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https://www.readbyqxmd.com/read/29055186/designed-inhibitors-with-hetero-linkers-for-gastric-proton-pump-h-k-atpase-steered-molecular-dynamics-and-metadynamics-studies
#1
Kalyanashis Jana, Tusar Bandyopadhyay, Bishwajit Ganguly
Acid suppressant SCH28080 and its derivatives reversibly reduce acid secretion activity of the H(+),K(+)-ATPase in a K(+) competitive manner. The results on homologation of the SCH28080 by varying the linker chain length suggested the improvement in efficacy. However, the pharmacokinetic studies reveal that the hydrophobic nature of the CH2 linker units may not help it to function as a better acid suppressant. We have exploited the role of linker unit to enhance the efficacy of such reversible acid suppressant drug molecules using hetero linker, i...
October 12, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29054985/caveolae-mediated-endocytosis-as-a-novel-mechanism-of-resistance-to-trastuzumab-emtansine-t-dm1
#2
Matthew Sung, Xingzhi Tan, Bingwen Lu, Jonathan Golas, Christine Hosselet, Fang Wang, Laurie Tylaska, Lindsay King, Dahui Zhou, Russell Dushin, Jeremy S Myers, Edward Rosfjord, Judy Lucas, Hans-Peter Gerber, Frank Loganzo
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that has demonstrated clinical benefit for patients with HER2+ metastatic breast cancer, however its clinical activity is limited by inherent or acquired drug resistance. The molecular mechanisms that drive clinical resistance to T-DM1, especially in HER2+ tumors, are not well understood. We used HER2+ cell lines to develop models of T-DM1 resistance utilizing a cyclical dosing schema in which cells received T-DM1 in an "on-off" routine until a T-DM1 resistant population was generated...
October 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29054927/the-c-terminal-region-of-a-kinase-anchor-protein-350-akap350a-enables-formation-of-microtubule-nucleation-centers-and-interacts-with-pericentriolar-proteins
#3
Elena Kolobova, Joseph T Roland, Lynne A Lapierre, Janice A Williams, Twila A Mason, James R Goldenring
Microtubules in animal cells assemble (nucleate) from both the centrosome and the cis-Golgi cisternae. A-kinase anchoring protein 350 KDa (AKAP350A, also called AKAP450/CG-NAP/AKAP9) is a large scaffolding protein located at both the centrosome and Golgi apparatus. Previous findings have suggested that AKAP350 is important for microtubule dynamics at both locations, but how this scaffolding protein assembles microtubule nucleation machinery is unclear. Here, we found that overexpression of the C-terminal third of AKAP350A, EGFP-AKAP350A(2691-3907), induces the formation of multiple microtubule-nucleation centers (MTNCs)...
October 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29053920/turn-on-fluorene-push-pull-probes-with-high-brightness-and-photostability-for-visualizing-lipid-order-in-biomembranes
#4
Janah Shaya, Mayeul Collot, Frédéric Benailly, Najiba Mahmoud, Yves Mély, Benoît Y Michel, Andrey S Klymchenko, Alain Burger
The rational design of environment-sensitive dyes with superior properties is critical for elucidating the fundamental biological processes and understanding the biophysical behavior of cell membranes. In this study, a novel group of fluorene-based push-pull probes was developed for imaging membrane lipids. The design of these fluorogenic conjugates is based on a propioloyl linker to preserve the required spectroscopic features of the core dye. This versatile linker allowed the introduction of a polar deoxyribosyl head, a lipophilic chain, and an amphiphilic/anchoring group to tune the cell membrane binding and internalization...
October 20, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29053855/rare-gabra3-variants-are-associated-with-epileptic-seizures-encephalopathy-and-dysmorphic-features
#5
Cristina Elena Niturad, Dorit Lev, Vera M Kalscheuer, Agnieszka Charzewska, Julian Schubert, Tally Lerman-Sagie, Hester Y Kroes, Renske Oegema, Monica Traverso, Nicola Specchio, Maria Lassota, Jamel Chelly, Odeya Bennett-Back, Nirit Carmi, Tal Koffler-Brill, Michele Iacomino, Marina Trivisano, Giuseppe Capovilla, Pasquale Striano, Magdalena Nawara, Sylwia Rzonca, Ute Fischer, Melanie Bienek, Corinna Jensen, Hao Hu, Holger Thiele, Janine Altmüller, Roland Krause, Patrick May, Felicitas Becker, Rudi Balling, Saskia Biskup, Stefan A Haas, Peter Nürnberg, Koen L I van Gassen, Holger Lerche, Federico Zara, Snezana Maljevic, Esther Leshinsky-Silver
Genetic epilepsies are caused by mutations in a range of different genes, many of them encoding ion channels, receptors or transporters. While the number of detected variants and genes increased dramatically in the recent years, pleiotropic effects have also been recognized, revealing that clinical syndromes with various degrees of severity arise from a single gene, a single mutation, or from different mutations showing similar functional defects. Accordingly, several genes coding for GABAA receptor subunits have been linked to a spectrum of benign to severe epileptic disorders and it was shown that a loss of function presents the major correlated pathomechanism...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053306/gw170814-a-three-detector-observation-of-gravitational-waves-from-a-binary-black-hole-coalescence
#6
B P Abbott, R Abbott, T D Abbott, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Afrough, B Agarwal, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, B Allen, G Allen, A Allocca, P A Altin, A Amato, A Ananyeva, S B Anderson, W G Anderson, S V Angelova, S Antier, S Appert, K Arai, M C Araya, J S Areeda, N Arnaud, K G Arun, S Ascenzi, G Ashton, M Ast, S M Aston, P Astone, D V Atallah, P Aufmuth, C Aulbert, K AultONeal, C Austin, A Avila-Alvarez, S Babak, P Bacon, M K M Bader, S Bae, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, S Banagiri, J C Barayoga, S E Barclay, B C Barish, D Barker, K Barkett, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, S D Barthelmy, J Bartlett, I Bartos, R Bassiri, A Basti, J C Batch, M Bawaj, J C Bayley, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, A S Bell, B K Berger, G Bergmann, J J Bero, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, S Biscoveanu, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, N Bode, M Boer, G Bogaert, A Bohe, F Bondu, E Bonilla, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, K Bossie, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, M Canepa, P Canizares, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, M F Carney, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, P Cerdá-Durán, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chase, E Chassande-Mottin, D Chatterjee, K Chatziioannou, B D Cheeseboro, H Y Chen, X Chen, Y Chen, H-P Cheng, H Chia, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, A K W Chung, S Chung, G Ciani, R Ciolfi, C E Cirelli, A Cirone, F Clara, J A Clark, P Clearwater, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, D Cohen, A Colla, C G Collette, L R Cominsky, M Constancio, L Conti, S J Cooper, P Corban, T R Corbitt, I Cordero-Carrión, K R Corley, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, G Dálya, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, D Davis, E J Daw, B Day, S De, D DeBra, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, N Demos, T Denker, T Dent, R De Pietri, V Dergachev, R De Rosa, R T DeRosa, C De Rossi, R DeSalvo, O de Varona, J Devenson, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, F Di Renzo, Z Doctor, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, C Dreissigacker, J C Driggers, Z Du, M Ducrot, P Dupej, S E Dwyer, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, D Estevez, Z B Etienne, T Etzel, M Evans, T M Evans, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, C Fee, H Fehrmann, J Feicht, M M Fejer, A Fernandez-Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, D Finstad, I Fiori, D Fiorucci, M Fishbach, R P Fisher, M Fitz-Axen, R Flaminio, M Fletcher, H Fong, J A Font, P W F Forsyth, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, M R Ganija, S G Gaonkar, C Garcia-Quiros, F Garufi, B Gateley, S Gaudio, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, D George, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, L Glover, E Goetz, R Goetz, S Gomes, B Goncharov, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, E M Gretarsson, P Groot, H Grote, S Grunewald, P Gruning, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, O Halim, B R Hall, E D Hall, E Z Hamilton, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, O A Hannuksela, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, C-J Haster, K Haughian, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, A W Heptonstall, M Heurs, S Hild, T Hinderer, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, C Horst, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, R Inta, G Intini, H N Isa, J-M Isac, M Isi, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, N K Johnson-McDaniel, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, C V Kalaghatgi, V Kalogera, B Kamai, S Kandhasamy, G Kang, J B Kanner, S J Kapadia, S Karki, K S Karvinen, M Kasprzack, M Katolik, E Katsavounidis, W Katzman, S Kaufer, K Kawabe, F Kéfélian, D Keitel, A J Kemball, R Kennedy, C Kent, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, Chunglee Kim, J C Kim, K Kim, W Kim, W S Kim, Y-M Kim, S J Kimbrell, E J King, P J King, M Kinley-Hanlon, R Kirchhoff, J S Kissel, L Kleybolte, S Klimenko, T D Knowles, P Koch, S M Koehlenbeck, S Koley, V Kondrashov, A Kontos, M Korobko, W Z Korth, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, R Kumar, S Kumar, L Kuo, A Kutynia, S Kwang, B D Lackey, K H Lai, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, N Leroy, N Letendre, Y Levin, T G F Li, S D Linker, T B Littenberg, J Liu, R K L Lo, N A Lockerbie, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, D Lumaca, A P Lundgren, R Lynch, Y Ma, R Macas, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, I Magaña Hernandez, F Magaña-Sandoval, L Magaña Zertuche, R M Magee, E Majorana, I Maksimovic, N Man, V Mandic, V Mangano, G L Mansell, M Manske, M Mantovani, F Marchesoni, F Marion, S Márka, Z Márka, C Markakis, A S Markosyan, A Markowitz, E Maros, A Marquina, P Marsh, F Martelli, L Martellini, I W Martin, R M Martin, D V Martynov, K Mason, E Massera, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, A Matas, F Matichard, L Matone, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, L McCuller, S C McGuire, G McIntyre, J McIver, D J McManus, L McNeill, T McRae, S T McWilliams, D Meacher, G D Meadors, M Mehmet, J Meidam, E Mejuto-Villa, A Melatos, G Mendell, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, H Miao, C Michel, H Middleton, E E Mikhailov, L Milano, A L Miller, B B Miller, J Miller, M Millhouse, M C Milovich-Goff, O Minazzoli, Y Minenkov, J Ming, C Mishra, S Mitra, V P Mitrofanov, G Mitselmakher, R Mittleman, D Moffa, A Moggi, K Mogushi, M Mohan, S R P Mohapatra, M Montani, C J Moore, D Moraru, G Moreno, S Morisaki, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, A Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A Muñiz, M Muratore, P G Murray, K Napier, I Nardecchia, L Naticchioni, R K Nayak, J Neilson, G Nelemans, T J N Nelson, M Nery, A Neunzert, L Nevin, J M Newport, G Newton, K K Y Ng, T T Nguyen, D Nichols, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, C North, L K Nuttall, J Oberling, G D O'Dea, G H Ogin, J J Oh, S H Oh, F Ohme, M A Okada, M Oliver, P Oppermann, R J Oram, B O'Reilly, R Ormiston, L F Ortega, R O'Shaughnessy, S Ossokine, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, M A Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, Howard Pan, Huang-Wei Pan, B Pang, P T H Pang, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, A Parida, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, M Patil, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pirello, M Pitkin, M Poe, R Poggiani, P Popolizio, E K Porter, A Post, J Powell, J Prasad, J W W Pratt, G Pratten, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, R Prix, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, B Rajbhandari, M Rakhmanov, K E Ramirez, A Ramos-Buades, P Rapagnani, V Raymond, M Razzano, J Read, T Regimbau, L Rei, S Reid, D H Reitze, W Ren, S D Reyes, F Ricci, P M Ricker, S Rieger, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, J D Romano, R Romano, C L Romel, J H Romie, D Rosińska, M P Ross, S Rowan, A Rüdiger, P Ruggi, G Rutins, K Ryan, S Sachdev, T Sadecki, L Sadeghian, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, L E Sanchez, N Sanchis-Gual, V Sandberg, J R Sanders, B Sassolas, B S Sathyaprakash, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, M Scheel, J Scheuer, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B W Schulte, B F Schutz, S G Schwalbe, J Scott, S M Scott, E Seidel, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, D A Shaddock, T J Shaffer, A A Shah, M S Shahriar, M B Shaner, L Shao, B Shapiro, P Shawhan, A Sheperd, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, L P Singer, A Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, S Somala, E J Son, J A Sonnenberg, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, K Staats, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, S P Stevenson, R Stone, D J Stops, K A Strain, G Stratta, S E Strigin, A Strunk, R Sturani, A L Stuver, T Z Summerscales, L Sun, S Sunil, J Suresh, P J Sutton, B L Swinkels, M J Szczepańczyk, M Tacca, S C Tait, C Talbot, D Talukder, D B Tanner, M Tápai, A Taracchini, J D Tasson, J A Taylor, R Taylor, S V Tewari, T Theeg, F Thies, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, S Tiwari, V Tiwari, K V Tokmakov, K Toland, M Tonelli, Z Tornasi, A Torres-Forné, C I Torrie, D Töyrä, F Travasso, G Traylor, J Trinastic, M C Tringali, L Trozzo, K W Tsang, M Tse, R Tso, L Tsukada, D Tsuna, D Tuyenbayev, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, S A Usman, H Vahlbruch, G Vajente, G Valdes, M Vallisneri, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, S P Vyatchanin, A R Wade, L E Wade, M Wade, R Walet, M Walker, L Wallace, S Walsh, G Wang, H Wang, J Z Wang, W H Wang, Y F Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, E K Wessel, P Weßels, J Westerweck, T Westphal, K Wette, J T Whelan, S E Whitcomb, B F Whiting, C Whittle, D Wilken, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Wofford, K W K Wong, J Worden, J L Wright, D S Wu, D M Wysocki, S Xiao, H Yamamoto, C C Yancey, L Yang, M J Yap, M Yazback, Hang Yu, Haocun Yu, M Yvert, A Zadrożny, M Zanolin, T Zelenova, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y-H Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, A B Zimmerman, M E Zucker, J Zweizig
On August 14, 2017 at 10∶30:43 UTC, the Advanced Virgo detector and the two Advanced LIGO detectors coherently observed a transient gravitational-wave signal produced by the coalescence of two stellar mass black holes, with a false-alarm rate of ≲1 in 27 000 years. The signal was observed with a three-detector network matched-filter signal-to-noise ratio of 18. The inferred masses of the initial black holes are 30.5_{-3.0}^{+5.7}M_{⊙} and 25.3_{-4.2}^{+2.8}M_{⊙} (at the 90% credible level). The luminosity distance of the source is 540_{-210}^{+130}  Mpc, corresponding to a redshift of z=0...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053265/step-economical-photoassisted-diversity-oriented-synthesis-sustaining-cascade-photoreactions-in-oxalyl-anilides-to-access-complex-polyheterocyclic-molecular-architectures
#7
Dmitry M Kuznetsov, Andrei G Kutateladze
Atom- and step-economy in photoassisted DOS is achieved with a versatile oxalyl linker offering rapid access to complex alkaloid mimics in very few experimentally simple steps: (i) it allows for fast tethering of the photoactive core to the unsaturated pendants, especially im-portant in the case of (hetero)aromatic amines - essentially a one pot reaction with no isolation of intermediates; (ii) the α-dicarbonyl tether acts as a chromophore enhancer, extending the conjugation chain and facilitating the 'harvest' of the lower energy photons for the primary and secondary photoreactions, (iii) it enhances the quantum yield of intersystem crossing (ISC), i...
October 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29053246/driving-chemical-reactions-in-plasmonic-nanogaps-with-electrohydrodynamic-flow
#8
William John Thrift, Cuong Quoc Nguyen, Mahsa Darvishzadeh-Varcheie, Siavash Zare, Nicholas Sharac, Robert Noboru Sanderson, Torin J Dupper, Allon I Hochbaum, Filippo Capolino, Mohammad Javad Abdolhosseini Qomi, Regina Ragan
Nanoparticles from colloidal solution - with controlled composition, size, and shape - serve as excellent building blocks for plasmonic devices and metasurfaces. However, understanding hierarchical driving forces affecting geometry of oligomers and interparticle gap spacings is still needed to fabricate high density architectures over large areas. Here, electrohydrodynamic (EHD) flow is used as a long-range driving force to enable carbodiimide crosslinking between nanospheres and produces oligomers exhibiting sub-nanometer gap spacing over mm(2) areas...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29053171/high-surface-area-thermally-stable-hydrophobic-microporous-rigid-gels-generat-ed-at-ambient-from-mesi-oet-3-eto-3sich2ch2si-oet-3-mixtures-by-f-catalyzed-hydrolysis
#9
Richard M Laine, Joseph C Furgal, Honami Yamane, Timothy R Odykirk, Eongyu Yi, Yoshiki Chujo
High surface area materials are of considerable interest for gas storage/capture, molecular sieving, catalyst supports, as well as for slow release drug delivery systems. We report here a very simple and fast route to very high surface area (> 1000 m2/g), mechanically robust, hydrophobic gels prepared by F- catalyzed hydrolysis of mixtures of MeSi(OEt)3 and bistriethoxysilylethane (BTSE) at ambiente. These materials offer surface areas up to 1300 m2/g, peak pore sizes of 0.8 nm and thermal stabilities above 200 °C...
October 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29052680/progressive-structural-modification-to-a-zinc-actuated-photoinduced-electron-transfer-pet-switch-in-the-context-of-intracellular-zinc-imaging
#10
Miguel Macias-Contreras, Kirsten L Daykin, J Tyler Simmons, John R Allen, Zachary S Hooper, Michael W Davidson, Lei Zhu
Photoinduced electron transfer (PeT)-type fluorescent molecular switches are often applied in ion-selective sensors. Zinc-targeting sensors that contain an anilino-based electron donor (aka, the PeT 'switch') have multiple advantages over those with an aliphatic amino switch. In addition to the lower pKa value of an aniline than that of a comparably substituted aliphatic amine, which reduces the interference of pH on the spectral properties of the attached fluorophore, the oxidation potentials of anilino groups are lower than those of aliphatic amino counterparts, which make them better electron donors in PeT...
October 20, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29052668/mussel-mimetic-hydrogels-with-defined-cross-linkers-achieved-via-controlled-catechol-dimerization-exhibiting-tough-adhesion-for-wet-biological-tissues
#11
Pengchao Zhao, Kongchang Wei, Qian Feng, Heng Chen, Dexter Siu Hong Wong, Xiaoyu Chen, Chia-Ching Wu, Liming Bian
The engineering of catechol-based hydrogels to bind to wet biological tissues with high adhesion energy remains a challenge. Herein, fast quinone-nucleophile coupling and dynamic boronate ester bond were used to enhance the interfacial adhesion and bulk cohesion of our dual-crosslinked hydrogels, respectively, for fabricating mussel-mimetic tough adhesives.
October 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29052597/syk-expression-in-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma
#12
Grit Mutzbauer, Katja Maurus, Clara Buszello, Jordan Pischimarov, Sabine Roth, Andreas Rosenwald, Andreas Chott, Eva Geissinger
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy associated T-cell lymphoma (type II EATL), is a rare, aggressive primary intestinal T-cell lymphoma with a poor prognosis and an incompletely understood pathogenesis. We collected 40 cases of MEITL and 27 cases of EATL, formerly known as type I EATL, and comparatively investigated the T-cell receptor (TCR) itself and associated signaling molecules using immunohistochemistry, amplicon deep sequencing and bisulfite pyrosequencing...
October 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29052422/thiabicyclononane-based-antimicrobial-polycations
#13
Zhishuai Geng, M G Finn
Bicyclo[3.3.1]nonane (BCN) polycations were synthesized by the reaction of the bivalent electrophile thiabicyclo[3.3.1]nonane dinitrate with a series of simple bis(pyridine) nucleophiles. Oligomers of moderate chain length were formed in a modular approach that tolerated the inclusion of functionalized and variable-length linkers between the pyridine units. Post-polymerization modification via copper-catalyzed azide-alkyne cyloaddition was enabled by the inclusion of terminal alkyne groups in these monomers...
October 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29052411/photoresponse-enhancement-in-monolayer-res2-phototransistor-decorated-with-cdse-cds-zns-quantum-dots
#14
Jing-Kai Qin, Dan-Dan Ren, Wen-Zhu Shao, Yang Li, Peng Miao, Zhao-Yuan Sun, PingAn Hu, Liang Zhen, Cheng-Yan Xu
ReS2 films is considered as a promising candidate for optoelectronic applications due to its direct bandgap character and optical/electrical anisotropy. However, the direct bandgap in a narrow spectrum and the low absorption of atomically thin flake weaken the prospect for light-harvesting applications. Here, we developed an efficient approach to enhance the performance of ReS2-based phototransistor by coupling CdSe-CdS-ZnS core-shell quantum dots. Under 589 nm laser irradiation, the responsivity of ReS2 phototransistor decorated with quantum dots could be enhanced by more than 25 times (up to ~654 A/W), and the rising and recovery time can be also reduced to 3...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29052191/histone-h1-purification-and-post-translational-modification-profiling-by-high-resolution-mass-spectrometry
#15
Maciej Kotliński, Andrzej Jerzmanowski
It has proven particularly difficult to purify Linker (H1) histones from the model plant Arabidopsis thaliana. This is most likely due to its low nuclear DNA content and the abundance of substances that interfere with protein isolation. These problems have hindered the use of Arabidopsis for in-depth characterization of nuclear proteins by modern techniques based on mass spectrometry (MS). Here, we describe an improved methodology for preparing pure Arabidopsis H1s and separating them by HPLC into fractions corresponding to nonallelic variants...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29051953/effects-of-multifunctional-cross-linkers-on-rheology-and-adhesion-of-soft-nanostructured-materials
#16
X Callies, C Véchambre, C Fonteneau, F Herbst, J-M Chenal, S Pensec, L Chazeau, W H Binder, L Bouteiller, C Creton
We investigate the nanostructure, the rheology and the adhesion of soft supramolecular materials elaborated by blending monofunctional and multifunctional poly(isobutene) (PIB) chains. Monofunctional PIB chains (PIBUT) are linear and unentangled polymer chains (Mn ≈ 3 kg mol(-1)) functionalized in the middle by a bis-urea interacting moiety, able to self-associate by four hydrogen bonds. Covalent coupling of monofunctional PIB allows us to synthesize longer chains bearing two or three interacting moieties...
October 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/29051376/defibrillation-of-soft-porous-metal-organic-frameworks-with-electric-fields
#17
A Knebel, B Geppert, K Volgmann, D I Kolokolov, A G Stepanov, J Twiefel, P Heitjans, D Volkmer, J Caro
Gas transport through metal-organic framework membranes (MOFs) was switched in situ by applying an external electric field (E-field). The switching of gas permeation upon E-field polarization could be explained by the structural transformation of the zeolitic imidazolate framework ZIF-8 into polymorphs with more rigid lattices. Permeation measurements under a direct-current E-field poling of 500 volts per millimeter showed reversibly controlled switching of the ZIF-8 into polar polymorphs, which was confirmed by x-ray diffraction and ab initio calculations...
October 20, 2017: Science
https://www.readbyqxmd.com/read/29050968/discovery-and-electrophysiological-characterization-of-skf-32802-a-novel-herg-agonist-found-through-a-large-scale-structural-similarity-search
#18
Brian T Donovan, Deepak Bandyopadhyay, Chaya Duraiswami, Christopher J Nixon, Claire Y Townsend, Stan F Martens
Despite the importance of the hERG channel in drug discovery and the sizable number of antagonist molecules discovered, only a few hERG agonists have been discovered. Here we report a novel hERG agonist; SKF-32802 and a structural analog of the agonist NS3623, SB-335573. These were discovered through a similarity search of published hERG agonists. SKF-32802 incorporates an amide linker rather than NS3623's urea, resulting in a compound with a different mechanism of action. We find that both compounds decrease the time constant of open channel kinetics, increase the amplitude of the envelope of tails assay, mildly increased the amplitude of the IV curve, bind the hERG channel in either open or closed states, increase the plateau of the voltage dependence of activation and modulate the effects of the hERG antagonist, quinidine...
October 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29050842/pseudo-template-molecularly-imprinted-polymer-for-determination-of-14-kind-of-%C3%AE-agonists-in-animal-urine-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#19
Decheng Suo, Ruiguo Wang, Peilong Wang, Xia Fan, Xiaoou Su
A pseudo template molecularly imprinted polymer (MIP) for selective extraction of β-agonists was prepared using 4-hydroxyphenethyl alcohol as pseudo template molecule, methyl acrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. Selectivity and adsorption capacity of prepared MIP were studied in detail. MIP selectively adsorbed 14 types of β-agonists. Advantages of the prepared polymer include non-template leakage in purification of target analytes and cheap cost. MIP was used to purify β-agonists in urine samples...
October 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29050346/identification-of-candidate-genes-related-to-pancreatic-cancer-based-on-analysis-of-gene-co-expression-and-protein-protein-interaction-network
#20
Tiejun Zhang, Xiaojuan Wang, Zhenyu Yue
Pancreatic cancer (PC) is one of the most common causes of cancer mortality worldwide. As the genetic mechanism of this complex disease is not uncovered clearly, identification of related genes of PC is of great significance that could provide new insights into gene function as well as potential therapy targets. In this study, we performed an integrated network method to discover PC candidate genes based on known PC related genes. Utilizing the subnetwork extraction algorithm with gene co-expression profiles and protein-protein interaction data, we obtained the integrated network comprising of the known PC related genes (denoted as seed genes) and the putative genes (denoted as linker genes)...
September 19, 2017: Oncotarget
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