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https://www.readbyqxmd.com/read/28437701/a-high-performance-and-highly-controllable-core-shell-imprinted-sensor-based-on-the-surface-enhanced-raman-scattering-for-detection-of-r6g-in-water
#1
Hongji Li, Jiaqi Jiang, Zirun Wang, Xiaonan Wang, Xiqing Liu, Yongsheng Yan, Chunxiang Li
A novel, sensitive sensor material combined the technique of surface enhance Raman scattering (SERS) and molecular imprinting was prepared. It was used the amino-functionalized SiO2 nanospheres as the supporting materials and anchored Ag nanoparticles on the surface by the function of coordination between Ag(+) and NH2(-). Then, it was used that the Rhodamine 6G (R6G) as the template, acrylamide (AM) as functional monomer, ethyleneglycol dimethacrylate (EGDMA) as cross-linker, 2,2'-azobis(2-methylpropionitrile) (AIBN) as initiator to prepare the core-shell molecular imprinted polymers...
April 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28437612/combinatorial-library-based-on-restriction-enzyme-mediated-modular-assembly
#2
Cuiping Ma, Chao Liang, Yifan Wang, Mei Pan, Qianqian Jiang, Chao Shi
Combinatorial approaches in directed evolution were proven to be more efficient for exploring sequence space and innovating the function of protein. We presented modular assembly of secondary structures (MASS) for constructing a combinatorial library. In this approach, secondary structure elements were extracted from natural existing proteins, the common linkers were flanking secondary structure elements, then digested by Hinf I restriction endonuclease that was used in the construction of combinatorial library for the first time...
April 24, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28437079/hierarchical-porous-polybenzimidazole-microsieves-an-efficient-architecture-for-anhydrous-proton-transport-via-polyionic-liquids
#3
Parashuram Kallem, Martin Drobek, Anne Julbe, Erik J Vriezekolk, Reyes Mallada, Maria Pilar Pina
Liquid-induced phase-separation micromolding (LIPSμM) has been successfully used for manufacturing hierarchical porous polybenzimidazole (HPBI) microsieves (42-46% porosity, 30-40 μm thick) with a specific pore architecture (pattern of macropores: ∼9 μm in size, perforated, dispersed in a porous matrix with a 50-100 nm pore size). Using these microsieves, proton-exchange membranes were fabricated by the infiltration of a 1H-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide liquid and divinylbenzene (as a cross-linker), followed by in situ UV polymerization...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28437019/extending-unique-1d-borate-chains-to-3d-framework-by-introducing-metallic-nodes
#4
Guo-Yu Yang, Qi Wei, Shi-Jia Sun, Jie Zhang
Two novel alkali/alkaline-earth borates, Ba6[B6O9 (OH)6]2(H3BO3) (1) and Li7MAlB12O24 (M = Ba, Sr, Ca) (2a-c), with 1- and 3-D structures have been hydrothermally made and characterized. 1 features a rarely 1-D anionic chain built by hexaborate clusters of B6O11(OH)6 made of six BO4/ BO2(OH)2 tetrahedra. The anionic chains are embedded in the channels of Ba6-based wheel cluster open-framework. On the basis of the structural analyses of 1, by incorporating the rational Al atoms as the linkers and tuning the reaction conditions, the anhydrous borates 2a-c have been success-fully obtained, showing novel 3-D aluminoborates (ABOs) constructed from B6O14-based cluster chains and AlO6 octa-hedra...
April 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28435866/layered-microporous-polymers-by-solvent-knitting-method
#5
Shaolei Wang, Chengxin Zhang, Yu Shu, Shulan Jiang, Qi Xia, Linjiang Chen, Shangbin Jin, Irshad Hussain, Andrew I Cooper, Bien Tan
Two-dimensional (2D) nanomaterials, especially 2D organic nanomaterials with unprecedentedly diverse and controlled structure, have attracted decent scientific interest. Among the preparation strategies, the top-down approach is one of the considered low-cost and scalable strategies to obtain 2D organic nanomaterials. However, some factors of their layered counterparts limited the development and potential applications of 2D organic nanomaterials, such as type, stability, and strict synthetic conditions of layered counterparts...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28434765/4-connected-azabicyclo-5-3-0-decane-smac-mimetics-zn-2-chelators-as-dual-action-antitumoral-agents
#6
Leonardo Manzoni, Alessandro Samela, Stefano Barbini, Silvia Cairati, Marta Penconi, Daniela Arosio, Daniele Lecis, Pierfausto Seneci
Putative dual action compounds (DACs 3a-d) based on azabicyclo[5.3.0]decane (ABD) Smac mimetic scaffolds linked to Zn(2+)-chelating 2,2'-dipicolylamine (DPA) through their 4 position are reported and characterized. Their synthesis, their target affinity (cIAP1 BIR3, Zn(2+)) in cell-free assays, their pro-apoptotic effects, and their cytotoxicity in tumor cells with varying sensitivity to Smac mimetics are described. A limited influence of Zn(2+) chelation on in vitro activity of DPA-substituted DACs 3a-d was sometimes perceivable, but did not lead to strong cellular synergistic effects...
April 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28434220/effects-of-the-backbone-and-chemical-linker-on-the-molecular-conductance-of-nucleic-acid-duplexes
#7
Edward Beall, Selma Ulku, Chaoren Liu, Emil Wierzbinski, Y Zhang, Yookyung Bae, Peng Zhang, Catalina Achim, David N Beratan, David H Waldeck
Scanning tunneling microscope-break junction measurements are used to examine how the molecular conductance of nucleic acids depends on the composition of their backbone and the linker group to the electrodes. Molecular conductances of 10-base pair long homoduplexes of DNA, aeg-PNA, γ-PNA, and a heteroduplex of DNA/aeg-PNA with identical nucleobase sequence were measured. The molecular conductance was found to vary by 12 to 13 times with the change in backbone. Computational studies show that the molecular conductance differences between nucleic acids of different backbones correlate with differences in backbone structural flexibility...
April 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28433828/poly-cyclodextrin-cryogels-with-aligned-porous-structure-for-removal-of-polycyclic-aromatic-hydrocarbons-pahs-from-water
#8
Fuat Topuz, Tamer Uyar
Cyclodextrins (CDs) are sugar-based cyclic oligosaccharides, which form inclusion complexes with small guest molecules through their hydrophobic cavity. Here we successfully synthesized highly porous poly-cyclodextrin (poly-CD) cryogels, which were produced under cryogenic conditions by the cross-linking of amine-functional CDs with PEG-based diepoxide cross-linker. The poly-CD cryogels showed aligned porous network structures owing to the directional freezing of the matrix, of which the pore size and architecture exposed variations depending on the composition of the reactants...
April 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28433029/early-stages-of-clathrin-aggregation-at-a-membrane-in-coarse-grained-simulations
#9
M Giani, W K den Otter, W J Briels
The self-assembly process of clathrin coated pits during endocytosis has been simulated by combining and extending coarse grained models of the clathrin triskelion, the adaptor protein AP2, and a flexible network membrane. The AP2's core, upon binding to membrane and cargo, releases a motif that can bind clathrin. In conditions where the core-membrane-cargo binding is weak, the binding of this motif to clathrin can result in a stable complex. We characterize the conditions and mechanisms resulting in the formation of clathrin lattices that curve the membrane, i...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28432983/improved-resolution-and-simplification-of-the-spin-diffusion-based-nmr-method-for-the-structural-analysis-of-mixed-linker-mofs
#10
Andraž Krajnc, Bart Bueken, Dirk De Vos, Gregor Mali
Nuclear magnetic resonance spectroscopy combined with modeling represents a powerful tool for the structural analysis of heterogeneous materials. In this contribution we describe an upgraded method, particularly suited for the structural analysis of mixed-linker metal-organic framework materials, which is based on the measurement and modeling of proton spin diffusion among constituents. We tested the method on a UiO-66-type metal-organic material, in which the organic building units were 1,4-benzenedicarboxylate and trans-1,4-cyclohexanedicarboxylate anions distributed within the framework in an unknown manner...
April 12, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28431353/discovery-of-potential-anticancer-multi-targeted-ligustrazine-based-cyclohexanone-and-oxime-analogs-overcoming-the-cancer-multidrug-resistance
#11
Gao-Feng Zha, Hua-Li Qin, Bahaa G M Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Ahmed H Abdelazeem, Syed Nasir Abbas Bukhari
The drug research and development nowadays is focusing on multi-target drugs. In the treatment of cancer, therapies using drugs inhibiting one numerous targets signify a novel viewpoint. In comparison with traditional therapy, multi-targeted drugs directly aim cell subpopulations which are involved in progression of tumor. The current study comprises the synthesis of 34 novel ligustrazine-containing α, β-unsaturated carbonyl-based compounds and oximes. The growth of 5 various cancer cell types was strongly inhibited by ligustrazine-containing oximes as revealed by biological evaluation...
April 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28430416/a-complimentary-benzophenone-cross-linking-mass-spectrometry-photochemistry
#12
Adam Belsom, Gemma Mudd, Sven H Giese, Manfred Auer, Juri Rappsilber
Use of a heterobifunctional photoactivatable cross-linker, sulfo-SDA (diazirine), has yielded high-density data that facilitated structure modelling of individual proteins. We expand the photoactivatable chemistry toolbox here with a second reagent, sulfo-SBP (benzophenone). This further increases the density of photo-cross-linking to a factor of 20x over conventional cross-linking. Importantly, the two different photoactivatable groups display orthogonal directionality, enabling access to different protein regions, unreachable with a single cross-linker...
April 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28430150/synthesis-and-self-assembly-of-shape-amphiphiles-based-on-poss-dendron-conjugates
#13
Yu Shao, Minyuan Ding, Yujie Xu, Fangjia Zhao, Hui Dai, Xia-Ran Miao, Shuguang Yang, Hui Li
Shape has been increasingly recognized as an important factor for self-assembly. In this paper, a series of shape amphiphiles have been built by linking polyhedral oligomeric silsesquioxane (POSS) and a dendron via linkers of different lengths. Three conjugates of octahedral silsesquioxanes (T₈-POSS) and dendron are designed and synthesized and are referred to as isobutyl T₈-POSS gallic acid derivatives (BPOSS-GAD-1, BPOSS-GAD-2, BPOSS-GAD-3). These samples have been fully characterized by ¹H-NMR, (13)C-NMR, Fourier transform infrared (FT-IR) spectroscopy and matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry to establish their chemical identity and purity...
April 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28429317/biochemistry-and-physiology-of-reactive-oxygen-species-in-euglena
#14
Takahiro Ishikawa, Shun Tamaki, Takanori Maruta, Shigeru Shigeoka
Reactive oxygen species (ROS) such as superoxide and hydrogen peroxide are by-products of various metabolic processes in aerobic organisms including Euglena. Chloroplasts and mitochondria are the main sites of ROS generation by photosynthesis and respiration, respectively, through the active electron transport chain. An efficient antioxidant network is required to maintain intracellular ROS pools at optimal conditions for redox homeostasis. A comparison with the networks of plants and animals revealed that Euglena has acquired some aspects of ROS metabolic process...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28428318/bottom-up-construction-of-a-superstructure-in-a-porous-uranium-organic-crystal
#15
Peng Li, Nicolaas A Vermeulen, Christos D Malliakas, Diego A Gómez-Gualdrón, Ashlee J Howarth, B Layla Mehdi, Alice Dohnalkova, Nigel D Browning, Michael O'Keeffe, Omar K Farha
Bottom-up construction of highly intricate structures from simple building blocks remains one of the most difficult challenges in chemistry. Here, we report a structurally complex, mesoporous uranium-based metal-organic framework (MOF) made from simple starting components. The structure is comprised of 10 uranium nodes and 7 tricarboxylate ligands (both crystallographically non-equivalent); resulting in a 173.3 angstrom cubic unit cell enclosing 816 uranium nodes and 816 organic linkers-the largest unit cell found for any nonbiological material...
April 20, 2017: Science
https://www.readbyqxmd.com/read/28428270/mutations-in-the-adaptor-binding-domain-and-associated-linker-region-of-p110%C3%AE-cause-activated-pi3k-%C3%AE-syndrome-1-apds1
#16
Lucie Heurtier, Hicham Lamrini, Loïc Chentout, Marie-Céline Deau, Amine Bouafia, Jérémie Rosain, Jean-Marc Plaza, Mélanie Parisot, Benoit Dumont, Delphine Turpin, Etienne Merlin, Despina Moshous, Nathalie Aladjidi, Bénédicte Neven, Capucine Picard, Marina Cavazzana, Alain Fischer, Anne Durandy, Jean-Louis Stephan, Sven Kracker
No abstract text is available yet for this article.
April 20, 2017: Haematologica
https://www.readbyqxmd.com/read/28428255/nucleosome-nucleosome-interactions-via-histone-tails-and-linker-dna-regulate-nuclear-rigidity
#17
Yuta Shimamoto, Sachiko Tamura, Hiroshi Masumoto, Kazuhiro Maeshima
Cells, as well as the nuclei inside them, experience significant mechanical stress in diverse biological processes including contraction, migration, and adhesion. The structural stability of nuclei must therefore be maintained in order to protect genome integrity. Despite extensive knowledge on nuclear architecture and components, however, the underlying physical and molecular mechanisms remain largely unknown. We addressed this in the present study by subjecting isolated human cell nuclei to microneedle-based quantitative micromanipulation with a series of biochemical perturbations of the chromatin...
April 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28427662/ultrasonic-assisted-synthesis-of-a-tetrazine-functionalized-mof-and-its-application-in-colorimetric-detection-of-phenylhydrazine
#18
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Ali Morsali
TMU-34(-2H), [Zn(OBA)(DPT)0.5].DMF, has been sonochemically synthesized by applying H2OBA, (4,4'-oxybis(benzoic acid)), as the dicarboxylate linker, and DPT, (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), as pillar spacer. Sonication time, concentration of initial reagents, sonication power and molar ratio of pyridine as modulator has been optimized to synthesize nano powder of TMU-34(-2H) including uniform plate morphology. Nano TMU-34(-2H), can detect phenylhydrazine (PH) by color changing from pink to deep purple...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427269/spatially-selective-binding-of-green-fluorescent-protein-on-designed-organosilane-nanopatterns-prepared-with-particle-lithography
#19
Zachary L Highland, Jayne C Garno
A practical approach for preparing protein nanopatterns has been to design surface templates of nanopatterns of alkanethiols or organosilanes that will selectively bind and localize the placement of biomolecules. Particle lithography provides a way to prepare millions of protein nanopatterns with a few basic steps. For our nanopatterning strategy, organosilanes with methoxy and sulfhydryl groups were chosen as a surface template. Green fluorescent protein (GFP) was selected as a model for patterning. Areas of 2-[methoxy (polyethyleneoxy)6-9propyl]trichlorosilane (MPT-silane) are effective as a matrix for resisting the attachment of proteins, whereas nanopatterns with sulfur groups provide reactive sites for binding linker groups to connect proteins...
April 19, 2017: Biointerphases
https://www.readbyqxmd.com/read/28426820/the-influence-of-cell-membrane-and-snap25-linker-loop-on-the-dynamics-and-unzipping-of-snare-complex
#20
Yi Shi, Yong Zhang, Jizhong Lou
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is composed of three neuronal proteins VAMP2, Syntaxin and SNAP25, which plays a core role during the process of membrane fusion. The zipping assembly of the SNARE complex releases energies and drives the vesicle and cell membrane into close proximity. In this study, we use all-atom molecular dynamics simulations to probe the dynamics of SNARE and its unzipping process in the context of membrane at the atomistic details...
2017: PloS One
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