keyword
https://read.qxmd.com/read/38517790/association-of-cancer-history-with-lifetime-risk-of-dementia-and-alzheimer-s-disease
#21
JOURNAL ARTICLE
Yaqi Li, Xinming Xu, Peilu Wang, Xiqun Chen, Qishan Yang, Liang Sun, Xiang Gao
BACKGROUND: The literature presents conflicting results regarding the potential protective effect of prevalent cancer on the development of dementia and Alzheimer's disease (AD). OBJECTIVE: Association between cancer and subsequent risk of dementia and/or AD was reported previously, but survival bias has been of concern. Here, we aimed to calculate the lifetime risk of dementia and AD and evaluate the association of cancer history with these two conditions. METHODS: In this retrospective analysis, we included 292,654 participants aged 60+ y during the follow-up and free of dementia at baseline, within the UK Biobank cohort...
March 22, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38517001/using-drosophila-amyloid-toxicity-models-to-study-alzheimer-s-disease
#22
REVIEW
Elli Tsintzas, Teresa Niccoli
Alzheimer's disease (AD) is the most prevalent form of dementia and is characterised by a progressive loss of neurons, which manifests as gradual memory decline, followed by cognitive loss. Despite the significant progress in identifying novel biomarkers and understanding the prodromal pathology and symptomatology, AD remains a significant unmet clinical need. Lecanemab and aducanumab, the only Food and Drug Administration approved drugs to exhibit some disease-modifying clinical efficacy, target Aβ amyloid, underscoring the importance of this protein in disease aetiology...
March 22, 2024: Annals of Human Genetics
https://read.qxmd.com/read/38515016/sarcopenia-in-subjects-with-alzheimer-s-disease-prevalence-and-comparison-of-agreement-between-egwsop1-egwsop2-and-fnih-criteria
#23
JOURNAL ARTICLE
Roberta Barone, Giulia Bramato, Valentina Gnoni, Alessia Giugno, Daniele Urso, Chiara Zecca, Salvatore Nigro, Marco Filardi, Giancarlo Logroscino
BACKGROUND: Sarcopenia is an age-related clinical syndrome characterized by the progressive loss of muscle mass and muscle strength. It appears to be closely linked to dementia, particularly Alzheimer's disease (AD); however, its prevalence among AD patients remains unclear. In this study, we assessed differences in sarcopenia prevalence between non-demented individuals and AD patients. Moreover, we assessed sex-specific differences in sarcopenia prevalence and explored the diagnostic value of the Muscle Quality Index (MQI) for diagnosing sarcopenia among AD patients...
March 22, 2024: BMC Geriatrics
https://read.qxmd.com/read/38512820/mutations-in-human-prion-like-domains-pathogenic-but-not-always-amyloidogenic
#24
REVIEW
Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are multifunctional proteins with integral roles in RNA metabolism and the regulation of alternative splicing. These proteins typically contain prion-like domains of low complexity (PrLDs or LCDs) that govern their assembly into either functional or pathological amyloid fibrils. To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD)...
December 2024: Prion
https://read.qxmd.com/read/38511196/anosognosia-is-associated-with-increased-prevalence-and-faster-development-of-neuropsychiatric-symptoms-in-mild-cognitive-impairment
#25
JOURNAL ARTICLE
Sharon Wang, Kayden Mimmack, Federica Cacciamani, Michael Elnemais Fawzy, Catherine Munro, Jennifer Gatchel, Gad A Marshall, Geoffroy Gagliardi, Patrizia Vannini
INTRODUCTION: Both the loss of awareness for cognitive decline (a. k.a anosognosia) and neuropsychiatric symptoms (NPS) are common in patients with Alzheimer's disease (AD) dementia, even in prodromal stages, and may exacerbate functional impairment and negatively impact caregiver burden. Despite the high impact of these symptoms on patients and their caregivers, our knowledge of how they develop across the AD spectrum is limited. Here, we explored the cross-sectional and longitudinal associations between anosognosia and NPS in individuals with mild cognitive impairment (MCI)...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38510617/the-spectrum-of-acute-and-chronic-consequences-of-neurotrauma-in-professional-and-amateur-boxing-a-call-to-action-is-advocated-to-better-understand-and-prevent-this-phenomenon
#26
REVIEW
Michele Da Broi, Abdullah Al Awadhi, Philippe Voruz, Aria Nouri, Karl Schaller
INTRODUCTION: Despite changes in regulations, boxing-related injuries and fatalities are still occurring. The numbers available in the literature regarding mortality and long-term consequences may not accurately represent the actual situation. Indeed, the real extent of this phenomenon remains poorly known. RESEARCH QUESTION: Delineating the spectrum of acute and chronic consequences of boxing-related traumatic brain injuries (TBI). MATERIAL AND METHODS: Narrative review of the literature concerning acute and chronic boxing-related TBI...
2024: Brain Spine
https://read.qxmd.com/read/38509587/ultrasensitive-and-multiple-biomarker-discrimination-for-alzheimer-s-disease-via-plasmonic-microfluidic-sensing-technologies
#27
JOURNAL ARTICLE
Lijiao Zu, Xicheng Wang, Peng Liu, Jiwei Xie, Xuejun Zhang, Weiru Liu, Zhencheng Li, Shiqing Zhang, Kaiwei Li, Ambra Giannetti, Wei Bi, Francesco Chiavaioli, Lei Shi, Tuan Guo
As the population ages, the worldwide prevalence of Alzheimer's disease (AD) as the most common dementia in the elderly is increasing dramatically. However, a long-term challenge is to achieve rapid and accurate early diagnosis of AD by detecting hallmarks such as amyloid beta (Aβ42 ). Here, a multi-channel microfluidic-based plasmonic fiber-optic biosensing platform is established for simultaneous detection and differentiation of multiple AD biomarkers. The platform is based on a gold-coated, highly-tilted fiber Bragg grating (TFBG) and a custom-developed microfluidics...
March 20, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38509130/performance-of-probable-dementia-classification-in-a-european-multi-country-survey
#28
JOURNAL ARTICLE
Matthias Klee, Kenneth M Langa, Anja K Leist
Feasibility constraints limit availability of validated cognitive assessments in observational studies. Algorithm-based identification of 'probable dementia' is thus needed, but no algorithm developed so far has been applied in the European context. The present study sought to explore the usefulness of the Langa-Weir (LW) algorithm to detect 'probable dementia' while accounting for country-level variation in prevalence and potential underreporting of dementia. Data from 56 622 respondents of the Survey of Health, Ageing and Retirement in Europe (SHARE, 2017) aged 60 years and older with non-missing data were analyzed...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38507621/listening-effort-an-overview-of-app-validation-and-testing-by-the-audiology-4-all-project
#29
JOURNAL ARTICLE
Luísa Passadouro, Carla Matos Silva, Cláudia Dos Reis, Cristina Nazaré, Sergio Paulo, Margarida Serrano
OBJECTIVE: To describe an application's development and validation process that aims to track hearing difficulties in adverse environments (a listening effort application). DESIGN: 71 subjects were evaluated, divided into two groups: 30 subjects aged between 18 and 30, and 41 subjects aged between 40 and 65. All subjects had European Portuguese as their native language; the Montreal Cognitive Assessment (MOCA) scored above 24, and all could read and write. All subjects performed the intelligibility test in noise and the test of listening effort...
March 18, 2024: International Tinnitus Journal
https://read.qxmd.com/read/38507290/emotion-regulation-coping-strategies-and-hazardous-drinking-among-family-caregivers-of-people-with-alzheimer-s-disease-and-related-dementias
#30
JOURNAL ARTICLE
Jessica Andrea Hernandez Chilatra, Wesley R Browning, Mustafa Yildiz, Tami P Sullivan, Carolyn E Pickering
PURPOSE: The current study investigated hazardous drinking and alcohol use disorders among 453 family caregivers of individuals living with Alzheimer's disease and related dementias (ADRD). METHOD: We examined the prevalence of hazardous drinking and its relationship with emotion regulation and coping strategies (problem-solving, social support, and avoidance) using data from the first wave of a longitudinal study on daily ADRD caregiving experiences. A binary logistic regression model was performed to predict the relationship between potential risk factors and hazardous drinking...
2024: Research in Gerontological Nursing
https://read.qxmd.com/read/38504433/bibliometric-insights-into-the-evolution-of-atrial-fibrillation-and-dementia-research-2002-2022
#31
JOURNAL ARTICLE
Yu Zhao, Dianbo Wang
BACKGROUND In response to the escalating prevalence of atrial fibrillation (AF) and its potential correlation with cognitive impairment and dementia, we conducted a comprehensive bibliometric analysis to assess current research trends, contributors, and collaborative networks in this evolving interdisciplinary field. MATERIAL AND METHODS Articles published between 2002 and 2022 were extracted from the Web of Science database and carefully screened, yielding 328 publications. Two reviewers independently conducted the screening and quality appraisal...
March 9, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38503405/migraine-is-a-risk-factor-for-pseudophakic-positive-dysphotopsia-following-monofocal-lens-implantation
#32
JOURNAL ARTICLE
Maggie J Xing, Thiago A Moulin, Tara Suresh, Joseph P Gira, Arsham Sheybani, Gregory P Van Stavern
OBJECTIVE: To identify neuroadaptation-related risk factors for persistent positive dysphotopsia (>6 months) following monofocal lens implantation. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients of an academic institution and a private practice in Saint Louis, Missouri. Inclusion criteria were adults with cataract extraction between January 2010 and April 2021 with monofocal intraocular lens implantation. Exclusion criteria included dementia, <20/40 acuity, visual pathway damage, visual field loss, and significant pathology causing photopsia...
March 16, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38500778/the-power-of-representation-statistical-analysis-of-diversity-in-us-alzheimer-s-disease-genetics-data
#33
JOURNAL ARTICLE
Diane Xue, Elizabeth E Blue, Matthew P Conomos, Alison E Fohner
INTRODUCTION: Alzheimer's disease (AD) is a complex disease influenced by genetics and environment. More than 75 susceptibility loci have been linked to late-onset AD, but most of these loci were discovered in genome-wide association studies (GWAS) exclusive to non-Hispanic White individuals. There are wide disparities in AD risk across racially stratified groups, and while these disparities are not due to genetic differences, underrepresentation in genetic research can further exacerbate and contribute to their persistence...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38499365/sleep-disturbance-in-people-living-with-dementia-or-mild-cognitive-impairment-a-realist-review-of-general-practice
#34
JOURNAL ARTICLE
Aidin Aryankhesal, Jessica Blake, Geoff Wong, Molly Megson, Simon Briscoe, Louise Allan, Niall M Broomfield, Zenahrai Eastwood, Leanne Greene, Andrea Hilton, Anne Killett, Alpar S Lazar, Rachael Litherland, Gill Livingston, Ian Maidment, Joanne Reeve, George Rook, Sion Scott, Jinpil Um, Jayden van Horik, Chris Fox
BACKGROUND: Sleep disturbance is a prevalent condition among people living with dementia (PLwD) or mild cognitive impairment (MCI). Its assessment and management within primary care is complex because of the comorbidities, older age, and cognitive impairment typical of this patient group. AIM: To explore how primary care clinicians assess, understand, and manage sleep disturbance for PLwD or MCI; if and why such initiatives work; and how people and their carers experience sleep disturbance and its treatment...
March 18, 2024: British Journal of General Practice
https://read.qxmd.com/read/38497236/delirium-is-more-common-and-associated-with-worse-outcomes-in-parkinson-s-disease-compared-to-older-adult-controls-results-of-two-prospective-longitudinal-cohort-studies
#35
JOURNAL ARTICLE
Florence Gerakios, Alison J Yarnall, Gemma Bate, Laura Wright, Daniel Davis, Blossom C M Stephan, Louise Robinson, Carol Brayne, Glenn Stebbins, John-Paul Taylor, David J Burn, Louise M Allan, Sarah J Richardson, Rachael A Lawson
BACKGROUND: Inpatient prevalence of Parkinson's disease (PD) delirium varies widely across the literature. Delirium in general older populations is associated with adverse outcomes, such as increased mortality, dementia, and institutionalisation. However, to date there are no comprehensive prospective studies in PD delirium. This study aimed to determine delirium prevalence in hospitalised PD participants and the association with adverse outcomes, compared to a control group of older adults without PD...
March 1, 2024: Age and Ageing
https://read.qxmd.com/read/38497228/validation-of-the-kimberley-cognitive-assessment-kica-cog-for-torres-strait-islander-peoples
#36
JOURNAL ARTICLE
Sarah G Russell, Rachel Quigley, Fintan Thompson, Betty Sagigi, Gavin Miller, Dina LoGiudice, Kate Smith, Leon Flicker, Nancy A Pachana, Sarah Kordick, Edward Strivens
OBJECTIVES: The aim of this study was to validate the Kimberley Indigenous Cognitive Assessment-Cognitive Component (KICA-Cog) adapted for dementia screening in Torres Strait Islander Peoples. METHODS: Data were obtained from a broader dementia prevalence study completed in the Torres Strait and Northern Peninsula Area between 2015 and 2018. Modifications were made to items from the original KICA-Cog to ensure they were culturally appropriate for the Torres Strait...
March 18, 2024: Australasian Journal on Ageing
https://read.qxmd.com/read/38494925/dementia-and-mild-cognitive-impairment-screening-in-an-emergency-homeless-shelter
#37
JOURNAL ARTICLE
Heather M Ross, Primrose Dzenga, Martha Myers, Alisa Squires, Stephanie Duncan, Jamilyn Caradine, Phillip Scharf, Diana M Bowman
INTRODUCTION: Older adults represent the fastest growing segment of the homeless community. Little is known about the prevalence of dementia and mild cognitive impairment (MCI) in this population. METHODS: Dementia and MCI screening using the Montreal Cognitive Assessment (MoCA) was incorporated into the standard senior evaluation for adult clients aged ≥ 55 in a large emergency homeless shelter. RESULTS: In a 6-week period, 104 of 112 (92...
March 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38493795/global-regional-and-national-burden-of-disorders-affecting-the-nervous-system-1990-2021-a-systematic-analysis-for-the-global-burden-of-disease-study-2021
#38
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage...
March 5, 2024: Lancet Neurology
https://read.qxmd.com/read/38491173/prognostic-factors-of-renal-cell-cancer-in-elderly-patients-a-population-based-cohort-study
#39
JOURNAL ARTICLE
Heini Pajunen, Thea Veitonmäki, Heini Huhtala, Jussi Nikkola, Antti Pöyhönen, Teemu Murtola
Mortality in renal cell cancer (RCC) is high in the elderly population. Comorbidities have a greater impact on overall prognosis of RCC among elderly patients than in younger patients. All new RCC cases were collected in people over 74 years of age between 1995 and 2018 from the Finnish cancer registry. The comorbidities were identified from the Care Registry for Healthcare. Charlson Comorbidity Index (CCI) was used to evaluate the risk of death based on comorbidities. The overall risk of death was analyzed using the Cox regression model...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38489188/neural-computation-based-methods-for-the-early-diagnosis-and-prognosis-of-alzheimer-s-disease-not-using-neuroimaging-biomarkers-a-systematic-review
#40
Ylermi Cabrera-León, Patricio García Báez, Pablo Fernández-López, Carmen Paz Suárez-Araujo
BACKGROUND: The growing number of older adults in recent decades has led to more prevalent geriatric diseases, such as strokes and dementia. Therefore, Alzheimer's disease (AD), as the most common type of dementia, has become more frequent too. BACKGROUND: Objective: The goals of this work are to present state-of-the-art studies focused on the automatic diagnosis and prognosis of AD and its early stages, mainly mild cognitive impairment, and predicting how the research on this topic may change in the future...
March 10, 2024: Journal of Alzheimer's Disease: JAD
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