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Idiopathic interstitial pneumonia

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https://www.readbyqxmd.com/read/29693298/prognostic-factors-and-disease-behaviour-of-pathologically-proven-fibrotic-non-specific-interstitial-pneumonia
#1
Hideaki Yamakawa, Hideya Kitamura, Tamiko Takemura, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Tae Iwasawa, Eri Hagiwara, Shinji Sato, Takashi Ogura
BACKGROUND AND OBJECTIVE: Non-specific interstitial pneumonia (NSIP) has heterogeneous characteristics in terms of background, disease behaviour and prognosis. This study of fibrotic NSIP (f-NSIP) aimed to elucidate prognosis and disease behaviour from the viewpoint of clinical background and determine whether long-term change of pulmonary function could provide useful prognostic information. METHODS: We analysed the medical records of 157 consecutive patients diagnosed with f-NSIP by surgical lung biopsy...
April 24, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29667101/clinical-features-risk-factors-and-outcomes-of-patients-with-interstitial-pneumonia-with-autoimmune-features-a-population-based-study
#2
Jinghong Dai, Lei Wang, Xin Yan, Hui Li, Kefeng Zhou, Jian He, Fanqing Meng, Siyi Xu, Geyu Liang, Hourong Cai
To investigate the clinical features, risk factors and outcomes of patients with interstitial pneumonia with autoimmune features (IPAF). A total of 1429 patients with idiopathic interstitial pneumonia (IIP) and undifferentiated connective tissue disease-associated interstitial lung disease (UCTD-ILD) were screened to identify patients who met IPAF criteria. Clinical, serological, and morphological features of patients with IPAF were characterized. Outcomes between patients with IPAF, UCTD-ILD, and IIP who were divided into idiopathic pulmonary fibrosis (IPF) and non-IPF groups were compared using survival as an endpoint...
April 18, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29642520/melatonin-protects-against-lung-fibrosis-by-regulating-the-hippo-yap-pathway
#3
Xiaoguang Zhao, Jian Sun, Wei Su, Huitong Shan, Bowen Zhang, Yining Wang, Azaliia Shabanova, Hongli Shan, Haihai Liang
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial pneumonia with high mortality. Melatonin, a hormone predominantly secreted by the pineal gland, has been reported to participate in the process of IPF. However, the mechanisms underlying the effect of melatonin in pulmonary fibrosis have not been elucidated to date. This study was designed to evaluate the anti-fibrotic role of melatonin in pulmonary fibrosis and to elucidate the potential mechanisms. We observed that melatonin markedly attenuated bleomycin (BLM)-induced experimental lung fibrosis in mice and inhibited TGF-β1-induced fibrogenesis in lung fibroblasts...
April 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29607151/lung-cancer-in-connective-tissue-disease-associated-interstitial-lung-disease-clinical-features-and-impact-on-outcomes
#4
Satoshi Watanabe, Keigo Saeki, Yuko Waseda, Akari Murata, Hazuki Takato, Yukari Ichikawa, Masahide Yasui, Hideharu Kimura, Yasuhito Hamaguchi, Takashi Matsushita, Kazunori Yamada, Mitsuhiro Kawano, Kengo Furuichi, Takashi Wada, Kazuo Kasahara
Backgrounds: Lung cancer (LC) adversely impacts survival in patients with idiopathic pulmonary fibrosis. However, little is known about LC in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). The aim of this study was to evaluate the prevalence of and risk factors for LC in CTD-ILD, and the clinical characteristics and survival of CTD-ILD patients with LC. Methods: We conducted a single-center, retrospective review of patients with CTD-ILD from 2003 to 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606857/the-reliability-of-lung-ultrasound-in-assessment-of-idiopathic-pulmonary-fibrosis
#5
REVIEW
Diana Manolescu, Lavinia Davidescu, Daniel Traila, Cristian Oancea, Voicu Tudorache
Idiopathic pulmonary fibrosis (IPF) is the severest form of idiopathic interstitial pneumonia, with a median survival time estimated at 2-5 years from the time of diagnosis. It occurs mainly in elderly adults, suggesting a strong link between the fibrosis process and aging. Although chest high-resolution computed tomography (HRCT) is currently the method of choice in IPF assessment, diagnostic imaging with typical usual interstitial pneumonia (UIP) provides definitive results in only 55%, requiring an invasive surgical procedure such as lung biopsy or cryobiopsy for the final diagnostic analysis...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29605213/interstitial-lung-abnormality-is-prevalent-and-associated-with-worse-outcome-in-patients-undergoing-transcatheter-aortic-valve-replacement
#6
Michael Kadoch, Aleksandar Kitich, Shehabaldin Alqalyoobi, Elyse Lafond, Elena Foster, Maya Juarez, Cesar Mendez, Thomas W Smith, Garrett Wong, Walter D Boyd, Jeffrey Southard, Justin M Oldham
BACKGROUND: Interstitial lung abnormality (ILA) is found in 5-10% of the general population and is associated with increased mortality risk. Risk factors for ILA, including advanced age and smoking history also increase the risk for aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) has become an increasingly utilized intervention for patients with severe AS, and requires a high-resolution computed tomography (HRCT) of the chest to assess aortic valve dimensions. OBJECTIVES: To determine the prevalence and clinical significance of ILA on HRCT performed in patients referred for TAVR...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29605201/distinctive-characteristics-and-prognostic-significance-of-interstitial-pneumonia-with-autoimmune-features-in-patients-with-chronic-fibrosing-interstitial-pneumonia
#7
Katsuhiro Yoshimura, Masato Kono, Yasunori Enomoto, Koji Nishimoto, Yoshiyuki Oyama, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hiromitsu Sumikawa, Takeshi Johkoh, Thomas V Colby, Haruhiko Sugimura, Takafumi Suda
BACKGROUND: Interstitial lung diseases are heterogeneous, and patients with chronic fibrosing interstitial pneumonia (CFIP) often have clinical, serologic, and morphologic features suggestive but not diagnostic of connective tissue disease. Recently, the concept of interstitial pneumonia with autoimmune features (IPAF) has been proposed as a platform for such patients. However, the prognostic role of IPAF, including the cumulative incidence of acute exacerbations (AEs), is not fully clear...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29604596/submicron-emulsion-of-cinnamaldehyde-ameliorates-bleomycin-induced-idiopathic-pulmonary-fibrosis-via-inhibition-of-inflammation-oxidative-stress-and-epithelial-mesenchymal-transition
#8
Li Yan, Fan Song, Hua Li, Yao Li, Jie Li, Qiao-Yan He, Di Zhang, Fang Wang, Meng Zhang, Hang Zhao, Tian Feng, Ying-Yong Zhao, Si-Wang Wang
AIMS: Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. The pathogenesis is associated with inflammation and oxidative stress and epithelial-mesenchymal transition (EMT). Cinnamaldehyde exhibits antiinflammatory and antioxidant properties, but its effect on IPF is unknown. The present study is to investigate the anti-fibrotic effect and action mechanism of cinnamaldehyde on IPF. MATERIALS AND METHODS: IPF was induced by intratracheal bleomycin in mice...
March 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29600055/clarithromycin-mitigates-radiation-pneumonitis-in-patients-with-lung-cancer-treated-with-stereotactic-body-radiotherapy
#9
Atsuya Takeda, Yuichiro Tsurugai, Naoko Sanuki, Tatsuji Enomoto, Masaharu Shinkai, Tomikazu Mizuno, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Yu Hara, Etsuo Kunieda
Background: Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and are used to treat respiratory inflammatory diseases. Radiation pneumonitis has similar pathology to them. Adverse reactions to macrolides are few and self-limited. We thus administered CAM to patients with high-risk factors for radiation pneumonitis, and retrospectively investigated whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29590152/clinical-spectrum-and-prognostic-factors-of-possible-uip-pattern-on-high-resolution-ct-in-patients-who-underwent-surgical-lung-biopsy
#10
Yasuhiro Kondoh, Hiroyuki Taniguchi, Kensuke Kataoka, Taiki Furukawa, Ayumi Shintani, Tomoyuki Fujisawa, Takafumi Suda, Machiko Arita, Tomohisa Baba, Kazuya Ichikado, Yoshikazu Inoue, Kazuma Kishi, Tomoo Kishaba, Osamu Nishiyama, Takashi Ogura, Keisuke Tomii, Sakae Homma
BACKGROUND: Few studies have reported the diagnostic variability in patients with a possible usual interstitial pneumonia (UIP) pattern on high-resolution CT (HRCT) who underwent surgical lung biopsy (SLB), and the prognostic factors for these patients have not been fully evaluated. We retrospectively investigated the frequency of idiopathic pulmonary fibrosis (IPF) and prognostic factors in patients with possible UIP pattern on HRCT. METHODS: Consecutive patients who had a possible UIP pattern on HRCT, underwent SLB, and had a diagnosis of IIPs before SLB were retrospectively recruited from 10 hospitals...
2018: PloS One
https://www.readbyqxmd.com/read/29587761/evaluation-of-oxidative-stress-biomarkers-in-idiopathic-pulmonary-fibrosis-and-therapeutic-applications-a-systematic-review
#11
REVIEW
Alessandro G Fois, Panagiotis Paliogiannis, Salvatore Sotgia, Arduino A Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is characterized by chronic and progressive fibrosing interstitial pneumonia which progressively impairs lung function. Oxidative stress is one of the main pathogenic pathways in IPF. The aim of this systematic review was to describe the type of markers of oxidative stress identified in different biological specimens and the effects of antioxidant therapies in patients with IPF. METHODS: We conducted a systematic search of publications listed in electronic databases (Pubmed, Web of Science, Scopus and Google Scholar) from inception to October 2017...
March 27, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29548309/acantholytic-squamous-cell-carcinoma-of-the-lung-with-marked-lymphogenous-metastases-and-high-titers-of-myeloperoxidase-antineutrophil-cytoplasmic-antibodies-a-case-report
#12
Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito
BACKGROUND: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. CASE PRESENTATION: We report the clinical and autopsy findings of a 71-year-old Japanese man with pulmonary ASQCC...
March 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29543042/nintedanib-reduces-pulmonary-fibrosis-in-a-model-of-rheumatoid-arthritis-associated-interstitial-lung-disease
#13
Elizabeth F Redente, Martin A Aguilar, Bart P Black, Benjamin Edelman, Ali Bahadur, Stephen M Humphries, David A Lynch, Lutz Wollin, David W H Riches
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) develops in approximately 20% of patients with RA. SKG mice, which are genetically prone to developing autoimmune arthritis, develop a pulmonary interstitial pneumonia that resembles human cellular and fibrotic non-specific interstitial pneumonia. Nintedanib, a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis, has been shown to reduce lung function decline. Therefore, we investigated the effect of nintedanib on the development of pulmonary fibrosis and joint disease in female SKG mice with arthritis induced by intraperitoneal injection of zymosan (5 mg)...
March 15, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29538081/pharmacogenetic-variants-and-vitamin-k-deficiency-a-risk-factor-or-trigger-for-fibrosing-interstitial-pneumonias
#14
Marjolein Drent, Petal Wijnen, Aalt Bast
PURPOSE OF REVIEW: Fibrosing interstitial pneumonias are associated with various stages of fibrosis. The cause of this group of syndromes remains largely unknown. For most of these diseases, a genetic basis, environmental factors and certain triggers have been suggested as possible risk factors. Various studies have found an association between genetic polymorphisms, or the presence of certain variant alleles, and the occurrence and/or progression of interstitial pneumonias of unknown origin...
March 13, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29532165/prevalence-of-myositis-specific-antibodies-in-idiopathic-interstitial-pneumonias
#15
Laurens J De Sadeleer, Ellen De Langhe, Nicolas Bodart, Alain Vigneron, Xavier Bossuyt, Wim A Wuyts
Although included in the serological domain of the 'interstitial pneumonia with auto-immune features' (IPAF) research statement, the search for myositis-specific antibodies (MSA) is not incorporated in routine clinical practice. The objective of the study was to evaluate MSA prevalence in an idiopathic interstitial pneumonia (IIP) cohort (n = 68) with suggestive morphological interstitial lung disease patterns. Twelve of 68 patients (17.6%) carried MSA, whereof only two were anti-nuclear antibody-positive...
March 12, 2018: Lung
https://www.readbyqxmd.com/read/29523572/prognostic-significance-of-autoantibodies-for-idiopathic-pulmonary-fibrosis-protocol-for-a-systematic-review
#16
Hiroyuki Kamiya, Ogee Mer Panlaqui
INTRODUCTION: Idiopathic pulmonary fibrosis(IPF) is chronic fibrosing interstitial pneumonia of unknown aetiology. IPF is diagnosed based on the exclusion of known causes such as connective tissue diseases(CTDs). However, some patients fail to meet defined CTD criteria regardless of an implication of immunological involvement and these cases were described in a variety of terms. The classification criteria of this clinical entity consist of a combination of clinical, serological and morphological findings and it is reported to be distinct from IPF...
March 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29514162/design-rationale-methodology-and-aims-of-a-greek-prospective-idiopathic-pulmonary-fibrosis-registry-investigating-idiopathic-pulmonary-fibrosis-in-greece-indulge-ipf
#17
Demosthenes Bouros, Zoe Daniil, Despoina Papakosta, Katerina M Antoniou, Katerina Markopoulou, Likurgos Kolilekas, George Konstantopoulos, Spyros Papiris
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrosing interstitial pneumonia of unknown origin. Despite the fact that the guidelines on the diagnosis and management of the disease were updated in 2015, incorporating novel agents recently introduced in the therapeutic approach of IPF, there is a lack of data on the epidemiology, disease status, and treatment in clinical practice. Contemporary data provided by national registries in IPF provide valuable information to guide clinical management of the disease in the real-world setting, adjusted to the local needs...
March 7, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29507864/distinct-profiles-of-cd163-positive-macrophages-in-idiopathic-interstitial-pneumonias
#18
Masahiro Yamashita, Ryoko Saito, Shinji Yasuhira, Yuh Fukuda, Hironobu Sasamo, Tamotsu Sugai, Kohei Yamauchi, Makoto Maemondo
Background: The types of cells most significantly linked to individual subtypes of idiopathic interstitial pneumonias (IIPs) remain unclear. Few studies have examined CD163+ macrophages in IIPs. Objective: We retrospectively aimed to immunohistochemically characterize the CD163+ macrophages in IIPs. Methods: Paraffin-embedded lung tissue samples were obtained from 47 patients with IIPs, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), and cryptogenic organizing pneumonia (COP), and 12 normal controls were immunohistochemically analyzed, using primary antibodies against CD68 and CD163 as indicators of pan and M2 macrophages, respectively...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29501253/clinical-significance-of-respiratory-virus-detection-in-patients-with-acute-exacerbation-of-interstitial-lung-diseases
#19
Takeshi Saraya, Hirokazu Kimura, Daisuke Kurai, Masaki Tamura, Yukari Ogawa, Sunao Mikura, Mitsuru Sada, Miku Oda, Takayasu Watanabe, Kosuke Ohkuma, Manami Inoue, Kojiro Honda, Masato Watanabe, Takuma Yokoyama, Masachika Fujiwara, Haruyuki Ishii, Hajime Takizawa
BACKGROUND: The impact of viral infections on acute exacerbations in idiopathic pulmonary fibrosis (IPF) and/or non-IPF interstitial lung disease (ILDs) has been scarcely described. OBJECTIVES: To elucidate the frequency of virus infections in patients with IPF or non-IPF ILDs including idiopathic interstitial pneumonia (IIP) or connective tissue disease (CTD)-associated pneumonia, and its influence on their short-term mortality. METHODS: We prospectively enrolled adult patients with acute exacerbation of IPF and non-IPF ILDs who were admitted to the hospital during the last 3 years, and examined the respiratory samples obtained from nasopharyngeal, sputum, and bronchoalveolar lavage fluid...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29486761/impaired-diversity-of-the-lung-microbiome-predicts-progression-of-idiopathic-pulmonary-fibrosis
#20
Youhei Takahashi, Atsushi Saito, Hirofumi Chiba, Koji Kuronuma, Kimiyuki Ikeda, Tomofumi Kobayashi, Shigeru Ariki, Motoko Takahashi, Yasushi Sasaki, Hiroki Takahashi
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathic interstitial pneumonias. Although IPF has not been thought to be associated with bacterial communities, recent papers reported the possible role of microbiome composition in IPF. The roles of microbiomes in respiratory functions and as clinical biomarkers for IPF remain unknown. In this study, we aim to identify the relationship between the microbial environment in the lung and clinical findings...
February 27, 2018: Respiratory Research
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