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macrophagy autophagy

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https://www.readbyqxmd.com/read/24561860/cardiomyocyte-glycophagy-is-regulated-by-insulin-and-exposure-to-high-extracellular-glucose
#1
Kimberley M Mellor, Upasna Varma, David I Stapleton, Lea M D Delbridge
Disturbed systemic glycemic and insulinemic status elicits cardiomyocyte metabolic stress and altered glucose handling. In diabetes, pathological myocardial glycogen accumulation occurs. Recently, evidence of a specific myocardial autophagic degradation pathway for glycogen ("glycophagy") has been reported, differentiated from the more well-characterized protein "macrophagy" pathway. The goal of this study was to identify potential mechanisms involved in cardiac glycogen accumulation, glycophagy, and macrophagy regulation using cultured neonatal rat ventricular myocytes (NRVMs)...
April 15, 2014: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/22509855/3-nitropropionic-acid-induces-autophagy-by-forming-mitochondrial-permeability-transition-pores-rather-than-activating-the-mitochondrial-fission-pathway
#2
Maria E Solesio, Sara Saez-Atienzar, Joaquin Jordan, Maria F Galindo
BACKGROUND AND PURPOSE: Huntington's disease is a neurodegenerative process associated with mitochondrial alterations. Inhibitors of the electron-transport channel complex II, such as 3-nitropropionic acid (3NP), are used to study the molecular and cellular pathways involved in this disease. We studied the effect of 3NP on mitochondrial morphology and its involvement in macrophagy. EXPERIMENTAL APPROACH: Pharmacological and biochemical methods were used to characterize the effects of 3NP on autophagy and mitochondrial morphology...
January 2013: British Journal of Pharmacology
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