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https://www.readbyqxmd.com/read/28449418/hif-prolyl-hydroxylases-as-therapeutic-targets-in-erythropoiesis-and-iron-metabolism
#1
REVIEW
Volker H Haase
A classic response to systemic hypoxia is the increase in red blood cell production. This response is controlled by the prolyl hydroxylase domain/hypoxia-inducible factor (HIF) pathway, which regulates a broad spectrum of cellular functions. The discovery of this pathway as a key regulator of erythropoiesis has led to the development of small molecules that stimulate the production of endogenous erythropoietin and enhance iron metabolism. This review provides a concise overview of the cellular and molecular mechanisms that govern HIF-induced erythropoietic responses and provides an update on clinical experience with compounds that target HIF-prolyl hydroxylases for anemia therapy...
June 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28446869/fnirs-studies-on-hemispheric-asymmetry-in-atypical-neural-function-in-developmental-disorders
#2
REVIEW
Hirokazu Doi, Kazuyuki Shinohara
Functional lateralization is highly replicable trait of human neural system. Many previous studies have indicated the possibility that people with attention-deficits/hyperactivity-disorder (ADHD) and autism spectrum disorder (ASD) show hemispheric asymmetry in atypical neural function. However, despite the abundance of relevant studies, there is still ongoing controversy over this issue. In the present mini-review, we provide an overview of the hemispheric asymmetry in atypical neural function observed in fNIRS studies on people with these conditions...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28446827/effects-of-various-pr%C3%A4-%C3%A1-%C3%A4-y%C3%A4-ma-on-cardiovascular-and-autonomic-variables
#3
REVIEW
L Nivethitha, A Mooventhan, N K Manjunath
Cardiovascular functions are controlled by neural factors, temperature, hormones, etc., Of these, neural factors primarily concern the autonomic nervous system, which plays a major role in maintaining and regulating cardiac functions, e.g., blood pressure and heart rate. Prāṇāyāma is one of the most important yogic practices. There are various review articles on Yoga and its effects but, though Prāṇāyāma is a part of yoga, there is lack of review articles. To the best of our knowledge there is no known review article on effect of various Prāṇāyāma on cardiovascular and autonomic variables...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28445233/preclinical-models-for-translational-sarcoma-research
#4
Rainer Hamacher, Sebastian Bauer
PURPOSE OF REVIEW: Sarcoma is a basket term for mesenchymal tumors for which more than 75 genetically and histologically distinct subtypes are recognized. Therapeutic progress has largely been achieved with classical chemotherapeutic drugs that were tested in empirical clinical trials. However, outcome in metastatic patients remains poor and with few exceptions numerous trials have failed or only provided limited improvement in recent years. RECENT FINDINGS: Given the genomic heterogeneity, preclinical model systems will be indispensable to identify new molecular targets and to prioritize drugs and drug combinations...
April 25, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28443096/the-microbiota-and-epigenetic-regulation-of-t-helper-17-regulatory-t-cells-in-search-of-a-balanced-immune-system
#5
REVIEW
Annie Luo, Steven T Leach, Romain Barres, Luke B Hesson, Michael C Grimm, David Simar
Immune cells not only affect tissue homeostasis at the site of inflammation but also exert systemic effects contributing to multiple chronic conditions. Recent evidence clearly supports an altered T helper 17/regulatory T cell (Th17/Treg) balance leading to the development and progression of inflammatory diseases that not only affect the gastrointestinal tract but also have whole-body manifestations, including insulin resistance. Epigenetic mechanisms are amenable to both environmental and circulating factors and contribute to determining the T cell landscape...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28442454/impact-of-information-and-communication-technologies-on-nursing-care-results-of-an-overview-of-systematic-reviews
#6
Geneviève Rouleau, Marie-Pierre Gagnon, José Côté, Julie Payne-Gagnon, Emilie Hudson, Carl-Ardy Dubois
BACKGROUND: Information and communication technologies (ICTs) are becoming an impetus for quality health care delivery by nurses. The use of ICTs by nurses can impact their practice, modifying the ways in which they plan, provide, document, and review clinical care. OBJECTIVE: An overview of systematic reviews was conducted to develop a broad picture of the dimensions and indicators of nursing care that have the potential to be influenced by the use of ICTs. METHODS: Quantitative, mixed-method, and qualitative reviews that aimed to evaluate the influence of four eHealth domains (eg, management, computerized decision support systems [CDSSs], communication, and information systems) on nursing care were included...
April 25, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28442394/granin-derived-peptides
#7
REVIEW
Josef Troger, Markus Theurl, Rudolf Kirchmair, Teresa Pasqua, Bruno Tota, Tommaso Angelone, Maria C Cerra, Yvonne Nowosielski, Raphaela Mätzler, Jasmin Troger, Jaur R Gayen, Vance Trudeau, Angelo Corti, Karen B Helle
The granin family comprises altogether 7 different proteins originating from the diffuse neuroendocrine system and elements of the central and peripheral nervous systems. The family is dominated by three uniquely acidic members, namely chromogranin A (CgA), chromogranin B (CgB) and secretogranin II (SgII). Since the late 1980ies it has become evident that these proteins are proteolytically processed, intragranularly and/or extracellularly into a range of biologically active peptides; a number of them with regulatory properties of physiological and/or pathophysiological significance...
April 22, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28441776/gold-nanoparticles-for-modulating-neuronal-behavior
#8
REVIEW
Chiara Paviolo, Paul R Stoddart
Understanding the detailed functioning and pathophysiology of the brain and the nervous system continues to challenge the scientific community, particularly in terms of scaling up techniques for monitoring and interfacing with complex 3D networks. Nanotechnology has the potential to support this scaling up, where the eventual goal would be to address individual nerve cells within functional units of both the central and peripheral nervous system. Gold nanoparticles provide a variety of physical and chemical properties that have attracted attention as a light-activated nanoscale neuronal interface...
April 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28441773/overview-of-four-functional-classification-systems-commonly-used-in-cerebral-palsy
#9
REVIEW
Andrea Paulson, Jilda Vargus-Adams
Cerebral palsy (CP) is the most common physical disability in childhood. CP comprises a heterogeneous group of disorders that can result in spasticity, dystonia, muscle contractures, weakness and coordination difficulty that ultimately affects the ability to control movements. Traditionally, CP has been classified using a combination of the motor type and the topographical distribution, as well as subjective severity level. Imprecise terms such as these tell very little about what a person is able to do functionally and can impair clear communication between providers...
April 24, 2017: Children
https://www.readbyqxmd.com/read/28440839/refugee-health-and-rehabilitation-challenges-and-response
#10
Fary Khan, Bhasker Amatya
BACKGROUND: The current global refugee crisis poses major challenges in providing effective healthcare to refugees, particularly for non-communicable diseases (NCDs) management and disability. This article provides an overview of refugee health and potential challenges from the rehabilitation perspective. METHODS: A literature search (both academic and grey literature) was conducted using medical and health science electronic databases and internet search engines (2001-2016)...
April 21, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28440673/mechanisms-of-craniofacial-pain
#11
Juliana Geremias Chichorro, Frank Porreca, Barry Sessle
Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight peripheral and central adaptations that may promote chronification of pain in craniofacial pain states such as migraine and temporomandibular disorders (TMD). Background Pain is a common symptom associated with disorders involving craniofacial tissues including the teeth and their supporting structures, the temporomandibular joint and the muscles of the head. Most acute painful craniofacial conditions are easily recognized and well managed, but others, especially those that are chronic (e...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28440188/trp-channels-as-novel-targets-for-endogenous-ligands-focus-on-endocannabinoids-and-nociceptive-signalling
#12
Maksim V Storozhuk, Alexander V Zholos
The endocannabinoid system is gaining steadily increasing research interest as its important role in the regulation of many fundamental physiological processes becomes more and more evident. One area which received particularly significant attention concerns targeting the endocannabinoid system as a useful strategy in pain control, especially in refractory, difficult to treat cases of chronic pain. Apart from the classical targets of cannabinoids, the CB1 and CB2 receptors, several members of the large TRP family of Ca2+-permeable cation channels have been designated as "ionotropic cannabinoid receptors" to highlight their role in cannabinoid signalling...
April 24, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28439959/chemical-and-biological-aspects-of-nutritional-immunity-perspectives-for-new-anti-infectives-targeting-iron-uptake-systems
#13
Sabine Laschat, Ursula Bilitewski, Joshua Blodgett, Anne-Kathrin Duhme-Klair, Sabrina Dallavalle, Anne Routledge, Rainer Schobert
Upon bacterial infection one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron leading to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, e.g. by stealing iron from the host or other bacteria by specific iron chelators with high binding affinity. Fortunately, these complex interactions between host and pathogen regarding metal homeostasis provide several opportunities for interception and thus allow the development of novel antibacterials...
April 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28439242/comprehensive-psychopathological-assessment-based-on-the-association-for-methodology-and-documentation-in-psychiatry-amdp-system-development-methodological-foundation-application-in-clinical-routine-and-research
#14
REVIEW
Rolf-Dieter Stieglitz, Achim Haug, Erdmann Fähndrich, Michael Rösler, Wolfgang Trabert
The documentation of psychopathology is core to the clinical practice of the psychiatrist and clinical psychologist. However, both in initial as well as further training and specialization in their fields, this particular aspect of their work receives scanty attention only. Yet, for the past 50 years, the Association for Methodology and Documentation in Psychiatry (AMDP) System has been in existence and available as a tool to serve precisely the purpose of offering a systematic introduction to the terminology and documentation of psychopathology...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28438806/emerging-affinity-based-proteomic-technologies-for-large-scale-plasma-profiling-in-cardiovascular-disease
#15
REVIEW
J Gustav Smith, Robert E Gerszten
Plasma biomarkers that reflect molecular states of the cardiovascular system are central for clinical decision making. Routinely used plasma biomarkers include troponins, natriuretic peptides, and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to cardiovascular disease. Systematic profiling of a larger portion of circulating plasma proteins (the plasma proteome) will provide opportunities for unbiased discovery of novel markers to improve diagnostic or predictive accuracy. In addition, proteomic profiling may inform pathophysiological understanding and point to novel therapeutic targets...
April 25, 2017: Circulation
https://www.readbyqxmd.com/read/28438785/nuclear-receptor-research-in-zebrafish
#16
Marcel J M Schaaf
Nuclear receptors (NRs) form a superfamily of transcription factors that can be activated by ligands and are involved in a wide range of physiological processes. NRs are well conserved between vertebrate species. The zebrafish, an increasingly popular animal model system, contains a total of 73 NR genes, and orthologues of almost all human NRs are present. In this review article, an overview is presented of NR research in which the zebrafish has been used as a model. Research is described on the three most studied zebrafish NRs: the Estrogen Receptors (ERs), Retinoic Acid Receptors (RARs) and Peroxisome Proliferator-Activated Receptors (PPARs)...
April 24, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28438669/the-effects-of-chinese-medicines-on-camp-pka-signaling-pathway-in-central-nervous-system-dysfunction
#17
REVIEW
Lin Li, Xiang Fan, Xi-Ting Zhang, Shao-Qian Yue, Zuo-Yan Sun, Jin-Qiang Zhu, Jun-Hua Zhang, Xiu-Mei Gao, Han Zhang
Neuropathological injury in adult mammal central nervous system (CNS) may cause axon disruption, neuronal death and produce lasting neurological deficits. Failure of axon regeneration is one of the major challenges for CNS function recovery. Recently, cAMP/PKA signaling pathway has been proven to be a critical regulator for neuronal regeneration, neuroplasticity and learning and memory ability. And previous studies have revealed the effects of Chinese medicines on prevention and treatment of CNS dysfunction medicated by cAMP/PKA signaling pathway partially...
April 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28438491/immunomodulatory-functions-of-neuronal-guidance-proteins
#18
REVIEW
Valbona Mirakaj, Peter Rosenberger
Neuronal guidance proteins (NGPs) were originally identified for their role during the embryonic development of the nervous system. Recent years have seen the discovery of NGP functions during immune responses. In this context, NGPs were demonstrated to control leukocyte migration and the release of cytokines during conditions of acute inflammation, such as lung injury or sepsis. However, NGPs also display potent actions in the resolution of inflammation, chronic inflammatory conditions, the development of atherosclerosis, and during ischemia followed by reperfusion...
April 21, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28438231/health-technology-assessment-in-evaluation-of-pharmaceuticals-in-the-czech-republic
#19
Lenka Vostalová, Jana Mazelová, Jiří Samek, Milan Vocelka
OBJECTIVES: In the Czech Republic, the health technology assessment (HTA) approaches have been implemented in evaluation of medicinal products since 2008. The aim of this study was to provide an overview of the implementation of HTA and different levels thereof in the evaluation process conducted by the State Institute for Drug Control (SUKL) and to describe the impact of HTA on the entrance of new medicinal entities into out-patient healthcare system including highly innovative and orphan drugs...
April 25, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28436837/passive-bci-in-operational-environments-insights-recent-advances-and-future-trends
#20
Pietro Arico, Gianluca Borghini, Gianluca Di Flumeri, Nicolina Sciaraffa, Alfredo Colosimo, Fabio Babiloni
OBJECTIVE: this mini-review aims to highlight recent important aspects to consider and evaluate when passive Brain-Computer Interface (pBCI) systems would be developed and used in operational environments, and remarks future directions of their applications. METHODS: Electroencephalography (EEG)-based pBCI has become an important tool for real-time analysis of brain activity, since it could potentially provide, covertly - without distracting the user from the main task - and objectively - not affected by the subjective judgement of an observer or the user itself - information about the operator cognitive state...
April 17, 2017: IEEE Transactions on Bio-medical Engineering
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