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Ryan madder

Ryan D Madder
No abstract text is available yet for this article.
October 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Sibin K Zacharias, Robert D Safian, Ryan D Madder, Ivan D Hanson, Mark C Pica, James L Smith, James A Goldstein, Amr E Abbas
The purpose of this study is to characterize the plaque morphology of severe stenoses in the superficial femoral artery (SFA) employing combined near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS). Atherosclerosis is the most common cause of symptomatic peripheral arterial disease. Plaque composition of SFA stenoses has been characterized as primarily fibrous or fibrocalcific by non-invasive and autopsy studies. NIRS has been validated to detect lipid-core plaque (LCP) in the coronary circulation...
August 2016: Vascular Medicine
Ryan D Madder, Rishi Puri, James E Muller, Jan Harnek, Matthias Götberg, Stacie VanOosterhout, Margaret Chi, David Wohns, Richard McNamara, Kathy Wolski, Sean Madden, Samuel Sidharta, Jordan Andrews, Stephen J Nicholls, David Erlinge
OBJECTIVE: In a previous exploratory analysis, intracoronary near-infrared spectroscopy (NIRS) found the majority of culprit lesions in ST-segment-elevation myocardial infarction (STEMI) to contain a maximum lipid core burden index in 4 mm (maxLCBI4mm) of >400. This initial study was limited by a small sample size, enrollment at a single center, and post hoc selection of the maxLCBI4mm ≥400 threshold. This study was designed a priori to substantiate the ability of NIRS to discriminate STEMI culprit from nonculprit segments and to confirm the performance of the maxLCBI4mm ≥400 threshold...
May 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Ryan D Madder, Mustafa Husaini, Alan T Davis, Stacie VanOosterhout, Mohsin Khan, David Wohns, Richard F McNamara, Kevin Wolschleger, John Gribar, J Stewart Collins, Mark Jacoby, Jeffrey M Decker, Michael Hendricks, Stephen T Sum, Sean Madden, James H Ware, James E Muller
AIMS: A recent study demonstrated that intracoronary near-infrared spectroscopy (NIRS) findings in non-target vessels are associated with major adverse cardiovascular and cerebrovascular events (MACCE). It is unknown whether NIRS findings at non-stented sites in target vessels are similarly associated with future MACCE. This study evaluated the association between large lipid-rich plaques (LRP) detected by NIRS at non-stented sites in a target artery and subsequent MACCE. METHODS AND RESULTS: This study evaluated 121 consecutive registry patients undergoing NIRS imaging in a target artery...
April 2016: European Heart Journal Cardiovascular Imaging
Ryan D Madder, Mohsin Khan, Mustafa Husaini, Margaret Chi, Sarah Dionne, Stacie VanOosterhout, Andrew Borgman, J Stewart Collins, Mark Jacoby
BACKGROUND: Neoatherosclerosis is an emerging phenomenon in which lipid-rich plaques (LRPs) develop within pre-existing stents. This study was undertaken to describe near-infrared spectroscopy (NIRS) and intravascular ultrasound findings in pre-existing stents and to compare NIRS findings in pre-existing stents, in which an increased lipid signal has been speculated to indicate neoatherosclerosis, and NIRS findings in a control group of freshly implanted stents, in which any lipid signal originates from fibroatheroma under the stent...
January 2016: Circulation. Cardiovascular Imaging
Abhay N Bilolikar, James A Goldstein, Ryan D Madder, Kavitha M Chinnaiyan
AIMS: This study was designed to determine whether coronary CT angiography (CTA) can detect features of plaque disruption in clinically stable patients and to compare lesion prevalence and features between stable patients and those with acute coronary syndrome (ACS). METHODS: We retrospectively identified patients undergoing CTA, followed by invasive coronary angiography (ICA) within 60 days. Quantitative 3-vessel CTA lesion analysis was performed on all plaques ≥25% stenosis to assess total plaque volume, low attenuation plaque (LAP, <50 HU) volume, and remodelling index...
March 2016: European Heart Journal Cardiovascular Imaging
Rishi Puri, Ryan D Madder, Sean P Madden, Stephen T Sum, Kathy Wolski, James E Muller, Jordan Andrews, Karilane L King, Yu Kataoka, Kiyoko Uno, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen, Renu Virmani, Akiko Maehara, Gary S Mintz, Stephen J Nicholls
OBJECTIVES: Pathological studies demonstrate the dual significance of plaque burden (PB) and lipid composition for mediating coronary plaque vulnerability. We evaluated relationships between intravascular ultrasound (IVUS)-derived PB and arterial remodeling with near-infrared spectroscopy (NIRS)-derived lipid content in ex vivo and in vivo human coronary arteries. APPROACH AND RESULTS: Ex vivo coronary NIRS and IVUS imaging was performed through blood in 116 coronary arteries of 51 autopsied hearts, followed by 2-mm block sectioning (n=2070) and histological grading according to modified American Heart Association criteria...
November 2015: Arteriosclerosis, Thrombosis, and Vascular Biology
Ryan D Madder, Amr E Abbas, Robert D Safian
No abstract text is available yet for this article.
February 2015: JACC. Cardiovascular Interventions
Ryan D Madder, Mustafa Husaini, Alan T Davis, Stacie VanOosterhout, Jan Harnek, Matthias Götberg, David Erlinge
OBJECTIVE: This study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BACKGROUND: A recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm)) ≥ 400. Whether culprit lesions in non-STEMI and UA are characterized by a similarly large lipid burden is unknown. METHODS: We studied 81 non-STEMI and UA patients undergoing culprit vessel NIRS imaging before stenting...
November 15, 2015: Catheterization and Cardiovascular Interventions
David Erlinge, Jan Harnek, Isabel Gonçalves, Matthias Götberg, James E Muller, Ryan D Madder
AIMS: Intracoronary near-infrared spectroscopy (NIRS) in ST-segment elevation myocardial infarction (STEMI) has demonstrated substantial lipid in STEMI culprit plaques. Thrombus aspiration during primary PCI reduces distal embolization and improves reperfusion. This study was performed to examine if aspiration thrombectomy reduces the lipid content of acute coronary syndrome (ACS) culprit plaques. METHODS AND RESULTS: NIRS-IVUS imaging was performed in patients with an ACS at two hospitals in the US and Sweden...
March 2015: European Heart Journal Cardiovascular Imaging
Geoffrey M Crimmins, Ryan D Madder, Victor Marinescu, Robert D Safian
OBJECTIVES: The purpose of this study was to evaluate the validity of estimates of glomerular filtration rate (eGFR) for assessing serial changes in renal function after renal artery stenting. BACKGROUND: eGFR are unreliable for assessing serial renal function in patients with atherosclerotic renal artery stenosis (RAS). eGFR have not been validated for assessment of serial renal function after renal artery stenting. METHODS: Serum creatinine (SCr) and (125)I-iothalamate GFR (iGFR) were measured in RAS patients before and after renal artery stenting...
May 2014: JACC. Cardiovascular Interventions
John J Lopez, Salman A Arain, Ryan Madder, Niraj Parekh, Adhir R Shroff, Don Westerhausen
Optical coherence tomography (OCT) is a novel intracoronary imaging modality that utilizes near-infrared light to provide information regarding lesion length and severity, vessel lumen diameter, plaque morphology, as well as the opportunity for stent procedure guidance and follow-up. While analogous to intravascular ultrasound (IVUS), the specific imaging properties, including significantly higher resolution, and technical specifications of OCT offer the ability for intracoronary diagnostic and interventional procedure guidance roles that require a thorough understanding of the technology...
November 1, 2014: Catheterization and Cardiovascular Interventions
Ryan D Madder, David H Wohns, James E Muller
With an estimated 300,000 cases occurring per year in the United States alone, sudden cardiac death remains a major public health problem and in many cases is the first manifestation of coronary artery disease. Autopsy studies have established that the causative event in many cases of sudden death is rupture of an intracoronary lipid core plaque with subsequent thrombus formation. Until recently, identification of lipid core plaque in vivo has not been possible; however, a combined near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) catheter has become available that can detect lipid core plaque in patients undergoing coronary angiography...
February 2014: Journal of Invasive Cardiology
Ryan D Madder, James A Goldstein, Sean P Madden, Rishi Puri, Kathy Wolski, Michael Hendricks, Stephen T Sum, Annapoorna Kini, Samin Sharma, David Rizik, Emmanouil S Brilakis, Kendrick A Shunk, John Petersen, Giora Weisz, Renu Virmani, Stephen J Nicholls, Akiko Maehara, Gary S Mintz, Gregg W Stone, James E Muller
OBJECTIVES: This study sought to describe near-infrared spectroscopy (NIRS) findings of culprit lesions in ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Although autopsy studies demonstrate that most STEMI are caused by rupture of pre-existing lipid core plaque (LCP), it has not been possible to identify LCP in vivo. A novel intracoronary NIRS catheter has made it possible to detect LCP in patients. METHODS: We performed NIRS within the culprit vessels of 20 patients with acute STEMI and compared the STEMI culprit findings to findings in nonculprit segments of the artery and to findings in autopsy control segments...
August 2013: JACC. Cardiovascular Interventions
Ryan Whitford, Ana Fernandez, Ricardo Tejos, Amparo Cuéllar Pérez, Jürgen Kleine-Vehn, Steffen Vanneste, Andrzej Drozdzecki, Johannes Leitner, Lindy Abas, Maarten Aerts, Kurt Hoogewijs, Pawel Baster, Ruth De Groodt, Yao-Cheng Lin, Véronique Storme, Yves Van de Peer, Tom Beeckman, Annemieke Madder, Bart Devreese, Christian Luschnig, Jiří Friml, Pierre Hilson
Growth and development are coordinated by an array of intercellular communications. Known plant signaling molecules include phytohormones and hormone peptides. Although both classes can be implicated in the same developmental processes, little is known about the interplay between phytohormone action and peptide signaling within the cellular microenvironment. We show that genes coding for small secretory peptides, designated GOLVEN (GLV), modulate the distribution of the phytohormone auxin. The deregulation of the GLV function impairs the formation of auxin gradients and alters the reorientation of shoots and roots after a gravity stimulus...
March 13, 2012: Developmental Cell
Jeffrey M Decker, Ryan D Madder, Leaden Hickman, Victor Marinescu, Anna Marandici, Shaheena Raheem, Lynn M Carlyle, Richard Van Dam, Judith A Boura, David E Haines
OBJECTIVE: The goals of this study were to determine: 1) if the CHADS(2) score correlates with left atrial (LA) or left atrial appendage (LAA) thrombus on pre-cardioversion transesophageal echocardiography (TEE) in nonvalvular atrial fibrillation (NVAF); and 2) what, if any, components of the CHADS(2) score are most important in predicting LA/LAA thrombus. BACKGROUND: It is unknown if CHADS(2) score, a marker of thromboembolic risk in NVAF, accurately predicts LA/LAA thrombus on pre-cardioversion TEE...
2011: American Journal of Cardiovascular Disease
Ryan D Madder, James L Smith, Simon R Dixon, James A Goldstein
BACKGROUND: Whereas acute coronary syndromes (ACS) typically develop from the rupture of lipid core plaque (LCP), lesions causing stable angina are believed to be composed of fibrocalcific plaque. In this study, intracoronary near-infrared spectroscopy (NIRS) was used to determine the frequency of LCP at target and remote sites in patients with ACS versus those with stable angina. METHODS AND RESULTS: The study was performed in patients having ≥1 target lesion identified by invasive angiography who also underwent NIRS before intervention...
February 1, 2012: Circulation. Cardiovascular Interventions
Ryan D Madder, Daniel H Steinberg, R David Anderson
Recent studies emphasize the importance of direct intracoronary imaging techniques that provide insights regarding not only lesion architecture but also plaque composition, particularly the presence or absence of lipid-core plaque (LCP). Intracoronary near-infrared spectroscopy (NIRS) is the only validated FDA approved device for in vivo detection of LCP. A recently introduced catheter provides simultaneous NIRS spectral data coregistered with standard intravascular ultrasound (IVUS) images in a single intracoronary pullback...
February 2013: Catheterization and Cardiovascular Interventions
Simon R Dixon, Cindy L Grines, Ahmad Munir, Ryan D Madder, Robert D Safian, George S Hanzel, Mark C Pica, James A Goldstein
Lipid core plaque (LCP) can extend beyond the angiographic margins of a target lesion, potentially resulting in incomplete lesion coverage. We sought to compare the target lesion length using near-infrared spectroscopy (NIRS) combined with conventional coronary angiography versus angiography alone. NIRS was performed in 69 patients (75 lesions) undergoing native vessel percutaneous coronary intervention (LipiScan Coronary Imaging System). Chemograms were analyzed for the presence and location of LCP, either within or extending beyond, the angiographic margins of the target lesion...
January 1, 2012: American Journal of Cardiology
Ryan D Madder, Robert D Safian, Michael Gallagher, Shaun R Senter, George S Hanzel
No abstract text is available yet for this article.
July 2011: JACC. Cardiovascular Interventions
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