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Hemispheric stroke

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https://www.readbyqxmd.com/read/28820296/long-term-hemodynamic-changes-and-blood-pressure-in-atherosclerotic-major-cerebral-artery-disease
#1
Hiroshi Yamauchi, Shinya Kagawa, Masaaki Takahashi, Tatsuya Higashi
In patients with major cerebral artery disease, lower blood pressure might reduce blood flow in the collateral pathways, thereby impairing the growth of cerebral collaterals, inhibiting hemodynamic improvement. We evaluated the hemodynamic status twice using positron emission tomography and (15)O-gas, over time, in 89 medically treated patients with atherosclerotic internal carotid artery or middle cerebral artery disease that had no ischemic episodes during follow-up (mean, 28 ± 23 months). Changes in the mean hemispheric values of hemodynamic parameters in the territory of the diseased artery at follow-up were correlated with the mean blood pressure values at the baseline and follow-up examinations...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28819123/active-prosthesis-dependent-functional-cortical-reorganization-following-stroke
#2
Christian Merkel, Janet Hausmann, Jens-Max Hopf, Hans-Jochen Heinze, Lars Buentjen, Mircea Ariel Schoenfeld
The present study investigated the neural correlates associated with gait improvements triggered by an active prosthesis in patients with drop-foot following stroke during the chronic stage. Eleven patients took part in the study. MEG recordings in conjunction with somatosensory stimulation of the left and right hand as well as gait analyses were performed shortly before or after prosthesis implantation surgery and 3-4 months later. Plastic changes of the sensorimotor cortex of the ipsi- and contralesional hemisphere were revealed...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814097/prominent-deep-medullary-veins-a-predictive-biomarker-for-stroke-risk-from-transient-ischemic-attack
#3
Yang Duan, Zhihua Xu, Hongyi Li, Xiaonan Cai, Cancan Chang, Benqiang Yang
Background Deep medullary veins (DMVs) are a biomarker of severity and prognosis in patients with acute cerebral infarction. However, their clinical significance remains unclear in patients with transient ischemic attack (TIA). Purpose To determine whether prominent deep medullary veins (PDMVs) are a predictive biomarker for stroke risk after TIA. Material and Methods Clinical and imaging data of 49 patients with TIA and 49 sex- and age-matched controls were studied. PDMVs were defined as DMVs with a score of 3 (TDMVs) or asymmetric DMVs (ADMVs), and the relationship between PDMVs and clinical features was analyzed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28813816/computational-rehabilitation-of-neglect-using-state-space-models-to-understand-the-recovery-mechanisms
#4
Giulia Sedda, Marcella Ottonello, Elena Fiabane, Caterina Pistarini, Anna Sedda, Vittorio Sanguineti
Unilateral spatial neglect is a neuropsychological syndrome often observed in right hemisphere stroke patients. The symptoms differ from subject to subject. A few rehabilitation approaches, e.g. prism adaptation, have demonstrated some effect in reducing the symptoms, but the underlying mechanisms are still largely unclear. Recently, neural models have been proposed to qualitatively describe cortical lesions, the resulting neglect symptoms and the effects of treatment. However, these predictions are qualitative and cannot be used to compare different hypotheses or to interpret symptoms at individual subjects level...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812421/right-hemispatial-ipsilesional-neglect-with-chronic-right-hemisphere-strokes
#5
John B Williamson, Damon G Lamb, D Brandon Burtis, Salsabil Haque, Eduardo M Zilli, Tigran Kesayan, Michal Harciarek, Kenneth M Heilman
BACKGROUND: Patients who present with spatial neglect after stroke often perform normally on tests for neglect after a few weeks. Whereas tests for neglect are often performed directly in front of a patient, in their actual environments many important stimuli may be present within their left or right hemispace. The presence and severity of neglect often depends on the hemisphere injured. It is possible, in chronic stroke, for spatial judgments to be influenced by an interaction of stroke laterality and the spatial location of stimuli...
August 16, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28811520/chronic-post-stroke-aphasia-severity-is-determined-by-fragmentation-of-residual-white-matter-networks
#6
Barbara K Marebwa, Julius Fridriksson, Grigori Yourganov, Lynda Feenaughty, Chris Rorden, Leonardo Bonilha
Many stroke survivors with aphasia in the acute period experience spontaneous recovery within the first six months after the stroke. However, approximately 30-40% sustain permanent aphasia and the factors determining incomplete recovery are unclear. Suboptimal recovery may be influenced by disruption of areas seemingly spared by the stroke due to loss of white matter connectivity and network integrity. We reconstructed individual anatomical whole-brain connectomes from 90 left hemisphere stroke survivors using diffusion MR images...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807138/prevalence-and-predictors-of-post-stroke-mood-disorders-a-meta-analysis-and-meta-regression-of-depression-anxiety-and-adjustment-disorder
#7
Alex J Mitchell, Bhavisha Sheth, John Gill, Motahare Yadegarfar, Brendon Stubbs, Mohammad Yadegarfar, Nick Meader
OBJECTIVE: To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. METHODS: Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28806209/refractory-intracranial-hypertension-the-role-of-decompressive-craniectomy
#8
Martin Smith
Raised intracranial pressure (ICP) is associated with worse outcomes after acute brain injury, and clinical guidelines advocate early treatment of intracranial hypertension. ICP-lowering therapies are usually administered in a stepwise manner, starting with safer first-line interventions, while reserving higher-risk options for patients with intractable intracranial hypertension. Decompressive craniectomy is a surgical procedure in which part of the skull is removed and the underlying dura opened to reduce brain swelling-related raised ICP; it can be performed as a primary or secondary procedure...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28805107/effects-of-high-frequency-repetitive-transcranial-magnetic-stimulation-on-reducing-hemiplegic-shoulder-pain-in-patients-with-chronic-stoke-a-randomized-controlled-trial
#9
Gyu-Sik Choi, Min Cheol Chang
OBJECTIVE: To examine whether high-frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS), applied over the primary motor cortex of the affected hemisphere, could be used to manage hemiplegic shoulder pain (HSP). METHODS: Twenty-four chronic stroke patients with chronic HSP, randomly assigned into the rTMS group (10 sessions of high-frequency stimulation) or the sham group (sham stimulation), was performed. The Numeric Rating Scale (NRS) was used to evaluate the intensity of pain at pre-treatment, and at one day, and one, two, and four weeks after treatment...
August 12, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28804453/delta-power-is-higher-and-more-symmetrical-in-ischemic-stroke-patients-with-cortical-involvement
#10
Chiara Fanciullacci, Federica Bertolucci, Giuseppe Lamola, Alessandro Panarese, Fiorenzo Artoni, Silvestro Micera, Bruno Rossi, Carmelo Chisari
A brain injury resulting from unilateral stroke critically alters brain functionality and the complex balance within the cortical activity. Such modifications may critically depend on lesion location and cortical involvement. Indeed, recent findings pointed out the necessity of applying a stratification based on lesion location when investigating inter-hemispheric balance in stroke. Here, we tested whether cortical involvement could imply differences in band-specific activity and brain symmetry in post stroke patients with cortico-subcortical and subcortical strokes...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28800341/robotic-assisted-gait-training-combined-with-transcranial-direct-current-stimulation-in-chronic-stroke-patients-a-pilot-double-blind-randomized-controlled-trial
#11
Han Gil Seo, Woo Hyung Lee, Seung Hak Lee, Youbin Yi, Kwang Dong Kim, Byung-Mo Oh
BACKGROUND: Although robotic-assisted gait training (RAGT) is becoming a standard method in stroke rehabilitation, its effect on chronic stroke patients is uncertain. OBJECTIVE: This study aimed to investigate whether anodal tDCS (transcranial direct current stimulation) enhances the effect of RAGT on functional ambulation in chronic stroke patients. METHODS: Chronic hemiplegic stroke patients with a Functional Ambulatory Category (FAC) score≤4 were randomly assigned to either the RAGT with anodal tDCS (Anodal) group or the sham tDCS (Sham) group...
August 11, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28799861/absence-of-cortical-vein-opacification-is-associated-with-lack-of-intra-arterial-therapy-benefit-in-stroke
#12
Ivo G H Jansen, Annemieke B van Vuuren, Wim H van Zwam, Ido R van den Wijngaard, Olvert A Berkhemer, Hester F Lingsma, Cornelis H Slump, Robert J van Oostenbrugge, Kilian M Treurniet, Diederik W J Dippel, Marianne A A van Walderveen, Aad van der Lugt, Yvo B W E M Roos, Henk A Marquering, Charles B L M Majoie, René van den Berg
Purpose To assess the degree of cortical vein opacification in patients with internal carotid artery or middle cerebral artery (MCA) stroke and to evaluate the relationship with treatment benefit from intra-arterial therapy (IAT). Materials and Methods Written informed consent was obtained from all patients in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands. From the trial's database, all patients (recruited from December 2010 until March 2014) with baseline computed tomographic (CT) angiograms were retrospectively included...
August 11, 2017: Radiology
https://www.readbyqxmd.com/read/28799142/what-to-do-in-failed-hemispherotomy-our-clinical-series-and-review-of-the-literature
#13
REVIEW
Andrea Bartoli, Y El Hassani, B Jenny, S Momjian, C M Korff, M Seeck, S Vulliemoz, K Schaller
Hemispherotomy is an established surgical technique to cure or palliate selected, mostly young patients suffering from refractory epilepsy. However, a few patients continue to have seizures despite the surgical hemispherical disconnection. We present a case series of patients who underwent redo hemispherotomy after a first unsuccessful hemispherical disconnection and provide a roadmap for subsequent workup and treatment. The institutional database of epilepsy surgery was reviewed. Twenty-four patients who underwent hemispherotomies for refractory epilepsy were identified between 2007 and 2016...
August 10, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28798783/mesh-covered-roadsaver-stent-as-a-new-treatment-modality-for-symptomatic-or-high-risk-carotid-stenosis
#14
Roman Machnik, Piotr Paluszek, Łukasz Tekieli, Karolina Dzierwa, Damian Maciejewski, Mariusz Trystuła, Andrzej Brzychczy, Krzysztof Banaszkiewicz, Robert Musiał, Piotr Pieniążek
INTRODUCTION: Prevention of periprocedural stroke has a crucial role in carotid artery stenting (CAS) procedures. AIM: To assess retrospectively 30-day safety and effectiveness of 41 procedures of internal and common carotid artery stenting using the Roadsaver double nitinol layer micromesh stent in 40 non-consecutive patients with symptomatic or high-risk carotid artery stenosis. MATERIAL AND METHODS: The patients were men (n = 31) and women (n = 9); mean age was 67...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28796033/rtms-treatments-combined-with-speech-training-for-a-conduction-aphasia-patient-a-case-report-with-mri-study
#15
Hui Zhang, Ying Chen, Ruiping Hu, Liqing Yang, Mengxing Wang, Jilei Zhang, Haifeng Lu, Yi Wu, Xiaoxia Du
RATIONALE: To date, little is known regarding the neural mechanisms of the functional recovery of language after repetitive transcranial magnetic stimulation (rTMS) in aphasia. Our aim was to investigate the mechanism that underlies rTMS and speech training in a case report. PATIENT CONCERNS AND DIAGNOSES: We report the case of a 39-year-old woman who was initially diagnosed with conduction aphasia following a left hemisphere stroke. INTERVENTIONS: The rTMS location comprised the left Broca area, and a frequency of 5 Hz for 20 min/d for 10 days during a 2-week period was used...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795363/fibroblast-growth-factor-type-1-fgf1-overexpressed-adipose-derived-mesenchaymal-stem-cells-ad-msc-fgf1-induce-neuroprotection-and-functional-recovery-in-a-rat-stroke-model
#16
Hamed Ghazavi, Seyed Javad Hoseini, Alireza Ebrahimzadeh-Bideskan, Baratali Mashkani, Soghra Mehri, Ahmad Ghorbani, Kayvan Sadri, Elahe Mahdipour, Faezeh Ghasemi, Fatemeh Forouzanfar, Azar Hoseini, Ali Reza Pasdar, Hamid Reza Sadeghnia, Majid Ghayour-Mobarhan
Stroke, as the second most common cause of death, imposes a great financial burden on both the individual and society. Mesenchymal stem cells from rodents have demonstrated efficacy in experimental animal models of stroke due to enhanced neurological recovery. Since FGF1 (fibroblast growth factor 1) displays neuroprotective properties, for the first time, we investigated the effect of acute intravenous administration of FGF1 gene transfected adipose-derived mesenchymal stem cell (AD-MSC(FGF1)) on transient experimental ischemic stroke in rats...
August 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28794518/pre-stroke-apathy-symptoms-are-associated-with-an-increased-risk-of-delirium-in-stroke-patients
#17
Elzbieta Klimiec, Katarzyna Kowalska, Paulina Pasinska, Aleksandra Klimkowicz-Mrowiec, Aleksandra Szyper, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic
Neuropsychiatric symptoms can be interrelated to delirium. We aimed to investigate an association between pre-stroke neuropsychiatric symptoms and the risk of delirium in stroke patients. We included 606 patients (median age: 73, 53% female) with stroke or transient ischemic attack admitted within 48 hours from symptoms onset. We assessed delirium on a daily basis during the first 7 days of hospitalization. To make diagnosis of delirium we used DSM-5 criteria. We used Neuropsychiatric Inventory to assess neuropsychiatric symptoms occurring within 4 weeks prior to stroke...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790974/selective-inhibition-of-janus-kinase-3-has-no-impact-on-infarct-size-or-neurobehavioral-outcomes-in-permanent-ischemic-stroke-in-mice
#18
Kelly M DeMars, Sean C Pacheco, Changjun Yang, David M Siwarski, Eduardo Candelario-Jalil
Janus kinase 3 (JAK3) is associated with the common gamma chain of several interleukin (IL) receptors essential to inflammatory signaling. To study the potential role of JAK3 in stroke-induced neuroinflammation, we subjected mice to permanent middle cerebral artery occlusion and investigated the effects of JAK3 inhibition with decernotinib (VX-509) on infarct size, behavior, and levels of several inflammatory mediators. Results from our double immunofluorescence staining showed JAK3 expression on neurons, endothelial cells, and microglia/macrophages in the ischemic mouse brain (n = 3)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28789579/reading-on-the-right-when-there-s-nothing-left-probabilistic-tractography-reveals-hemispheric-asymmetry-in-pure-alexia
#19
Michele Veldsman, Tobias Loetscher, Amanda Wood, Amy Brodtmann
We present a patient with reading inexpertise and right hemianopia following left posterior cerebral artery (PCA) stroke. We examine the extent of disruption to reading performance and the extent of white matter tract damage relative to a patient with more limited PCA infarction and isolated right hemianopia. We show white matter disconnection of the temporal occipital fusiform cortex in our pure alexia patient. Connectivity-based laterality indices revealed right hemisphere laterality in the alexia patient; this was not associated with improved reading function...
August 9, 2017: Neurocase
https://www.readbyqxmd.com/read/28782913/screening-with-doppler-ultrasound-for-carotid-artery-stenosis-in-patients-with-stroke-or-transient-ischaemic-attack
#20
Tatiana Kristensen, Peter Hovind, Helle K Iversen, Ulrik B Andersen
INTRODUCTION: Carotid endarterectomy of symptomatic internal carotid artery stenosis in patients with stroke or transient ischaemic attack reduces the risk of recurrent stroke, particularly if performed within 2 weeks from the first event. We evaluated the efficiency of a screening programme based on Doppler ultrasound in patients hospitalized with stroke or transient ischaemic attack in the stroke centre at Rigshospitalet, Glostrup, Denmark, concerning timeliness of referral to the vascular surgeon and performance of carotid endarterectomy according to national recommendations...
August 7, 2017: Clinical Physiology and Functional Imaging
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