Asami Nishikawa, Isao Ito, Atsushi Yonezawa, Kotaro Itohara, Takeshi Matsubara, Yuki Sato, Katsuyuki Matsumura, Satoshi Hamada, Naoya Tanabe, Shinichi Kai, Eishi Imoto, Kohei Yoshikawa, Shigeru Ohtsuru, Motoko Yanagita, Toyohiro Hirai, Tomohiro Terada
Remdesivir plays a key role in the treatment of coronavirus disease in 2019 (COVID-19). Haemodialysis is sometimes required for hospitalised patients with COVID-19, and patients undergoing haemodialysis are at an increased risk of severe COVID-19. In the present study, we report the serum concentrations of GS-441524, the active metabolite of remdesivir, in four patients undergoing continuous renal replacement therapy (CRRT). Patient 1, a male aged 70s, received a loading dose of 200 mg remdesivir on day 1, followed by 100 mg remdesivir from day 2, according to the package insert as in non-haemodialysis patients...
October 20, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy