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https://www.readbyqxmd.com/read/28230531/exercise-induced-alterations-in-nk-cell-cytotoxicity-methodological-issues-and-future-perspectives
#1
Philipp Zimmer, Alexander Schenk, Markus Kieven, Michelle Holthaus, Jonas Lehmann, Lukas Lövenich, Wilhelm Bloch
With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory...
2017: Exercise Immunology Review
https://www.readbyqxmd.com/read/28228718/current-concepts-on-the-physiopathological-relevance-of-dopaminergic-receptors
#2
REVIEW
Ada Ledonne, Nicola B Mercuri
Dopamine (DA) is a key neurotransmitter modulating essential functions of the central nervous system (CNS), like voluntary movement, reward, several cognitive functions and goal-oriented behaviors. The factual relevance of DAergic transmission can be well appreciated by considering that its dysfunction is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD) and associated movement disorders, as well as, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) and addiction...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28228078/nanocarriers-mediated-topical-drug-delivery-for-psoriasis-treatment
#3
Sevgi Güngör, Meriem Rezigue
BACKGROUND: Psoriasis is a chronic autoimmune inflammatory skin disease affecting 2 to 3% of people worldwide. Topical therapy as first option in the management of psoriasis is an attractive strategy by delivering drugs efficiently into target sites of disease, minimizing systemic side effects of drugs and ensuring high patient compliance. However, the delivery of antipsoriatic agents via conventional topical formulations is limited due to their poor percutaneous penetration and targeting into deeper layers of the skin...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28227685/graphical-user-interface-for-a-robotic-workstation-in-a-surgical-environment
#4
A Bielski, C P Lohmann, M Maier, D Zapp, M A Nasseri, A Bielski, C P Lohmann, M Maier, D Zapp, M A Nasseri, M A Nasseri, M Maier, D Zapp, C P Lohmann, A Bielski
Surgery using a robotic system has proven to have significant potential but is still a highly challenging task for the surgeon. An eye surgery assistant has been developed to eliminate the problem of tremor caused by human motions endangering the outcome of ophthalmic surgery. In order to exploit the full potential of the robot and improve the workflow of the surgeon, providing the ability to change control parameters live in the system as well as the ability to connect additional ancillary systems is necessary...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227038/secure-access-to-patient-s-health-records-using-speechxrays-a-mutli-channel-biometrics-platform-for-user-authentication
#5
Emmanouil G Spanakis, Marios Spanakis, Apostolos Karantanas, Kostas Marias, Emmanouil G Spanakis, Marios Spanakis, Apostolos Karantanas, Kostas Marias, Emmanouil G Spanakis, Apostolos Karantanas, Marios Spanakis, Kostas Marias
The most commonly used method for user authentication in ICT services or systems is the application of identification tools such as passwords or personal identification numbers (PINs). The rapid development in ICT technology regarding smart devices (laptops, tablets and smartphones) has allowed also the advance of hardware components that capture several biometric traits such as fingerprints and voice. These components are aiming among others to overcome weaknesses and flaws of password usage under the prism of improved user authentication with higher level of security, privacy and usability...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226570/a-wearable-signal-acquisition-system-for-physiological-signs-including-throat-ppg
#6
Yizhou Zhong, Yun Pan, Ling Zhang, Kwang-Ting Cheng, Yizhou Zhong, Yun Pan, Ling Zhang, Kwang-Ting Cheng, Yizhou Zhong, Ling Zhang, Kwang-Ting Cheng, Yun Pan
This paper presents a wearable signal acquisition system, which can measure physiological signs, i.e., electrocardiogram (ECG) and photoplethysmogram (PPG). The system is comprised of two parts: (1) an ECG sensor implemented in the master board which will be mounted on the chest and, (2) a combined PPG and motion sensor implemented in the slave board which will be worn around the neck area. The single-lead ECG, the single-channel PPG, and the 3-channel accelerometer signals are all sampled at 200Hz, and transmitted to an Android app through Bluetooth® low energy (BLE) in real time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225733/supporting-the-call-to-action-a-review-of-nutrition-educational-interventions-in-the-health-professions-literature-and-mededportal
#7
Timothy M Dang, Lauren A Maggio
PURPOSE: Despite calls to improve nutrition education, training for medical students is inadequate. This systematic review provides an overview of published educational interventions for undergraduate-level health professionals and makes recommendations for improving nutrition training. METHOD: The authors conducted a systematic review of articles (through July 16, 2015) and examined resources in MedEdPORTAL (through September 28, 2015) focused on materials published since January 2004 that describe nutrition educational interventions for undergraduate-level health professionals...
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28225542/historical-overview-of-leprosy-control-in-cuba
#8
Enrique Beldarraín-Chaple
INTRODUCTION Leprosy, an infectious disease caused by Mycobacterium leprae, affects the nervous system, skin, internal organs, extremities and mucous membranes. Biological, social and environmental factors influence its occurrence and transmission. The first effective treatments appeared in 1930 with the development of dapsone, a sulfone. The main components of a control and elimination strategy are early case detection and timely administration of multidrug therapy. OBJECTIVES Review the history of leprosy control in Cuba, emphasizing particularly results of the National Leprosy Control Program, its modifications and influence on leprosy control...
January 2017: MEDICC Review
https://www.readbyqxmd.com/read/28225096/dimension-controlled-ion-pairing-assemblies-based-on-%C3%AF-electronic-charged-species
#9
Yohei Haketa, Hiromitsu Maeda
This feature article summarizes the recent progress in the study of ion-pairing assemblies based on π-electronic ion pairs, including anion complexes of π-electronic molecules. Recently, ionic self-assembly (or ion-pairing assembly) has been widely investigated and utilized in the fabrication of various functional materials including soft materials, surface morphologies and organic-inorganic hybrid materials. It is significantly important to precisely design and synthesize charged π-electronic systems for obtaining highly organized assemblies, but the development of π-electronic ion pairs with an aim to fabricate soft materials has hardly been examined...
February 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28224938/overview-on-the-challenges-and-benefits-of-using-telehealth-tools-in-a-pediatric-population
#10
REVIEW
Patrick D Brophy
Telehealth in Pediatric Medicine presents many of the same benefits and challenges noted in adult-based medicine. In terms of health care delivery, the promise of improving access and reducing costs using telehealth in Pediatrics, particularly chronic care, is high. The ability to address clinician shortages and provide remote guidance for chronic care pathways from pediatric subspecialists to rural-based referring physicians is a developing model that represents a sustainable and cost-effective strategy to improve pediatric care...
January 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28224116/persistence-of-functional-protein-domains-in-mycoplasma-species-and-their-role-in-host-specificity-and-synthetic-minimal-life
#11
Tjerko Kamminga, Jasper J Koehorst, Paul Vermeij, Simen-Jan Slagman, Vitor A P Martins Dos Santos, Jetta J E Bijlsma, Peter J Schaap
Mycoplasmas are the smallest self-replicating organisms and obligate parasites of a specific vertebrate host. An in-depth analysis of the functional capabilities of mycoplasma species is fundamental to understand how some of simplest forms of life on Earth succeeded in subverting complex hosts with highly sophisticated immune systems. In this study we present a genome-scale comparison, focused on identification of functional protein domains, of 80 publically available mycoplasma genomes which were consistently re-annotated using a standardized annotation pipeline embedded in a semantic framework to keep track of the data provenance...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28224105/nutrient-stimulation-of-mesenteric-blood-flow-implications-for-older-critically-ill-patients
#12
REVIEW
Thu An Nguyen, Yasmine Ali Abdelhamid, Liza K Phillips, Leeanne S Chapple, Michael Horowitz, Karen L Jones, Adam M Deane
Nutrient ingestion induces a substantial increase in mesenteric blood flow. In older persons (aged ≥ 65 years), particularly those with chronic medical conditions, the cardiovascular compensatory response may be inadequate to maintain systemic blood pressure during mesenteric blood pooling, leading to postprandial hypotension. In older ambulatory persons, postprandial hypotension is an important pathophysiological condition associated with an increased propensity for syncope, falls, coronary vascular events, stroke and death...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28222974/primary-health-care-attributes-and-responses-to-intimate-partner-violence-in-spain
#13
Isabel Goicolea, Paola Mosquera, Erica Briones-Vozmediano, Laura Otero-García, Marta García-Quinto, Carmen Vives-Cases
OBJECTIVE: This study provides an overview of the perceptions of primary care professionals on how the current primary health care (PHC) attributes in Spain could influence health-related responses to intimate partner violence (IPV). METHODS: A qualitative study was conducted using semi-structured interviews with 160 health professionals working in 16 PHC centres in Spain. Data were analysed using a qualitative content analysis. RESULTS: Four categories emerged from the interview analysis: those committed to the PHC approach, but with difficulties implementing it; community work relying on voluntarism; multidisciplinary team work or professionals who work together?; and continuity of care hindered by heavy work load...
February 18, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28222780/advanced-biosensors-for-detection-of-pathogens-related-to-livestock-and-poultry
#14
REVIEW
Jasmina Vidic, Marisa Manzano, Chung-Ming Chang, Nicole Jaffrezic-Renault
Infectious animal diseases caused by pathogenic microorganisms such as bacteria and viruses threaten the health and well-being of wildlife, livestock, and human populations, limit productivity and increase significantly economic losses to each sector. The pathogen detection is an important step for the diagnostics, successful treatment of animal infection diseases and control management in farms and field conditions. Current techniques employed to diagnose pathogens in livestock and poultry include classical plate-based methods and conventional biochemical methods as enzyme-linked immunosorbent assays (ELISA)...
February 21, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28222352/status-of-pharmaceuticals-in-african-water-bodies-occurrence-removal-and-analytical-methods
#15
REVIEW
Lawrence Mzukisi Madikizela, Nikita Tawanda Tavengwa, Luke Chimuka
In this review paper, the milestones and challenges that have been achieved and experienced by African Environmental Scientists regarding the assessment of water pollution caused by the presence of pharmaceutical compounds in water bodies are highlighted. The identification and quantification of pharmaceuticals in the African water bodies is important to the general public at large due to the lack of information. The consumption of pharmaceuticals to promote human health is usually followed by excretion of these drugs via urine or fecal matter due to their slight transformation in the human metabolism...
February 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28220435/rapid-construction-of-multiplexed-crispr-cas9-systems-for-plant-genome-editing
#16
Levi Lowder, Aimee Malzahn, Yiping Qi
Multiplex CRISPR-Cas9 nuclease mediated genome editing is an efficient method for disrupting gene function in plants. Use of CRISPR-Cas9 has escalated rapidly in recent years and is expected to become routine practice in molecular biology and related fields of research. Due to the relatively novel and widespread adoption of this technology, first-time users may not have regular access to experienced guidance or technical support from peers or mentors. Here, we offer guidance and technical support in the form of a detailed and tested protocol for simultaneous targeting of three separate loci on the TRANSPARENT TESTA 4 (TT4) gene in Arabidopsis thaliana using multiplex CRISPR-Cas9...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28220120/neutrophil-extracellular-traps-and-its-implications-in-inflammation-an-overview
#17
REVIEW
Vidal Delgado-Rizo, Marco A Martínez-Guzmán, Liliana Iñiguez-Gutierrez, Alejandra García-Orozco, Anabell Alvarado-Navarro, Mary Fafutis-Morris
In addition to physical barriers, neutrophils are considered a part of the first line of immune defense. They can be found in the bloodstream, with a lifespan of 6-8 h, and in tissue, where they can last up to 7 days. The mechanisms that neutrophils utilize for host defense are phagocytosis, degranulation, cytokine production, and, the most recently described, neutrophil extracellular trap (NET) production. NETs are DNA structures released due to chromatin decondensation and spreading, and they thus occupy three to five times the volume of condensed chromatin...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28219320/microorganism-and-agricultural-based-biosorbents-towards-removal-of-cadmium-from-waste-water-an-overview
#18
Souvik Pal, Subhankar Mukherjee, Nabarun Bhattacharyya
BACKGROUND: Non-degradable and persistent nature of Cadmium (Cd) poses high toxicity to human, plants and animals. Several industrial processes generated wastes are the main anthropogenic pathway through which Cd enters into the environment. Although, World Health Organization (WHO) has set the limit of Cd in drinking water is 0.005 mg L-1, the industrial activities release much higher concentrations of metal ions to the water stream than the prescribed limits, which leads to the increasing health hazards and environmental pollution...
February 20, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/28219316/from-disorder-to-mis-order-structural-aspects-of-pathogenic-oligomerization-in-conformational-diseases
#19
Chin Pang Benny Yiu, Yu Wai Chen
Proteins implicated in neurological conformational diseases contain substantial amounts of "intrinsic disorder". These native monomeric functional states may transit into some oligomeric states that have high β-sheet contents and seed the formation of insoluble amyloid fibrils. The prevailing view is that these "toxic" oligomers should be targeted for drug development. Here, an overview of the diseases was presented, within the general framework of the oligomerization of intrinsically disordered proteins. These systems pose some specific challenges to structural studies: the toxic oligomers are transient, low in concentration, and often need to be studied in a heterogeneous environment...
February 20, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28218487/radiolabelled-polymeric-materials-for-imaging-and-treatment-of-cancer-quo-vadis
#20
REVIEW
Kritee Pant, Ondřej Sedláček, Robin A Nadar, Martin Hrubý, Holger Stephan
Owing to their tunable blood circulation time and suitable plasma stability, polymer-based nanomaterials hold a great potential for designing and utilising multifunctional nanocarriers for efficient imaging and effective treatment of cancer. When tagged with appropriate radionuclides, they may allow for specific detection (diagnosis) as well as the destruction of tumours (therapy) or even customization of materials, aiming to both diagnosis and therapy (theranostic approach). This review provides an overview of recent developments of radiolabelled polymeric nanomaterials (natural and synthetic polymers) for molecular imaging of cancer, specifically, applying nuclear techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
February 20, 2017: Advanced Healthcare Materials
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