. pylori eradication alone does not eliminate GC, as pre-neoplastic lesions (atrophic gastritis, intestinal metaplasia and dysplasia) may have already developed in some patients. It is therefore necessary to identify patients at high-risk for gastric cancer after H. pylori eradication to streamline the management plan. If the patients have not undergone endoscopy with histologic assessment, the identification of certain clinical risk factors and non-invasive testing (serum pepsinogen) can predict the risk of atrophic gastritis...
May 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29767318/strategies-for-effective-discontinuation-of-proton-pump-inhibitors
#2
REVIEW
Judith Kim, John W Blackett, Daniela Jodorkovsky
PURPOSE OF REVIEW: Proton pump inhibitors (PPIs) are effective for many conditions but are often overprescribed. Recent concerns about long-term risks have made patients re-evaluate their need to take PPIs chronically, though these population-based studies have methodological weaknesses. The goal of this review is to provide evidenced-based strategies for discontinuation of PPI therapy. RECENT FINDINGS: Given that some patients experience rebound symptoms when abruptly stopping continuous PPI therapy due to its effect on hypergastrinemia, strategies focus on avoiding rebound...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29756023/endoscopic-polymer-injection-and-endoluminal-plication-in-treatment-of-gastroesophageal-reflux-disease-evaluation-of-long-term-results
#3
Eduardo Guimarães Hourneaux De Moura, Rubens A A Sallum, Ary Nasi, Martin Coronel, Diogo Turiani Hourneaux De Moura, Eduardo Turiani Hourneaux De Moura, Mauricio Kazuyoshi Minata, Marcelo Cury, Angela Falcão, Ivan Cecconello, Paulo Sakai
Background and study aims:  Us of proton pump inhibitors (PPIs) has made endoscopic treatment of gastroesophageal reflux disease (GERD) more efficient, with reduction in morbidity and complications. However, some patients persist with symptoms despite medical treatment and some are not compliant with it or cannot afford it for financial reasons, and thus they require non-pharmacological therapeutic options such as surgical fundoplication. Surgery may be effective in the short term, but there is related morbidity and concern about its long-term efficacy...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29739175/potent-potassium-competitive-acid-blockers-a-new-era-for-the-treatment-of-acid-related-diseases
#4
REVIEW
Tadayuki Oshima, Hiroto Miwa
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by cytochrome P450 polymorphisms, unsatisfactory effects at night, and instability in acidic conditions. Alternative formulations of conventional PPIs have been developed to overcome these problems; however, these drugs have only introduced small advantages for controlling acid secretion compared to conventional PPIs...
May 9, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29739099/short-term-effect-of-high-dose-pantoprazol-on-serum-and-urinary-magnesium-levels
#5
Seyit Uyar, Suleyman Dolu, Basak O Yolcular, Hamit Y Ellidag, Mehmet Kok, Feyzi Bostan, Yasin Sahinturk, Ayhan H Cekin
BACKGROUND: Proton pump inhibitor (PPI) induced hypomagnesemia is a completely unexplained issue and cases are still being reported. Long-term use is the main factor, but there are a few articles stating that it may also emerge with short-term use. We aimed to evaluate the changes of serum and urine magnesium levels during shortterm high dose pantoprazol treatment. METHODS: The serum and 24-hour urine magnesium levels of 58 patients were evaluated during the course of 2 days...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29730946/-adverse-effects-of-long-term-proton-pump-inhibitor-therapy-on-adults
#6
Iván Igaz, Gábor Simonyi, Sándor Balogh, Miklós Szathmári
In the last few decades, proton-pump inhibitors have become the mainstay of the treatment of acid-related disorders. Despite their efficacy, these drugs are not without risks. Recently several articles have been published on their long-term adverse effects. Among these adverse effects, the higher risk of bone fractures, the vitamin B12 and magnesium deficiencies and the higher risk of Clostridium difficile infection may be relevant. As these drugs are prescribed more and more frequently all over the world, the knowledge of the long-term adverse effects is very important not only for the specialists but for the general practitioners as well...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29676433/proton-pump-inhibitors-and-long-term-risk-of-community-acquired-pneumonia-in-older-adults
#7
Jan Zirk-Sadowski, Jane A Masoli, Joao Delgado, Willie Hamilton, W David Strain, William Henley, David Melzer, Alessandro Ble
OBJECTIVES: To estimate associations between long-term use of proton pump inhibitors (PPIs) and pneumonia incidence in older adults in primary care. DESIGN: Longitudinal analyses of electronic medical records. SETTING: England PARTICIPANTS: Individuals aged 60 and older in primary care receiving PPIs for 1 year or longer (N=75,050) and age- and sex-matched controls (N=75,050). MEASUREMENTS: Net hazard ratios for pneumonia incidence in Year 2 of treatment were estimated using the prior event rate ratio (PERR), which adjusts for pneumonia incidence differences before initiation of treatment...
April 20, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29669681/the-diagnosis-and-treatment-of-functional-dyspepsia
#8
Ahmed Madisch
BACKGROUND: Functional dyspepsia (FD) is one of the more common functional disorders, with a prevalence of 10-20%. It affectsthe gastrointestinal tract. METHODS: This article is based on publications retrieved by a selective search of PubMed, with special attention to controlled trials, guidelines, and reviews. RESULTS: Typical dyspeptic symptoms in functional dyspepsia include epigastric pain, sensations of pressure and fullness, nausea, and early subjective satiety...
March 30, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29658189/side-effects-of-long-term-proton-pump-inhibitor-use-a-review
#9
Peter Fentz Haastrup, Wade Thompson, Jens Søndergaard, Dorte Ejg Jarbøl
Proton pump inhibitors (PPIs) are widely used, and concerns about overuse have been raised. Therefore, side effects are important to be aware of and several suggested side effects of long-term use have been studied. In this MiniReview, we sum up the evidence of side effects related to long-term PPI treatment. Suspected side effects are mainly related to increased susceptibility to infections, secondary hypergastrinaemia, impeded absorption of micronutrients or idiosyncratic reactions. This article is protected by copyright...
April 15, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29649837/-cost-effectiveness-and-cost-utility-analyses-of-antireflux-medicine
#10
Ines Gockel, Undine Gabriele Lange, Olaf Schürmann, Boris Jansen-Winkeln, Rainer Sibbel, Orestis Lyros, Nikolaus von Dercks
INTRODUCTION: Laparoscopic antireflux surgery and medical therapy with proton pump inhibitors are gold standards of gastroesophageal reflux treatment. On account of limited resources and increasing healthcare needs and costs, in this analysis, not only optimal medical results, but also superiority in health economics of these 2 methods are evaluated. METHODS: We performed an electronic literature survey in MEDLINE, PubMed, Cochrane Library, ISRCTN (International Standard Randomization Controlled Trial Number) as well as in the NHS Economic Evaluation Database, including studies published until 1/2017...
April 12, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29625507/efficacy-of-transoral-incisionless-fundoplication-for-refractory-gastroesophageal-reflux-disease-a-systematic-review-and-meta-analysis
#11
Thomas R McCarty, Michael Itidiare, Basile Njei, Tarun Rustagi
BACKGROUND:  Given poor symptomatic response rates and rising awareness of the adverse events associated with the long-term use of proton pump inhibitors (PPIs), endoscopic modalities for treatment of refractory gastroesophageal reflux disease (GERD) have become more prominent. The aim of this study was to perform a systematic review and meta-analysis to evaluate feasibility, efficacy, and tolerability of transoral incisionless fundoplication (TIF) for the treatment of refractory GERD...
April 6, 2018: Endoscopy
https://www.readbyqxmd.com/read/29605975/advantages-and-disadvantages-of-long-term-proton-pump-inhibitor-use
#12
REVIEW
Yoshikazu Kinoshita, Norihisa Ishimura, Shunji Ishihara
Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases including gastroesophageal reflux disease and secondary prevention of aspirin/NSAID-induced ulcers. Although clinically important adverse effects of PPIs can occur, just as with other drugs, those are not frequently observed during or after administration. Thus, PPIs are regarded as relatively safe and considered to be clinically beneficial. Recently, PPIs have become frequently administered to patients with functional gastrointestinal diseases or primary prevention of drug-related gastroduodenal damage, even though their beneficial effects for those conditions have not been fully confirmed...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29551615/effect-of-proton-pump-inhibitors-in-hospitalization-on-mortality-of-patients-with-hepatic-encephalopathy-and-cirrhosis-but-no-active-gastrointestinal-bleeding
#13
Tsung-Hsing Hung, Hsing-Feng Lee, Chih-Wei Tseng, Chih-Chun Tsai, Chen-Chi Tsai
BACKGROUND: Hepatic encephalopathy (HE) is a neuropsychiatric complication of decompensated cirrhosis. Proton pump inhibitors (PPIs), used as potent acid suppressants, are associated with HE occurrence in cirrhotic patients. However, it is still unknown if PPIs contribute to mortality in cirrhotic patients with HE and no active gastrointestinal bleeding. METHODS: We used the Taiwan National Health Insurance Database to identify 1004 cirrhotic patients with HE and no active gastric bleeding, who received oral PPIs between January 1, 2010 and December 31, 2013...
March 15, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29526982/-rhabdomyolysis-associated-with-long-term-treatment-of-esomeprazole
#14
Jun Nishikawa, Ayumu Hosokawa, Mayo Fuchino, Shunsuke Takatori, Masaya Iwamoto, Yoshiro Kashii, Tadashi Bando, Tetsuro Shimizu, Masami Minemura, Toshiro Sugiyama
Proton pump inhibitors (PPIs) have been widely used in the treatment of gastroesophageal reflux disease and peptic ulcer disease. Although they have a potent acid suppressive effect and excellent efficacy in acid-related diseases, PPI-induced rhabdomyolysis has been reported. Here, we report the case of a patient with reflux esophagitis who developed rhabdomyolysis after esomeprazole treatment. A 67-year-old man with reflux esophagitis who had started esomeprazole treatment for the preceding 10 months complained of back and limb fatigue and myalgia...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29509636/long-term-treatment-with-proton-pump-inhibitors-is-effective-in-children-with-eosinophilic-esophagitis
#15
Carolina Gutiérrez-Junquera, Sonia Fernández-Fernández, M Luz Cilleruelo, Ana Rayo, Luis Echeverría, Belén Borrell, Enriqueta Román
OBJECTIVES: Proton pump inhibitor (PPI)-responsive eosinophilic esophagitis (EoE) is frequently observed in children, but data on long-term treatment are scarce. The objective of this study is to evaluate the long-term efficacy and safety of PPIs in children with EoE. METHODS: This prospective study enrolled children with EoE and histological remission to an 8-week esomeprazole trial (1 mg/kg/dose, twice daily). Esomeprazole was maintained at 1 mg/kg/day for 1 year...
March 5, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29481917/cost-effectiveness-of-generic-celecoxib-in-knee-osteoarthritis-for-average-risk-patients-a-model-based-evaluation
#16
E Losina, I M Usiskin, S R Smith, J K Sullivan, K C Smith, D J Hunter, S P Messier, A D Paltiel, J N Katz
OBJECTIVE: The cost-effectiveness of the recently-introduced generic celecoxib in knee OA has not been examined. METHOD: We used the Osteoarthritis Policy (OAPol) Model, a validated computer simulation of knee OA, to evaluate long-term clinical outcomes, costs, and cost-effectiveness of generic celecoxib in persons with knee OA. We examined eight treatment strategies consisting of generic celecoxib, over-the-counter (OTC) naproxen, or prescription naproxen, with or without prescription or OTC proton-pump-inhibitors (PPIs) to reduce gastrointestinal (GI) toxicity...
May 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29406201/proton-pump-inhibitors-review-of-emerging-concerns
#17
REVIEW
Avinash K Nehra, Jeffrey A Alexander, Conor G Loftus, Vandana Nehra
First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are currently approved by the US Food and Drug Administration for the management of a variety of gastrointestinal disorders including symptomatic peptic ulcer disease, gastroesophageal reflux disease, and nonulcer dyspepsia as well as for prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy. PPIs inhibit gastric acid secretion, and the most commonly associated adverse effects include abdominal pain, diarrhea, and headache...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29405886/the-tempo-trial-at-5-years-transoral-fundoplication-tif-2-0-is-safe-durable-and-cost-effective
#18
Karim S Trad, William E Barnes, Elizabeth R Prevou, Gilbert Simoni, Jennifer A Steffen, Ahmad B Shughoury, Mamoon Raza, Jeffrey A Heise, Mark A Fox, Peter G Mavrelis
BACKGROUND: Questions remain about the therapeutic durability of transoral incisionless fundoplication (TIF). In this study, clinical outcomes were evaluated at 5 years post-TIF 2.0. METHODS: A total of 63 chronic gastroesophageal reflux disease (GERD) sufferers with troublesome symptoms refractory to proton pump inhibitor (PPI) therapy, absent or ≤2 cm hiatal hernia, and abnormal esophageal acid exposure were randomized to the TIF group or PPI group. Following the 6-month evaluation, all patients in the PPI group elected for crossover to TIF; therefore, all 63 patients underwent TIF 2...
April 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29393198/does-the-novel-potassium-competitive-acid-blocker-vonoprazan-cause-more-hypergastrinemia-than-conventional-proton-pump-inhibitors-a-multicenter-prospective-cross-sectional-study
#19
Yuichi Kojima, Toshihisa Takeuchi, Makoto Sanomura, Ken Higashino, Keishi Kojima, Kenji Fukumoto, Kou Takata, Hiroki Sakamoto, Masahiro Sakaguchi, Kazunari Tominaga, Kazuhide Higuchi
BACKGROUND/AIM: The long-term administration of proton pump inhibitors (PPIs) is useful for preventing recurrent reflux esophagitis. On the other hand, several adverse reactions, such as an increase in the blood gastrin level, have been reported. The aim of the present study was to examine the increase in the blood gastrin level due to the long-term administration of conventional PPIs compared with vonoprazan. METHODS: A prospective cross-sectional study was conducted...
2018: Digestion
https://www.readbyqxmd.com/read/29343945/the-impact-of-pharmaceutical-interventions-on-the-rational-use-of-proton-pump-inhibitors-in-a-chinese-hospital
#20
Chuanwei Xin, Zhu Dong, Mengmeng Lin, Gong-Hua Li
Background: The prescriptions of proton pump inhibitors (PPIs) have raised concern due to both huge increase in medical expenditure and the possible long-term adverse events caused by them; therefore, an approach to taper off the irrational use of PPIs by patients is clinically warranted. The aim of this study was to evaluate the impact of pharmaceutical interventions on the rational use of PPIs. Patients and methods: A single-center, pre- to post-intervention study (pharmaceutical interventions group and control group) was performed in a Chinese hospital...
2018: Patient Preference and Adherence
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