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Acute meningitis

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https://www.readbyqxmd.com/read/29662169/distinct-myeloid-cell-subsets-promote-meningeal-remodeling-and-vascular-repair-after-mild-traumatic-brain-injury
#1
Matthew V Russo, Lawrence L Latour, Dorian B McGavern
Mild traumatic brain injury (mTBI) can cause meningeal vascular injury and cell death that spreads into the brain parenchyma and triggers local inflammation and recruitment of peripheral immune cells. The factors that dictate meningeal recovery after mTBI are unknown at present. Here we demonstrated that most patients who had experienced mTBI resolved meningeal vascular damage within 2-3 weeks, although injury persisted for months in a subset of patients. To understand the recovery process, we studied a mouse model of mTBI and found extensive meningeal remodeling that was temporally reliant on infiltrating myeloid cells with divergent functions...
April 16, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29659414/repeated-audiometry-after-bacterial-meningitis-consequences-for-future-management
#2
Marian B A Rodenburg-Vlot, Liesbet Ruytjens, Rianne Oostenbrink, Marc P van der Schroeff
OBJECTIVE: Sensorineural hearing loss is a common sequela of bacterial meningitis. The objective of this study is to delineate the incidence and course of hearing loss after bacterial meningitis. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary referral center. PATIENTS: Data of 655 patients who suffered from bacterial meningitis between 1985 and 2015 were analyzed. INTERVENTIONS: None...
April 13, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29655501/acute-streptococcal-meningitis-presenting-as-bilateral-conductive-hearing-loss
#3
Matthew J Dougherty, Austin T Smith
Bacterial meningitis is a relatively uncommon condition encountered in the emergency department and the constellation of symptoms varies. Hearing loss has been well documented in the literature as a complication of the disease process, but not as the presenting complaint. We describe a case of a 59-year-old female who presented to the emergency department with sudden onset bilateral hearing loss who was found to have S. pneumonia meningitis bacterial meningitis. Even with advances in therapy, bacterial meningitis still carries a significant mortality rate...
April 5, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29652642/powassan-virus-disease-in-the-united-states-2006-2016
#4
Elisabeth R Krow-Lucal, Nicole P Lindsey, Marc Fischer, Susan L Hills
BACKGROUND: Powassan virus (POWV) is a tick-borne flavivirus that causes rare, but often severe, disease in humans. POWV neuroinvasive disease was added to the U.S. nationally notifiable disease list in 2001 and nonneuroinvasive disease was added in 2004. The only previous review of the epidemiology of POWV disease in the United States based on cases reported to the Centers for Disease Control and Prevention (CDC) covered the period from 1999 through 2005. METHODS: We describe the epidemiology and clinical features of laboratory-confirmed POWV disease cases reported to CDC from 2006 through 2016...
March 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29649601/adjuvant-non-bacteriolytic-and-anti-inflammatory-combination-therapy-in-pneumococcal-meningitis-an-investigation-in-a-mouse-model
#5
Matthias Klein, Christopher Höhne, Barbara Angele, Tobias Högen, Hans-Walter Pfister, Hatice Tüfekci, Uwe Koedel
OBJECTIVES: Therapy with antibiotics, dexamethasone, and supportive intensive care has improved the prognosis of pneumococcal meningitis but mortality remains high. Here, we investigated an adjunctive combination therapy of the non-bacteriolytic antibiotic daptomycin plus several anti-inflammatory agents to identify the currently most promising adjunctive combination therapy for pneumococcal meningitis. METHODS: C57BL/6 mice were infected by injection of pneumococci into the cisterna magna...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29626023/management-of-acute-meningitis
#6
Michael J Griffiths, Fiona McGill, Tom Solomon
Acute meningitis remains a devastating disease. Clinicians need a low threshold for suspecting meningitis, to undertake appropriate investigations and provide treatment in a timely manner, to minimise the risk of poor outcome in bacterial disease, while limiting unnecessary treatment in viral meningitis.
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29626017/systemic-inflammatory-disorders-in-patients-admitted-for-aseptic-meningitis
#7
Marine Boudot de la Motte, Rachid Abbas, Fanny Jouan, Damien van Gysel, Marie Paule Chauveheid, Thomas Papo, Karim Sacre
Acute meningitis can be the first manifestation of an underlying systemic inflammatory disorder (SID). In the current study, we aimed to identify clinical indicators for SIDs in patients admitted for acute aseptic meningitis. All patients hospitalised for acute aseptic meningitis over a 4-year period in a department of internal medicine were included retrospectively. Patients with neoplastic meningitis were excluded. Extraneurological signs were recorded using a systematic panel. Systemic inflammatory disorder diagnosis was made according to current international criteria...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29611100/resveratrol-acts-anti-inflammatory-and-neuroprotective-in-an-infant-rat-model-of-pneumococcal-meningitis-by-modulating-the-hippocampal-mirnome
#8
Karina Barbosa de Queiroz, Thaís Dos Santos Fontes Pereira, Márcio Sobreira Silva Araújo, Ricardo Santiago Gomez, Roney Santos Coimbra
Resveratrol (RSV) is anti-inflammatory and neuroprotective, cross the blood-brain barrier (BBB) and has a safe profile. Besides, RSV modulates the expression of some miRNAs related to neurological disorders. Thus, we hypothesized that RSV can be neuroprotective in pneumococcal meningitis by modulating the global microRNA expression profile (miRNome). Eleven-day old rats were intracysternally infected with S. pneumoniae (~ 2 × 106 c.f.u.) and were orally administered with RSV (50 mg/kg) or vehicle in pre-treatment (before infection) or post-treatment schedules (3 and 18 h p...
April 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29604972/cryptococcal-meningitis-in-aids
#9
Andrej Spec, William G Powderly
Cryptococcal meningitis remains a significant cause of morbidity and mortality amongst patients living with human immunodeficiency virus (HIV). The prevalence in the developed world has decreased as HIV is being diagnosed earlier, but is still significant, and the prevalence in resource-limited settings is exceedingly high. The presenting symptoms usually include a headache, fever, and, less often, cranial nerve abnormalities. Space-occupying lesions do occur, but are rare. Once diagnosed, patients should be treated with a combination of amphotericin and flucytosine, with step-down therapy to fluconazole for a minimum of a year, or until the CD4 count is above 100 cells/μL, whichever is longer...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29603593/phase-i-trial-of-the-mtor-inhibitor-everolimus-in-combination-with-multi-agent-chemotherapy-in-relapsed-childhood-acute-lymphoblastic-leukemia
#10
Andrew E Place, Yana Pikman, Kristen E Stevenson, Marian H Harris, Melinda Pauly, Maria-Luisa Sulis, Nobuko Hijiya, Lia Gore, Todd M Cooper, Mignon L Loh, Giovanni Roti, Donna S Neuberg, Sarah K Hunt, Sarah Orloff-Parry, Kimberly Stegmaier, Stephen E Sallan, Lewis B Silverman
BACKGROUND: We sought to determine the feasibility of co-administering everolimus with a four-drug reinduction in children and adolescents with acute lymphoblastic leukemia (ALL) experiencing a first marrow relapse. PROCEDURE: This phase I study tested everolimus with vincristine, prednisone, pegaspargase and doxorubicin in patients with marrow relapse occurring >18 months after first complete remission (CR). The primary aim was to identify the maximum tolerated dose of everolimus...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29599819/the-new-who-decision-making-framework-on-vaccine-use-in-acute-humanitarian-emergencies-msf-experience-in-minkaman-south-sudan
#11
Monica Rull, Sophie Masson, Nicolas Peyraud, Marco Simonelli, Alexandre Ventura, Claire Dorion, Francisco J Luquero, Florent Uzzeni, Iza Cigleneki
Introduction: The main causes of death during population movements can be prevented by addressing the population's basic needs. In 2013, the World Health Organization (WHO) issued a framework for decision making to help prioritize vaccinations in acute humanitarian emergencies. This article describes MSF's experience of applying this framework in addition to addressing key population needs in a displacement setting in Minkaman, South Sudan. Case description: Military clashes broke out in South Sudan in December 2013...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29595417/genotypic-characterization-of-haemophilus-influenzae-isolates-from-paediatric-patients-in-japan
#12
Yoko Adachi, Mariko Ando, Miyuki Morozumi, Kimiko Ubukata, Satoshi Iwata
PURPOSE: β-lactamase-negative ampicillin-resistant (BLNAR) Haemophilus influenzae is frequently isolated from respiratory samples and is particularly problematic in Japan. The aim of this study was to characterize circulating isolates of H. influenzae genotypically by BLNAR-PCR and multilocus sequence typing (MLST), and to determine any associations between them. METHODS: H. influenzae isolates (n=191) were collected from paediatric patients (1 month to 12 years old) between 2000 and 2011 for three types of infections: pneumonia (n=61), acute otitis media (AOM) (n=68) and meningitis (n=62)...
March 29, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29590188/overview-of-systematic-reviews-assessing-the-evidence-for-shorter-versus-longer-duration-antibiotic-treatment-for-bacterial-infections-in-secondary-care
#13
Igho J Onakpoya, A Sarah Walker, Pui S Tan, Elizabeth A Spencer, Oghenekome A Gbinigie, Johanna Cook, Martin J Llewelyn, Christopher C Butler
Our objective was to assess the clinical effectiveness of shorter versus longer duration antibiotics for treatment of bacterial infections in adults and children in secondary care settings, using the evidence from published systematic reviews. We conducted electronic searches in MEDLINE, Embase, Cochrane, and Cinahl. Our primary outcome was clinical resolution. The quality of included reviews was assessed using the AMSTAR criteria, and the quality of the evidence was rated using the GRADE criteria. We included 6 systematic reviews (n = 3,162)...
2018: PloS One
https://www.readbyqxmd.com/read/29582731/vector-borne-disease-is-a-common-cause-of-hospitalized-febrile-illness-in-india
#14
Matthew L Robinson, Dileep Kadam, Sandhya Khadse, Usha Balasubramanian, Priyanka Raichur, Chhaya Valvi, Ivan Marbaniang, Savita Kanade, Jonathan Sachs, Anita Basavaraj, Renu Bharadwaj, Anju Kagal, Vandana Kulkarni, Jonathan Zenilman, George Nelson, Yukari C Manabe, Aarti Kinikar, Amita Gupta, Vidya Mave
Acute febrile illness (AFI) is a major cause of morbidity and mortality in India and other resource-limited settings, yet systematic etiologic characterization of AFI has been limited. We prospectively enrolled adults ( N = 970) and children (age 6 months to 12 years, N = 755) admitted with fever from the community to Sassoon General Hospital in Pune, India, from July 2013 to December 2015. We systematically performed a standardized clinical history, clinical laboratories, and diagnostics. Results from additional testing ordered by treating clinicians were also recorded...
March 26, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29581813/atypical-presentation-of-acute-myeloid-leukemia
#15
Kavita Agrawal, Levin Miles, Nirav Agrawal, Asim Khan
We present a case of a 48-year-old male who presented with worsening pleuritic chest pain for 2 h. He also complained of fever, malaise, headache and severe neck pain. Electrocardiogram (ECG) showed ST segment elevation in leads I, II, aVL and V5 with PR elevation and ST depression in aVR. On admission, troponin-I was 14.8 ng/mL. Based on ECG changes, elevated troponin and family history of early coronary artery disease, the patient was emergently taken to cardiac catheterization lab. Angiography showed non-obstructive coronaries, mild hypokinesis of mid inferior and anterolateral wall with ejection fraction (EF) of 40-45%...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29579812/neurocritical-patient-characteristics-related-to-brain-death
#16
M C Bacqué, M E Barone, A Yankowski, A Antik, L Trunzo, S Fioretti, P Penone
BACKGROUND: The lack of viable organs for transplantation led to the creation in Argentina of the Glasgow 7 Program based on the detection and follow-up of acute neurologic patients admitted with Glasgow scores ≤7 in selected hospitals. The objective of this study was to determine the likelihood of hospitalized acute neurologic patients progressing to brain death (BD) based on several variables, including age, sex, and admission diagnosis. METHODS: This study was a retrospective cohort analysis of data obtained from the SINTRA (Procurement and Transplantation National Information System) database between 2006 and 2015...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29575852/streptococcus-suis-a-re-emerging-pathogen-associated-with-occupational-exposure-to-pigs-or-pork-products-part-ii-pathogenesis
#17
Jacek Dutkiewicz, Violetta Zając, Jacek Sroka, Bernard Wasiński, Ewa Cisak, Anna Sawczyn, Anna Kloc, Angelina Wójcik-Fatla
<i>Streptococcus suis</i> is a re-emerging zoonotic pathogen that may cause severe disease, mostly meningitis, in pigs and in humans having occupational contact with pigs and pork, such as farmers, slaughterhose workers and butchers. The first stage of the pathogenic process, similar in pigs and humans, is adherence to and colonisation of mucosal and/or epithelial surface(s) of the host. The second stage is invasion into deeper tissue and extracellular translocation of bacterium in the bloodstream, either free in circulation or attached to the surface of monocytes...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29567898/kikuchi-s-disease-histiocytic-necrotizing-lymphadenitis-a-rare-presentation-with-acute-kidney-injury-peripheral-neuropathy-and-aseptic-meningitis-with-cutaneous-involvement
#18
Jyoti Jain, Shashank Banait, Iadarilang Tiewsoh, Madhura Choudhari
Kikuchi's disease (KD) also known as histiocytic necrotizing lymphadenitis is rare, idiopathic, generally self-limited cause of lymphadenitis. We present a case of twenty year young female who presented in critically ill state with fever, cervical and axillary lymphadenopathy, rash, vomiting and altered sensorium and found to have neurological, hepatic, renal and dermatological involvement. Kikuchi's disease should be considered in differential diagnosis of fever and lymphadenopathy and though benign can sometimes present with multi-organ involvement...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29564346/kawasaki-disease-among-egyptian-children-a-case-series
#19
Tarek Hamed Attia, Saed M Morsy, Bashier A Hassan, Al Shymaa A Ali
Kawasaki disease is an acute vasculitis of early childhood. Its incidence varies among different ethnic groups with higher rates among Asians. In this case series, we presented four cases of Kawasaki disease with incomplete or atypical presentations in Egyptian children. Two cases presented with meningitis, which is not a criteria for the diagnosis of Kawasaki disease. The other two cases presented with pharyngitis and fever, which did not respond to antibiotics. The clinical criteria for diagnosis of Kawasaki disease were either incomplete or appeared sequentially...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29562995/a-study-of-atrial-and-brain-natriuretic-peptides-in-tuberculous-meningitis-and-acute-encephalitis
#20
U K Misra, J Kalita, M Kumar, A Tripathi
OBJECTIVE: To report atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels in patients with tuberculous meningitis (TBM) and acute encephalitis syndrome (AES), and evaluate their relationship with hyponatraemia. METHODS: Consecutive patients with TBM and AES were included in the study. Hyponatraemia was categorised as cerebral salt wasting (CSW), syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and a miscellaneous group based on clinical and laboratory criteria...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
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