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https://www.readbyqxmd.com/read/28432742/living-donor-uterus-transplantation-a-single-center-s-observations-and-lessons-learned-from-early-setbacks-to-technical-success
#1
G Testa, E C Koon, L Johannesson, G McKenna, T Anthony, G B Klintmalm, R T Gunby, A M Warren, J M Putman, G dePrisco, J M Mitchell, K Wallis, M Olausson
Uterus transplantation is a vascularized composite allograft transplantation. It allows women who do not have a uterus to become pregnant and deliver a baby. In this paper we analyze the first 5 cases of Living Donor Uterus Transplantation performed in the US. The first 3 recipients lost their uterus grafts at day 14, 12 and 6 after transplant. Vascular complications, related to both inflow and outflow problems, were identified as the primary reason for the graft losses. Two recipients, 6 and 3 months post-transplant have functioning grafts with regular menstrual cycles...
April 22, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28426522/patient-safety-culture-survey-in-pediatric-complex-care-settings-a-factor-analysis
#2
Amanda J Hessels, Meghan Murray, Bevin Cohen, Elaine L Larson
OBJECTIVES: Children with complex medical needs are increasing in number and demanding the services of pediatric long-term care facilities (pLTC), which require a focus on patient safety culture (PSC). However, no tool to measure PSC has been tested in this unique hybrid acute care-residential setting. The objective of this study was to evaluate the psychometric properties of the Nursing Home Survey on Patient Safety Culture tool slightly modified for use in the pLTC setting. METHODS: Factor analyses were performed on data collected from 239 staff at 3 pLTC in 2012...
April 19, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28424565/invasive-pneumococcal-disease-still-lots-to-learn-and-a-need-for-standardized-data-collection-instruments
#3
T J Marrie, G J Tyrrell, Sumit R Majumdar, Dean T Eurich
Background. Large studies of invasive pneumococcal disease (IPD) are frequently lacking detailed clinical information. Methods. A population-based 15-year study of IPD in Northern Alberta. Results. 2435 patients with a mean age of 54.2 years formed the study group. Males outnumbered females and Aboriginal and homeless persons were overrepresented. High rates of smoking, excessive alcohol use, and illicit drug use were seen. Almost all (87%) had a major comorbidity and 15% had functional limitations prior to admission...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28419223/removal-of-batch-effects-using-distribution-matching-residual-networks
#4
Uri Shaham, Kelly P Stanton, Jun Zhao, Huamin Li, Khadir Raddassi, Ruth Montgomery, Yuval Kluger
Motivation: Sources of variability in experimentally derived data include measurement error in addition to the physical phenomena of interest. This measurement error is a combination of systematic components, originating from the measuring instrument, and random measurement errors. Several novel biological technologies, such as mass cytometry and single-cell RNA-seq, are plagued with systematic errors that may severely affect statistical analysis if the data is not properly calibrated...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28417516/discovering-what-matters-interrogating-clinician-responses-to-ethics-consultation
#5
Stuart G Finder, Virginia L Bartlett
Against the background assumptions that (a) knowing what clinical ethics consultation represents to those with whom ethics consultants work most closely is a necessary component for being responsible in the practice of ethics consultation, and (b) the complexities of soliciting and understanding colleague evaluations require another inherent responsibility for the methods by which ethics consultations are evaluated, in this article we report our experience soliciting, analyzing, and trying to understand retrospective evaluations of our Clinical Ethics Consultation Service...
May 2017: Bioethics
https://www.readbyqxmd.com/read/28412771/drug-cue-reactivity-involves-hierarchical-instrumental-learning-evidence-from-a-biconditional-pavlovian-to-instrumental-transfer-task
#6
Lorna Hardy, Chris Mitchell, Tina Seabrooke, Lee Hogarth
RATIONALE: Drug cue reactivity plays a crucial role in addiction, yet the underlying mechanisms are poorly understood. According to the binary associative account, drug stimuli retrieve an expectation of the drug outcome, which, in turn, elicits the associated drug-seeking response (S-O-R). By contrast, according to the hierarchical account, drug stimuli retrieve an expectation that the contingency between the drug-seeking response and the drug outcome is currently more effective, promoting performance of the drug-seeking response (S:R-O)...
April 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28409343/use-of-xenopus-frogs-to-study-renal-development-repair
#7
Shoshoni T Droz, Kelly A McLaughlin
The Xenopus genus includes several members of aquatic frogs native to Africa but is perhaps best known for the species Xenopus laevis and Xenopus tropicalis. These species were popularized as model organisms from as early as the 1800s and have been instrumental in expanding several biological fields including cell biology, environmental toxicology, regenerative biology, and developmental biology. In fact, much of what we know about the formation and maturation of the vertebrate renal system has been acquired by examining the intricate genetic and morphological patterns that epitomize nephrogenesis in Xenopus...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28408411/active-avoidance-neural-mechanisms-and-attenuation-of-pavlovian-conditioned-responding
#8
Emily A Boeke, Justin Moscarello, Joseph E LeDoux, Elizabeth A Phelps, Catherine A Hartley
Patients with anxiety disorders often experience a relapse in symptoms after exposure therapy. Similarly, threat responses acquired during Pavlovian threat conditioning often return after extinction learning. Accordingly, there is a need for alternative methods to persistently reduce threat responding. Studies in rodents have suggested that exercising behavioral control over an aversive stimulus can persistently diminish threat responses, and that these effects are mediated by the amygdala, ventromedial prefrontal cortex (vmPFC), and striatum...
April 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28404541/making-air-pollution-visible-a-tool-for-promoting-environmental-health-literacy
#9
Ekaterina Galkina Cleary, Allison P Patton, Hsin-Ching Wu, Alan Xie, Joseph Stubblefield, William Mass, Georges Grinstein, Susan Koch-Weser, Doug Brugge, Carolyn Wong
BACKGROUND: Digital maps are instrumental in conveying information about environmental hazards geographically. For laypersons, computer-based maps can serve as tools to promote environmental health literacy about invisible traffic-related air pollution and ultrafine particles. Concentrations of these pollutants are higher near major roadways and increasingly linked to adverse health effects. Interactive computer maps provide visualizations that can allow users to build mental models of the spatial distribution of ultrafine particles in a community and learn about the risk of exposure in a geographic context...
April 12, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28398984/experiences-of-pre-licensure-or-pre-registration-health-professional-students-and-their-educators-in-working-with-intra-professional-teams-a-qualitative-systematic-review
#10
Diane L Butcher, Karen MacKinnon, Anne Bruce, Carol Gordon, Clare Koning
BACKGROUND: Inter-professional initiatives are prevalent in the healthcare landscape, requiring professionals to collaborate effectively to provide quality patient care. Little attention has been given to intra-professional relationships, where professionals within one disciplinary domain (such as degree and diploma nursing students) collaborate to provide care. New care models are being introduced where baccalaureate and diploma students of a particular discipline (such as nursing, occupational therapy, dentistry or physiotherapy) work closely together in teams to deliver care...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28398391/-the-italian-instrument-evaluating-the-nursing-students-clinical-learning-quality
#11
Alvisa Palese, Luca Grassetti, Irene Mansutti, Anne Destrebecq, Stefano Terzoni, Pietro Altini, Anita Bevilacqua, Anna Brugnolli, Carla Benaglio, Adriana Dal Ponte, Laura De Biasio, Valerio Dimonte, Benedetta Gambacorti, Adriana Fasci, Silvia Grosso, Franco Mantovan, Oliva Marognolli, Sandra Montalti, Raffaela Nicotera, Giulia Randon, Brigitte Stampfl, Morena Tollini, Federica Canzan, Luisa Saiani, Lucia Zannini
. The Clinical Learning Quality Evaluation Index for nursing students. INTRODUCTION: The Italian nursing programs, the need to introduce tools evaluating the quality of the clinical learning as perceived by nursing students. Several tools already exist, however, several limitations suggesting the need to develop a new tool. AIM: A national project aimed at developing and validating a new instrument capable of measuring the clinical learning quality as experience by nursing students...
January 2017: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/28398390/-a-comparison-of-the-most-used-instruments-to-assess-the-quality-of-clinical-learning-environments-of-nursing-students
#12
Raffaella Nicotera, Pietro Altini, Valerio Dimonte
. A comparison of the most used instruments to assess the quality of clinical learning environments of nursing students. INTRODUCTION: A clinical learning environment (CLE) promotes the development of professional competences, of critical and diagnostic reasoning in future nurses, thus the continuous assessment of its quality is pivotal. AIM: To describe and compare the most used instruments to measure the nursing students' perception of the quality of CLEs. METHODS: Six validated questionnaires were identified and compared: CLE (Clinical Learning Environment), CLEDI (Clinical Learning Environment Diagnostic Inventory), SECEE (Student Evaluation of Clinical Education Environment), CLEI (Clinical Learning Environment Inventory), CLES (Clinical Learning Environment and Supervision), CLES+T (Clinical Learning Environment and Supervision plus Teacher nurse)...
January 2017: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/28397582/the-interactive-candidate-assessment-tool-a-new-way-to-interview-residents
#13
Michael P Platt, Vafa Akhtar-Khavari, Rafael Ortega, Jeffrey I Schneider, Tabitha Fineberg, Kenneth M Grundfast
The purpose of the residency interview is to determine the extent to which a well-qualified applicant is a good fit with a residency program. However, questions asked during residency interviews tend to be standard and repetitive, and they may not elicit information that best differentiates one applicant from another. The iCAT (interactive Candidate Assessment Tool) is a novel interview instrument that allows both interviewers and interviewees to learn about each other in a meaningful way. The iCAT uses a tablet computer to enable the candidate to select questions from an array of video and nonvideo vignettes...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28396705/changing-the-impact-of-nursing-assistants-education-in-seniors-care-the-living-classroom-in-long-term-care
#14
REVIEW
Veronique M Boscart, Josie d'Avernas, Paul Brown, Marlene Raasok
BACKGROUND: Evidence-informed care to support seniors is based on strong knowledge and skills of nursing assistants (NAs). Currently, there are insufficient NAs in the workforce, and new graduates are not always attracted to nursing home (NH) sectors because of limited exposure and lack of confidence. Innovative collaborative approaches are required to prepare NAs to care for seniors. METHODS: A 2009 collaboration between a NH group and a community college resulted in the Living Classroom (LC), a collaborative approach to integrated learning where NA students, college faculty, NH teams, residents, and families engage in a culture of learning...
March 2017: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28396050/value-of-the-cumulative-sum-test-for-the-assessment-of-a-learning-curve-application-to-the-introduction-of-patient-specific-instrumentation-for-total-knee-arthroplasty-in-an-academic-department
#15
Marco De Gori, Benjamin Adamczewski, Jean-Yves Jenny
BACKGROUND: The purpose of the study was to use the cumulative summation (CUSUM) test to assess the learning curve during the introduction of a new surgical technique (patient-specific instrumentation) in total knee arthroplasty (TKA) in an academic department. METHODS: The first 50TKAs operated on at an academic department using patient-specific templates (PSTs) were scheduled to enter the study. All patients had a preoperative computed tomography scan evaluation to plan bone resections...
April 7, 2017: Knee
https://www.readbyqxmd.com/read/28395907/emotion-based-learning-systems-and-the-development-of-morality
#16
R J R Blair
In this paper it is proposed that important components of moral development and moral judgment rely on two forms of emotional learning: stimulus-reinforcement and response-outcome learning. Data in support of this position will be primarily drawn from work with individuals with the developmental condition of psychopathy as well as fMRI studies with healthy individuals. Individuals with psychopathy show impairment on moral judgment tasks and a pronounced increased risk for instrumental antisocial behavior. It will be argued that these impairments are developmental consequences of impaired stimulus-aversive conditioning on the basis of distress cue reinforcers and response-outcome learning in individuals with this disorder...
April 7, 2017: Cognition
https://www.readbyqxmd.com/read/28394393/multifrequency-afm-from-origins-to-convergence
#17
Sergio Santos, Chia-Yun Lai, Tuza Olukan, Matteo Chiesa
Since the inception of the atomic force microscope (AFM) in 1986, influential papers have been presented by the community and tremendous advances have been reported. Being able to routinely image conductive and non-conductive surfaces in air, liquid and vacuum environments with nanoscale, and sometimes atomic, resolution, the AFM has long been perceived by many as the instrument to unlock the nanoscale. From exploiting a basic form of Hooke's law to interpret AFM data to interpreting a seeming zoo of maps in the more advanced multifrequency methods however, an inflection point has been reached...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28392994/medical-big-data-promise-and-challenges
#18
Choong Ho Lee, Hyung-Jin Yoon
The concept of big data, commonly characterized by volume, variety, velocity, and veracity, goes far beyond the data type and includes the aspects of data analysis, such as hypothesis-generating, rather than hypothesis-testing. Big data focuses on temporal stability of the association, rather than on causal relationship and underlying probability distribution assumptions are frequently not required. Medical big data as material to be analyzed has various features that are not only distinct from big data of other disciplines, but also distinct from traditional clinical epidemiology...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28391197/virtual-character-animation-based-on-affordable-motion-capture-and-reconfigurable-tangible-interfaces
#19
Fabrizio Lamberti, Gianluca Paravati, Valentina Gatteschi, Alberto Cannavo, Paolo Montuschi
Software for computer animation is generally characterized by a steep learning curve, due to the entanglement of both sophisticated techniques and interaction methods required to control 3D geometries. This paper proposes a tool designed to support computer animation production processes by leveraging the affordances offered by articulated tangible user interfaces and motion capture retargeting solutions. To this aim, orientations of an instrumented prop are recorded together with animator's motion in the 3D space and used to quickly pose characters in the virtual environment...
April 3, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28390030/we-need-more-replication-research-a%C3%A2-case-for-test-retest-reliability
#20
REVIEW
Jimmie Leppink, Patricia Pérez-Fuster
Following debates in psychology on the importance of replication research, we have also started to see pleas for a more prominent role for replication research in medical education. To enable replication research, it is of paramount importance to carefully study the reliability of the instruments we use. Cronbach's alpha has been the most widely used estimator of reliability in the field of medical education, notably as some kind of quality label of test or questionnaire scores based on multiple items or of the reliability of assessment across exam stations...
April 7, 2017: Perspectives on Medical Education
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