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study of development of persistant gestational trophoblastic disease in H mole patient

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https://www.readbyqxmd.com/read/16085294/the-curative-effect-of-a-second-curettage-in-persistent-trophoblastic-disease-a-retrospective-cohort-survey
#1
Nienke E van Trommel, Leon F A G Massuger, René H M Verheijen, Fred C G J Sweep, Chris M G Thomas
OBJECTIVE: To assess the curative effect of a second curettage in patients with low-risk Persistent Trophoblastic Disease (PTD) after molar pregnancy. METHODS: A retrospective cohort survey was performed on 2122 patients registered with the Dutch Central Registry for Hydatidiform Moles between 1987 and 2003. Of these, 422 patients developed PTD. For various reasons, 128 patients were excluded. The study group comprised 85 patients with, according to the Dutch guidelines, low-risk PTD who underwent a second therapeutic curettage as a part of the treatment for PTD...
October 2005: Gynecologic Oncology
https://www.readbyqxmd.com/read/15768863/molar-gestations-and-hydropic-abortions-differentiated-by-p57-immunostaining
#2
Rita L Romaguera, Maria M Rodriguez, Jocelyn H Bruce, Tania Zuluaga, Ana Viciana, Manuel A Penalver, Nadji Mehrdad
Classification of molar gestations into complete and partial and their differentiation from hydropic abortions traditionally are accomplished by morphology alone. The process sometimes may be inaccurate or inconclusive. With the availability of p57 immunostaining it may be possible to objectively classify these lesions. We used p57 for the differential diagnosis of hydropic abortions and molar gestations and correlated the findings with the clinical outcome of patients in each category. First, 86 cases were originally classified by histomorphology into hydropic abortion (42) and molar gestations (23 complete and 21partial)...
March 2004: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/15361212/is-normal-beta-hcg-regression-curve-helpful-in-the-diagnosis-of-persistent-trophoblastic-disease
#3
N Behtash, F Ghaemmaghami, H Honar, K Riazi, A Nori, M Modares, A Mousavi
OBJECTIVE: The aim of this study was to evaluate the probable usefulness of normal beta-human chorionic gonadotropin (beta-hCG) regression curve in the diagnosis of persistent trophoblastic disease (PTD). METHODS: A log-value regression curve was developed from the means and 95% confidence limits of serial weekly serum beta-hCG titers of 43 patients with uneventful complete hydatidiform moles and 14 patients, who were previously confirmed as PTD. RESULTS: All 14 PTD patients (100%) had abnormal values, beyond normal range, within 4 weeks...
September 2004: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/15195503/the-prognostic-value-of-serum-inhibin-17-beta-estradiol-and-progesterone-in-cases-of-hydatidiform-mole
#4
H M Hegab, A E Schindler
The purpose of this study was to provide a diagnostic and a prognostic variable that could easily be measured in the laboratory, and that would predict the need for future therapy of persistent gestational trophoblastic disease. There would no longer be a need to treat all cases of hydatidiform mole prophylactically, to improve the outcome in only about 20% predicted to develop malignant gestational trophoblastic tumors. Circulating beta-human chorionic gonadotropin (beta-hCG), progesterone, 17 beta-estradiol and inhibin levels were measured using standard radioimmunoassays in 60 patients with complete hydatidiform mole and in 20 normal pregnant women of a corresponding duration of pregnancy and having a maternal indication for therapeutic abortion...
February 2004: Gynecological Endocrinology
https://www.readbyqxmd.com/read/11739009/human-chorionic-gonadotropin-hcg-beta-core-fragment-is-produced-by-degradation-of-hcg-or-free-hcg-beta-in-gestational-trophoblastic-tumors-a-possible-marker-for-early-detection-of-persistent-postmolar-gestational-trophoblastic-disease
#5
T Okamoto, K Matsuo, R Niu, M Osawa, H Suzuki
The present study was undertaken to investigate whether human chorionic gonadotropin (hCG) beta-core fragment (hCG beta cf) was directly produced by gestational trophoblastic tumors. Immunoreactivity of hCG beta cf was demonstrated in the extracts as well as in the culture media of hydatidiform mole tissues. It was also present in the extracts of choriocarcinoma tissues, and its molar concentration exceeded that of intact hCG. The presence of hCG beta cf was then confirmed by gel chromatography and Western blot analysis...
December 2001: Journal of Endocrinology
https://www.readbyqxmd.com/read/11286568/twin-pregnancy-consisting-of-46-xy-heterozygous-complete-mole-coexisting-with-a-live-fetus
#6
Y Kashimura, M Tanaka, N Harada, M Shinmoto, T Morishita, H Morishita, M Kashimura
Complete hydatidiform mole and coexistent fetus (CMCF) is a rare occurrence and is associated with an increased risk of persistent gestational trophoblastic diseases. The aim of this study was to reveal a potential risk factor and to determine optimum management of CMCF cases. Molar tissues are cytogenetically divided into two types, homozygous and heterozygous. The molar tissue of our case showed a 46, XY heterozygous complete mole. Genomic DNA was analyzed by the polymerase chain reaction using sets of unlabelled forward and Cy-5-labelled reverse primers for DNA marker loci...
April 2001: Placenta
https://www.readbyqxmd.com/read/9602692/p21waf1-cip1-expression-in-gestational-trophoblastic-disease-correlation-with-clinicopathological-parameters-and-ki67-and-p53-gene-expression
#7
A N Cheung, D H Shen, U S Khoo, L C Wong, H Y Ngan
BACKGROUND: The p21WAF1/CIP1 gene mediates growth arrest by inhibiting G1 cyclin dependent kinases and has been considered as a downstream effector of the tumour suppressor gene p53. AIM: To analyse the role of p21WAF1/CIP1 in gestational trophoblastic disease. METHODS: The immunohistochemical expression of p21WAF1/CIP1 gene was measured in 33 placentas, 28 partial hydatidiform moles, 54 complete hydatidiform moles, and 13 choriocarcinomas in paraffin wax embedded tissue...
February 1998: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/8102616/the-significance-of-proliferating-cell-nuclear-antigen-in-human-trophoblastic-disease-an-immunohistochemical-study
#8
A N Cheung, H Y Ngan, W Z Chen, S L Loke, R J Collins
The expression of proliferating cell nuclear antigen (PCNA) in human trophoblastic disease was assessed immunohistochemically in tissue from 29 spontaneous abortions, 33 partial moles, 40 complete moles and 23 choriocarcinomas using the monoclonal antibody PC10. PCNA immunoreactivity occurred predominantly in the cytotrophoblasts in each of the four types of tissues. Quantitative analysis showed that the choriocarcinoma group gave a statistically significant higher PCNA index than the other three. There was no significant difference between the groups of spontaneous abortion, partial or complete mole...
June 1993: Histopathology
https://www.readbyqxmd.com/read/8089214/assessment-of-cell-proliferation-in-hydatidiform-mole-using-monoclonal-antibody-mib1-to-ki-67-antigen
#9
COMPARATIVE STUDY
A N Cheung, H Y Ngan, R J Collins, Y L Wong
AIMS: To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole. METHODS: Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIB1. RESULTS: Ki67 immunoreactivity was significantly higher in the tissue from normal first trimester placentas than in that from normal term placentas and spontaneous abortions...
July 1994: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/7835778/detection-of-heterozygous-xy-complete-hydatidiform-mole-by-chromosome-in-situ-hybridization
#10
A N Cheung, A S Sit, L P Chung, H Y Ngan, K O'Hanlan, L C Wong, H K Ma
Complete hydatidiform mole has a substantial risk of developing persistent gestational trophoblastic disease (PTD). Whether heterozygous complete moles, arising from dispermy, have a higher risk of such progression than their homozygous counterparts is controversial. In this study, the frequency of heterozygous XY complete mole in 93 consecutive cases of histologically proven complete moles managed in Hong Kong was assessed by the technique of chromosome in situ hybridization (CISH) using DNA probes specific for the short arm of the Y chromosome...
December 1994: Gynecologic Oncology
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